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2022
Fathy, M., K. A. Abdel-moein, W. A. Osman, A. H. M. E. D. M. ERFAN, A. Prince, A. A. Elgabaly, and A. M. Elkattan, "Occurrence of Toxigenic Clostridium difficile among Diarrheic Sheep and Goats in Rural Settings: Public Health Concern", International Journal of Veterinary Science, vol. https://doi.org/10.47278/journal.ijvs/2022.156, pp. 2305-4360, 2022.
Osama E. Gouda, and Adel Z. El Dein, "Online Monitoring of High Voltage Polluted Insulators Severity", International Journal of Applied Energy Systems,, vol. 4, issue 1, pp. 8- 15, 2022.
Abdelfattah, M. G., S. F. Hegazy, N. F. F. Areed, and S. S. A. Obayya, "Optical cryptosystem for visually meaningful encrypted images based on gyrator transform and Hénon map", Optical and Quantum Electronics, vol. 54, no. 2: Springer US, pp. 1–22, 2022. Abstract
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Afify, S. M., G. Hassan, H. M. Nawara, M. H. Zahra, Y. Xu, M. J. Alam, K. Saitoh, H. Mansour, H. A. Abu Quora, M. Sheta, et al., "Optimization of production and characterization of a recombinant soluble human Cripto-1 protein inhibiting self-renewal of cancer stem cells.", Journal of cellular biochemistry, 2022. Abstract

Human Cripto-1 is a member of the epidermal growth factor (EGF)-Cripto-FRL-1-Cryptic (CFC) family family and performs critical roles in cancer and various pathological and developmental processes. Recently we demonstrated that a soluble form of Cripto-1 suppresses the self-renewal and enhances the differentiation of cancer stem cells (CSCs). A functional form of soluble Cripto-1 was found to be difficult to obtain because of the 12 cysteine residues in the protein which impairs the folding process. Here, we optimized the protocol for a T7 expression system, purification from inclusion bodies under denatured conditions refolding of a His-tagged Cripto-1 protein. A concentrations of 0.2-0.4 mM isopropyl β-D-1-thiogalactopyranoside (IPTG) at 37°C was found to be the optimal concentration for Cripto-1 expression while imidazole at 0.5 M was the optimum concentration to elute the Cripto-1 protein from a Ni-column in the smallest volume. Cation exchange column chromatography of the Cripto-1 protein in the presence of 8 M urea exhibited sufficient elution profile at pH 5, which was more efficient at recovery. The recovery of the protein reached to more than 26.6% after refolding with arginine. The purified Cripto-1 exhibited high affinity to the anti-ALK-4 antibody and suppressed sphere forming ability of CSCs at high dose and induced cell differentiation.

Osman, H., S. Alshammary, M. Rassouli, I. Al-Diri, I. Fadhil, A. Hassan, O. Shamieh, S. Alsirafy, and G. Alarieh, "Palliative care in the Eastern Mediterranean Region: An overview.", Cancer control Eastern Mediterranean Region special report. , Suffolk, Global Health Dynamics Limited, 2022.
Nour, I. H., R. S. Hamdy, A. K. Osman, and M. O. Badry, "Palynological study of Allium L. (Amaryllidaceae) in the flora of Egypt", Palynology, pp. 1-15, 2022.
Gouda, O. E., A. D. E. L. Z. E. I. N. E. L. D. E. I. N. MOHAMED, M. O. S. L. E. H. M. AL-HARTHI, S. A. R. A. Y. A. S. S. I. N. OMAR, and S. H. E. R. I. F. S. M. GHONEIM, "Performance of Grounding Electrodes under Lightning Strokes in Uniform and Two-Layer Soils Considering Soil Ionization", IEEE OPEN ACCESS, vol. 10, pp. 76855-76869, 2022.
Abdel-Qader, D. H., W. Hayajneh, A. Albassam, N. M. Obeidat, A. M. Belbeisi, N. Al Mazrouei, A. F. Al-Shaikh, K. E. Nusair, A. Z. Al Meslamani, A. A. El-Shara, et al., "Pharmacists-physicians collaborative intervention to reduce vaccine hesitancy and resistance: A randomized controlled trial", Vaccine: X, vol. 10, 2022. AbstractWebsite
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El Gaafary, M., F. R. Saber, E. A. Mahrous, R. M. Ashour, M. O. N. A. M. OKBA, L. Jin, S. J. Lang, M. Schmiech, T. Simmet, and T. Syrovets, "The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells", Food and Chemical Toxicology, vol. 162: Elsevier, pp. 112896, 2022. Abstract
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Fadel, F. I., H. A. Madani, S. M. Kamel, A. horouk Othman, and D. M. Salah, "Plasma Netrin-1 & Cardiovascular Risk in Children with End Stage Renal Disease", International Journal of Health Sciences, vol. 6 , issue S4, pp. 1747-1772, 2022. 429584-plasma-netrin-1-cardiovascular-risk-in-c-ba3baed1.pdf
Osama E. Gouda, M. O. H. A. M. E. D. M. F. DARWISH, M. A. T. T. I. LEHTONEN, K. A. R. A. R. MAHMOUD, and T. A. M. E. R. M. ELKHODRAGY, "Pollution Severity Monitoring of High Voltage Transmission Line Insulators Using Wireless Device Based on Leakage Current Bursts", IEEE OPEN ACCESS, vol. 10, pp. 53713-53723, 2022.
AbdelGhaffar, M. M., D. Omran, A. Elgebaly, E. I. Bahbah, shimaa afify, M. AlSoda, M. El-Shiekh, E. S. ElSayed, S. S. Shaaban, S. AbdelHafez, et al., "Prediction of mortality in hospitalized Egyptian patients with Coronavirus disease-2019: A multicenter retrospective study.", PloS one, vol. 17, issue 1, pp. e0262348, 2022. Abstract

