UNLABELLED: Zirconia ceramic (ZC) implants are becoming more common, but comparisons between preclinical histology and long-term clinical trials are rare. This investigation comprised (1) 8-year clinical follow-up of one-piece ZC or titanium (Ti) implants supporting full overdentures and (2) histomorphometric analysis of the same implants in an animal model, comparing implants with various surface treatments.

METHODS: (1) Clinical trial: 24 completely edentulous participants (2 groups of N = 12) received 7 implants (one-piece ball-abutment ZC or Ti; maxilla N = 4, mandible N = 3) restored with implant overdentures. Outcomes after 8-years included survival, peri-implant bone levels, soft-tissue responses, and prosthodontic issues. (2) Preclinical trial: 10 New Zealand sheep received 4 implants bilaterally in the femoral condyle: Southern Implants ZC or Ti one-piece implants, identical to the clinical trial, and controls: Southern ITC two-piece implants with the same surface or Nobel (NBC) anodised (TiUnite™) surface. %Bone-implant contact (%BIC) was measured after 12 weeks of unloaded healing.

RESULTS: 8 of 24 participants (33%) of an average age of 75 ± 8 years were recalled; 21% of original participants had died, and 46% could not be contacted. 80.4% of implants survived; excluding palatal sites, 87.5% of Ti and 79% of ZC implants survived. All failed implants were in the maxilla. Three ZC implants had fractured. Bone loss was similar for Ti vs. ZC; pocket depths ( = 0.04) and attachment levels ( = 0.02) were greater for Ti than ZC implants. (1.7 ± 1.6 mm vs. 1.6 ± 1.3 mm). All implants in sheep femurs survived. %BIC was not statistically different for one-piece blasted surface Ti (80 ± 19%) versus ZC (76 ± 20%) or ITC (75 ± 16 mm); NBC had significantly higher %BIC than ITC (84 ± 17%, = 0.4).

CONCLUSION: Short-term preclinical results for ZC and Ti one-piece implants showed excellent bone-implant contact in unloaded femoral sites. This differed from the long-term clinical results in older-aged, edentulous participants. While ZC and Ti implants showed equivalent performance, the risks of peri-implantitis and implant loss in older, completely edentulous patients remain a significant factor.

During the last few decades, sustainable development (SD) has increasingly received attention globally. Therefore, international organizations and researchers sought to assess progress towards SD at different territorial levels. However, most of the studies were conducted at the city level and a very small number of studies has conducted at the urban periphery territory. This study aims to fill the current research gap through assessing the progress towards SD in the urban periphery of Greater Cairo (GC) in Egypt between 1996-2017. Eight composite indicators have been employed to assess the progress towards SD in this territory. These composite indicators were constructed based on the 14 individual indicators associated with sustainable development goals. The results showed meaningful progress achieved in the peripheral municipalities of GC, particularly in infrastructure and education indicators, while the economic and environmental indicators have deteriorated, particularly after the civic revolution of 2011. In addition, the study found a development gap between the urban periphery and the main urban agglomeration in GC, particularly in the infrastructure aspect. These results highlight the deficiencies that exist in the urban periphery of GC which help decision-makers to prepare appropriate policies to improve SD in such territory.

120Objectives: To demonstrate the value of FDG PET/CT in evaluation of childhood patient with Langerhans cell histiocytosis (LCH) and its added value in clinical management including initial staging and assessment of treatment response.Methods: A prospective analysis of 30 patients (27 males and 8 females; age ranged from 2.7 months to 9 years with a mean of 2.7 ± 2.0 years) with histopathological proven LCH who were under treatment and/or regular follow up from September 2013 till November 2016. All patients received specific therapy for LCH in the form of chemotherapy {&}/or surgical resection according to the standard institutional protocol. The findings of the PET/CT were compared with skeletal survey and computed tomography (CT) findings within time interval less than 1 month. The choice of methods depended on tumor location. Analysis criteria included the following: any focal FDG uptake was considered abnormal when it was greater than that of hepatic uptake or in presence of an abnormal changes on CT with any degree of FDG uptake, FDG avid lymph nodes on PET/CT were interpreted as positive on PET/CT basis regardless of the size.Results: According to PET/CT result, 21 patients (70{%}) presented with multi-system disease (bone, LNs, liver, lungs, soft tissue and skin), 6 patients (20{%}) had unifocal lesions (five with bone and one lymph nodes) and 3 patients (10{%}) presented by multi-focal lesions (two with bone lesions and a single patient with nodal involvement). At the end of study 21 patients (70{%}) were disease free with no recurrence. Only nine patients (30{%}) had disease recurrence. Twenty three patient (76.7{%}) had low risk of mortality and only seven patients (23.3{%}) were of high risk state. At the end of study, 21 patients (70{%}) were disease free with no recurrence. Only nine patients (30{%}) had disease recurrence. No statistically significant association could be detected between disease recurrence with age, sex, presenting organ, disease extent, risk of mortality, SUVmax of leading lesion. Disease extent showed a border line significant association with risk of mortality (p 0.05).Conclusion: PET/CT is a useful tool to assess known LCH lesions and rule out the presence of other organ infiltration and to provide a reference basis of classification, staging, treatment plan, and evaluation of therapy effect. FDG PET/CT not only provides the characteristics of lesions in CT scan, but also the lesions activity by FDG uptake. 18F-FDG PET/CT should be incorporated in patient management to facilitate disease stratification and avoid un-necessary interventions. Research Support: none

