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Otify, A. M., A. M. El-Sayed, C. G. Michel, and M. A. Farag, "Metabolites profiling of date palm (Phoenix dactylifera L.) commercial by-products (pits and pollen) in relation to its antioxidant effect: a multiplex approach of MS and NMR metabolomics.", Metabolomics : Official journal of the Metabolomic Society, vol. 15, issue 9, pp. 119, 2019. Abstract

INTRODUCTION: Phoenix dactylifera L. (date palm) is one of the most valued crops worldwide for its economical and nutraceutical applications of its date fruit (pericarp). Currently date pits, considered as a waste product, is employed as coffee substitute post roasting. Whereas, pollen represents another valuable by-product used as a dietary supplement.

OBJECTIVES: In this study, a large-scale comparative metabolomics approach was performed for the first characterization and standardization of date palm by-products viz., date pits and pollen. Moreover, roasting impact on date pit metabolite composition was also assessed.

METHODS: Metabolites profiling of pits and pollen was determined via a multiplex approach of UPLC-MS and NMR, coupled to multivariate analysis, in relation to its antioxidant activities.

RESULTS: Chemical analyses led to the identification of 67 metabolites viz., phenolic acids, flavonols, fatty acids, sphingolipids, steroids and saponins of which 10 are first time to be reported. The enrichment of steroids in date pollen accounts for its fertility promoting properties, whereas date pit was found a rich source for antioxidant polyphenols using metabolomics.

Otify, A. M., A. M. El-Sayed, C. G. Michel, and M. A. Farag, "Metabolites profiling of date palm (Phoenix dactylifera L.) commercial by-products (pits and pollen) in relation to its antioxidant effect: a multiplex approach of MS and NMR metabolomics.", Metabolomics : Official journal of the Metabolomic Society, vol. 15, issue 9, pp. 119, 2019. Abstract

INTRODUCTION: Phoenix dactylifera L. (date palm) is one of the most valued crops worldwide for its economical and nutraceutical applications of its date fruit (pericarp). Currently date pits, considered as a waste product, is employed as coffee substitute post roasting. Whereas, pollen represents another valuable by-product used as a dietary supplement.

OBJECTIVES: In this study, a large-scale comparative metabolomics approach was performed for the first characterization and standardization of date palm by-products viz., date pits and pollen. Moreover, roasting impact on date pit metabolite composition was also assessed.

METHODS: Metabolites profiling of pits and pollen was determined via a multiplex approach of UPLC-MS and NMR, coupled to multivariate analysis, in relation to its antioxidant activities.

RESULTS: Chemical analyses led to the identification of 67 metabolites viz., phenolic acids, flavonols, fatty acids, sphingolipids, steroids and saponins of which 10 are first time to be reported. The enrichment of steroids in date pollen accounts for its fertility promoting properties, whereas date pit was found a rich source for antioxidant polyphenols using metabolomics.

Otify, A. M., A. - M. M. Hammam, and M. Aly Farag, "Phoenix dactylifera L. date tree pollen fertility effects on female rats in relation to its UPLC-MS profile via a biochemometric approach.", Steroids, vol. 173, pp. 108888, 2021. Abstract

Date palm (Phoenix dactylifera L.) is among the most ancient cultivated crops, of special value owing to its fruits high nutritive and economic benefits. Asides, date palm pollen is a high energy material that has been used traditionally used for fertility enhancement. In this study, effects of date palm pollen crude extract and its fractions viz., petroleum ether, methylene chloride, ethyl acetate and n-butanol on the female reproductive system were evaluated for the first time in relation to its metabolite fingerprint. Fertility activity was evaluated in immature female rats by assessing their FSH-, LH- and estrogen- activities. To pinpoint active hormonal agents in crude pollen extract and fractions, UPLC- MS analysis was employed for metabolites profiling, and in correlation to extract/fraction bioassays using multivariate OPLS analysis. Results revealed that both polar n-butanol and non-polar petroleum ether fractions exhibited the strongest activities; with a significant increase in FSH (25.7 mIU/ml in n-butanol group), estradiol (414.7 pg/ml in petroleum ether group) and progesterone levels (122.4 pg/ml in n-butanol group). Correlation between UPLC-MS and fraction bioassays was attempted using multivariate OPLS analysis to reveal for bioactive hits in these fractions. This study provides the first report on the fertility effect of date palm pollen in female rats and in relation to its metabolite fingerprint.