We aimed to assess the epidemiological, clinical, and laboratory characteristics associated with mortality among hospitalized Egyptian patients with COVID-19. A multicenter, retrospective study was conducted on all polymerase chain reaction (PCR)-confirmed COVID-19 cases admitted through the period from April to July 2020. A generalized linear model was reconstructed with covariates based on predictor's statistical significance and clinically relevance. The odds ratio (OR) was calculated by using stepwise logistic regression modeling. A total of 3712 hospitalized patients were included; of them, 900 deaths were recorded (24.2%). Compared to survived patients, non-survived patients were more likely to be older than 60 years (65.7%), males (53.6%) diabetic (37.6%), hypertensive (37.2%), and had chronic renal insufficiency (9%). Non-survived patients were less likely to receive azithromycin (p <0.001), anticoagulants (p <0.001), and steroids (p <0.001). We found that age ≥ 60 years old (OR = 2.82, 95% CI 2.05-3.86; p <0.0001), diabetes mellitus (OR = 1.58, 95% CI 1.14-2.19; p = 0.006), hypertension (OR = 1.69, 95% CI 1.22-2.36; p = 0.002), chronic renal insufficiency (OR = 3.15, 95% CI 1.84-5.38; p <0.0001), tachycardia (OR = 1.65, 95% CI 1.22-2.23; p <0.001), hypoxemia (OR = 5.69, 95% CI 4.05-7.98; p <0.0001), GCS <13 (OR 515.2, 95% CI 148.5-1786.9; p <0.0001), the use of therapeutic dose of anticoagulation (OR = 0.4, 95% CI 0.22-0.74, p = 0.003) and azithromycin (OR = 0.16, 95% CI 0.09-0.26; p <0.0001) were independent negative predictors of mortality. In conclusion, age >60 years, comorbidities, tachycardia, hypoxemia, and altered consciousness level are independent predictors of mortality among Egyptian hospitalized patients with COVID-19. On the other hand, the use of anticoagulants and azithromycin is associated with reduced mortality.

Salman, M. A., A. Rabiee, A. Salman, A. Elewa, M. Tourky, A. A. Mahmoud, A. Moustafa, H. E. - D. Shaaban, A. A. Ismail, K. Noureldin, et al., "Predictors of type-2 diabetes remission following bariatric surgery after a two-year follow up.", Asian journal of surgery, 2022. Abstract

PURPOSE: Bariatric surgery is evolving as a successful tool for managing morbid obesity and T2DM. This study aimed to identify predictors of diabetes remission after two types of bariatric procedures.

METHODS: This prospective study enrolled 172 patients with morbid obesity associated with T2DM scheduled for bariatric surgery. Two laparoscopic bariatric procedures were done; single anastomosis gastric bypass (SAGB, n = 83) and sleeve gastrectomy (LSG, n = 68). Lipid accumulation product index (LAP) and quantitative insulin sensitivity check index (QUICKI) were used to evaluate lipid profile and insulin sensitivity. Two years after surgery condition of DM was evaluated as complete remission (CR), partial remission (PR), or improvement. The primary outcome measure was predictors of diabetes remission.

