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2022
Kamel, M. G., F. M. Sroor, A. M. Othman, K. F. Mahrous, F. M. Saleh, H. M. Hassaneen, T. A. Abdallah, I. A. Abdelhamid, and M. M. A. Teleb, "Structure-based design of novel pyrazolyl–chalcones as anti-cancer and antimicrobial agents: synthesis and in vitro studies", Monatshefte für Chemie-Chemical Monthly: Springer Vienna, pp. 1-11, 2022. Abstract
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Osman, R., S. Fathy, H. A. N. A. N. SHAFIK, N. Momen, R. Kandil, and R. Zayed, "Study of epigenetic regulation of H3K27me3 in acute myeloid leukemia", International Journal of Laboratory hematology, vol. 44, pp. e111-e114, 2022.
Selim, N., H. Omair, H. El-Karaksy, M. Fathy, E. Mahmoud, sherif Baroudy, M. Fathy, and N. Yassin, "A study of exons 14, 15, and 24 of the ABCB11 gene in Egyptian children with normal GGT cholestasis", Arab Journal of Gastroenterology, vol. 23, no. 1: Elsevier, pp. 15–19, 2022. Abstract
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Eldin, A. M., E. Hossny, K. Wassif, and F. A. Omara, "Survey of Blockchain Methodologies in Healthcare Industry", The 5th IEEE International Conference on Computing and Informatics - March 9-10, 2022, Cairo, Egypt. (ICCI’2022), 2022.
Shah, Z. A., M. A. Dar, E. A. Dar, C. A. Obianefo, A. H. Bhat, M. T. Ali, M. El-Sharnouby, M. Shukry, H. Kesba, and S. Sayed, "Sustainable Fruit Growing: An Analysis of Differences in Apple Productivity in the Indian State of Jammu and Kashmir", Sustainability , vol. 14, issue 21, pp. 14544, 2022. samy09_sustainability-14-14544.pdf
Halim, P. A., R. A. Hassan, K. O. Mohamed, S. O. Hassanin, M. G. Khalil, A. M. Abdou, and E. O. Osman, "Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, issue 1, pp. 189-201, 2022.
Halim, P. A., R. A. Hassan, K. O. Mohamed, S. O. Hassanin, M. G. Khalil, A. M. Abdou, and E. O. Osman, "Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer", J Enzyme Inhib Med Chem. , vol. 37, issue 1, pp. 189–201, 2022.
Chandrasekar, S. S., Y. Phanse, M. Riel, R. E. Hildebrand, M. Hanafy, J. E. Osorio, S. S. Abdelgayed, and A. M. Talaat, "Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2", Viruses, vol. 14, issue 1262, pp. 1-20, 2022. viruses-14-01262-v2.pdf
Chandrasekar, S. S., Y. Phanse, M. Riel, R. E. Hildebrand, M. Hanafy, J. E. Osorio, S. S. Abdelgayed, and A. M. Talaat, "Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2", Viruses, vol. 14, no. 6, 2022. AbstractWebsite

Antibody measurements are primarily used to evaluate experimental and approved COVID-19 vaccines, which is unilateral considering our immune responses’ complex nature. Previously, we showed that nanoparticle plasmid DNA adjuvant system, QAC, and MVA based vaccines were immunogenic against SARS-CoV-2. Here, we report on the protective efficacy of systemic humoral and mucosal cell-mediated immune responses in transgenic mice models against SARS-CoV-2 following nanoparticle immunization. Parenteral, intramuscular administration of QAC-based plasmid DNA vaccine-encoding SARS-CoV-2 S and N led to the induction of significant serum neutralizing humoral responses, which reduced viral burden in the lungs and prevented viral dissemination to the brain. In contrast, the mucosal, intranasal administration of a heterologous vaccine elicited significant mucosal cell-mediated immune responses in the lungs that limited lung viral replication. The presented results demonstrate that serum neutralizing humoral and local lung T-cell immune responses are critical for the control of SARS-CoV-2 replication.

