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Othman, A. A., A. R. El-Beialy, S. A. Fawzy, A. H. Kandil, A. M. El-Bialy, and Y. A. Mostafa, "Methods for managing 3-dimensional volumes", American Journal of Orthodontics and Dentofacial Orthopedics, vol. 137, no. 2: Elsevier, pp. 266–273, 2010. Abstract
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Othman, F. H., N. Afifi, A. Elmelegy, and O. A. Mostafa, "Factors Affecting Poor glycemic Control among Diabetic patients in Outpatient Clinic at Kasralainy Hospital ", The Med Journal of cairo University, vol. 84, pp. 91-197, 2016.
Othman, I. S., S. A. Eissa, M. S. Kotb, and S. H. Sadek, "S ubthreshold diode-laser micropulse photocoagulation as a primary and secondary line of treatment in management of diabetic macular edema", Clinical Ophthalmology, vol. 8, pp. 653–659, 2014.
Othman, A. A., W. M. Amer, M. Fayez, and N. A. Hegazi, "Rhizosheath of Sinai desert plants is a potential repository for associative diazotrophs", Microbiological Research, vol. 159, pp. 285-293, 2004.
Othman, I. A. M., and N. H. Sweilam, "Electrohydrodynamic instability in a horizontal viscoelastic fluid layer in the presence of internal heat generation", Canadian journal of physics, vol. 80, no. 6: NRC Research Press, pp. 697–705, 2002. Abstract
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Othman, A. M., M. E. El-Houseini, M. S. El-Sofy, and H. Y. Aboul-Enein, "Potentiometric Determination of ?-Lfucosidase Enzyme by using2-Chloro-4nitrophenol-Rhodamine Bionpair Chemical Recognition in PVC Membrane Sensor", Anal Bioanal Chem, 2011. Abstract

Abstract The activity of the ?-L-fucosidase (AFU) enzymerepresents an excellent test for diagnosis of hepatocellularcarcinoma (HCC) and fucosidosis recognized ininborn disorder of metabolism and increases the sensitivityof detection to 95.5% in patients with HCC. Therefore, thedetermination of the activity of AFU enzyme is veryimportant and can be used as a screening tool for the earlydiagnosis of tumors for HCC patients. A simple, accurate,and sensitive potentiometric method was developed formeasuring the activity of AFU. The method was based uponmeasuring the concentration of 2-chloro-4-nitrophenol

Othman, E. M., H. A. Hamada, G. I. Mohamed, G. A. AbdAllah, Z. S. Ahmed, A. M. Al-Shenqiti, and A. M. Kadry, "Clinical and histopathological responses to bee venom phonophoresis in treating venous and diabetic ulcers: a single-blind randomized controlled trial", Frontiers in Medicine, vol. 10, issue 2023, 2023.
Othman, A. A., and M. S. Abdelazim, "Ventilator-associated pneumonia in adult intensive care unit prevalence and complications", The Egyptian Journal of Critical Care Medicine, vol. 5, issue 2, pp. 61-63, 2017. vap_paper.pdf
Othman, A., M. el Tamawy, H. Amer, A. Nawito, M. Basheer, E. Shaker, and N. Kishk, "Status Epilepticus; An Egyptian Hospital-Based Prospective Study On Clinical Characteristics & Outcome Of Admission", EPILEPSIA, vol. 60: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. 247-247, 2019. Abstract

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Othman, K., and H. Abdelwahab, "Prediction of the soil compaction parameters using deep neural networks", Transportation Infrastructure Geotechnology: Springer US, pp. 1-18, 2021. Abstract
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Othman, E. M., and A. Gehan, "Effectiveness of Hyperbaric Oxygen Therapy in Treatment of Well Leg Compartment Syndrome Post Urologic Surgeries", International Journal of PharmTech Research, vol. 9, issue 12, pp. 1015-1022, 2016. Abstract

