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2022
El-Bashar, R., M. Hussein, S. F. Hegazy, Y. Badr, B. M. A. Rahman, K. T. V. Grattan, M. F. Hameed, S. S. A. Obayya, and others, "Electrical performance of efficient quad-crescent-shaped Si nanowire solar cell", Scientific Reports, vol. 12, no. 1: Nature Publishing Group, pp. 1–20, 2022. Abstract
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Rambow, A. - C., I. Aschenbach, S. Hagelund, D. Tawfik, J. - P. Gundlach, S. Weiße, N. Maass, A. Trauzold, and others, "Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells", Frontiers in cell and developmental biology, vol. 10, 2022. Abstract
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Ouf, S. A., M. I. Ali, M. G. Haggag, D. O. Elsafty, and A. H. I. Faraag, "Enhancement of antidermatophytic activities of Citrullus colocynthis Schrad collected from different ecological habitats in Egypt using fluconazole", Phytomedicine Plus, vol. 2, no. 1, pp. 100178, 2022. AbstractWebsite

Background Dermatophytes may cause various and severe types of fungal infections in several communities. Herbal plant extracts may be inhibitory against cutaneous fungi related to Epidermophyton, Microsporum, and Trichophyton. The extract may be more efficient by its mixing with a low concentration of the antifungal agent. Purpose This study demonstrates the antidermatophytic activities of seed methanol extract of Citrullus colocynthis from different habitats in Egypt, namely Sinai desert, El-Wadi El-Gadid, and Wadi Qena. Methods A broth microdilution assay was used to determine the MIC and MFC of the extracts against the investigated fungal strains according to the Clinical and Laboratory Standards Institute (CLSI) M38-Ed3 guidelines. GC/MS was employed for the identification of the active constituents. Keratinase, lipase, phospholipase, and protease were measured spectrophotometrically or by determining the diameter of the reaction zone according to standard methods using a specific medium. Results C.colocynthis seed methanol extract from Sinai desert combined with 0.5 μg/ml of the antifungal drug fluconazole (FLU) was more effective than the extract or FLU, each on its own, in decreasing spore viability and reduction of fungal enzyme activities. The phytochemical analyses of the methanolic seed extract of the three cultivars show the presence of three common main compounds, namely, (9Z,12Z)-methyl octadeca-9,12-dienoate, (9Z,12E)-methyl octadeca-9,12-dienoate, and (9E,12E)-methyl octdeca-9,12-dienoate. The in-silico docking activity of the main compounds toward fungal enzymes showed a high binding affinity between the first compound and lipase enzymes of Microsporum canis and Trichophyton mentagrophytes. Conclusions The variation in the bioactivity of the plant extracts of a certain species may be varied due to the difference of the active constituents that are formed under specific conditions or stress. The inhibitory action of the extract to a certain pathogen could be improved when combined with lower drug concentration. Longer chain carbon compounds were frequently detected in the cultivar of Sinai compared to the compounds identified from the other localities suggesting that there was a variation in the active constituents according to the surveyed habitat although the main core of the constituents is maintained.