Pardieck, I. N., T. C. van der Sluis, E. T. I. van der Gracht, D. M. B. Veerkamp, F. M. Behr, S. van Duikeren, G. Beyrend, J. Rip, R. Nadafi, E. Beyranvand Nejad, et al., "A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.", Nature communications, vol. 13, issue 1, pp. 3966, 2022. Abstract

Understanding the mechanisms and impact of booster vaccinations are essential in the design and delivery of vaccination programs. Here we show that a three dose regimen of a synthetic peptide vaccine elicits an accruing CD8 T cell response against one SARS-CoV-2 Spike epitope. We see protection against lethal SARS-CoV-2 infection in the K18-hACE2 transgenic mouse model in the absence of neutralizing antibodies, but two dose approaches are insufficient to confer protection. The third vaccine dose of the single T cell epitope peptide results in superior generation of effector-memory T cells and tissue-resident memory T cells, and these tertiary vaccine-specific CD8 T cells are characterized by enhanced polyfunctional cytokine production. Moreover, fate mapping shows that a substantial fraction of the tertiary CD8 effector-memory T cells develop from re-migrated tissue-resident memory T cells. Thus, repeated booster vaccinations quantitatively and qualitatively improve the CD8 T cell response leading to protection against otherwise lethal SARS-CoV-2 infection.

Darwish, E., R. Ghosh, A. Ontiveros-Cisneros, H. C. Tran, M. Petersson, L. De Milde, M. Broda, A. Goossens, A. Van Moerkercke, K. Khan, et al., "Touch signaling and thigmomorphogenesis are regulated by complementary CAMTA3- and JA-dependent pathways.", Science advances, vol. 8, issue 20, pp. eabm2091, 2022. Abstract

Plants respond to mechanical stimuli to direct their growth and counteract environmental threats. Mechanical stimulation triggers rapid gene expression changes and affects plant appearance (thigmomorphogenesis) and flowering. Previous studies reported the importance of jasmonic acid (JA) in touch signaling. Here, we used reverse genetics to further characterize the molecular mechanisms underlying touch signaling. We show that Piezo mechanosensitive ion channels have no major role in touch-induced gene expression and thigmomorphogenesis. In contrast, the receptor-like kinase Feronia acts as a strong negative regulator of the JA-dependent branch of touch signaling. Last, we show that calmodulin-binding transcriptional activators CAMTA1/2/3 are key regulators of JA-independent touch signaling. CAMTA1/2/3 cooperate to directly bind the promoters and activate gene expression of JA-independent touch marker genes like and . In agreement, mutants show a near complete loss of thigmomorphogenesis and touch-induced delay of flowering. In conclusion, we have now identified key regulators of two independent touch-signaling pathways.

Fadeel, D. A. A., M. Fadel, A. Tawfik, and Y. Omar, "Transfersomal eosin topical delivery assisted by fractional CO2 laser for photodynamic treatment of palmar hyperhidrosis: case study", Drug Delivery and Translational Research, 2022. AbstractWebsite
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Zaki, S. A., S. A. Ouf, K. A. Abd-Elsalam, A. A. Asran, M. M. Hassan, A. Kalia, and F. M. Albarakaty, "Trichogenic Silver-Based Nanoparticles for Suppression of Fungi Involved in Damping-Off of Cotton Seedlings", Microorganisms, vol. 10, no. 2, 2022. AbstractWebsite

Mycogenic silver nanoparticles (AgNPs) produced by some biocontrol agents have shown the ability to inhibit the growth of numerous plant pathogenic fungi, which may be a unique method of disease management. This study describes the extracellular production of AgNPs by Trichoderma harzianum. The size, shape, charge, and composition of the AgNPs were subsequently studied by UV-visible spectroscopy, DLS, zeta potential, TEM, SEM, and EDX, among other methods. The AgNPs had sizes ranging from 6 to 15 nm. The antifungal activities of bio-synthesized AgNPs and two commercial fungicides (Moncut and Maxim XL) were tested against three soil-borne diseases (Fusarium fujikuroi, Rhizoctonia solani, and Macrophomina phaseolina). Cotton seedling illnesses were significantly reduced under greenhouse settings after significant in vitro antifungal activity was documented for the control of plant pathogenic fungi. The use of biocontrol agents such as T. harzianum, for example, may be a safe strategy for synthesizing AgNPs and using them to combat fungus in Egyptian cotton.

Salman, M. A., A. Salman, U. S. Mohamed, A. M. Hussein, M. A. Ameen, H. S. E. Omar, A. Elewa, A. Hamdy, A. A. - K. Elias, M. Tourky, et al., "Ursodeoxycholic acid for the prevention of gall stones after laparoscopic sleeve gastrectomy: a prospective controlled study.", Surgical endoscopy, 2022. Abstract

BACKGROUND: Obesity is a risk factor for cholelithiasis. Besides, rapid weight loss after bariatric surgery upsurges the rate of cholelithiasis and acute cholecystitis. This study aimed to compare gallstone development frequency after LSG under ursodeoxycholic acid (UDCA) prophylaxis.

