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2021
Baghdadi, H. B., E. O. M. Omer, D. M. Metwally, and R. Abdel-Gaber, "Prevalence of head lice (Pediculus humanus capitis) infestation among schools workers in the Eastern Region, Saudi Arabia", Saudi Journal of Biological Sciences, vol. 28, pp. 5662–5666, 2021.
Saeed, A., M. S. H-Elaga, M. Osama, and S. M. Shousha, "The prevalence of keratoconus in children with allergic eye disease in an Egyptian population", European Journal of ophthalmology, pp. 1-6, 2021.
Haberfellner, E., M. Elbaroody, A. F. Alkhamees, A. Alaosta, S. Eaton, E. Quint, S. Shahab, A. O'Connor, J. Im, A. Khan, et al., "Primary Spinal Melanoma: Case Report and Systematic Review.", Clinical neurology and neurosurgery, vol. 205, pp. 106649, 2021. Abstract

INTRODUCTION: Primary malignant melanoma of the spinal cord (PSM) is a rare condition with limited evidence regarding its diagnosis (clinical and radiographic), management, and prognosis. Our aim was to report an extremely rare two cases of primary malignant melanoma of the spine one of them is sacral melanoma which represents the second reported case in the literature and to conduct a systematic review of the relevant literature.

METHODS: The diagnosis and management of these cases were retrospectively reviewed. Using the PRISMA guideline, we conducted a systematic review of the literature to analyze different management strategies and the prognosis of such pathology.

RESULTS: All two patients were operated on, and received gross total removal of their tumors, with extended follow up for tumor recurrences. One of the cases involved a sacral tumor, which was resected without adjuvant therapy. The other one was seen by oncology and received post-operative chemo- and radio- therapy. In addition to the aforementioned cases, we present a comprehensive review of the literature on PSM from 1950 to the present, demonstrating that PSM is a very rare tumor, with a limited counted number of cases reported worldwide.

CONCLUSION: In conclusion, we report an exceedingly rare two cases of primary malignant melanoma of the spine. Early surgical intervention is key to the management of these rare and aggressive tumors. GTR should be attempted if possible.

Haberfellner, E., M. Elbaroody, A. F. Alkhamees, A. Alaosta, S. Eaton, E. Quint, S. Shahab, A. O'Connor, J. Im, A. Khan, et al., "Primary Spinal Melanoma: Case Report and Systematic Review.", Clinical neurology and neurosurgery, vol. 205, pp. 106649, 2021. Abstract

INTRODUCTION: Primary malignant melanoma of the spinal cord (PSM) is a rare condition with limited evidence regarding its diagnosis (clinical and radiographic), management, and prognosis. Our aim was to report an extremely rare two cases of primary malignant melanoma of the spine one of them is sacral melanoma which represents the second reported case in the literature and to conduct a systematic review of the relevant literature.

METHODS: The diagnosis and management of these cases were retrospectively reviewed. Using the PRISMA guideline, we conducted a systematic review of the literature to analyze different management strategies and the prognosis of such pathology.

RESULTS: All two patients were operated on, and received gross total removal of their tumors, with extended follow up for tumor recurrences. One of the cases involved a sacral tumor, which was resected without adjuvant therapy. The other one was seen by oncology and received post-operative chemo- and radio- therapy. In addition to the aforementioned cases, we present a comprehensive review of the literature on PSM from 1950 to the present, demonstrating that PSM is a very rare tumor, with a limited counted number of cases reported worldwide.

CONCLUSION: In conclusion, we report an exceedingly rare two cases of primary malignant melanoma of the spine. Early surgical intervention is key to the management of these rare and aggressive tumors. GTR should be attempted if possible.

Zahra, H. O., G. A. Omran, A. G. Gewely, A. F. Eldehn, W. Abdo, E. K. Elmahallawy, and T. M. Okda, "Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy.", Diagnostics (Basel, Switzerland), vol. 11, issue 11, 2021. Abstract

Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with diagnostic whole-body imaging. Serum thyroglobulin (TG) and thyroglobulin antibodies (TGAb) are biochemical tumor markers used to monitor WDTC. A global rise in the prevalence of WDTC is increasing the number of thyroidectomized patients requiring lifelong monitoring for persistent or recurrent diseases. The present study aimed to identify the most successful prognostic factors in well-defined thyroid carcinoma patients following total thyroidectomy and RAI therapy, followed by an estimation of the cutoff value of TG and TGAb. In this context, a total of 100 subjects were recruited and classified as follows: 60 thyroid carcinoma patients underwent total thyroidectomy and successful RAI therapy, while 40 normal healthy individuals matched for age, sex, and socioeconomic status constituted the control group. Interestingly, the levels of TG did not differ significantly between the relapsed and non-relapsed cases, but the levels of TGAb differed significantly between the relapsed and non-relapsed cases. Collectively, TG and TGAb are considered the most successful prognostic factors in well-defined thyroid carcinoma patients after total thyroidectomy and RAI therapy. The present study also concluded that the TGAb determination was better than that of the TG level, with a cutoff value of 10 ng/mL. These findings provide baseline information for follow-up and lifelong monitoring of thyroidectomized WDTC patients. Further research is warranted to explore more about serum TG and TGAb in thyroid carcinoma patients on a larger scale.

Sitohy, M., S. Taha, M. Abdel-Hamid, A. Abdelbacki, A. Hamed, and A. Osman, "Protecting potato plants against PVX and PVY viral infections by the application of native and chemically modified legume proteins", Journal of Plant Diseases and Protection, vol. 128, no. 4, pp. 1101-1114, 2021. AbstractWebsite
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Sitohy, M., S. Taha, M. Abdel-Hamid, A. Abdelbacki, A. Hamed, and A. Osman, "Protecting potato plants against PVX and PVY viral infections by the application of native and chemically modified legume proteins", Journal of Plant Diseases and Protection, vol. 128, no. 4: Springer, pp. 1101–1114, 2021. Abstract
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Almusawa, H., K. K. Ali, A. - M. Wazwaz, M. S. Mehanna, D. Baleanu, and M. S. Osman, "Protracted study on a real physical phenomenon generated by media inhomogeneities", Results in Physics, vol. 31, pp. 104933, 2021.
Omar, S., H. H. Zedan, and M. T. Ibrahim, "Quorum sensing inhibitory effect of bergamot oil and aspidosperma extract against Chromobacterium violaceum and Pseudomonas aeruginosa.) 203:4663–4675", Archives of Microbiology , issue 203, pp. 4663–4675 , 2021.
Abd-Elghany, A. A., A. A. Sulieman, E. Osman, and K. Alzimami, "Radiation exposure during therapeutic cardiac interventional procedures", Radiation physics and chemistry, vol. 188, 2021. radiation_exposure_during_therapeutic_cardiac_interventional_procedures.pdf
Majmundar, A. J., F. Buerger, T. A. Forbes, V. Klämbt, R. Schneider, K. Deutsch, T. M. Kitzler, S. E. Howden, M. Scurr, K. S. Tan, et al., "Recessive variants impair actin remodeling and cause glomerulopathy in humans and mice.", Science advances, vol. 7, issue 1, 2021. Abstract

Nephrotic syndrome (NS) is a leading cause of chronic kidney disease. We found recessive variants in two families with early-onset NS by exome sequencing. Overexpression of wild-type (WT) , but not cDNA constructs bearing patient variants, increased active CDC42 and promoted filopodia and podosome formation. Pharmacologic inhibition of CDC42 or its effectors, formin proteins, reduced NOS1AP-induced filopodia formation. knockdown reduced podocyte migration rate (PMR), which was rescued by overexpression of WT but not by constructs bearing patient variants. PMR in knockdown podocytes was also rescued by constitutively active or the formin Modeling a patient variant in knock-in human kidney organoids revealed malformed glomeruli with increased apoptosis. mice recapitulated the human phenotype, exhibiting proteinuria, foot process effacement, and glomerulosclerosis. These findings demonstrate that recessive variants impair CDC42/DIAPH-dependent actin remodeling, cause aberrant organoid glomerulogenesis, and lead to a glomerulopathy in humans and mice.

SH.M.Shehataa, R.Misrab, A.M.I.Osmana, O.M.Shalabiea, and Z.M.Hayman, "Redshift evolution of X-ray spectral index of quasars observed by XMM-NEWTON/SDSS", Journal of High Energy Astrophysics, vol. Volume 31, pp. 37-43, 2021. 1-s2.0-s2214404821000215-main.pdf
Burgmaier, K., L. Brinker, F. Erger, B. B. Beck, M. R. Benz, C. Bergmann, O. Boyer, L. Collard, C. Dafinger, M. Fila, et al., "Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.", Kidney international, 2021. Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The main cause of ARPKD are variants in the PKHD1 gene encoding the large transmembrane protein fibrocystin. The mechanisms underlying the observed clinical heterogeneity in ARPKD remain incompletely understood, partly due to the fact that genotype-phenotype correlations have been limited to the association of biallelic null variants in PKHD1 with the most severe phenotypes. In this observational study we analyzed a deep clinical dataset of 304 patients with ARPKD from two independent cohorts and identified novel genotype-phenotype correlations during childhood and adolescence. Biallelic null variants frequently show severe courses. Additionally, our data suggest that the affected region in PKHD1 is important in determining the phenotype. Patients with two missense variants affecting amino acids 709-1837 of fibrocystin or a missense variant in this region and a null variant less frequently developed chronic kidney failure, and patients with missense variants affecting amino acids 1838-2624 showed better hepatic outcome. Variants affecting amino acids 2625-4074 of fibrocystin were associated with poorer hepatic outcome. Thus, our data expand the understanding of genotype-phenotype correlations in pediatric ARPKD patients and can lay the foundation for more precise and personalized counselling and treatment approaches.