Edible sprouts are rich in flavonoids and other polyphenols, as well as proteins, minerals, and vitamins. Increasing sprout consumption necessitates improving their quality, palatability, and bioactivity. The purpose of this study was to test how KNO3 priming affects the sprouting process species on three Medicago species (Medicago indicus, Medicago interexta, and Medicago polymorpha) and their nutritional values. Targeted species of Medicago were primed with KNO3, and the levels of different primary and secondary metabolites were determined. KNO3 induced biomass accumulation in the sprouts of the three species, accompanied by an increased content of total mineral nutrients, pigments, vitamins, and essential amino acids. Besides, our results showed that KNO3 enhanced the activity of nitrate reductase (NR), glutamate dehydrogenase (GDH), and glutamine synthetase (GS) enzymes, which are involved in the nitrogen metabolism and GOGAT cycle, which, in turn, increase the nitrogen and protein production. KNO3 treatment improved the bioactive compound activities of Medicago sprouts by increasing total phenolic and flavonoid contents and enhancing the antioxidant and antidiabetic activities. Furthermore, species-specific responses toward KNO3 priming were noticeable, where Medicago interexta showed the highest antioxidant and antidiabetic activities, followed by Medicago polymorpha. Overall, this study sheds the light on the physiological and biochemical bases of growth, metabolism, and tissue quality improvement impact of KNO3 on Medicago sprouts.

The Greater Cairo Metropolitan Region (GCMR) in its seeking to sustainable development (SD) by the year of 2050 facing the serious challenge of around 65 percent of Cairenes live in unplanned settlements. In this respect, the authors examined the effect of urban characteristics of unplanned settlements on SD in the Egyptian context, focusing on the type of unplanned growth on agricultural land. The output of the analysis were fourfold. First of all, we provide a brief overview of previous research on the main types of unplanned settlements in GCMR and the sustainability definition according to the Egyptian context. Secondly, we had a discussion with the local government during our field survey in GCMR to determine the study samples, the main urban characteristics, and the sustainability evaluation criteria in the Egyptian context. Thirdly, through the comparative analysis and geographic information system (GIS), we examined how the character of urban development affected per capita four urban measures in a cross-section of two settlements, one represented the unplanned settlements and other as a comparative planned sample to determine the real gap. Finally, by using the evaluation matrix, the help and block items are estimated for each measure of urban characteristics, providing substantive evidence on how the four measures of urban characteristics have been affected by the urban sprawl.

Marrubium vulgare is a valuable source of natural bioactive molecules with high preventive and therapeutic effectiveness. Therefore, this study aimed to study the chemical polymorphism of natural populations of M. vulgare in Tunisia by quantitative chemical markers and the estimation of divergence between populations. Phytochemical analyses of the eight natural populations of Tunisian Marrubium vulgare prospected in different bioclimatic stages, revealed 42 compounds of essential oils representing 96.08% to 100% of the total oil. Hydrocarbon sesquiterpenes were the main fraction of all the populations studied and $\beta$-bisabolene was the major compound (from 30.11% to 71.35% of the total oil). The phytochemical investigation of the M. vulgare plant indicated the presence of essential oil with significant percentages of phenolic compounds. A significant quantitative and qualitative variation in the essential oils is detected for both major and minor compounds. The principal components analysis (PCA) performed in the single and combined traits provides a good distinction among populations, not according to their geographical and/or bioclimatic origins. Moreover, the phytochemical analysis of the leaves showed that the Tunisian populations, i.e., the populations of Kasserine, Kef, and Beja, were very rich in phenolic compounds (from 20.8 to 44.65 mg GAE/g DW). Flavonoids compounds were also the main class of total polyphenols present in all the tested populations (from 8.91 to 37.48 mg RE/g DW). The quantitative genetic diversity estimated by the population's structure, based on PCA analysis, was an adaptation to the changes in the environmental conditions. Overall, our study indicated that natural populations of M. vulgare had different chemotypes of essential oils and they were rich in phenolic compounds, particularly flavonoids, which opens a new prospect for industrial use and differential exploitation of this species.

A double-blind, placebo-controlled, parallel-group, 24-week, multicenter trial was conducted to evaluate the efficacy and safety of 3 doses of ABT-126, an α7 nicotinic receptor agonist, for the treatment of cognitive impairment in nonsmoking subjects with schizophrenia. Clinically stable subjects were randomized in 2 stages: placebo, ABT-126 25 mg, 50 mg or 75 mg once daily (stage 1) and placebo or ABT-126 50 mg (stage 2). The primary analysis was the change from baseline to week 12 on the MATRICS Consensus Cognitive Battery (MCCB) neurocognitive composite score for ABT-126 50 mg vs placebo using a mixed-model for repeated-measures. A key secondary measure was the University of California Performance-based Assessment-Extended Range (UPSA-2ER). A total of 432 subjects were randomized and 80% (344/431) completed the study. No statistically significant differences were observed in either the change from baseline for the MCCB neurocognitive composite score (+2.66 [±0.54] for ABT-126 50 mg vs +2.46 [±0.56] for placebo at week 12; P>0.05) or the UPSA-2ER. A trend for improvement was seen at week 24 on the 16-item Negative Symptom Assessment Scale total score for ABT-126 50 mg (change from baseline -4.27±[0.58] vs -3.00±[0.60] for placebo; P=0.059). Other secondary analyses were generally consistent with the primary end point results. Adverse event rates were similar for ABT-126 and placebo. ABT-126 did not demonstrate a consistent effect on cognition in nonsmoking subjects with schizophrenia; however, a trend toward an effect was observed on negative symptoms. ClincalTrials.gov registration: NCT01655680.