METHODS: This prospective controlled study included 332 patients scheduled for LSG randomized to receive 500 mg UDCA daily for 12 months (UDCA Group) or no treatment (Control Group). Ultrasonography was done 6 and 12 months after surgery to detect gallstones. Cholecystectomy was done for complicated cases of cholelithiasis.

RESULTS: Seventy-one patients were lost to follow-up, and 3 developed severe adverse effects of UDCA and excluded. Data are presented for 130 patients in the UDCA group and 128 in the Control group. Collectively, 11 patients (8.5%) of the UDCA group and 41 (32.0%) of the Control group developed gall stones during the first postoperative year (p < 0.001). Cholecystectomy was indicated in 3 patients (2.3%) of the UDCA group and 9 (7.0%) of the Control group (p = 0.072). On multivariate analysis, higher BMI, dyslipidemia, and lacking UDCA prophylaxis were the independent factors significantly associated with stone development. Also, stone development was associated with higher weight loss after 6 and 12 months.

CONCLUSION: UDCA 500 mg once daily for 12 months after LSG is effective in reducing gallstone formation at 1 year. UDCA administration reduced the frequency of cholecystectomies from 7 to 2.3%. High BMI and dyslipidemia are the independent preoperative factors significantly associated with stone development.

Cag, Y., M. Al Madadha, H. Ankarali, Y. A. S. E. M. İ. N. ÇAĞ, K. Onder, A. Seremet-Keskin, F. Kizilates, R. Civljak, G. Shehata, and H. Alay, "Vaccine hesitancy and refusal among parents: An international ID-IRI survey", Journal of Infection in Developing Countries, vol. 16, issue 6, 2022. Abstract
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Zrig, A., A. Saleh, F. Hamouda, M. K. Okla, W. H. Al-Qahtani, Y. A. Alwasel, A. Al-Hashimi, M. Y. Hegab, A. H. A. Hassan, and H. AbdElgawad, "{Impact of sprouting under potassium nitrate priming on nitrogen assimilation and bioactivity of three medicago species}", Plants, vol. 11, no. 1, 2022. Abstract

Edible sprouts are rich in flavonoids and other polyphenols, as well as proteins, minerals, and vitamins. Increasing sprout consumption necessitates improving their quality, palatability, and bioactivity. The purpose of this study was to test how KNO3 priming affects the sprouting process species on three Medicago species (Medicago indicus, Medicago interexta, and Medicago polymorpha) and their nutritional values. Targeted species of Medicago were primed with KNO3, and the levels of different primary and secondary metabolites were determined. KNO3 induced biomass accumulation in the sprouts of the three species, accompanied by an increased content of total mineral nutrients, pigments, vitamins, and essential amino acids. Besides, our results showed that KNO3 enhanced the activity of nitrate reductase (NR), glutamate dehydrogenase (GDH), and glutamine synthetase (GS) enzymes, which are involved in the nitrogen metabolism and GOGAT cycle, which, in turn, increase the nitrogen and protein production. KNO3 treatment improved the bioactive compound activities of Medicago sprouts by increasing total phenolic and flavonoid contents and enhancing the antioxidant and antidiabetic activities. Furthermore, species-specific responses toward KNO3 priming were noticeable, where Medicago interexta showed the highest antioxidant and antidiabetic activities, followed by Medicago polymorpha. Overall, this study sheds the light on the physiological and biochemical bases of growth, metabolism, and tissue quality improvement impact of KNO3 on Medicago sprouts.

Osman, N. O., D. E. E. Faheem, W. A. El-Sherief, H. H. Abdel-Aal, and S. Alsirafy, "Olanzapine for anorexia in cancer cachexia patients: A placebo-controlled randomized trial", ESMO Congress 2022, Paris, 10 September, 2022. Abstract

Background: Cancer-associated cachexia (CAC) is a complex multifactorial syndrome. Various antipsychotics have been associated with weight gain, especially olanzapine (OLZ) which is suggested to have a role in the management of CAC. It remains unclear whether OLZ has an ameliorating effect on cancer patients’ anorexia, even when those patients exhibit no nausea or vomiting. Given the potential effect of OLZ on CAC and the mixed findings regarding this subject, the current trial aims at evaluating the efficacy of OLZ as a monotherapy in incurable cancer patients with cancer cachexia-associated anorexia.

