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2021
SH.M.Shehataa, R.Misrab, A.M.I.Osmana, O.M.Shalabiea, and Z.M.Hayman, "Redshift evolution of X-ray spectral index of quasars observed by XMM-NEWTON/SDSS", Journal of High Energy Astrophysics, vol. Volume 31, pp. 37-43, 2021. 1-s2.0-s2214404821000215-main.pdf
Burgmaier, K., L. Brinker, F. Erger, B. B. Beck, M. R. Benz, C. Bergmann, O. Boyer, L. Collard, C. Dafinger, M. Fila, et al., "Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.", Kidney international, 2021. Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The main cause of ARPKD are variants in the PKHD1 gene encoding the large transmembrane protein fibrocystin. The mechanisms underlying the observed clinical heterogeneity in ARPKD remain incompletely understood, partly due to the fact that genotype-phenotype correlations have been limited to the association of biallelic null variants in PKHD1 with the most severe phenotypes. In this observational study we analyzed a deep clinical dataset of 304 patients with ARPKD from two independent cohorts and identified novel genotype-phenotype correlations during childhood and adolescence. Biallelic null variants frequently show severe courses. Additionally, our data suggest that the affected region in PKHD1 is important in determining the phenotype. Patients with two missense variants affecting amino acids 709-1837 of fibrocystin or a missense variant in this region and a null variant less frequently developed chronic kidney failure, and patients with missense variants affecting amino acids 1838-2624 showed better hepatic outcome. Variants affecting amino acids 2625-4074 of fibrocystin were associated with poorer hepatic outcome. Thus, our data expand the understanding of genotype-phenotype correlations in pediatric ARPKD patients and can lay the foundation for more precise and personalized counselling and treatment approaches.

Elazab, H. A., A. O. Okasha, M. A. Radwan, M. A. Sadek, A. Firouzi, and T. T. El-Idreesy, "Removal of Methylene Blue by Adsorption of Water Hyacinth Derived Active Carbon Embedded with Cobalt Nanoparticles", Letters in Applied NanoBioScience, vol. 10, issue 4, pp. 2697-2705, 2021.
Abdellatif, A. A., M. S. Mogawer, M. El-Shazli, H. El-Karaksy, A. Salah, A. Abdel-Maqsod, M. E. - Amir, M. Said, N. Zayed, K. Hosny, et al., "Resuming post living donor liver transplantation in the COVID-19 pandemic: real- life experience, single-center experience", Egyptian Liver Journal, vol. 11, issue 92, 2021. resuming_post_living_donor_liver_transplantation_i.pdf
El-Hussein, A., S. L. Manoto, S. Ombinda-Lemboumba, Z. A. Alrowaili, and P. Mthunzi-Kufa, "A Review of Chemotherapy and Photodynamic Therapy for Lung Cancer Treatment.", Anti-cancer agents in medicinal chemistry, 2021. Abstract

Cancer is among the leading causes of mortality and morbidity worldwide. Among the different types of cancers, lung cancer is the considered to be the leading cause of death related to cancer and the most commonly diagnosed form of such disease. Chemotherapy remains a dominant treatment modality for many types of cancers at different stages. However, in many cases cancer cells develop drug resistance and become non-response to chemotherapy; thus necessitating the exploration of alternative and /or complementary treatment modalities. Photodynamic Therapy (PDT) has emerged as an effective treatment modality for various malignant neoplasia and tumors. In PDT, the photochemical interaction of light, Photosensitizer (PS) and molecular oxygen produces Reactive Oxygen Species (ROS) which induces cell death. Combination therapy by using PDT and chemotherapy can promote synergistic effect against this fatal disease with the elimination of drug resistance, and enhancement the efficacy of cancer eradication. In this review, we give an overview of chemotherapeutic modalities, PDT and the different types of drugs associated with each therapy. Furthermore, we also explored the combined use of chemotherapy and PDT in the course of lung cancer treatment and how this approach could be the last resort for thousands of patients that have been diagnosed by this fatal disease.

