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Journal Article
Ahmed, M. A., N. Okasha, and B. Hussein, "Synthesis, characterization and studies on magnetic and electrical properties of LaAlyFe1-yO3 nanomultiferroic", Journal of Alloys and Compounds, vol. 553, pp. 308 - 315, 2013. AbstractWebsite

Multiferroic LaAlyFe1-yO3; 0.00 ≤ y ≤ 0.20 were successfully synthesized using citrate autocombustion method and their properties were systematically studied. All the samples were crystallized in a perovskite structure. The evaluation of the unit-cell parameters by X-ray diffraction technique revealed that the lattice constants and volume of the unit cell decreased along with increase of Al content, while the Fe-O octahedra became less distorted. The Goldschmidt tolerance factor for the perovskite increases from 0.905 for LaFeO3 to 0.914 for LaAl 0.2Fe0.8O3 confirming that the crystal structure is orthorhombic. All the magnetic parameters such as μeff, χM, and magnetization (MRT) decrease as Al content increases, while Néel temperature indicates the highest value (834 K) at y = 0.1. The magnetic measurements revealed that it has a superparamagnetic behavior with coercive field Hc nearly zero. Dielectric and activation energy results agree well with the other measurements. © 2012 Elsevier B.V. All rights reserved.

Ragheb, M. A., R. S. Omar, M. H. Soliman, A. H. M. Elwahy, and I. A. Abdelhamid, "Synthesis, characterization, DNA photocleavage, in silico and in vitro DNA/BSA binding properties of novel hexahydroquinolines", Journal of Molecular Structure, vol. 1267: Elsevier, pp. 133628, 2022. Abstract
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Ragheb, M. A., R. S. Omar, M. H. Soliman, A. H. M. Elwahy, and I. A. Abdelhamid, "Synthesis, characterization, DNA photocleavage, in silico and in vitro DNA/BSA binding properties of novel hexahydroquinolines", Journal of Molecular Structure, vol. 1267: Elsevier, pp. 133628, 2022. Abstract
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Ragheb, M. A., R. S. Omar, M. H. Soliman, A. H. M. Elwahy, and I. A. Abdelhamid, "Synthesis, characterization, DNA photocleavage, in silico and in vitro DNA/BSA binding properties of novel hexahydroquinolines", Journal of Molecular Structure, vol. 1267, pp. 133628, 2022.
Abou-Seri, S. M., A. A. M. Eissa, M. G. M. Behery, and F. A. Omar, "Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2.", Bioorganic chemistry, vol. 116, pp. 105334, 2021. Abstract

The ensuing research presents the results of in vitro anticancer activity of novel 28 compounds of isoxazole-based carboxamides 3(a-d); ureates 4(a-g), 5, 6, 7a,b, 8; and hydrazones 9(a-f), 10(a-d), 11a,b as potential inhibitors of VEGFR2. The carboxamides and ureates were synthesized by converting 5-(aryl)-isoxzaole-3-carbohydrazides 1a,b to the corresponding carbonylazides 2a,b followed by treatment with the appropriate amines. The hydrazones were directly obtained through condensation of the carbohydrazide 1a,b with aldehydes and/or ketones. The structures of the target compounds were confirmed by elemental and spectral analyses. A preliminary in vitro anticancer screening of solutions (10M) on 60 cancer cell lines (NCI, USA) revealed that the carboxamide 3c is the most promising growth inhibitor. Explicitly, 3c showed potent anticancer activity at 10µ M against leukemia (HL-60(TB), K-562 and MOLT-4), colon cancer (KM12) and melanoma (LOX IMVI) cell lines with %GI range = 70.79-92.21. Evaluation of growth inhibitory activity of the synthesized compounds against hepatocellular carcinoma (HepG2), that overexpresses VEGFR2, showed superior activity of compounds 8, 10a and 10c with IC in sub micromolar concentrations of 0.84, 0.79 and 0.69 μM, respectively, which is better than that of the reference drug, Sorafenib (IC = 3.99 µM). Moreover, these compounds displayed high selective cytotoxicity for HepG2 cancer cells over the nontumorigenic THLE2 liver cells (SI range = 26.37-38.60) which reflect their safety. The results of VEGFR2 kinase inhibition assay demonstrate that, compounds 8 and 10a are the most active inhibitors with IC = 25.7 and 28.2 nM, respectively, (Sorafenib IC = 28.1 nM). Molecular docking of the synthesized derivatives to VEGFR2 (PDB: 3WZE) showed similar binding modes to that of the co-crystallized ligand, sorafenib. Moreover, the results of computational assessment of ADME and drug-likeness characteristics inspire further investigations of the new isoxazole-based derivatives to afford more potent, safe and orally active VEGFR2 inhibitors as potential anticancer drug candidates.