Urologic surgeries concerns the surgical treatment disorders that affect urologic pelvic structures as
cancer of the prostate, adrenal glands, bladder, kidneys, ureters, testicles, and penis1.
Compartment syndrome is a condition in which increased pressure within a limited space which
compromises the circulation and function of the tissues within that space. There are numerous causes of acute
compartment syndrome, including fractures, soft tissue trauma, and prolonged limb compression following drug
overdose, burns, and reperfusion of ischemic tissue, however the most common precipitating factor is traumatic
injury 2.
Well leg compartment syndrome (WLCS)is being increasingly recognized after urological,
gynaecologic, orthopedic or general surgical procedures with the common denominator of patient positioning in
the lithotomy or hemilithotomy position3.The lithotomy position is commonly used to access the pelvis and
perineum during urological, colorectal, and gynecologicalsurgery. Lower limb compartment syndrome is
caused by abnormal increases in intracompartmental pressures within a non-expansile fascial space and has
been recognized after prolonged elevation of the lower limbs during surgical procedures in the lithotomy
position. Commonly compartment syndrome involves ischaemia, hypoxia and oedema4. If prolonged urological
procedure is necessary patient should be monitored post operatively for early and prompt treatment of this
complication. Early diagnosis and proper treatment is the main-stay of the treatment in cases of acute
compartment syndrome following unavoidable prolonged urological procedures in lithotomy position5.
Hyperbaric oxygenation (HBO) therapy is defined as a treatment in which the patient breathes 100%
oxygen at pressures greater than atmospheric; this causes the P02 to increase in proportion to the increase in
ambient pressure. True HBO therapy only refers to the systemic delivery of oxygen via the lungs and is not
related to “topical oxygen therapy, in which only a specific body part is subjected to locally delivered oxygen
under pressure6.
A further form of conservative treatment for compartment syndrome is hyperbaric oxygenation. This
specifically reduces oedema and floods the tissues with oxygen dissolved in the extracellular fluid. This oxygen
is available to the compromised cells without the energy expenditure otherwise required for its transfer from
haemoglobin. In a series of patients with compartment syndrome who were treated with hyperbaric oxygen, that
none progressed and none required a fasciotomy7.

Othman, M. A., T. M. Abuelfadl, and A. M. E. Safwat, "Dual-band inductively-loaded miniaturized antenna", Antennas and Propagation Society International Symposium (APSURSI), 2012 IEEE: IEEE, pp. 1–2, 2012. Abstract
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Othman, A. B. M., M. H. Ismail, and M. M. S. El-Soudani, "Performance analysis of multiple-antenna cooperative networks under Weibull fading", AEU-International Journal of Electronics and Communications, vol. 66, no. 10: Urban & Fischer, pp. 817–827, 2012. Abstract
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Othman, S. H., M. S. El-Deab, and T. Ohsaka, "Superior Electrocatalytic Activity of Au (110)-like Gold Nanoparticles towards the Oxygen Evolution Reaction", International Journal of Electrochemical Science, vol. 6, pp. 6209-6219, 2011.
Othman, A. A., A. H. Newman, and N. D. Eddington, "Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling.", The Journal of pharmacology and experimental therapeutics, vol. 322, issue 2, pp. 760-9, 2007 Aug. AbstractWebsite

