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Journal Article
Elkhadem, A., and N. Orabi, "Weak evidence suggests higher risk for bracket bonding failure with self-etch primer compared to conventional acid etch over 12 months.", Evidence-based dentistry, vol. 14, issue 2, pp. 52-3, 2013. Abstract

DATA SOURCES: Medline, Embase, Cochrane Oral Health Group's Trials Register and the Cochrane Central Register of Controlled Trials (CENTRAL). Unpublished data were sought by searching ClinicalTrials.gov, the National Research Register and Pro-Quest Dissertation Abstracts and Thesis database. There were no language restrictions.

STUDY SELECTION: Randomised and controlled clinical trials (including split mouth) directly comparing self-etch and acid-etch primers including patients with full-arch, fixed and bonded orthodontic appliances (not banded) with follow-up periods of at least 12 months were included.

DATA EXTRACTION AND SYNTHESIS: Two authors abstracted data independently, with disagreements being resolved by a third. The Cochrane Risk of Bias tool was used to assess study quality. A random effects meta-analysis was undertaken.

RESULTS: Eleven studies were included in the qualitative summary with five studies contributing to a meta-analysis. These five studies (n =3444 brackets, 1721 acid-etch, 1723 self-etch) had relatively low statistical and clinical heterogeneity. Meta-analysis demonstrated a tendency for a higher risk of failure (odds ratio 1.35; 95% CI, 0.99-1.83; P 5 0.06) with self-etch primers. The use of self-etch techniques was also associated with a small but statistically significant time saving (weighted mean difference 23.2 seconds per bracket; 95% CI, 20.7-25.8; P \0.001). There was insufficient evidence to assess the effect of bonding modality on demineralisation rates.

CONCLUSIONS: There is weak evidence indicating higher odds of failure with self-etch primer than acid-etch over 12 months in orthodontic patients, and there is strong evidence that a self-etch primer is likely to result in modest time savings (eight minutes for full bonding) compared with acid-etch.

Rady, E. H. A. B. -, A. A. El-Sheikh, and M. A. ould Oumar, A Wealth Index of Households Living Conditions in Mauritania, , 2011.
Osman, T. A., S. Yousef, A. H. Abdalla, and G. A. Zohdy, "Wear Characterization of Carbon Nanotubes Reinforced Acetal Spur, Helical, Bevel and Worm Gears Using a TS Universal Test Rig", JOM, vol. 67, issue 12, pp. 2892–2899, 2015.
Yousef, S., A. Khattab, M. Zaki, and T. A. Osman, Wear Characterization of Carbon Nanotubes Reinforced Polymer Gears, , 2013.
A., A., Moussa I. M., S. O., and A. S., "Wear Effect of Different Abrasive Materials on Tooth Enamel: A Comparative Study, ", The Egyptian Journal of Hospital Medicine, vol. 70 (4), issue (4), pp. 539-543, 2018. 704_4.pdf
Eldib, M. Y., and H. M. Onsi, "Web Image Mining Age Estimation Framework", ICGST International Journal on Graphics, Vision and Image Processing, GVIP 01/2011; , vol. 11:1-8, 2011. CU-PDF.pdf
Eldib, M. Y., and H. M. Onsi, "Web Image Mining Age Estimation Framwork", ICGST-GVIP Journal, vol. 11, issue 1, 2011.
OMAR, A. L. A. A. A., S. H. AHMED, Y. A. E. Mobdy, H. A. Amra, and E. A. Abdel-Rahim, "Well-Developed Nanostructure Incorporated with Euphorbia Umbellata Extract into A Unique Form with Greater Biocompatibility ", PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, vol. 22, issue 27-28, pp. 143-156 , 2021.
Kenawy, E., T. Osman, and A. Alshamndy, "What are the main challenges impeding implementation of the spatial plans in Egypt using ecotourism development as an example?", Social sciences, vol. 6, no. 3: Multidisciplinary Digital Publishing Institute, pp. 75, 2017. Abstract
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Abdel-Halim, M. R. E., M. M. Fawzy, M. A. Saleh, S. Ibrahim, E. El Nabarawy, A. E. L. Tawdy, M. A. El-latif, S. Shalaby, M. Amer, M. S. El Hawary, et al., "What is your diagnosis? Clinicopathological correlation", Journal of the Egyptian Women’s Dermatologic Society, vol. 12, no. 2: LWW, pp. 142–143, 2015. Abstract
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Braun, D. A., M. Schueler, J. Halbritter, H. Y. Gee, J. D. Porath, J. A. Lawson, R. Airik, S. Shril, S. J. Allen, D. Stein, et al., "Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity.", Kidney international, 2015 Oct 21. AbstractWebsite