Osama E. Gouda, and Adel Z. El Dein, "Enhancement of the thermal analysis of harmonics impacts on low voltage underground power cables capacity", Electric Power Systems Research, vol. 04 (2022) , pp. 107719- 107728, 2022.
Adnan Awad, S., O. Brück, N. Shanmuganathan, T. Jarvinen, H. Lähteenmäki, J. Klievink, H. Ibrahim, S. Kytölä, P. Koskenvesa, T. P. Hughes, et al., "Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation", Blood cancer journal, vol. 12, no. 4: Nature Publishing Group, pp. 1–4, 2022. Abstract
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Hassan, A. S., R. S. Elshaarawy, R. Onyango, and H. F. Nagy, "Estimating system reliability using neoteric and median RSS data for generalized exponential distribution", International Journal of Mathematics and Mathematical Sciences, vol. 2022, 2022.
Hassan, A. S., R. S. Elshaarawy, R. Onyango, and H. F. Nagy, "Estimating System Reliability Using Neoteric and Median RSS Data for Generalized Exponential Distribution", International Journal of Mathematics and Mathematical Sciences, 2022. estimating_ss_neoteric_and_median_rss.pdf
Abdel-Tawab, M. S., H. Fouad, A. M. Othman, R. A. Eid, M. Abdeltawab Mohammed, A. H. M. E. D. HASSAN, and H. R. Reyad, "Evaluation of gene expression of PLEKHS1, AADAC, and CDKN3 as novel genomic markers in gastric carcinoma", PloS one, vol. 17, no. 4: Public Library of Science San Francisco, CA USA, pp. e0265184, 2022. Abstract
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SherienS. Kamell, Amna H. Faid2, Omnia Hamdy3*, E. A. Eltayeb1, and A. A. Zaky1, "Evaluationof Gold Nanoparticles for the Detection of Oral Squamous Cell Carcinoma Using RamanSpectroscopy: In-Vitro Study", NeuroQuantology, vol. Volume 20 , issue Issue 10, pp. Page 2284-2296, 2022.
Tegally, H., J. E. San, M. Cotten, B. Tegomoh, G. Mboowa, D. P. Martin, C. Baxter, M. Moir, A. Lambisia, A. Diallo, et al., "The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.", medRxiv: Cold Spring Harbor Laboratory Press, 2022. Abstract
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Kamal, N. M., M. M. Omair, R. Attar, S. A. Abosabie, N. M. Asiri, L. M. Sherief, and M. El-Shabrawi, "Facial Asymmetry in a Newly Born Baby: Diagnostic Challenge!", Clinical medicine insights. Case reports, vol. 15, pp. 11795476221088487, 2022. Abstract10.1177_11795476221088487_facial_asymmetry.pdf

Introduction: Facial asymmetry during crying in neonates is an important entity which might be due to an underlying true paralysis of the facial nerve or due to the benign overlooked diagnosis of congenital absence of the depressor angularis oris muscle (DAOM).

Case Report: We report a full-term newborn delivered by normal spontaneous vertex delivery with uneventful pregnancy and Apgar score of 9 and 10 at 1 and 5 minutes respectively. His parents are first-degree cousins with 4 living normal siblings. His birth weight was appropriate for his gestational age. His initial neonatal assessment was normal apart from facial asymmetry during crying in the form of deviation of the angle of the mouth to the left with an otherwise normal facial appearance. The facial asymmetry disappears at rest (without crying). This condition usually poses a diagnostic dilemma. Developmental and traumatic facial paralysis and being part of some syndromes like Mobius and CHARGE syndromes are among the most important differential diagnosis but the disappearance of the facial asymmetry at rest is diagnostic of absent DAOM which is a relatively common but missed diagnosis.

Conclusions: Pediatricians should be aware about the diagnosis of DAOM in neonates with asymmetric crying face if the face was completely normal at rest with deviation of the angle of the mouth on crying which disappears on rest.

Kamal, N. M., A. E. M. Alzeky, M. R. Omair, R. A. Attar, A. M. Alotaibi, A. Safar, N. S. Alosaimi, and S. A. S. Abosabie, "First report of SYNE1 arthrogryposis multiplex congenita from Saudi Arabia with a novel mutation: a case report.", Italian journal of pediatrics, vol. 48, issue 1, pp. 107, 2022. Abstracts13052-022-01301-x_syn_myopathy.pdf

BACKGROUND: Myogenic Arthrogryposis Multiplex Congenita type 3 (AMC-3), is a rare congenital condition characterized by severe hypotonia, club feet, and multiple joint contractures often affecting both arms and legs which start prior to birth.

CASE PRESENTATION: We report a full-term neonate born to first-degree cousins from fourth-generation consanguineous families, who had with antenatal history of reduced fetal movements. At birth, he was noticed to have bilateral club feet, arthrogryposis, severe hypotonia, and absent deep tendon reflexes. The patient developed difficulty in breathing probably attributed to his generalized severe hypotonia, necessitating mechanical ventilation. His creatinine-phospho-kinase, electromyogram, and brain magnetic resonance imaging were normal. Whole-exome sequencing (WES) was requested for the genetic diagnosis of the case. WES identified a novel homozygous variant c.23415-3799C > G p. in the synaptic nuclear envelope protein1 [SYNE1] gene. Seven out of 20 bioinformatic in silico programs predicted a pathogenic effect for this variant. Segregation analysis of the variant in the parents and siblings revealed that both parents and one sibling were heterozygous for the same mutation which proved the variant significance and its autosomal recessive pattern of inheritance.

