Publications

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Othman, M. A., S. A. Mazen, and E. Ezzat, "A Proposed Framework for Managing Technical People in Software Projects", IOSR Journal of Computer Engineering, vol. 16, issue 4, pp. PP 56-61, 2014.
Othman, M., H. Hassan, R. Moawad, and A. M. Idrees, "A Linguistic Approach for Opinionated Documents Summary", Future Computing and Informatics Journal, vol. In Press, Corrected Proof, Available online 11 November 2017, 2017.
Othman, A. S., M. S. El-Tamawy, H. Amer, N. A. Kishk, A. M. Nawito, E. Shaker, M. A. Basheer, N. Alieldin, and R. Magdy, "Characteristics and outcome in an Egyptian Cohort with status epilepticus", Acta Neurologica Scandinavica, vol. 144, issue 4, pp. 375-382, 2021.
Othman, E., K. Shaalan, and A. Rafea, "Towards resolving ambiguity in understanding Arabic sentence", International Conference on Arabic Language Resources and Tools, Cairo, Egypt, NEMLAR, pp. 118–122, sep, 2004. Abstractambiguity_resol_nemlar.pdf

Ambiguity is a major reason why computers do not yet understand natural language. We have made great deal strides towards developing tools for morphological and syntactic analyzers for Arabic in recent years. The absence of diacritics, which represent most vowels, in the written text creates ambiguity which hinders the development of Arabic natural language processing applications. Thus, ambiguity increases the range of possible interpretations of natural language. In this paper, we give a road map of solutions to common ambiguity problems inherent in parsing of Arabic sentence.

Othman, A. I., "Histopathological and histochemical studies on hepatotoxicity induced by aluminium. ", Egyp. J. Zool.,, vol. 45, pp. 303-314, 2005.
Othman, A. A., G. Haig, H. Florian, C. Locke, L. Gertsik, and S. Dutta, "The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.", British journal of clinical pharmacology, vol. 77, issue 6, pp. 965-74, 2014 Jun. AbstractWebsite

AIMS: ABT-288 is a potent and selective H3 receptor antagonist with procognitive effects in several preclinical models. In previous studies, 3 mg once daily was the maximal tolerated dose in healthy volunteers. This study characterized the safety, tolerability and pharmacokinetics of ABT-288 in stable subjects with schizophrenia.

METHODS: This was a randomized, double-blind, placebo-controlled, dose-escalating study of ABT-288 (10 dose levels, from 1 to 60 mg once daily for 14 days) in stable subjects with schizophrenia treated with an atypical antipsychotic. In each dose group, five to seven and two to three participants were assigned to ABT-288 and placebo, respectively.

RESULTS: Of the 67 participants enrolled, nine participants (on ABT-288) were prematurely discontinued, in seven of these due to adverse events. ABT-288 was generally safe and tolerated at doses up to 45 mg once daily. The most common adverse events, in decreasing frequency (from 31 to 5%), were abnormal dreams, headache, insomnia, dizziness, somnolence, dysgeusia, dry mouth, psychotic disorder, parosmia and tachycardia. Adverse events causing early termination were psychotic events (four) and increased creatine phosphokinase, pyrexia and insomnia (one each). The half-life of ABT-288 ranged from 28 to 51 h, and steady state was achieved by day 12 of dosing. At comparable multiple doses, ABT-288 exposure in subjects with schizophrenia was 45% lower than that previously observed in healthy subjects. At trough, ABT-288 cerebrospinal fluid concentrations were 40% of the total plasma concentrations.

CONCLUSIONS: ABT-288 was tolerated at a 15-fold higher dose and 12-fold higher exposures in subjects with schizophrenia than previously observed in healthy volunteers. The greater ABT-288 tolerability was not due to limited brain uptake.