Chronically increased echogenicity on renal ultrasound is a sensitive early finding of chronic kidney disease that can be detected before manifestation of other symptoms. Increased echogenicity, however, is not specific for a certain etiology of chronic kidney disease. Here, we performed whole exome sequencing in 79 consanguineous or familial cases of suspected nephronophthisis in order to determine the underlying molecular disease cause. In 50 cases, there was a causative mutation in a known monogenic disease gene. In 32 of these cases whole exome sequencing confirmed the diagnosis of a nephronophthisis-related ciliopathy. In 8 cases it revealed the diagnosis of a renal tubulopathy. The remaining 10 cases were identified as Alport syndrome (4), autosomal-recessive polycystic kidney disease (2), congenital anomalies of the kidney and urinary tract (3), and APECED syndrome (1). In 5 families, in whom mutations in known monogenic genes were excluded, we applied homozygosity mapping for variant filtering and identified 5 novel candidate genes (RBM48, FAM186B, PIAS1, INCENP, and RCOR1) for renal ciliopathies. Thus, whole exome sequencing allows the detection of the causative mutation in 2/3 of affected individuals, thereby presenting the etiologic diagnosis, and allows identification of novel candidate genes.Kidney International advance online publication, 21 October 2015; doi:10.1038/ki.2015.317.

Warejko, J. K., W. Tan, A. Daga, D. Schapiro, J. A. Lawson, S. Shril, S. Lovric, S. Ashraf, J. Rao, T. Hermle, et al., "Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome.", Clinical journal of the American Society of Nephrology : CJASN, vol. 13, issue 1, pp. 53-62, 2018 Jan 06. Abstract

BACKGROUND AND OBJECTIVES: Steroid-resistant nephrotic syndrome overwhelmingly progresses to ESRD. More than 30 monogenic genes have been identified to cause steroid-resistant nephrotic syndrome. We previously detected causative mutations using targeted panel sequencing in 30% of patients with steroid-resistant nephrotic syndrome. Panel sequencing has a number of limitations when compared with whole exome sequencing. We employed whole exome sequencing to detect monogenic causes of steroid-resistant nephrotic syndrome in an international cohort of 300 families.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Three hundred thirty-five individuals with steroid-resistant nephrotic syndrome from 300 families were recruited from April of 1998 to June of 2016. Age of onset was restricted to <25 years of age. Exome data were evaluated for 33 known monogenic steroid-resistant nephrotic syndrome genes.

RESULTS: In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a mutation in a gene that causes a phenocopy of steroid-resistant nephrotic syndrome. This is consistent with our previously published identification of mutations using a panel approach. We detected a causative mutation in a known steroid-resistant nephrotic syndrome gene in 38% of consanguineous families and in 13% of nonconsanguineous families, and 48% of children with congenital nephrotic syndrome. A total of 68 different mutations were detected in 20 of 33 steroid-resistant nephrotic syndrome genes. Fifteen of these mutations were novel.,,, andwere the most common genes in which we detected a mutation. In another 28% of families, we detected mutations in one or more candidate genes for steroid-resistant nephrotic syndrome.

CONCLUSIONS: Whole exome sequencing is a sensitive approach toward diagnosis of monogenic causes of steroid-resistant nephrotic syndrome. A molecular genetic diagnosis of steroid-resistant nephrotic syndrome may have important consequences for the management of treatment and kidney transplantation in steroid-resistant nephrotic syndrome.

Shehata, M. M. A., A. Maged, amal Kotb, A. I. Ogila, Y. Lasheen, N. Salah, R. A. Mohsen, M. Fouad, and A. S. Abd-elazeim, "Whole-body vibration versus supervised aerobic exercise on hormonal parameters and inflammatory status in women with premenstrual syndrome: A randomized controlled trial", International journal of Gynecology and Obstetrics, 2023.
ElHawary, R., S. Meshaal, A. Mauracher, L. Optiz, D. ABDELAZIZ, S. Lotfy, and et al, "Whole-exome sequencing of T-B+ severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants ", Clin. Exp. Immunol., 2020.
Soliman, H. K., M. Abouelhoda, M. N. El Rouby, O. S. Ahmed, G. Esmat, Z. K. Hassan, M. M. Hafez, D. A. Mehaney, M. Selvaraju, R. K. Darwish, et al., "Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report.", Virology journal, vol. 16, issue 1, pp. 132, 2019. Abstract

BACKGROUND: Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Our aim was to determine, by deep next-generation sequencing (NGS), the entire genome sequence of HPgV that was discovered in an Egyptian patient while analyzing HCV sequence from the same patient. We also inspected whether the co-infection of HCV and HPgV will affect the patient response to HCV viral treatment. To the best of our knowledge, this is the first report for a newly isolated HPgV in an Egyptian patient who is co-infected with HCV.

