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2022
Ogunyemi, O. M., G. A. Gyebi, I. M. Ibrahim, A. M. Esan, C. O. Olaiya, M. M. Soliman, and G. E. - S. Batiha, "Identification of promising multi-targeting inhibitors of obesity from Vernonia amygdalina through computational analysis", Molecular Diversity: Springer, pp. 1–25, 2022. Abstract
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Nawar, M., A. El-Attar, T. Osman, and H. M. El-Barmelgy*, "Identifying Main Driving Forces Affecting Urban Sprawl in the Vicinity of Cultural Heritage Sites in Egypt", Civil Engineering and Architecture, vol. 10, issue 5A, pp. 391-409, 2022. Website
Omar, A. R., A. E. Dakrory, M. M. Abdelaal, and H. Bassiony, "Impact of intrauterine exposure to the insecticide coragen on the developmental and genetic toxicity in female albino rats", Egyptian Journal of Basic and Applied Sciences, vol. 9, issue 1, pp. 23-42, 2022.
Hady, D. A. A., A. M. Yousef, M. M. Yosri, F. M. Okeel, A. R. A. H. ElWahab, O. M. Mabrouk, and S. A. Mohamed, "Impact of Kegel Exercises and Transcutaneous Tibial Nerve Stimulation on Low Back Pain in Women with Stress Urinary Incontinence: A Randomized Controlled Trial", International Journal of Thin Films Science and Technology, vol. 11, issue S1,Recent Updates in Medical & Health Science and Technology, pp. 29-36, 2022.
Hady, D. A. A., A. M. Yousef, M. M. Yosri, F. M. Okeel, A. R. A. H. ElWahab, O. M. Mabrouk, and S. A. Mohamed, "Impact of Kegel Exercises and Transcutaneous Tibial Nerve Stimulation on Low Back Pain in Women with Stress Urinary Incontinence: A Randomized Controlled Trial", International Journal of Thin Films Science and Technology, vol. 11, issue S1,Recent Updates in Medical & Health Science and Technology, pp. 29-36, 2022.
Hady, D. A. A., A. M. Yousef, M. M. Yosri, F. M. Okeel, A. R. A. H. ElWahab, O. M. Mabrouk, and S. A. Mohamed, "Impact of Kegel Exercises and Transcutaneous Tibial Nerve Stimulation on Low Back Pain in Women with Stress Urinary Incontinence: A Randomized Controlled Trial", International Journal of Thin Films Science and Technology, vol. 11, issue S1,Recent Updates in Medical & Health Science and Technology, pp. 29-36, 2022.
Hady, D. A. A., A. M. Yousef, M. M. Yosri, F. M. Okeel, A. R. A. H. ElWahab, O. M. Mabrouk, and S. A. Mohamed, "Impact of Kegel Exercises and Transcutaneous Tibial Nerve Stimulation on Low Back Pain in Women with Stress Urinary Incontinence: A Randomized Controlled Trial", International Journal of Thin Films Science and Technology, vol. 11, issue S1,Recent Updates in Medical & Health Science and Technology, pp. 29-36, 2022. kegel_ex__ttns_on_lbp.pdf
on Collaborative, G. H. R. G. C. ’s N. - C. D., "Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study", BMJ Open, vol. 12, no. 4: British Medical Journal Publishing Group, 2022. AbstractWebsite

Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs.Design A multicentre, international, collaborative cohort study.Setting 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020.Participants Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, Hodgkin lymphoma, Wilms’ tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer.Main outcome measure All-cause mortality at 30 days and 90 days.Results 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001).Conclusions The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally.Data are available on reasonable request. Deidentified date will be shared on request.

, Jouini R, "Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study", BMJ Open, vol. 12, no. 4: British Medical Journal Publishing Group, 2022. AbstractWebsite

Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs.Design A multicentre, international, collaborative cohort study.Setting 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020.Participants Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, Hodgkin lymphoma, Wilms’ tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer.Main outcome measure All-cause mortality at 30 days and 90 days.Results 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001).Conclusions The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally.Data are available on reasonable request. Deidentified date will be shared on request.