Previous studies indicated that the chloro-benztropine analogs differed significantly in their cocaine-like activity, which was not expected based on the similarity in their in vitro binding affinity and functional potency at the dopamine transporter (DAT). The present study was designed to extend the understanding of the involvement of both pharmacokinetic and pharmacodynamic factors in mediating the behavioral differences among these analogs. The pharmacokinetics of 3'-chloro-3alpha-(diphenylmethoxy)tropane (3'-Cl BZT), the analog showing a cocaine-like behavioral profile in rodents, was compared with previously reported pharmacokinetic characteristics of cocaine and 4',4''-dichloro-3alpha-(diphenylmethoxy)tropane (4',4''-diCl BZT), an analog totally devoid of cocaine-like actions. Microdialysis studies in rats were conducted to determine whether 3'-Cl and 4',4''-diCl BZT differed significantly in their effect on nucleus accumbens extracellular dopamine levels, with cocaine serving as a reference. A mechanistic model based on DAT association/dissociation kinetics was used to describe the time delay between the plasma concentrations of the chloro-analogs and their dopaminergic effects. 3'-Cl BZT had plasma elimination half-life of 1.9 h versus 0.5 and 21.1 h for cocaine and 4',4''-diCl BZT, respectively. 4',4''-diCl BZT increased the DA levels at a slower rate and to a significantly lower extent relative to 3'-Cl BZT that were, in turn, lower than cocaine. The duration of dopamine elevation was as follows: 4',4''-diCl BZT > 3'-Cl BZT > cocaine. The model indicated faster association and dissociation with DAT for 3'-Cl BZT relative to 4',4''-diCl BZT. The present results indicate that behavioral differences among the chloro-analogs may be explainable based on both the dopamine and rate hypotheses of drug abuse.

Othman, M. A., S. A. Mazen, and E. Ezzat, "Survey: Problems Related to Human in Software Projects", IOSR Journal of Computer Engineering (IOSR-JCE), vol. 10, no. 1, pp. 67–70, 2013. Abstract
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Othman, A. A., A. R. El-Beialy, S. A. Fawzy, A. H. Kandil, A. M. El-Bialy, and Y. A. Mostafa, "Methods for managing 3-dimensional volumes", Journal of Orthodontics and Dentofacial Orthopedics,, vol. 137, issue Elsevier, pp. 266-273, 2010.
Othman, A.I., Abdin, A.R., Amin, and A. H. Mahmoud, "A bioclimatic design approach for the urban open space design at business parks", Journal of Engineering and Applied Science, vol. 67, issue 8, pp. 1883–1901, 2020.
Othman, A. - B. M., M. H. Ismail, and M. S. El-Soudani, "Pilot-Aided Channel Estimation in Cooperative SFBC-OFDM Networks", Proc. of the 2010 International Conference on Signal and Information Processing (ICSIP 2010),, Changsha, China, December, 2010.
Othman, M. A., I. A. Eshrah, and T. M. Abuelfadl, "Analysis of waveguide discontinuities using eigenmode expansion", Microwave Symposium Digest (IMS), 2013 IEEE MTT-S International: IEEE, pp. 1–3, 2013. Abstract
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Othman, A. A., R. A. Lenz, J. Zhang, J. Li, W. M. Awni, and S. Dutta, "Single- and multiple-dose pharmacokinetics, safety, and tolerability of the selective alpha7 neuronal nicotinic receptor agonist, ABT-107, in healthy human volunteers.", Journal of clinical pharmacology, vol. 51, issue 4, pp. 512-26, 2011 Apr. AbstractWebsite

ABT-107 is a potent, selective α7 nicotinic receptor agonist under development for treatment of Alzheimer's disease and cognitive deficits associated with schizophrenia. The pharmacokinetics, safety, and tolerability of escalating single oral doses (1, 3, 10, 30, 60, 80, and 100 mg; double-blind, placebo-controlled, randomized, incomplete crossover design) and multiple oral doses (2, 6, and 15 mg once daily for 7 days; double-blind, placebo-controlled, randomized, parallel-group design) of ABT-107 were evaluated. Additionally, effect of food on ABT-107 pharmacokinetics (20-mg single dose) was evaluated using an open-label, 2-period, fasting and nonfasting, randomized, complete crossover design. ABT-107 exhibited nonlinear (more than dose-proportional) pharmacokinetics. ABT-107 half-life ranged from 7 to 10 hours, and steady state was achieved by day 6 of dosing. Food did not have a clinically meaningful effect on ABT-107 exposure. ABT-107 was safe and well tolerated over the tested dose range. The most frequently reported adverse events were nausea, headache, and tremor following single dosing and somnolence following multiple dosing. The pharmacokinetics, safety, and tolerability profiles of ABT-107 pose it as a good candidate for further development.

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