CONCLUSIONS: AMC3 should be suspected in patients with decreased fetal movements, severe hypotonia, absent deep tendon reflexes, and arthrogryposis. SYNE1 gene mutations can be the underlying genetic defect and molecular genetic testing can prove the diagnosis.

Kamal, N. M., A. E. M. Alzeky, M. R. Omair, R. A. Attar, A. M. Alotaibi, A. Safar, N. S. Alosaimi, and S. A. S. Abosabie, "First report of SYNE1 arthrogryposis multiplex congenita from Saudi Arabia with a novel mutation: a case report.", Italian journal of pediatrics, vol. 48, issue 1, pp. 107, 2022. Abstracts13052-022-01301-x_syn_myopathy.pdf

BACKGROUND: Myogenic Arthrogryposis Multiplex Congenita type 3 (AMC-3), is a rare congenital condition characterized by severe hypotonia, club feet, and multiple joint contractures often affecting both arms and legs which start prior to birth.

CASE PRESENTATION: We report a full-term neonate born to first-degree cousins from fourth-generation consanguineous families, who had with antenatal history of reduced fetal movements. At birth, he was noticed to have bilateral club feet, arthrogryposis, severe hypotonia, and absent deep tendon reflexes. The patient developed difficulty in breathing probably attributed to his generalized severe hypotonia, necessitating mechanical ventilation. His creatinine-phospho-kinase, electromyogram, and brain magnetic resonance imaging were normal. Whole-exome sequencing (WES) was requested for the genetic diagnosis of the case. WES identified a novel homozygous variant c.23415-3799C > G p. in the synaptic nuclear envelope protein1 [SYNE1] gene. Seven out of 20 bioinformatic in silico programs predicted a pathogenic effect for this variant. Segregation analysis of the variant in the parents and siblings revealed that both parents and one sibling were heterozygous for the same mutation which proved the variant significance and its autosomal recessive pattern of inheritance.

CONCLUSIONS: AMC3 should be suspected in patients with decreased fetal movements, severe hypotonia, absent deep tendon reflexes, and arthrogryposis. SYNE1 gene mutations can be the underlying genetic defect and molecular genetic testing can prove the diagnosis.

Elbagoury, W. S., T. M. El-Saeed, K. A. Olama, and M. I. Kamel, "Functional outcomes of verbal-directed training versus visual-directed training in children with unilateral cerebral palsy", Current Pediatric Research, vol. 26, issue 1, pp. 1205-1210, 2022.
Shymaa Hatem, Seham A. Elkheshen, A. O.kamel, Maha Nasrc, Noha H. Moftah, Maha H Ragai, R. S. Elezaby, and N. E. M. Hoffy, "Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment", Drug Delivery, vol. VOL. 29, , , issue NO. 1, pp. 1212–1231, 2022.
Lazarus, J. V., H. E. Mark, M. Villota-Rivas, A. Palayew, P. Carrieri, M. Colombo, M. Ekstedt, G. Esmat, J. George, G. Marchesini, et al., "The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?", Journal of hepatology, vol. 76, issue 4, pp. 771-780, 2022. Abstract

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely underappreciated liver condition which is closely associated with obesity and metabolic disease. Despite affecting an estimated 1 in 4 adults globally, NAFLD is largely absent on national and global health agendas.

METHODS: We collected data from 102 countries, accounting for 86% of the world population, on NAFLD policies, guidelines, civil society engagement, clinical management, and epidemiologic data. A preparedness index was developed by coding questions into 6 domains (policies, guidelines, civil awareness, epidemiology and data, NAFLD detection, and NAFLD care management) and categorising the responses as high, medium, and low; a multiple correspondence analysis was then applied.

RESULTS: The highest scoring countries were India (42.7) and the United Kingdom (40.0), with 32 countries (31%) scoring zero out of 100. For 5 of the domains a minority of countries were categorised as high-level while the majority were categorised as low-level. No country had a national or sub-national strategy for NAFLD and <2% of the different strategies for related conditions included any mention of NAFLD. National NAFLD clinical guidelines were present in only 32 countries.