Othman, A. A., W. M. Amer, M. Fayez, M. Monib, and N. A. Hegazi, "Biodiversity of diazotrophs associated to the plant cover of north Sinai deserts", Archives of Agronomy and Soil Science, vol. 49, pp. 683-705, 2003.
Othman, N. - A., O. - G. Shaker, H. - M. Elshenawy, W. Abd-Elmoniem, A. - M. Eldin, and M. - Y. Fakhr, "The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients", journal of clinical and experimental dentistry, vol. 8, issue 5, pp. 566-570, 2016.
mohamed othman, E., Y. H. L. Mohamed, A. M. Kenawy, and R. A. Z. E. ­A. Toson, "Effect of Polarized Light on Post Burn Hypertrophic Scars", Polish Journal of Physiotherapy, 2021.
Othman, A. I., M. M. Amin, S. K. Abu-Elyazid, and G. A. Abdelbary, "Trimetazidine Dihydrochloride Pulsatile-Release Tablets for the Treatment of Morning Anginal Symptoms: Dual Optimization, Characterization and Pharmacokinetic Evaluation.", Current drug delivery, vol. 18, issue 8, pp. 1182-1196, 2021. Abstract

OBJECTIVE: This research work aimed to target the early morning peak symptoms of chronic stable angina through formulating antianginal drug, Trimetazidine (TMZ) in a pulsatile-release tablet.

METHODS: The core formulae were optimized using 22 .31 factorial design to minimize disintegration time (DT) and maximize drug release after 5 minutes (Q5min). Different ratios of Eudragit S100 and Eudragit L100 were used as a coating mixture for the selected core with or without a second coating layer of hydroxypropyl methylcellulose (HPMC E50). The different formulation variables were statistically optimized for their effect on lag time and drug release after 7 hours (Q7h) using BoxBehnken design. The optimized formula (PO) was subjected to stability study and pharmacokinetic assessment on New Zealand rabbits.

RESULTS: The optimal core (F8) was found to have 1.76 min disintegration time and 61.45% Q5min PO showed a lag time of 6.17 h with 94.80% Q7h and retained good stability over three months. The pharmacokinetics study confirmed the pulsatile-release pattern with Cmax of 206.19 ng/ml at 5.33 h (Tmax) and 95.85% relative bioavailability compared to TMZ solution.

CONCLUSION: Overall pulsatile-release tablets of TMZ successfully released the drug after a desirable lag time, providing a promising approach for early morning anginal symptoms relief.

Othman, S. H., M. S. El-Deab, T. Okajima, and T. Ohsaka, "Novel procedure for the fabrication of gold nanostructures enriched in Au (110) facet orientation", Electrochemistry Communications, vol. 11, pp. 1273-1276, 2009.
Othman, A. A., A. R. El-Beialy, S. A. Fawzy, A. H. Kandil, E. - B. A. Mohammed, and Y. A. Mostafa, "Methods for managing 3-dimensional volumes", American Journal of Orthodontics and Dentofacial Orthopedics, vol. 137, issue 2, pp. 266-273,, 2009.
OTHMAN, E. M., W. K. Abdelbasset, S. H. ELSAYED, R. S. HUSSEIN, and H. M. Mohamady, "Effect of ultrasound-enhanced bee venom on selected post inguinal hernioplasty complications: a single-blind randomized controlled trial", European Review for Medical and Pharmacological Sciences, vol. 27, 2023.
Othman, M. A., T. M. Abuelfadl, and A. M. E. Safwat, "Dual-band low-profile stripline-fed Z-antenna", Microwave and Optical Technology Letters, vol. 55, no. 2: Wiley Subscription Services, Inc., A Wiley Company, pp. 286–290, 2013. Abstract
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Othman, H. T., W. A. A. Elhamed, D. M. Hassan, M. S. Soliman, and R. A. W. Baset, "Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two", J Infect Dev Ctries, vol. 10, issue 3, pp. 283-289, 2016.
Othman, M. A., T. Abuelfadl, and A. Safwat, "Dual and Wide-Band Inductively-Loaded Dipole-Based Antennas for WLAN/UMTS Applications", IEEE Transactions on Antennas and Propagation, vol. 61, no. 3: IEEE, pp. 1430–1435, 2013. Abstract
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Othman, A. A., S. A. Syed, A. H. Newman, and N. D. Eddington, "Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse.", The Journal of pharmacology and experimental therapeutics, vol. 320, issue 1, pp. 344-53, 2007 Jan. AbstractWebsite

