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Othman, A. - B. M., M. H. Ismail, and M. S. El-Soudani, "Pilot-Aided Channel Estimation in Cooperative SFBC-OFDM Networks", Proc. of the 2010 International Conference on Signal and Information Processing (ICSIP 2010),, Changsha, China, December, 2010.
Othman, M. A., I. A. Eshrah, and T. M. Abuelfadl, "Analysis of waveguide discontinuities using eigenmode expansion", Microwave Symposium Digest (IMS), 2013 IEEE MTT-S International: IEEE, pp. 1–3, 2013. Abstract
Othman, I. A. M., and N. H. Sweilam, "Electrohydrodynamic instability in a horizontal viscoelastic fluid layer in the presence of internal heat generation", Canadian journal of physics, vol. 80, no. 6: NRC Research Press, pp. 697–705, 2002. Abstract
Othman, S. H., M. S. El-Deab, and T. Ohsaka, "Superior Electrocatalytic Activity of Au (110)-like Gold Nanoparticles towards the Oxygen Evolution Reaction", International Journal of Electrochemical Science, vol. 6, pp. 6209-6219, 2011.
Othman, A. A., A. H. Newman, and N. D. Eddington, "Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling.", The Journal of pharmacology and experimental therapeutics, vol. 322, issue 2, pp. 760-9, 2007 Aug. AbstractWebsite

Previous studies indicated that the chloro-benztropine analogs differed significantly in their cocaine-like activity, which was not expected based on the similarity in their in vitro binding affinity and functional potency at the dopamine transporter (DAT). The present study was designed to extend the understanding of the involvement of both pharmacokinetic and pharmacodynamic factors in mediating the behavioral differences among these analogs. The pharmacokinetics of 3'-chloro-3alpha-(diphenylmethoxy)tropane (3'-Cl BZT), the analog showing a cocaine-like behavioral profile in rodents, was compared with previously reported pharmacokinetic characteristics of cocaine and 4',4''-dichloro-3alpha-(diphenylmethoxy)tropane (4',4''-diCl BZT), an analog totally devoid of cocaine-like actions. Microdialysis studies in rats were conducted to determine whether 3'-Cl and 4',4''-diCl BZT differed significantly in their effect on nucleus accumbens extracellular dopamine levels, with cocaine serving as a reference. A mechanistic model based on DAT association/dissociation kinetics was used to describe the time delay between the plasma concentrations of the chloro-analogs and their dopaminergic effects. 3'-Cl BZT had plasma elimination half-life of 1.9 h versus 0.5 and 21.1 h for cocaine and 4',4''-diCl BZT, respectively. 4',4''-diCl BZT increased the DA levels at a slower rate and to a significantly lower extent relative to 3'-Cl BZT that were, in turn, lower than cocaine. The duration of dopamine elevation was as follows: 4',4''-diCl BZT > 3'-Cl BZT > cocaine. The model indicated faster association and dissociation with DAT for 3'-Cl BZT relative to 4',4''-diCl BZT. The present results indicate that behavioral differences among the chloro-analogs may be explainable based on both the dopamine and rate hypotheses of drug abuse.

Othman, A. I., and A. A. Qurtam, "Immunohistochemical and histopathological alterations in the gastric mucosa of rats treated with ketorolac and warfarin.", Ciencia e Tecnica Vitivinicola Journal, vol. 34(3), issue 2416-3953, pp. 164-166, 2019.
Othman, A. A., W. Nothaft, W. M. Awni, and S. Dutta, "Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials", British Journal of Clinical Pharmacology, vol. 75, no. 4, pp. 1029–1040, 2013. AbstractWebsite