CONCLUSIONS: Although NAFLD is a pressing public health problem, no country was found to be well prepared to address it. There is a pressing need for strategies to address NAFLD at national and global levels.

LAY SUMMARY: Around a third of the countries scored a zero on the NAFLD policy preparedness index, with no country scoring over 50/100. Although NAFLD is a pressing public health problem, a comprehensive public health response is lacking in all 102 countries. Policies and strategies to address NAFLD at the national and global levels are urgently needed.

Elnaggar, R. K., A. M. Osailan, S. F. Alsubaie, S. A. Moawd, and W. A. Abd El-Nabie, "Graded aerobic exercise (GAEx): An effective exercise regimen to improve cardio-respiratory fitness and physical and psychosocial functioning in children with burn sequelae of the chest.", Burns : journal of the International Society for Burn Injuries, vol. 48, issue 2, pp. 337-344, 2022. Abstract

PURPOSE: The cardio-respiratory function is compromised in children recovering from burns, particularly, those who sustain a burn injury across the chest, which leads to further prejudicial effects on physical and psychosocial health. This study endeavored to explore the efficacy of 12 weeks of graded aerobic exercise (GAEx) on the cardiorespiratory capacity and physical and psychosocial functioning in children with burn sequelae of the chest.

METHODS: Thirty-six burn-injured children aged 10-18 years (%TBSA: 24.2 ± 4.9, and 38.8 ± 12.9 months since injury) were randomly assigned to GAEx group (n = 18; undergone a 12-week intensity- and time-graded aerobic exercise program plus standard rehabilitation) or control group (n = 18; received the standard rehabilitation only). The cardio-respiratory fitness [marked by the peak oxygen uptake (VO), minute ventilation (V), ventilatory equivalent of inhaled oxygen (VEq/VO), oxygen pulse (OP), respiratory exchange ratio (RER), maximum heart rate (HR), and the heart rate recovery at one minute (HRR)] and physical and psychosocial functioning were assessed pre- and post-intervention.

RESULTS: Children in the GAEx group showed significant increases in VO (P = 0.013), V (P = 0.026), OP (P = 0.034), HR (P = 0.035), and HRR (P = 0.04) and declines in VEq/VO (P = 0.009) and RER (P = 0.011) as compared to the control group. Additionally, the GAEx group reported higher physical (P = 0.029) and psychosocial (P = 0.012) functioning.

CONCLUSION: Twelve weeks of GAEx has salutary effects on cardio-respiratory capacity and physical and psychosocial functioning in children with burn sequelae of the chest. These findings suggest that adding GAEx as a complementary therapy to the long-term rehabilitation protocol for this patient population is worthwhile.

Shehata, S. A., H. S. Omar, A. G. S. Elfaidy, S. S. F. EL‑Sayed, M. E. Abuarab, and E. A. Abdeldaym, "Grafting enhances drought tolerance by regulating stress‑responsive gene expression and antioxidant enzyme activities in cucumbers", BMC Plant Biology, vol. 22, issue 408, pp. 1-17, 2022.
Sapena, V., M. Enea, F. Torres, C. Celsa, J. Rios, G. E. M. Rizzo, P. Nahon, Z. Mariño, R. Tateishi, T. Minami, et al., "Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis.", Gut, vol. 71, issue 3, pp. 593-604, 2022. Abstract

OBJECTIVE: The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration.

DESIGN: We pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death risk was expressed as HCC recurrence or death per 100 person-years (100PY). Propensity score-matched patients from the ITA.LI.CA. cohort (n=328) served as DAA-unexposed controls (no-DAA group). Risk factors for HCC recurrence were identified using random-effects Poisson.

RESULTS: Recurrence rate and death risk per 100PY in DAA-treated patients were 20 (95% CI 13.9 to 29.8, I=74.6%) and 5.7 (2.5 to 15.3, I=54.3), respectively. Predictive factors for recurrence were alpha-fetoprotein logarithm (relative risk (RR)=1.11, 95% CI 1.03 to 1.19; p=0.01, per 1 log of ng/mL), HCC recurrence history pre-DAA initiation (RR=1.11, 95% CI 1.07 to 1.16; p<0.001), performance status (2 vs 0, RR=4.35, 95% CI 1.54 to 11.11; 2 vs 1, RR=3.7, 95% CI 1.3 to 11.11; p=0.01) and tumour burden pre-HCC treatment (multifocal vs solitary nodule, RR=1.75, 95% CI 1.25 to 2.43; p<0.001). No significant difference was observed in RR between the DAA-exposed and DAA-unexposed groups in propensity score-matched patients (RR=0.64, 95% CI 0.37 to 1.1; p=0.1).