Sayed, E. G., and M. A. Ouis, "Improvement of pea plants growth, yield, and seed quality using glass fertilizers and biofertilizers", Environmental Technology & Innovation, vol. 26: Elsevier, pp. 102356, 2022. Abstract
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Shousha, H. I., A. O. Abdelaziz, M. M. Nabeel, D. A. H. Omran, A. H. Abdelmaksoud, T. M. Elbaz, A. Salah, S. T. E. G. Harb, K. A. Hosny, A. Osman, et al., "infection and the occurrence, characteristics, and survival of patients with hepatocellular carcinoma: an observational study over a decade.", Pathogens and global health, vol. 116, issue 2, pp. 119-127, 2022. Abstract

infection (SMI) is suspected to be directly and indirectly involved in hepato-carcinogenesis. This study evaluated the association of a previous SMI with hepatocellular carcinoma (HCC) development, patients, tumor characteristics, treatment outcomes, and survival. This observational study included patients with HCC with and without previous SMI who presented to the multidisciplinary HCC clinic, Kasr-Alainy hospital (November 2009 to December 2019). It also included 313 patients with liver cirrhosis without HCC. Clinical and laboratory features of the patients (complete blood count, liver/renal functions , alpha-fetoprotein, and hepatitis B/C status), tumor characteristics (Triphasic CT and/or dynamic MRI), liver stiffness (transient elastography), HCC treatment outcome, and overall survival were studied. This study included 1446 patients with HCC; 688(47.6%) composed group-1, defined by patients having a history of SMI, and 758(52.4%) were in group-2 and without history of SMI. Male sex, smoking, diabetes mellitus, splenomegaly, deteriorated performance status, synthetic liver functions, and platelet count were significantly higher in group-1. The groups did not differ with regard to liver stiffness, tumor characteristics, or the occurrence of post-HCC treatment hepatic decompensation or recurrence. HCC treatment response was better in group-2. Group-1 showed lower sustained virological response to hepatitis C direct-acting antivirals (DAAs) compared with group-2 (60% versus 84.3%, respectively, P = 0.027). Prior SMI was associated with HCC (adjusted odds ratio = 1.589, 95% confidence interval = 1.187-2.127), and it was concluded that it increases the risk of HCC. In addition, it significantly affects the performance status, laboratory characteristics, response to DAAs, and overall survival.

Okasha, H., A. M. Abu-Seida, A. A. Hashem, S. E. H. Ashry, and M. M. Nagy, "Inflammatory response and immunohistochemical characterization of experimental calcium silicate-based perforation repair material", International Journal of Experimental Pathology, vol. 103, issue 4, pp. 156-163, 2022. inflammatory_response_of_experimental.pdf
Fadl, A. M., E. A. Abdelnaby, H. R. El-Sherbiny, and others, "INRA82 extender enhances semen quality in ram under cooled and cryopreserved stages", Asian Pacific Journal of Reproduction, vol. 11, no. 2: Medknow Publications, pp. 100, 2022. Abstract
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Abdel-Rahman, R. F., A. El-Desoky, H. Handoussa, M. R. Meselhy, G. F. Asaad, S. El-Mekkawy, and others, "LC-MS-based chemical profiling and in-vivo evaluation of the anti-inflammatory and anti-nociceptive activities of the defatted methanolic extract of Crataegus sinaica (Rosaceae) fruits", Egyptian Journal of Chemistry, vol. 65, no. 4: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 161–173, 2022. Abstract
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Kamel, A. M., N. A. H. L. A. M.ELSHARKAWY, Eman Z. Kandeel, M. Hanafi, M. Samra, and R. A. Osman, "Leukemia Stem Cell Frequency at Diagnosis Correlates With Measurable/Minimal Residual Disease and Impacts Survival in Adult Acute Myeloid Leukemia", Frontiers in Oncology , vol. 12, pp. 867684-867684, 2022.
Kamel, A. M., N. M. El Sharkawy, E. Z. Kandeel, M. Hanafi, M. Samra, and R. A. Osman, "Leukemia Stem Cell Frequency at Diagnosis Correlates With Measurable/Minimal Residual Disease and Impacts Survival in Adult Acute Myeloid Leukemia.", Frontiers in oncology, vol. 12, pp. 867684, 2022. Abstractleukemia_stem_cell_frequency_at_diagnosis.pdf