Aim To characterize quantitatively the relationship between ABT-102, a potent and selective TRPV1 antagonist, exposure and its effects on body temperature in humans using a population pharmacokinetic/pharmacodynamic modelling approach. Methods Serial pharmacokinetic and body temperature (oral or core) measurements from three double-blind, randomized, placebo-controlled studies [single dose (2, 6, 18, 30 and 40 mg, solution formulation), multiple dose (2, 4 and 8 mg twice daily for 7 days, solution formulation) and multiple-dose (1, 2 and 4 mg twice daily for 7 days, solid dispersion formulation)] were analyzed. nonmem was used for model development and the model building steps were guided by pre-specified diagnostic and statistical criteria. The final model was qualified using non-parametric bootstrap and visual predictive check. Results The developed body temperature model included additive components of baseline, circadian rhythm (cosine function of time) and ABT-102 effect (Emax function of plasma concentration) with tolerance development (decrease in ABT-102 Emax over time). Type of body temperature measurement (oral vs. core) was included as a fixed effect on baseline, amplitude of circadian rhythm and residual error. The model estimates (95% bootstrap confidence interval) were: baseline oral body temperature, 36.3 (36.3, 36.4)°C; baseline core body temperature, 37.0 (37.0, 37.1)°C; oral circadian amplitude, 0.25 (0.22, 0.28)°C; core circadian amplitude, 0.31 (0.28, 0.34)°C; circadian phase shift, 7.6 (7.3, 7.9) h; ABT-102 Emax, 2.2 (1.9, 2.7)°C; ABT-102 EC50, 20 (15, 28) ng ml−1; tolerance T50, 28 (20, 43) h. Conclusions At exposures predicted to exert analgesic activity in humans, the effect of ABT-102 on body temperature is estimated to be 0.6 to 0.8°C. This effect attenuates within 2 to 3 days of dosing.

Othman, M. I. A., and N. H. Sweilam, "Electrohydrodynamic instability in a horizontal viscoelastic fluid layer in the presence of internal heat generation", Canadian Journal of Physics, vol. 80, 2002. Abstract
Othman, A. A., W. M. Amer, M. Fayez, and N. A. Hegazi, "Rhizosheath of sinai desert plants is a potential repository for associative diazotrophs", Microbiological Research, vol. 159, issue 3, pp. 285 - 293, 2004. AbstractWebsite

Among 42 plant species representing the flora of north Sinai, two possessed sand grain sheath encasing the roots. They are Panicum turgidum Forssk. and Stipagrostis scoparia (Trin.and Rupr.) deWinter. Rhizosheaths, compared to surrounding free sand, accommodated higher population density of microorganisms including associative diazotrophs. Isolates secured belonged to the species of Bacillus circulans, Paenib. macerans (Bacillus macerans), Enterobacter agglomerans, Agrobacterium radiobacter and Chryseomonas luteola (Pseudomonos luteola). The rhizosheath potentiality in re-vegetating sand dunes and arid lands, through nitrogen fixation, plant-water relationship and root continuity for nutrient uptake, are discussed. © 2004 Elsevier GmbH. All rights reserved.

Othman, A. A., R. A. Lenz, J. Zhang, J. Li, W. M. Awni, and S. Dutta, "Single- and multiple-dose pharmacokinetics, safety, and tolerability of the selective alpha7 neuronal nicotinic receptor agonist, ABT-107, in healthy human volunteers.", Journal of clinical pharmacology, vol. 51, issue 4, pp. 512-26, 2011 Apr. AbstractWebsite

ABT-107 is a potent, selective α7 nicotinic receptor agonist under development for treatment of Alzheimer's disease and cognitive deficits associated with schizophrenia. The pharmacokinetics, safety, and tolerability of escalating single oral doses (1, 3, 10, 30, 60, 80, and 100 mg; double-blind, placebo-controlled, randomized, incomplete crossover design) and multiple oral doses (2, 6, and 15 mg once daily for 7 days; double-blind, placebo-controlled, randomized, parallel-group design) of ABT-107 were evaluated. Additionally, effect of food on ABT-107 pharmacokinetics (20-mg single dose) was evaluated using an open-label, 2-period, fasting and nonfasting, randomized, complete crossover design. ABT-107 exhibited nonlinear (more than dose-proportional) pharmacokinetics. ABT-107 half-life ranged from 7 to 10 hours, and steady state was achieved by day 6 of dosing. Food did not have a clinically meaningful effect on ABT-107 exposure. ABT-107 was safe and well tolerated over the tested dose range. The most frequently reported adverse events were nausea, headache, and tremor following single dosing and somnolence following multiple dosing. The pharmacokinetics, safety, and tolerability profiles of ABT-107 pose it as a good candidate for further development.