RESULTS: Two years after surgery, 151 patients were available for evaluation, where 75 patients (49.7%) achieved CR, while PR was found in 36 (23.8%). CR was significantly associated with younger age, shorter duration of DM (p < 0.001, for both), higher C-peptide and GLP-1 levels (p < 0.001 and p = 0.002, respectively), and bypass surgery (p = 0.027). On multivariate analysis, shorter duration of DM, lower BMI, and higher C-peptide levels were the independent factors predicting CR.

CONCLUSION: Complete remission of T2DM can be achieved in nearly half of the patients two years after SG or SAGB. The duration of diabetes and preoperative BMI and C-peptide levels are the independent factors predicting complete remissions.

Osman, A. A. E., R. A. El-Khoribi, M. E. Shoman, and M. W. A. Shalaby, "Preprocessing Trajectory Learning Techniques For Robots: A comparative study", 2022 International Conference on Decision Aid Sciences and Applications (DASA): IEEE, pp. 1412-1415, 2022. Abstract
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Omar, M. G., A. M. Yousef, H. E. - D. H. Kamel, and M. M. Yosri, "Prevalence of pelvic floor dysfunction among women with polycystic ovarian syndrome: a case- control study", Journal/ Conference International journal of thin film science21th international conference of physical therapy (Physical therapy and quality of life), grand nile tower, 2022.
SAMIR, S. A. R. A. M. O. H. A. M. E. D., S. M. Elkady, U. M. Rashad, A. F. AbdelMonem, D. A. Osman, and A. M. E. - S. Zedan, "Prevalence of Shoulder pathologies in Cairo and Qalubiya - Egypt: Hospital- based cross sectional study", International Journal of Health Sciences, vol. 6, issue S6, pp. 1437–1447, 2022. AbstractWebsite

Background: Pathological conditions of the Shoulder joint are very common as the shoulder is the most freely movable joint in the body (and hence the most unstable). These conditions can lead to pain and disability that affect individuals socially and economically. Purpose: This study was conducted to identify the prevalence and characteristics of shoulder pathologies in two main hospitals in two Egyptian governorates as up to researchers’ knowledge, no previous epidemiological studies of shoulder conditions attending orthopedic physical therapy outpatient clinics have been carried out in Egypt, sothe current study provides valuable information about diseases’ burden for researchers and healthcare policy makers, thus assisting in disease prevention , identifying health economic models and establishing guidelines. Methodology: A hospital- based record study was made for 1633 patients, 101 patients of them were suffering from shoulder pathologies, data were collected from patients’ referral records to orthopedic physical therapy outpatient clinics in two hospitals (Kasr Aini educational hospital) (KA) in Cairo and (Benha educational hospital) in Qalubiya – Egypt, that are reviewed from the first of January 2019 to 31 December 2019. Demographic characteristics including (gender, affected side) and different types of pathologies were described. Results: One –year prevalence of shoulder pathologies was 6.1% (101/1633 cases). Male to female ratio was 1:2.6. The most frequent type of shoulder pathologies was impingement syndrome (38.6%), followed by rotator cuff tear (17.8%). Right side was most frequently affected (43.6%). Conclusion: Shoulder impingement syndrome (SIS) and rotator cuff tear (RCT) were the two main types of shoulder pathologies among people living in Cairo and Qalubiya- Egypt. Concerning gender, higher prevalence was in women, and finally when considering the affected side, right side was commonly affected.

Abdelhak, Y. I., F. Kamel, M. Hafez, H. E. Kotb, H. A. Omran, T. Ismail, and H. Mostafa, "Radio Optical Network Simulation Tool (RONST)", CMC-Computers, Materials & Continua, vol. 71, no. 2: doi:10.32604/cmc.2022.022470, pp. 3685–3702, 2022. Abstract
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Aziz, H. A., H. Omar, M. Khalil, A. Cordie, R. Mohamed, M. Abdallah, M. H. Abdel Maksoud, N. El Garhy, L. Ali, M. E. Serafy, et al., "Real-life experience of treating HCV co-infection among HIV-infected population in Egypt: single-center experience.", Expert review of anti-infective therapy, vol. 20, issue 5, pp. 789-795, 2022. Abstract

BACKGROUND: Liver disease has emerged as a leading cause of death among PLHIV coinfected with HCV.

METHODS: A retrospective study involving all HCV viremic patients coinfected with HIV who presented to HCV/HIV multidisciplinary clinics located at Embaba fever hospital. Patients were assigned to receive DAAs according to the national treatment guidelines. The primary endpoint was SVR12.