Acute myeloid leukemia (AML) is a heterogenous disease in which the initiation and maintenance of the malignant clone is blamed on a rare population of leukemia stem cells (LSCs). The persistence of such a malignant population is referred to as measurable/minimal residual disease (MRD). Evaluation of MRD is the gold standard for follow-up of therapy and constitutes an independent prognostic parameter. As LSCs are the main contributor to the persistence of MRD, then MRD should correlate with the bulk of LSCs at the individual case level. MRD is measured at defined time points during therapy. However, LSCs can be evaluated at diagnosis, which ensures the advantage of early prediction of high-risk patients and allows for early therapeutic decisions. Using two simple four-color monoclonal antibody combinations (CD38/CD123/CD34/CD45 and CD90/CD133/CD45/CD33) and the prism function of the Coulter Navios flow cytometer, the frequency of LSC subsets was evaluated in 84 newly diagnosed adult AML patients. For each panel, 16 possible combinations were detected. Our results showed that there was extreme variability in the percentage of the LSC fraction between different cases, as well as at the individual case level. For each LSC subset, the median value was used to divide cases into low and high expressors. LSC subsets that showed an impact on overall survival (OS) and disease-free survival (DFS) included CD123+, CD 123+/CD34-, CD34-/CD38+/CD123+, CD34+/CD38-/CD123+, CD133+, and CD133+/CD33-. On multivariate analysis, only CD123 (p ≤ 0.001, SE = 0.266, HR = 2.8, 95% CI = 1.74.7) and CD133+/CD33- (p = 0.017, SE = 0.263, HR = 1.9, 95% CI = 1.1-3.1) retained their significance for OS. Likewise, only CD34+/CD38-/CD123+ (p ≤ 0.001, HR 2.3, SE: 0.499, 95% CI: 2.4-17.4) and CD133 (p = 0.015, HR 2.3, SE 0.34, 95% CI: 1.2-4.4) retained their statistical significance for DFS. The LSC frequency at diagnosis showed a moderate to strong correlation with MRD status at day 14 and day 28. In conclusion, the level of LSCs at diagnosis correlated with MRD status at day 14 and day 28 in AML patients and had a deleterious impact on OS and DFS. It may be used as an early marker for high-risk patients allowing for early therapeutic decisions.

Kamel, A. M., N. M. El Sharkawy, E. Z. Kandeel, M. Hanafi, M. Samra, and R. A. Osman, "Leukemia Stem Cell Frequency at Diagnosis Correlates With Measurable/Minimal Residual Disease and Impacts Survival in Adult Acute Myeloid Leukemia.", Frontiers in oncology, vol. 12, pp. 867684, 2022. Abstract

Acute myeloid leukemia (AML) is a heterogenous disease in which the initiation and maintenance of the malignant clone is blamed on a rare population of leukemia stem cells (LSCs). The persistence of such a malignant population is referred to as measurable/minimal residual disease (MRD). Evaluation of MRD is the gold standard for follow-up of therapy and constitutes an independent prognostic parameter. As LSCs are the main contributor to the persistence of MRD, then MRD should correlate with the bulk of LSCs at the individual case level. MRD is measured at defined time points during therapy. However, LSCs can be evaluated at diagnosis, which ensures the advantage of early prediction of high-risk patients and allows for early therapeutic decisions. Using two simple four-color monoclonal antibody combinations (CD38/CD123/CD34/CD45 and CD90/CD133/CD45/CD33) and the prism function of the Coulter Navios flow cytometer, the frequency of LSC subsets was evaluated in 84 newly diagnosed adult AML patients. For each panel, 16 possible combinations were detected. Our results showed that there was extreme variability in the percentage of the LSC fraction between different cases, as well as at the individual case level. For each LSC subset, the median value was used to divide cases into low and high expressors. LSC subsets that showed an impact on overall survival (OS) and disease-free survival (DFS) included CD123+, CD 123+/CD34-, CD34-/CD38+/CD123+, CD34+/CD38-/CD123+, CD133+, and CD133+/CD33-. On multivariate analysis, only CD123 (p ≤ 0.001, SE = 0.266, HR = 2.8, 95% CI = 1.74.7) and CD133+/CD33- (p = 0.017, SE = 0.263, HR = 1.9, 95% CI = 1.1-3.1) retained their significance for OS. Likewise, only CD34+/CD38-/CD123+ (p ≤ 0.001, HR 2.3, SE: 0.499, 95% CI: 2.4-17.4) and CD133 (p = 0.015, HR 2.3, SE 0.34, 95% CI: 1.2-4.4) retained their statistical significance for DFS. The LSC frequency at diagnosis showed a moderate to strong correlation with MRD status at day 14 and day 28. In conclusion, the level of LSCs at diagnosis correlated with MRD status at day 14 and day 28 in AML patients and had a deleterious impact on OS and DFS. It may be used as an early marker for high-risk patients allowing for early therapeutic decisions.