Othman, S. H., M. S. El-Deab, and T. Ohsaka, "Superior electrocatalytic Activity of Au(110)-Like Gold Nanoparticles Towards The Oxygen Evolution Reaction", Int. J. Electrochemical Science, 2011. Abstract

This study is concerned with the electocatalytic evolution of oxygen gas at novel gold nanoparticles (nano-Au) modified glassy carbon (GC) electrodes in 0.5 M KOH. The electrochemical measurements show a superior enhancement of the nano-Au/GC towards the oxygen evolution reaction (OER) compared to bulk GC and Au electrodes. That is, the onset potential of the OER is shifted by ca. 600 mV in the negative direction compared with bulk Au and unmodified GC electrodes. The enrichment in the Au (110) facet orientation (of the electrodeposited nano-Au) [1] at the expense of other low facets orientations induces a favorable geometric arrangements of the Au surface atoms which is believed to facilitate the OH- adsorption and, hence, the charge transfer process during the water electrolysis into molecular oxygen. Thus, the OER is accelerated and realized at less positive potential.

Othman, M. A., S. A. Mazen, and E. Ezzat, "A Proposed Framework for Managing Technical People in Software Projects", IOSR Journal of Computer Engineering, vol. 16, issue 4, pp. PP 56-61, 2014.
mohamed othman, D. R. E., D. M. khalaf, and A. Fahim, "Validity and feasibility of short form of Mcgill pain questionnaire to assess pain after liver resection", The medical journal of Cairo university, 2016.
Othman, M., H. Hassan, R. Moawad, and A. M. Idrees, "A Linguistic Approach for Opinionated Documents Summary", Future Computing and Informatics Journal, vol. In Press, Corrected Proof, Available online 11 November 2017, 2017.
Othman, E., K. Shaalan, and A. Rafea, "Towards resolving ambiguity in understanding Arabic sentence", International Conference on Arabic Language Resources and Tools, Cairo, Egypt, NEMLAR, pp. 118–122, sep, 2004. Abstractambiguity_resol_nemlar.pdf

Ambiguity is a major reason why computers do not yet understand natural language. We have made great deal strides towards developing tools for morphological and syntactic analyzers for Arabic in recent years. The absence of diacritics, which represent most vowels, in the written text creates ambiguity which hinders the development of Arabic natural language processing applications. Thus, ambiguity increases the range of possible interpretations of natural language. In this paper, we give a road map of solutions to common ambiguity problems inherent in parsing of Arabic sentence.

Othman, A. I., "Histopathological and histochemical studies on hepatotoxicity induced by aluminium. ", Egyp. J. Zool.,, vol. 45, pp. 303-314, 2005.
Othman, A. A., G. Haig, H. Florian, C. Locke, L. Gertsik, and S. Dutta, "The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.", British journal of clinical pharmacology, vol. 77, issue 6, pp. 965-74, 2014 Jun. AbstractWebsite

AIMS: ABT-288 is a potent and selective H3 receptor antagonist with procognitive effects in several preclinical models. In previous studies, 3 mg once daily was the maximal tolerated dose in healthy volunteers. This study characterized the safety, tolerability and pharmacokinetics of ABT-288 in stable subjects with schizophrenia.

METHODS: This was a randomized, double-blind, placebo-controlled, dose-escalating study of ABT-288 (10 dose levels, from 1 to 60 mg once daily for 14 days) in stable subjects with schizophrenia treated with an atypical antipsychotic. In each dose group, five to seven and two to three participants were assigned to ABT-288 and placebo, respectively.