RESULTS: Of the 519 patients enrolled, 38.73% LTFU; either not initiated (n = 170) or did not complete the treatment (n = 31). The main identified reasons behind LTFU were schedule conflict (19%) or hospitalization (13%). Among 318 patients who completed their DAAs course, nine patients had a relapse after the end of treatment and 97% had attained SVR12. There were significant differences among different virological response groups in baseline factors including smoking (p = 0.005), history of dental procedure (p = 0.007), CD4 count (p = 0.007), and HIV viral load (p = <0.001). Among responders (n = 309), there was a significant reduction of baseline hemoglobin and significant improvement of baseline platelets (p = 0.005) at on-treatment week 8. Baseline necro-inflammatory markers showed significant improvement across follow-up time points (p < 0.001).

CONCLUSIONS: DAAs are an effective and safe choice to treat HCV in PLHIV. Social stigma could be a major cause for lacking adherence to follow-up visits. ALT: Alanine Aminotransferase; ARV: Antiretroviral treatment; AST: Aspartate Aminotransferase; DAAs: Direct acting antivirals; ARVs: antiretroviral therapy; EMR: Eastern Mediterranean region; HCV: Hepatitis C virus; kPa: Kilopascal; LTFU: Patient lost to follow up; NCCVH: The National Committee for Control of Viral Hepatitis; PWID: People who inject drugs; SVR: Sustained virological response;UNAIDS: The Joint United Nations Programme on HIV/AIDS.

Attia, N. F., S. E. A. Elashery, A. A. Galhoum, H. Oh, and I. E. E. T. Sayed, "Recyclable Porous Adsorbents As Environmentally Approach for Greenhouse Gas Capture", SUSTAINABLE SOLUTIONS FOR ENVIRONMENTAL POLLUTION, Volume 2: Scrivener Publishing and John Wiley and Sons, 2022.
Salman, M. A., A. Salman, A. Elewa, A. Rabiee, M. Tourky, H. E. - D. Shaaban, M. Issa, A. Abdalla, M. Khattab, Ahmed Refaat, MD, et al., "Secondary Hyperparathyroidism Before and After Bariatric Surgery: a Prospective Study with 2-Year Follow-Up.", Obesity surgery, 2022. Abstract

PURPOSE: Secondary hyperparathyroidism (SHPT) is linked to obesity. Bariatric surgery may be associated with calcium and vitamin D deficiencies leading to SHPT. This study aimed to detect the prevalence of SHPT before and after bariatric surgery.

METHODS: This prospective study assessed the prevalence of SHPT after sleeve gastrectomy (SG, n = 38) compared to one-anastomosis gastric bypass (OAGB, n = 86). All patients were followed up for 2 years. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry.

RESULTS: Of the 124 patients, 71 (57.3%) were females, and 53 (42.7%) were males, with a mean age of 37.5 ± 8.8 years. Before surgery, 23 patients (18.5%) suffered from SHPT, and 40 (32.3%) had vitamin D deficiency. The prevalence of SHPT increased to 29.8% after 1 year and 36.3% after 2 years. SHPT was associated with lower levels of vitamin D and calcium and higher reduction of BMD in the hip but not in the spine. After 2 years, SHPT was associated with a significantly lower T-score in the hip. SHPT and vitamin D deficiency were significantly more common in patients subjected to OAGB compared to SG (p = 0.003, and p < 0.001, respectively). There is a strong negative correlation between vitamin D levels and parathormone levels before and after surgery.

CONCLUSION: Prevalence of SHPT is high in obese patients seeking bariatric surgery, especially with lower vitamin D levels. Bariatric surgery increases the prevalence of SHPT up to 2 years. Gastric bypass is associated with a higher risk of developing SHPT compared to SG.

El-Sokkary, R., H. Erdem, R. Kullar, A. U. Pekok, F. Amer, S. Grgić, B. Carevic, A. El-Kholy, A. Liskova, and M. Özdemir, "Self-reported antibiotic stewardship and infection control measures from 57 intensive care units: An international ID-IRI survey", Journal of Infection and Public Health: Elsevier, 2022. Abstract
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Kohyama, A., M. J. Kim, R. Yokoyama, S. Sun, A. M. Omar, N. D. Phan, M. R. Meselhy, K. Tsuge, S. Awale, and Y. Matsuya, "Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate", Bioorganic & Medicinal Chemistry, vol. 54: Pergamon, pp. 116563, 2022. Abstract
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Kamel, M. G., F. M. Sroor, A. M. Othman, K. F. Mahrous, F. M. Saleh, H. M. Hassaneen, T. A. Abdallah, I. A. Abdelhamid, and M. M. A. Teleb, "Structure-based design of novel pyrazolyl–chalcones as anti-cancer and antimicrobial agents: synthesis and in vitro studies", Monatshefte für Chemie-Chemical Monthly: Springer Vienna, pp. 1-11, 2022. Abstract
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