Elazab, H. A., A. O. Okasha, M. A. Radwan, M. A. Sadek, A. Firouzi, and T. T. El-Idreesy, "Removal of Methylene Blue by Adsorption of Water Hyacinth Derived Active Carbon Embedded with Cobalt Nanoparticles", Letters in Applied NanoBioScience, vol. 10, issue 4, pp. 2697-2705, 2021.
Abdellatif, A. A., M. S. Mogawer, M. El-Shazli, H. El-Karaksy, A. Salah, A. Abdel-Maqsod, M. E. - Amir, M. Said, N. Zayed, K. Hosny, et al., "Resuming post living donor liver transplantation in the COVID-19 pandemic: real- life experience, single-center experience", Egyptian Liver Journal, vol. 11, issue 92, 2021. resuming_post_living_donor_liver_transplantation_i.pdf
El-Hussein, A., S. L. Manoto, S. Ombinda-Lemboumba, Z. A. Alrowaili, and P. Mthunzi-Kufa, "A Review of Chemotherapy and Photodynamic Therapy for Lung Cancer Treatment.", Anti-cancer agents in medicinal chemistry, 2021. Abstract

Cancer is among the leading causes of mortality and morbidity worldwide. Among the different types of cancers, lung cancer is the considered to be the leading cause of death related to cancer and the most commonly diagnosed form of such disease. Chemotherapy remains a dominant treatment modality for many types of cancers at different stages. However, in many cases cancer cells develop drug resistance and become non-response to chemotherapy; thus necessitating the exploration of alternative and /or complementary treatment modalities. Photodynamic Therapy (PDT) has emerged as an effective treatment modality for various malignant neoplasia and tumors. In PDT, the photochemical interaction of light, Photosensitizer (PS) and molecular oxygen produces Reactive Oxygen Species (ROS) which induces cell death. Combination therapy by using PDT and chemotherapy can promote synergistic effect against this fatal disease with the elimination of drug resistance, and enhancement the efficacy of cancer eradication. In this review, we give an overview of chemotherapeutic modalities, PDT and the different types of drugs associated with each therapy. Furthermore, we also explored the combined use of chemotherapy and PDT in the course of lung cancer treatment and how this approach could be the last resort for thousands of patients that have been diagnosed by this fatal disease.

Nassar, A., I. M. Ibrahim, F. G. Amin, M. Magdy, A. M. Elgharib, E. B. Azzam, F. Nasser, K. Yousry, I. M. Shamkh, S. M. Mahdy, et al., "A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses", Molecules, vol. 26, no. 21: Multidisciplinary Digital Publishing Institute, pp. 6455, 2021. Abstract
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Valera-Medina, A., F. Amer-Hatem, A. K. Azad, I. C. Dedoussi, D. M. Joannon, R. X. Fernandes, P. Glarborg, H. Hashemi, X. He, S. Mashruk, et al., "Review on ammonia as a potential fuel: from synthesis to economics", Energy & Fuels, vol. 35, issue 9, pp. 6964–7029, 2021.
Hammam, N., S. Tharwat, R. E. R. Shereef, A. M. Elsaman, N. M. Khalil, H. M. Fathi, M. N. Salem, H. M. El-Saadany, N. Samy, A. S. El-Bahnasawy, et al., "Rheumatology university faculty opinion on coronavirus disease-19 (COVID-19) vaccines: the vaXurvey study from Egypt.", Rheumatology international, vol. 41, issue 9, pp. 1607-1616, 2021. Abstract

OBJECTIVES: The aim of the present work was to explore the perspectives of Egyptian Rheumatology staff members as regards the coronavirus disease-19 (COVID-19) vaccine.

METHODS: The survey is composed of 25 questions. Some questions were adapted from the global rheumatology alliance COVID-19 survey for patients.