Otify, A. M., A. Serag, A. Porzel, L. A. Wessjohann, and M. A. Farag, NMR Metabolome-Based Classification of Cymbopogon Species: a Prospect for Phyto-equivalency of its Different Accessions Using Chemometric Tools, , 2022. AbstractWebsite

Cymbopogon species are widely distributed worldwide and known for their high essential oil content with potential commercial and medicinal benefits justifying for their inclusion in food and cosmetics. Most species received scant characterization regarding their full complement of bioactive constituents necessary to explain their medicinal activities. In this study, the metabolite profiles of 5 Cymbopogon species, C. citratus, C. flexuosus, C. procerus, C. martini, and C. nardus, were characterized via NMR-based metabolomics. The results of 13 shoot accessions revealed the identification and quantification of 23 primary and secondary metabolites belonging to various compound classes. Multivariate analyses were used for species classification, though found not successful in discrimination based on geographical origin. Nevertheless, C. citratus was found particularly enriched in neral, geranial, (E)-aconitic acid, isoorientin, and caffeic acid as the major characterizing metabolites compared to other species, while an unknown apigenin derivative appeared to discriminate C. martini. The high essential oil and phenolic content in C. citratus emphasizes its strong antioxidant activity, whereas (E)-aconitic acid accounts for its traditional use as insecticide. This study affords the first insight into metabolite compositional differences among Cymbopogon species. Moreover, antimicrobial, insecticidal, antidiabetic, and antioxidant compounds were identified that can be utilized as biomarkers for species authentication.

Ott, C. P., I. I. Omara, M.E. Persia, and R. A. Dalloul, "The impact of β-glucans on performance and response of broiler chickens during a coccidiosis challenge ", Poultry Science, vol. 97, issue 8, pp. 2713–2721, 2018.
Otte, J., M. Abdel-Hamid, and A. Osman, "Comparative assessment of peptide concentration in milk protein hydrolysates and fractions", International Journal of Dairy Science, vol. 10, no. 5, pp. 228-235, 2015. AbstractWebsite
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Otte, J., M. Abdel-Hamid, and A. Osman, "Comparative assessment of peptide concentration in milk protein hydrolysates and fractions", International Journal of Dairy Science, vol. 10, no. 5, pp. 228-235, 2015. AbstractWebsite
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Otte, J., M. Abdel-Hamid, and A. Osman, "Comparative assessment of peptide concentration in milk protein hydrolysates and fractions", International Journal of Dairy Science, vol. 10, no. 5: Asian Network for Scientific Information, pp. 228-235, 2015. AbstractWebsite

A comparative study using the Kjeldahl method and two colorimetric methods for the determination of total protein/peptide concentrations in a range of intact and hydrolysed milk protein was carried out. The samples were goat whey, camel whey, buffalos milk retentate and hydrolysates of these made with different enzymes as well as hydrolysate fractions. Bicinchoninic acid (BCA) and o-phthaldialdehyde (OPA) were used as coloring agents to specifically react with proteins and peptides. The results obtained with the BCA method and bovine serum albumin as standard did not correlate with the results obtained by the Kjeldahl method (r2 = 0.17). The OPA method showed better agreement with the Kjeldahl method (r2 = 0.69) and with the use of a whey protein hydrolysate as standard good estimates of the peptide contents in the hydrolysed milk protein samples was obtained compared to the results obtained with the Kjeldahl method. © 2015 Academic Journals Inc.

Otte, J., M. Abdel-Hamid, and A. Osman, "Comparative assessment of peptide concentration in milk protein hydrolysates and fractions", International Journal of Dairy Science, vol. 10, no. 5, pp. 228-235, 2015. AbstractWebsite
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Otto, E. A., G. Ramaswami, S. Janssen, M. Chaki, S. J. Allen, W. Zhou, R. Airik, T. W. Hurd, A. K. Ghosh, M. T. Wolf, et al., "Mutation Analysis of 18 Nephronophthisis Associated Ciliopathy Disease Genes using a DNA Pooling and Next Generation Sequencing Strategy", Journal of Medical Genetics, 2011. Abstract

Nephronophthisis associated ciliopathies (NPHP-AC) comprise a group of autosomal recessive cystic kidney diseases that includes nephronophthisis (NPHP), Senior-Loken syndrome (SLS),

Otto, E. A., G. Ramaswami, S. Janssen, M. Chaki, S. J. Allen, W. Zhou, R. Airik, T. W. Hurd, A. K. Ghosh, M. T. Wolf, et al., "Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy", Journal of Medical Genetics, vol. 48, issue 11, pp. 105-116, 2011.
Otu, A., M. Hashmi, A. H. M. E. D. M. MUKHTAR, A. Kwizera, S. Tiberi, B. Macrae, A. Zumla, M. W. Dünser, and M. Mer, "The critically ill patient with tuberculosis in intensive care: Clinical presentations, management and infection control.", Journal of critical care, vol. 45, pp. 184-196, 2018. Abstract