Nassar, A., I. M. Ibrahim, F. G. Amin, M. Magdy, A. M. Elgharib, E. B. Azzam, F. Nasser, K. Yousry, I. M. Shamkh, S. M. Mahdy, et al., "A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses", Molecules, vol. 26, no. 21: Multidisciplinary Digital Publishing Institute, pp. 6455, 2021. Abstract
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Valera-Medina, A., F. Amer-Hatem, A. K. Azad, I. C. Dedoussi, D. M. Joannon, R. X. Fernandes, P. Glarborg, H. Hashemi, X. He, S. Mashruk, et al., "Review on ammonia as a potential fuel: from synthesis to economics", Energy & Fuels, vol. 35, issue 9, pp. 6964–7029, 2021.
Hammam, N., S. Tharwat, R. E. R. Shereef, A. M. Elsaman, N. M. Khalil, H. M. Fathi, M. N. Salem, H. M. El-Saadany, N. Samy, A. S. El-Bahnasawy, et al., "Rheumatology university faculty opinion on coronavirus disease-19 (COVID-19) vaccines: the vaXurvey study from Egypt.", Rheumatology international, vol. 41, issue 9, pp. 1607-1616, 2021. Abstract

OBJECTIVES: The aim of the present work was to explore the perspectives of Egyptian Rheumatology staff members as regards the coronavirus disease-19 (COVID-19) vaccine.

METHODS: The survey is composed of 25 questions. Some questions were adapted from the global rheumatology alliance COVID-19 survey for patients.

RESULTS: 187 rheumatology staff members across Egypt from 18 universities and authorizations actively participated with a valid response. The mean time needed to complete the survey was 17.7 ± 13 min. Participants were 159 (85%) females (F:M 5.7:1). One-third agreed that they will be vaccinated once available, 24.6% have already received at least one dose, 29.4% are unsure while 16% will not take it. Furthermore, 70.1% agreed that they will recommend it to the rheumatic diseases (RD) patients once available, 24.1% are not sure while 5.9% will not recommend it. RD priority to be vaccinated against COVID-19 in descending order include SLE (82.9%), RA (55.1%), vasculitis (51.3%), systemic sclerosis (39.6%), MCTD (31.6%), Behcet's disease (28.3%). The most common drugs to be avoided before vaccination included biologics (71.7%), DMARDs (44.4%), biosimilars (26.7%), IVIg (17.1%) and NSAIDs (9.1%).

CONCLUSIONS: The results of the study and specifically the low rate of acceptability are alarming to Egyptian health authorities and should stir further interventions to reduce the levels of vaccine hesitancy. As rheumatic disease patients in Egypt were not systematically provided with the vaccine till present, making the vaccine available could as well enhance vaccine acceptance. Further studies to investigate any possible side effects, on a large scale of RD patients are warranted.

Liu, X., Y. Xu, J. Li, X. Ong, S. A. Ibrahim, T. Buonassisi, and X. Wang, "A robust low data solution: Dimension prediction of semiconductor nanorods", Journal of Computers & Chemical Engineering, vol. 150, issue 107315, pp. 1-10. doi: 10.1016/j.compchemeng.2021.107315, 2021.
Okasha, H. H., M. - N. Wifi, A. Awad, Y. Abdelfath, D. Abdelfatah, S. S. El‑Sawy, A. Alzamzamy, S. Abou-Elenin, A. Abou‑Elmagd, R. ElHusseiny, et al., "Role of EUS in detection of liver metastasis not seen by computed tomography or magnetic resonance imaging during staging of pancreatic, gastrointestinal, and thoracic malignancies", Endoscopic Ultrasound Journal, vol. 10, issue 5, pp. 344-354, 2021.
Okasha, H. H., M. - N. Wifi, A. Awad, Y. Abdelfatah, D. Abdelfatah, S. S. El-Sawy, A. Alzamzamy, S. Abou-Elenin, A. Abou-Elmagd, R. ElHusseiny, et al., "Role of EUS in detection of liver metastasis not seen by computed tomography or magnetic resonance imaging during staging of pancreatic, gastrointestinal, and thoracic malignancies.", Endoscopic ultrasound, vol. 10, issue 5, pp. 344-354, 2021. Abstract