Trial design: This is a single institution double-blind placebo-controlled randomized clinical trial. One hundred and sixty-four patients are being recruited from December 2021. The trial includes adult patients with incurable solid tumor, CAC, loss of appetite (≥4 score on the 0 to 10 loss of appetite scale of the Edmonton Symptom Assessment System [ESAS]), Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 and a predicted survival >3 months. Causes for exclusion are: highly emetogenic chemotherapy, antipsychotic or appetite stimulant administration, nausea or vomiting score >3 on the 0 to 10 scale of the ESAS, weight gain for a known cause (e.g., oedema) or central nervous system disease. Participants will be 1:1 randomized to the intervention arm (OLZ 5 mg tablet once a night for 28 days) or the control arm (placebo tablet once at night for 28 days). The primary endpoint is the change in the loss of appetite score on the 0 to 10 scale of the ESAS from day 0 to day 7 of treatment. The secondary endpoints include the change in loss of appetite score from day 0 to days 14, 21 and 28 and the change in quality of life, handgrip strength, body mass index, body weight, lean body mass, fatigue and c-reactive protein level from day 0 to day 28.

Clinical trial identification: NCT05243251.

Lackner, M., S. G. de Hoog, L. Yang, L. F. Moreno, S. A. Ahmed, F. Andreas, J. Kaltseis, M. Nagl, C. Lass-Flörl, B. Risslegger, et al., Correction to: Proposed nomenclature for Pseudallescheria, Scedosporium and related genera, , vol. 113, issue 1, pp. 193 - 194, 2022. AbstractWebsite
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Vitale, A., F. Della Casa, G. Ragab, I. A. Almaghlouth, G. Lopalco, R. M. Pereira, S. Guerriero, M. Govoni, P. P. Sfikakis, R. Giacomelli, et al., "Development and implementation of the AIDA International Registry for patients with Behçet’s disease", Internal and Emergency Medicine: Springer Science and Business Media Deutschland GmbH, 2022. AbstractWebsite
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Vitale, A., F. Della Casa, G. Lopalco, R. M. Pereira, P. Ruscitti, R. Giacomelli, G. Ragab, F. La Torre, E. Bartoloni, E. Del Giudice, et al., "Development and Implementation of the AIDA International Registry for Patients With Still's Disease", Frontiers in Medicine, vol. 9: Frontiers Media S.A., 2022. AbstractWebsite
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Della Casa, F., A. Vitale, G. Lopalco, P. Ruscitti, F. Ciccia, G. Emmi, M. Cattalini, E. Wiesik-Szewczyk, M. C. Maggio, B. Ogunjimi, et al., "Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases", Frontiers in Medicine, vol. 9: Frontiers Media S.A., 2022. AbstractWebsite
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Méndez-Sánchez, N., E. Bugianesi, R. G. Gish, F. Lammert, H. Tilg, M. H. Nguyen, S. K. Sarin, N. Fabrellas, S. Zelber-Sagi, J. - G. Fan, et al., "Global multi-stakeholder endorsement of the MAFLD definition", The Lancet Gastroenterology & HepatologyThe Lancet Gastroenterology & Hepatology, vol. 7, issue 5: Elsevier, pp. 388 - 390, 2022. AbstractWebsite
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Zhang, T., X. Wu, S. M. Shaheen, H. Abdelrahman, E. F. Ali, N. S. Bolan, Y. S. Ok, G. Li, D. C. W. Tsang, and J. Rinklebe, "Improving the humification and phosphorus flow during swine manure composting: A trial for enhancing the beneficial applications of hazardous biowastes", Journal of Hazardous Materials, vol. 425, pp. 127906, 2022. AbstractWebsite

Improving the recovery of organic matter and phosphorus (P) from hazardous biowastes such as swine manure using acidic substrates (ASs) in conjunction with aerobic composting is of great interest. This work aimed to investigate the effects of ASs on the humification and/or P migration as well as on microbial succession during the swine manure composting, employing multivariate and multiscale approaches. Adding ASs, derived from wood vinegar and humic acid, increased the degree of humification and thermal stability of the compost. The 31P nuclear magnetic resonance spectroscopy and X-ray absorption near-edge structure analyses demonstrated compost P was in the form of struvite crystals, Ca/Al-P phases, and Poly-P (all inorganic P species) as well as inositol hexakisphosphate and Mono-P (organophosphorus species). However, the efficiency of P recovery could be improved by generating more struvite by adding the ASs. The flows among nutrient pools resulted from the diversity in the dominant microbial communities in different composting phases after introducing the ASs and appearance of Bacillus spp. in all phases. These results demonstrate the potential value of ASs for regulating and/or improving nutrients flow during the composting of hazardous biowastes for producing higher quality compost, which may maximize their beneficial benefits and applications.