RESULTS: Of the 67 participants enrolled, nine participants (on ABT-288) were prematurely discontinued, in seven of these due to adverse events. ABT-288 was generally safe and tolerated at doses up to 45 mg once daily. The most common adverse events, in decreasing frequency (from 31 to 5%), were abnormal dreams, headache, insomnia, dizziness, somnolence, dysgeusia, dry mouth, psychotic disorder, parosmia and tachycardia. Adverse events causing early termination were psychotic events (four) and increased creatine phosphokinase, pyrexia and insomnia (one each). The half-life of ABT-288 ranged from 28 to 51 h, and steady state was achieved by day 12 of dosing. At comparable multiple doses, ABT-288 exposure in subjects with schizophrenia was 45% lower than that previously observed in healthy subjects. At trough, ABT-288 cerebrospinal fluid concentrations were 40% of the total plasma concentrations.

CONCLUSIONS: ABT-288 was tolerated at a 15-fold higher dose and 12-fold higher exposures in subjects with schizophrenia than previously observed in healthy volunteers. The greater ABT-288 tolerability was not due to limited brain uptake.

Othman, A. A., W. M. Amer, M. Fayez, M. Monib, and N. A. Hegazi, "Biodiversity of diazotrophs associated to the plant cover of north Sinai deserts", Archives of Agronomy and Soil Science, vol. 49, pp. 683-705, 2003.
Othman, N. - A., O. - G. Shaker, H. - M. Elshenawy, W. Abd-Elmoniem, A. - M. Eldin, and M. - Y. Fakhr, "The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients", journal of clinical and experimental dentistry, vol. 8, issue 5, pp. 566-570, 2016.
Othman, M., H. Hassan, R. Moawad, and A. M. Idrees, "A linguistic approach for opinionated documents summary", Future Computing and Informatics Journal, vol. 3, no. 2: Elsevier, pp. 152–158, 2018. Abstract
Othman, A. I., M. M. Amin, S. K. Abu-Elyazid, and G. A. Abdelbary, "Trimetazidine Dihydrochloride Pulsatile-Release Tablets for the Treatment of Morning Anginal Symptoms: Dual Optimization, Characterization and Pharmacokinetic Evaluation.", Current drug delivery, vol. 18, issue 8, pp. 1182-1196, 2021. Abstract

OBJECTIVE: This research work aimed to target the early morning peak symptoms of chronic stable angina through formulating antianginal drug, Trimetazidine (TMZ) in a pulsatile-release tablet.

METHODS: The core formulae were optimized using 22 .31 factorial design to minimize disintegration time (DT) and maximize drug release after 5 minutes (Q5min). Different ratios of Eudragit S100 and Eudragit L100 were used as a coating mixture for the selected core with or without a second coating layer of hydroxypropyl methylcellulose (HPMC E50). The different formulation variables were statistically optimized for their effect on lag time and drug release after 7 hours (Q7h) using BoxBehnken design. The optimized formula (PO) was subjected to stability study and pharmacokinetic assessment on New Zealand rabbits.

RESULTS: The optimal core (F8) was found to have 1.76 min disintegration time and 61.45% Q5min PO showed a lag time of 6.17 h with 94.80% Q7h and retained good stability over three months. The pharmacokinetics study confirmed the pulsatile-release pattern with Cmax of 206.19 ng/ml at 5.33 h (Tmax) and 95.85% relative bioavailability compared to TMZ solution.

CONCLUSION: Overall pulsatile-release tablets of TMZ successfully released the drug after a desirable lag time, providing a promising approach for early morning anginal symptoms relief.

Othman, S. H., M. S. El-Deab, T. Okajima, and T. Ohsaka, "Novel procedure for the fabrication of gold nanostructures enriched in Au (110) facet orientation", Electrochemistry Communications, vol. 11, pp. 1273-1276, 2009.