Recently, extensive behavioral research has been conducted on the benztropine (BZT) analogs with the goal of developing successful therapeutics for cocaine abuse. The present study was conducted to characterize the contribution of dispositional factors in mediating the behavioral differences among the chloro BZT analogs and to identify cytochrome P450 enzymes involved in their metabolism. Bidirectional transport and efflux studies of four of the chloro BZT analogs were conducted. Screening with a panel of human and rat Supersomes was performed for 4',4''-diCl BZT. In addition, pharmacokinetic and brain distribution studies for 4'-Cl and 4',4''-diCl BZT in Sprague-Dawley rats were conducted. The permeability of the chloro analogs ranged from 8.26 to 32.23 and from 1.37 to 21.65 x 10(-6) cm/s, whereas the efflux ratios ranged from 2.1 to 6.9 and from 3.3 to 28.4 across Madin-Darby canine kidney-multidrug resistance 1 (MDCK-MDR1) and Caco-2 monolayers, respectively. The P-glycoprotein (P-gp) inhibitor verapamil reduced the efflux ratios and enhanced the absorptive transport of the chloro BZT analogs. 4',4''-diCl BZT was a substrate of human CYP2D6 and 2C19 and rat 2C11 and 3A1. The brain uptake for 4'-Cl and 4',4''-diCl BZT was comparable and higher than previously reported for cocaine (brain-to-plasma partition coefficient = 4.6-4.7 versus 2.1 for cocaine). The rank order for t(1/2) was 4',4''-diCl BZT > 4'-Cl BZT > cocaine and for steady-state volume of distribution was 4'-Cl BZT > 4',4''-diCl BZT > cocaine. In conclusion, the chloro analogs differ significantly in their clearance and duration of action, which correlates to their behavioral profiles and abuse liability. Furthermore, these results suggest that the distinctive behavioral profile of these analogs is not due to limited brain exposure.

Othman, M. A., A. D. Alwakil, M. Shafee, T. M. Abuelfadl, and A. M. E. Safwat, "Novel even/odd mode-based CRLH unit cells", Microwave Symposium Digest (MTT), 2012 IEEE MTT-S International: IEEE, pp. 1–3, 2012. Abstract
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Othman, I. A. M., and N. H. Sweilam, "Electrohydrodynamic instability in a horizontal viscoelastic fluid layer in the presence of internal heat generation", Canadian journal of physics, vol. 80, no. 6: NRC Research Press, pp. 697–705, 2002. Abstract
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Othman., S. G. A., and R. B., "Comparative study between conventional and mini dental implants of different diameters supporting mandibular overdentures. A finite element stress analysis study.", Egyptian Dental Journal, vol. 64, no. 169-p4: WWW,E D A-EGYPT.ORG, pp. 1–9, 2018. Abstract
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Otify, A., C. George, A. Elsayed, and M. A. Farag, "Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics", Food & Function, vol. 6, issue 12: The Royal Society of Chemistry, pp. 3807 - 3817, 2015. AbstractWebsite

Passiflora edulis Sims F. flavicarpa along with several other plants belonging to the genus Passiflora have been reported as sedatives and for treatment or prevention of central disorders. This study evaluated the anxiolytic effect of P. edulis ethanol extract and its fractions (viz. chloroform, ethyl acetate and butanol) using the elevated plus-maze model of anxiety and assessment of [gamma]-aminobutyric acid levels. The results revealed that butanol and chloroform extracts exhibit the strongest effect followed by ethyl acetate suggesting that a combination of different classes of metabolites is likely to mediate for P. edulis anxiolytic effect in these fractions. To further pinpoint bioactive agents in fractions, ultra-performance liquid chromatography (UPLC) coupled to high resolution qTOF-MS was used for secondary metabolite profiling. A total of 65 metabolites were characterized including O-flavonoids, C-flavonoids, cyanogenic glycosides and fatty acids. Harman type alkaloids found in P. incarnata were not detected in P. edulis ethanol extract or any of its fractions suggesting that they do not mediate for its CNS modulating effects. Multivariate data analysis (PCA) was further applied to identify metabolite markers for fractions and revealed that enrichment of C-glycoside type flavonoids in chloroform/ethyl acetate fractions versus the exclusive presence of cyanogenic glycosides in its butanol fraction.