CONCLUSION: Effects of DAA exposure on HCC recurrence risk remain inconclusive. Active clinical and radiological follow-up of patients with HCC after HCV eradication with DAA is justified.

Eid, K., Q. Lu, S. sayed abdel-Azeim, A. Soliman, A. M. Abdullah, A. M. Abdelgwad, R. P. Forbes, K. I. Ozoemena, R. S. Varma, and M. Shibl, "Highly Exfoliated Ti3C2Tx MXene Nanosheets Atomically Doped with Cu for Efficient Electrochemical CO2 Reduction: An Experimental and Theoretical Study", Journal of Materials Chemistry A, vol. 10: Royal Society of Chemistry, pp. 1965-1975, 2022. Abstract

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Gamal, Y., B. M. Younis, S. F. Hegazy, Y. Badr, M. F. O. Hameed, and S. S. A. Obayya, "Highly Sensitive Multi-Functional Plasmonic Biosensor Based on Dual Core Photonic Crystal Fiber", IEEE Sensors Journal, vol. 22, no. 7: IEEE, pp. 6731–6738, 2022. Abstract
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Gamal, Y., B. M. Younis, S. F. Hegazy, Y. Badr, M. F. O. Hameed, and S. S. A. Obayya, "Highly Sensitive Multi-Functional Plasmonic Biosensor Based on Dual Core Photonic Crystal Fiber", IEEE Sensors Journal, vol. 22, no. 7: IEEE, pp. 6731–6738, 2022. Abstract
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Olawale, F., O. Iwaloye, K. Olofinsan, O. M. Ogunyemi, G. A. Gyebi, and I. M. Ibrahim, "Homology modelling, vHTS, pharmacophore, molecular docking and molecular dynamics studies for the identification of natural compound-derived inhibitor of MRP3 in acute leukaemia treatment", Chemical Papers: Springer, pp. 1–29, 2022. Abstract
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van Unen, V., L. F. Ouboter, N. Ali, M. Schreurs, T. Abdelaal, Y. Kooy-Winkelaar, G. Beyrend, T. Höllt, J. P. W. Maljaars, L. M. Mearin, et al., "Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease.", Frontiers in immunology, vol. 13, pp. 893803, 2022. Abstract

Chronic intestinal inflammation underlies inflammatory bowel disease (IBD). Previous studies indicated alterations in the cellular immune system; however, it has been challenging to interrogate the role of all immune cell subsets simultaneously. Therefore, we aimed to identify immune cell types associated with inflammation in IBD using high-dimensional mass cytometry. We analyzed 188 intestinal biopsies and paired blood samples of newly-diagnosed, treatment-naive patients (=42) and controls (=26) in two independent cohorts. We applied mass cytometry (36-antibody panel) to resolve single cells and analyzed the data with unbiased Hierarchical-SNE. In addition, imaging-mass cytometry (IMC) was performed to reveal the spatial distribution of the immune subsets in the tissue. We identified 44 distinct immune subsets. Correlation network analysis identified a network of inflammation-associated subsets, including HLA-DRCD38 EM CD4 T cells, T regulatory-like cells, PD1 EM CD8 T cells, neutrophils, CD27 TCRγδ cells and NK cells. All disease-associated subsets were validated in a second cohort. This network was abundant in a subset of patients, independent of IBD subtype, severity or intestinal location. Putative disease-associated CD4 T cells were detectable in blood. Finally, imaging-mass cytometry revealed the spatial colocalization of neutrophils, memory CD4 T cells and myeloid cells in the inflamed intestine. Our study indicates that a cellular network of both innate and adaptive immune cells colocalizes in inflamed biopsies from a subset of patients. These results contribute to dissecting disease heterogeneity and may guide the development of targeted therapeutics in IBD.