Background and Objectives: Liver metastases might not be detected by computed tomography (CT) and magnetic resonance imaging (MRI) due to their small size, but they can be detected by EUS. Furthermore, EUS-FNA has a significant impact on improving the diagnostic accuracy of EUS. The purpose of this study was to assess the feasibility of EUS in detection of occult small hepatic focal lesions at the time of primary tumor staging, not seen by CT or MRI.

Methods: This prospective study included 730 patients who underwent EUS for staging or sampling of gastrointestinal, pancreatic, or thoracic malignancy. The liver was examined thoroughly for detection of occult lesions. CT or MRI was done within 1 week of EUS examination.

Results: EUS examination of the liver detected focal lesions in 150 patients (20.5%) and metastases in 118 patients (16.2%); meanwhile, CT and MRI detected focal lesions in 99 patients (13.6%) and metastases in 82 patients (11.2%). EUS missed focal lesions in 7 patients, 6 of which were liver metastases (1.0% and 0.8%, respectively), while CT and MRI missed focal lesions in 58 patients, 42 of which were metastases (7.9% and 5.8%, respectively), which were detected by EUS.

Conclusion: Thorough dedicated EUS examination of the liver is a feasible useful tool for detection of small hepatic lesions missed by CT and MRI. It is not considered an extra financial burden to the patient or health-care system because those patients are indicated for EUS examination for evaluation of their original lesion in the first place. Furthermore, EUS-FNA can add another advantage in diagnosing the etiology of such lesions.

Yassa, M. E., H. H. Arnaout, S. K. Botros, E. N. Obaid, W. M. Mahmoud, and D. S. Morgan, "The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a casecontrol study", Egyptian Journal of Medical Human Genetics, vol. 22, issue 17, 2021.
Elmeligy, E., S. Oikawa, S. A. Mousa, S. A. Bayoumi, A. Hafez, R. H, and A. -lethieA. Al-lethie, "Role of insulin, insulin sensitivity and abomasal functions monitors in evaluation of the therapeutic regimen in ketotic dairy cattle using combination therapy with referring to milk yield rates", Open Veterinary Journal , vol. 11, issue 2, pp. 228-237, 2021.
Adnan Awad, S., O. Dufva, A. Ianevski, B. Ghimire, J. Koski, P. Maliniemi, D. Thomson, A. Schreiber, C. A. Heckman, P. Koskenvesa, et al., "RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses", Leukemia, vol. 35, no. 4: Nature Publishing Group, pp. 1087–1099, 2021. Abstract
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Omar, H. A., M. - S. H. El-Agha, M. A. Hassaballah, and N. M. Khalil, "Safety and Efficacy of Epithelial Island Crosslinking in Keratoconus with Thinnest Pachymetry less than 400µ.", Middle East African journal of ophthalmology, vol. 28, issue 1, pp. 11-17, 2021. Abstract

PURPOSE: To evaluate the efficacy and safety of epithelial-island crosslinking (EI-CXL) in keratoconus with corneas thinner than 400 µm.

METHODS: Twenty-six patients (30 eyes) underwent EI-CXL (preserving the epithelium over the thinnest area), using standard protocol (3 mW/cm for 30 min). Uncorrected and best spectacle-corrected distance visual acuity (UCDVA, BCDVA), manifest refractive spherical equivalent (SEQ), mean simulated keratometry (Kmean), maximum keratometry (Kmax), and thinnest corneal thickness (TCT) were determined preoperatively and at 1, 3, 6, and 12 months following CXL. Endothelial cell count (ECC) was determined preoperatively and at 6 months. Anterior segment optical coherence tomography (AS-OCT) was done at 1 month to determine the depth of the corneal stromal demarcation line (DL).