Tuberculosis (TB) is one of the top ten causes of death worldwide. In 2016, there were 490,000 cases of multi-drug resistant TB globally. Over 2 billion people have asymptomatic latent Mycobacterium tuberculosis infection. TB represents an important, but neglected management issue in patients presenting to intensive care units. Tuberculosis in intensive care settings may present as the primary diagnosis (active drug sensitive or resistant TB disease). In other patients TB may be an incidental co-morbid finding as previously undiagnosed sub-clinical or latent TB which may re-activate under conditions of stress and immunosuppression. In Sub-Saharan Africa, where co-infection with the human immunodeficiency virus and other communicable diseases is highly prevalent, TB is one of the most frequent clinical management issues in all healthcare settings. Acute respiratory failure, septic shock and multi-organ dysfunction are the most common reasons for intensive care unit admission of patients with pulmonary or extrapulmonary TB. Poor absorption of anti-TB drugs occurs in critically ill patients and worsens survival. The mortality of patients requiring intensive care is high. The majority of early TB deaths result from acute cardiorespiratory failure or septic shock. Important clinical presentations, management and infection control issues regarding TB in intensive care settings are reviewed.

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Ötünçtemur, A., S. S. {\c{C}}akır, M. Dursun, E. C. Polat, A. Somay, N. Özbay, M. {\c{C}}ekmen, E. Özbek, A. Ötünçtemur, S. S. {\c{C}}akır, et al., "Scientific Program for 30th World Congress of Endourology & SWL", Journal of Endourology, vol. 26, no. S1: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. P1–A572, 2012. Abstract
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Oualla, K., Heba M. El-Zawahry, B. Arun, H. G. El-Din, B. Lim, N. T. Ueno, N. Mellas, James M. Reuben, W. A. Woodward, and T. M. Fouad, "Novel therapeutic strategies in the treatment of triple-negative breast cancer", Therapeutic Advances in Medical Oncology, vol. 9, issue 7, pp. 493-511, 2017. novel_therapeutic_strategies_in_the_treatment_of_triple-negative_breast_cancer.pdf
Ouannas, A., A. T. Azar, T. Ziar, and A. G. Radwan, "A Study on Coexistence of Different Types of Synchronization Between Different Dimensional Fractional Chaotic Systems", Fractional Order Control and Synchronization of Chaotic Systems: Springer International Publishing, pp. 637–669, 2017. Abstract
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Ouannas, A., G. Grassi, A. T. Azar, A. G. Radwan, C. Volos, V. - T. Pham, T. Ziar, I. M. Kyprianidis, and I. N. Stouboulos, "Dead-beat synchronization control in discrete-time chaotic systems", Modern Circuits and Systems Technologies (MOCAST), 2017 6th International Conference on: IEEE, pp. 1–4, 2017. Abstract
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Ouannas, A., A. T. Azar, and A. G. Radwan, "On inverse problem of generalized synchronization between different dimensional integer-order and fractional-order chaotic systems", Microelectronics (ICM), 2016 28th International Conference on: IEEE, pp. 193–196, 2016. Abstract
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Ouannas, A., A. T. Azar, T. Ziar, and A. G. Radwan, "A Study on Coexistence of Different Types of Synchronization Between Different Dimensional Fractional Chaotic Systems", Fractional Order Control and Synchronization of Chaotic Systems: Springer, Cham, pp. 637–669, 2017. Abstract
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Ouannas, A., A. T. Azar, T. Ziar, and A. G. Radwan, "Generalized Synchronization of Different Dimensional Integer-Order and Fractional Order Chaotic Systems", Fractional Order Control and Synchronization of Chaotic Systems: Springer International Publishing, pp. 671–697, 2017. Abstract
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Ouannas, A., A. T. Azar, and A. G. Radwan, "On inverse problem of generalized synchronization between different dimensional integer-order and fractional-order chaotic systems", Microelectronics (ICM), 2016 28th International Conference on: IEEE, pp. 193–196, 2016. Abstract
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Ouannas, A., A. T. Azar, T. Ziar, and A. G. Radwan, "Generalized Synchronization of Different Dimensional Integer-Order and Fractional Order Chaotic Systems", Fractional Order Control and Synchronization of Chaotic Systems: Springer, Cham, pp. 671–697, 2017. Abstract
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Ouda, B. K., B. M. Tawfik, A. - B. M. Youssef, and Y. M. Kadah, "Adaptive denoising technique for robust analysis of functional magnetic resonance imaging data", Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 3, 2001. Abstract
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Ouda, B. K., N. S. K. Saleh, and A. S. A. Mohamed, "The Effect of Useful Life and Vendor Performance on Replacement Decision of Medical Equipment", 2012 Cairo International Biomedical Engineering Conference (CIBEC 2012): IEEE, pp. 114–117, 2012. Abstract
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Ouda, O., E. AbdelMaksoud, A. A. Abd El-Aziz, and M. Elmogy, "Multiple Ocular Disease Diagnosis Using Fundus Images Based on Multi-Label Deep Learning Classification", Electronics, vol. 11, no. 13, pp. 1–27, 2022. Abstract
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