Awad, M., E. - D. S. Ibrahim, E. I. Osman, W. H. Elmenofy, A. W. M. Mahmoud, M. A. M. Atia, and M. A. M. Moustafa, "Nano-insecticides against the black cutworm Agrotis ipsilon (Lepidoptera: Noctuidae): Toxicity, development, enzyme activity, and DNA mutagenicity", PLoS ONE, vol. 17, issue 2, pp. e0254285, 2022.
Awad, M., E. - D. S. Ibrahim, E. I. Osman, W. H. Elmenofy, A. W. M. Mahmoud, M. A. M. Atia, and M. A. M. Moustafa, "Nano-insecticides against the black cutworm Agrotis ipsilon (Lepidoptera: Noctuidae): Toxicity, development, enzyme activity, and DNA mutagenicity", Plos one, vol. 17, issue 2: Public Library of Science, pp. e0254285, 2022. Abstract
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Yassine, I. A., A. M. Ghanem, N. S. Metwalli, A. Hamimi, R. Ouwerkerk, J. R. Matta, M. A. Solomon, J. M. Elin, A. M. Gharib, and K. Z. Abd-Elmoniem, "Native-resolution myocardial principal Eulerian strain mapping using convolutional neural networks and Tagged Magnetic Resonance Imaging", Computers in biology and medicine, vol. 141, pp. 105041, 2022.
Abdulaziz, K. S., M. H. Mohamed, D. R. A. Gad, L. S. E. - D. Mahmoud, E. E. A. Elshimy, and D. A. Osman, "Neuromodulation effect of laser acupuncture on female stress urinary incontinence: a randomized controlled trial", SPORT TK-Revista EuroAmericana de Ciencias del Deporte, vol. 11, issue 2, 2022. Website
Okda, T. M., G. M. K. Atwa, A. F. Eldehn, N. Dahran, K. F. Alsharif, and E. K. Elmahallawy, "A Novel Role of Galectin-3 and Thyroglobulin in Prognosis and Differentiation of Different Stages of Thyroid Cancer and Elucidation of the Potential Contribution of Bcl-2, IL-8 and TNF-α.", Biomedicines, vol. 10, issue 2, 2022. Abstract

Thyroid cancer is among the most prevalent cancers with different types and stages. New markers are required for the prognosis and diagnosis of the disease. The present study aimed to detect the role of new markers, including galectin-3 (Gal-3) and thyroglobulin (TG), in the prognosis and staging of thyroid cancer. The study also investigated the potential apoptotic and inflammatory mechanisms involved in thyroid cancer through the determination of B-cell lymphoma 2 (Bcl-2), interleukin-8 (IL-8) and tumor necrosis factor α (TNFα) during the different stages of the cancer using a series of molecular methods. Histopathological and immunohistochemical examinations were also performed. A total of 300 subjects were classified into: 100 normal healthy subjects matched in age and sex, 100 patients with thyroid carcinoma stage I (T1N0M0) and 100 patients with thyroid carcinoma stage 2 (T2N1M1). Interestingly, the present study revealed a significant increase in the levels of TG and Gal-3 in thyroid cancer patients compared to the control group. Furthermore, the levels of Bcl-2, IL-8 and TNF-α significantly increased in the patient serum. The histopathological examination and immunohistochemical observations confirmed the molecular and hematological findings. Collectively, the present study concluded that serum TG and Gal-3 could be useful markers in the prognosis and staging of patients with thyroid cancer. Furthermore, the determination of Bax, Bcl-2, IL-8 and TNF-α levels constitute a major important marker for investigation of the mechanisms of apoptosis and inflammation in thyroid cancer. To our knowledge, this is the first study that used both galectin-3 and TG as tumor markers in the prognosis and differentiation between the different stages of cancer.

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