RESULTS: 187 rheumatology staff members across Egypt from 18 universities and authorizations actively participated with a valid response. The mean time needed to complete the survey was 17.7 ± 13 min. Participants were 159 (85%) females (F:M 5.7:1). One-third agreed that they will be vaccinated once available, 24.6% have already received at least one dose, 29.4% are unsure while 16% will not take it. Furthermore, 70.1% agreed that they will recommend it to the rheumatic diseases (RD) patients once available, 24.1% are not sure while 5.9% will not recommend it. RD priority to be vaccinated against COVID-19 in descending order include SLE (82.9%), RA (55.1%), vasculitis (51.3%), systemic sclerosis (39.6%), MCTD (31.6%), Behcet's disease (28.3%). The most common drugs to be avoided before vaccination included biologics (71.7%), DMARDs (44.4%), biosimilars (26.7%), IVIg (17.1%) and NSAIDs (9.1%).

CONCLUSIONS: The results of the study and specifically the low rate of acceptability are alarming to Egyptian health authorities and should stir further interventions to reduce the levels of vaccine hesitancy. As rheumatic disease patients in Egypt were not systematically provided with the vaccine till present, making the vaccine available could as well enhance vaccine acceptance. Further studies to investigate any possible side effects, on a large scale of RD patients are warranted.

Basyoni, A. M., A. A. E. - R. I. Mohamed, H. E. - S. K. Ghazy, N. A. - K. Abdel-Daiem, and others, "Risk factors for adolescents’ substance abuse", Egyptian Nursing Journal, vol. 18, no. 3: Medknow Publications, pp. 160, 2021. Abstract
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Liu, X., Y. Xu, J. Li, X. Ong, S. A. Ibrahim, T. Buonassisi, and X. Wang, "A robust low data solution: Dimension prediction of semiconductor nanorods", Journal of Computers & Chemical Engineering, vol. 150, issue 107315, pp. 1-10. doi: 10.1016/j.compchemeng.2021.107315, 2021.
Okasha, H. H., M. - N. Wifi, A. Awad, Y. Abdelfath, D. Abdelfatah, S. S. El‑Sawy, A. Alzamzamy, S. Abou-Elenin, A. Abou‑Elmagd, R. ElHusseiny, et al., "Role of EUS in detection of liver metastasis not seen by computed tomography or magnetic resonance imaging during staging of pancreatic, gastrointestinal, and thoracic malignancies", Endoscopic Ultrasound Journal, vol. 10, issue 5, pp. 344-354, 2021.
Okasha, H. H., M. - N. Wifi, A. Awad, Y. Abdelfatah, D. Abdelfatah, S. S. El-Sawy, A. Alzamzamy, S. Abou-Elenin, A. Abou-Elmagd, R. ElHusseiny, et al., "Role of EUS in detection of liver metastasis not seen by computed tomography or magnetic resonance imaging during staging of pancreatic, gastrointestinal, and thoracic malignancies.", Endoscopic ultrasound, vol. 10, issue 5, pp. 344-354, 2021. Abstract

Background and Objectives: Liver metastases might not be detected by computed tomography (CT) and magnetic resonance imaging (MRI) due to their small size, but they can be detected by EUS. Furthermore, EUS-FNA has a significant impact on improving the diagnostic accuracy of EUS. The purpose of this study was to assess the feasibility of EUS in detection of occult small hepatic focal lesions at the time of primary tumor staging, not seen by CT or MRI.

Methods: This prospective study included 730 patients who underwent EUS for staging or sampling of gastrointestinal, pancreatic, or thoracic malignancy. The liver was examined thoroughly for detection of occult lesions. CT or MRI was done within 1 week of EUS examination.

Results: EUS examination of the liver detected focal lesions in 150 patients (20.5%) and metastases in 118 patients (16.2%); meanwhile, CT and MRI detected focal lesions in 99 patients (13.6%) and metastases in 82 patients (11.2%). EUS missed focal lesions in 7 patients, 6 of which were liver metastases (1.0% and 0.8%, respectively), while CT and MRI missed focal lesions in 58 patients, 42 of which were metastases (7.9% and 5.8%, respectively), which were detected by EUS.

Conclusion: Thorough dedicated EUS examination of the liver is a feasible useful tool for detection of small hepatic lesions missed by CT and MRI. It is not considered an extra financial burden to the patient or health-care system because those patients are indicated for EUS examination for evaluation of their original lesion in the first place. Furthermore, EUS-FNA can add another advantage in diagnosing the etiology of such lesions.

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