CASE PRESENTATION: The deep Next Generation Sequencing (NGS) technique was used to detect HCV sequence in hepatitis C patient's plasma. The results revealed the presence of HPgV with HCV. This co-infection was confirmed using conventional PCR of the HPgV 5' untranslated region. The patient was then subjected to direct-acting-antiviral treatment (DAA). At the end of the treatment, the patient showed a good response to the HCV treatment (i.e., no HCV-RNA was detected in the plasma), while the HPgV-RNA was still detected. Sequence alignment and phylogenetic analyses demonstrated that the detected HPgV was a novel isolate and was not previously published.

CONCLUSION: We report a new variant of HPgV in a patient suffering from hepatitis C viral infection.

Soliman, H. K., M. Abouelhoda, M. N. El Rouby, O. S. Ahmed, G. Esmat, Z. K. Hassan, M. M. Hafez, D. A. Mehaney, M. Selvaraju, R. K. Darwish, et al., "Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report.", Virology journal, vol. 16, issue 1, pp. 132, 2019. Abstract

BACKGROUND: Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Our aim was to determine, by deep next-generation sequencing (NGS), the entire genome sequence of HPgV that was discovered in an Egyptian patient while analyzing HCV sequence from the same patient. We also inspected whether the co-infection of HCV and HPgV will affect the patient response to HCV viral treatment. To the best of our knowledge, this is the first report for a newly isolated HPgV in an Egyptian patient who is co-infected with HCV.

CASE PRESENTATION: The deep Next Generation Sequencing (NGS) technique was used to detect HCV sequence in hepatitis C patient's plasma. The results revealed the presence of HPgV with HCV. This co-infection was confirmed using conventional PCR of the HPgV 5' untranslated region. The patient was then subjected to direct-acting-antiviral treatment (DAA). At the end of the treatment, the patient showed a good response to the HCV treatment (i.e., no HCV-RNA was detected in the plasma), while the HPgV-RNA was still detected. Sequence alignment and phylogenetic analyses demonstrated that the detected HPgV was a novel isolate and was not previously published.

CONCLUSION: We report a new variant of HPgV in a patient suffering from hepatitis C viral infection.

Hawary, E. R., S. Meshaal, A. A. Mauracher, L. Opitz, A. D. Elaziz, S. Lotfy, A. Eldash, J. Boutros, N. Galal, P. J. Schmid, et al., "Whole‐exome sequencing of T‐B+ severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants", Clinical and experimental immunology, vol. 203, issue 3, pp. 448-457, 2021.
Osman, E. E. A., A. Rehemtulla, and N. Neamati, "Why All the Fury over Furin?", Journal of medicinal chemistry, vol. 65, issue 4, pp. 2747-2784, 2021. Abstract

Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best-characterized member of the mammalian proprotein convertases, is an ubiquitously expressed single pass type 1 transmembrane protein. Cleavage of SARS-CoV-2 spike protein by furin promotes viral entry into lung cells. While furin knockout is embryonically lethal, its knockout in differentiated somatic cells is not, thus furin provides an exciting therapeutic target for viral pathogens including SARS-CoV-2 and bacterial infections. Several peptide-based and small-molecule inhibitors of furin have been recently reported, and select cocrystal structures have been solved, paving the way for further optimization and selection of clinical candidates. This perspective highlights furin structure, substrates, recent inhibitors, and crystal structures with emphasis on furin's role in SARS-CoV-2 infection, where the current data strongly suggest its inhibition as a promising therapeutic intervention for SARS-CoV-2.

Enany, E. G., N. Nagui, H. Nada, S. SHALABY, I. Sany, A. Nada, S. Orabi, E. O. Ghanam, and A. - M. Halim, "Widespread Keratotic Spiky Follicular Papules Associated With Hyperpigmentation: Answer", Am J Dermatopathol, vol. 42, issue 10, pp. 787–788, 2020.
Enany, G. E., N. Nagui, H. Nada, S. Shalaby, I. Sany, A. Nada, S. Orabi, O. El Ghanam, and M. R. E. Abdel-Halim, "Widespread Keratotic Spiky Follicular Papules Associated With Hyperpigmentation: Answer.", The American Journal of dermatopathology, vol. 42, issue 10, pp. 787-788, 2020.
Enany, E. G., N. Nagui, H. Nada, S. SHALABY, I. Sany, A. Nada, S. Orabi, E. O. Ghanam, and M. Abdel-Halim, "Widespread Keratotic Spiky Follicular Papules associated With Hyperpigmentation: Challenge", Am J Dermatopathol, vol. 42, issue 10, pp. e134–e135, 2020.
Abdelrahman, A. M., H. M. A. ElSaied, R. S. H. M. Allam, and M. H. Osman, "Wipe-out’ after subscleral trabeculectomy in advanced glaucoma patients", Delta Journal of ophthalmology, vol. 18, issue 2, pp. 94-98, 2017.
Omar, H. A., N. Lu, W. Zhuang, and S. Shen, "Wireless access technologies for vehicular network safety applications", IEEE Network, vol. 30, pp. 22-26, 2016. Abstract

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Tourism