RESULTS: After 1 year, mean UCDVA improved from 1.29 preoperatively to 1.17 ( = 0.001) and BCDVA from 0.62 to 0.57 ( = 0.011). Mean manifest SEQ decreased from -7.63 to-7.32D ( = 0.001). Mean Kmean decreased from 54.92 to 54.81D ( = 0.045), and Kmax from 67.60 to 67.42D ( = 0.072), and mean TCT changed minimally from 377.17 to 375.30 µ ( = 0.11). The mean ECC decreased from 2329 to 2268 cells/mm (2.6% decrease, < 0.001). AS-OCT showed a DL in 29 out of 30 eyes at an average depth of 215.9 µ under the spared epithelium, and 299.9 µ in the de-epithelialized cornea.

CONCLUSION: EI-CXL halted keratoconus progression over a 1-year period. This was associated with statistically significant endothelial loss, but less than seen with conventional epi-off CXL in thinner corneas.

El Kassas, M., N. Abdeen, D. Omran, M. Alboraie, M. Salaheldine, M. Eltabbakhe, R. Farghaly, M. Emadeldeen, shimaa afify, and A. Sweedy, "Safety and efficacy of sofosbuvir/ledipasvir and sofosbuvir/daclatasvir in the treatment of hepatitis C in patients with decompensated cirrhosis", European Journal of Gastroenterology & Hepatology, vol. 33, issue 1S Suppl 1, pp. e877-e882., 2021.
Gyebi, G. A., O. M. Ogunyemi, I. M. Ibrahim, O. B. Ogunro, A. P. Adegunloye, and S. O. Afolabi, "SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids", Journal of Genetic Engineering and Biotechnology, vol. 19, no. 1: Springer, pp. 1–22, 2021. Abstract
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Alfaar, A. S., A. M. Saad, M. T. KhalafAllah, O. E. Elsherif, M. H. Osman, and O. Strauß, "Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body", Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 259, pp. 515–526, 2021.
Badawy, T., M. S. MANSOUR, A. M. Daabo, M. A. M. Aziz, A. A. Othman, F. Barsoum, M. Basouni, M. Hussien, M. Ghareeb, M. Hamza, et al., "Selection of second-generation crop for biodiesel extraction and testing its impact with nano additives on diesel engine performance and emissions", Energy, vol. 237, pp. 121605, 2021.
Osman, H. M., N. E. R. Basha, A. F. Mansour, and M. O. F. Hanna, "Serum IFNγ–induced protein 10 (IP10/CXCL10): association with asthma exacerbations and severity in children", Journal of Asthma, 2021.
Orabi, M., "A simple simulation model to estimate indoor absorbed c radiation doses in air", Indian J Phys, vol. 95, issue 2, pp. 337–347, 2021.
Zaghloul, A. S., A. E. R. M. ElNashar, sameh fayek gamalEl Din, S. Z. Said, H. M. Saad, H. R. Eldebs, and I. A. L. Osman, "Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet rich plasma in patients with erectile dysfunction: A prospective pilot study", Andrologia, vol. 53, pp. e14162., 2021.
Barman, H. K., A. M. Akbar, M. S. Osman, K. S. Nisar, M. Zakarya, A. - H. Abdel-Aty, and H. Eleuch, "Solutions to the Konopelchenko-Dubrovsky equation and the Landau-Ginzburg-Higgs equation via the generalized Kudryashov technique", Results in Physics, vol. 24: Elsevier, pp. 104092, 2021. Abstract
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Hadda, T. B., F. S. S. Deniz, I. E. Orhan, H. Zgou, A. Rauf, Y. N. Mabkhot, B. Bennani, D. R. Emam, N. A. Kheder, A. Asayari, et al., "Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies", Medicinal Chemistry, vol. 17, pp. 834-843, 2021.
Khalid, A., A. Rehan, K. S. Nisar, and M. S. Osman, "Splines solutions of boundary value problems that arises in sculpturing electrical process of motors with two rotating mechanism circuit", Physica Scripta, vol. 96, issue 10, pp. 104001, 2021.