Mohammed, E. Z., W. R. Mahmoud, R. F. George, G. S. Hassan, F. A. Omar, and H. H. Georgey, "Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)", Bioorganic Chemistry, vol. 116, pp. 105347, 2021.
Mohammed, E. Z., W. R. Mahmoud, R. F. George, G. S. Hassan, F. A. Omar, and H. H. Georgey, "Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)", Bioorganic Chemistry, vol. 116, pp. 105347-105361, 2021.
Mohammed, E. Z., W. R. Mahmoud, R. F. George, G. S. Hassan, F. A. Omar, and H. H. Georgey, "Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).", Bioorganic Chemistry, vol. 116, pp. 105347, 2021. Bioorganic_2021.pdf
Macky, T. A., C. Oelkers, U. Rix, M. L. Heredia, E. Künzel, M. Wimberly, B. Rohrer, C. E. Crosson, and J. Rohr, "Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate.", Journal of medicinal chemistry, vol. 45, issue 5, pp. 1122-7, 2002 Feb 28. Abstract

A novel conjugate of mitomycin C (MMC) and triamcinolone acetonide (TA) was synthesized using glutaric acid as a linker molecule. To determine the rate of hydrolysis, the conjugate was dissolved in aqueous solution and the rate of appearance of free MMC and TA was determined by high-performance liquid chromatography analysis. Antiproliferative activity of the MMC-TA conjugate and parent compounds was assessed using an NIH 3T3 fibroblast cell line. Cell growth was quantified using the MTT assay. Kinetic analysis of the hydrolysis rate demonstrated that the conjugate had a half-life of 23.6 h in aqueous solutions. The antiproliferative activities of the MMC-TA conjugate and MMC were both concentration dependent, with similar IC(50) values of 2.4 and 1.7 microM, respectively. However, individual responses at concentrations above 3 microM showed that the conjugate was less active than MMC alone. TA alone showed only limited inhibition of cell growth. Studies evaluating intravitreal injection of the conjugate demonstrate that this agent produced no measurable toxicity. Our data provide evidence that the MMC-TA conjugate could be used as a slow-release drug delivery system. This could in turn be used to modulate a posttreatment wound healing process or to treat various proliferative diseases.

El-halim, H. A. F., M. M. Omar, and G. G. Mohamed, "Synthesis, Structural, Thermal Studies and Biological Activity of A Tridentate Schiff Base Ligand and their Transition Metal Complexes", Spectrochimica Acta, 2011. Abstract

Schiff base (L) ligand is prepared via condensation of pyridine-2,6-dicarboxaldehyde with 2-aminopyridine. The ligand and its metal complexes are characterized based on elemental analysis, mass, IR, solid re?ectance, magnetic moment, molar conductance, and thermal analyses (TG, DTG and DTA). The molar conductance reveals that all the metal

Leon, H., H. Osman, M. Georgy, and M. Ibrahim, "System Dynamics Approach for Forecasting Performance of Construction Projects", Journal of Management in Engineering, vol. 34, issue 1, 2018.
Omran, L. N., A. M. El-Bialy, A. H. kandil, and S. A. Fawzy, "A System for Simulating the Orthodontic Treatment Plan", International Journal of Multidisciplinary Approach and Studies, vol. 2, issue 2348 – 537X, pp. 90-99, 2015. treatmentplan.pdf
Omran, L. N., A. M. El-Bialy, A. H. kandil, and S. A. Fawzy, "A System for Simulating the Orthodontic Treatment Plan", International Journal of Multidisciplinary Approach & Studies, vol. 2, no. 2, 2015. Abstract
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Laban, N. E. D., M. ElSaban, A. Nasr, and H. Onsi, "System refinement for content based satellite image retrieval", The Egyptian Journal of Remote Sensing and Space Sciences, vol. 15, pp. 91-97, 2012.
Laban, N. E. D., M. E. Saban, A. Nasr, and H. Onsi, "System refinement for content based satellite image retrieval", The Egyptian Journal of Remote Sensing and Space Science, vol. 15, no. 1: Elsevier, pp. 91–97, 2012. Abstract
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Soliman, R., C. Heneghan, N. S. Bolous, I. Sidhom, S. Ahmed, N. Roberts, J. Oke, and A. Elhaddad, "Systematic review of costs and cost-effectiveness of treatment for relapsed/refractory acute leukemia in children and young adults.", Expert review of hematology, vol. 15, issue 4, pp. 345-357, 2022. Abstract

INTRODUCTION: Survival outcomes of children with relapsed/refractory (r/r) acute leukemia remain poor. Novel expensive treatments have been developed to improve their outcomes, yet, limited evidence exists about cost-effectiveness of alternative treatment strategies.

AREAS COVERED: A systematic review was conducted to summarize health-economic evidence about costs/cost-effectiveness of treating r/r acute leukemia in children/young adults. We searched Medline, Embase, and Cochrane databases until August 13th, 2021. Eligible articles included peer-reviewed original studies addressing r/r pediatric/young-adult acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). Quality assessment was conducted using Consolidated Health Economics Evaluation Reporting Standards (CHEERS) checklist.

EXPERT OPINION: The majority of papers focused on CAR-T cell therapy, which is still a novel treatment for r/r ALL, and was found to be cost-effective, yet, there remain concerns over its long-term effectiveness, affordability, and equity in access. The next best treatment option is Blinatumomab, followed by Clofarabine therapy, whereas FLA-IDA salvage chemotherapy provides least value for money. The quality of evidence is moderate to high, with limited generalizability of findings due to high variability in outcomes obtained from modeling studies. Limited studies evaluated r/r AML. We provide recommendations to deliver cost-effective treatments in real-world contexts, with implications for healthcare policy and practice.

Omar, M. T. A., A. A. M. Shaheen, and H. Zafar, "A systematic review of the effect of low-level laser therapy in the management of breast cancer-related lymphedema", Supportive Care in Cancer , vol. 20, issue 11, pp. 1546-0, 2012.
Zygogiannis, K., D. Wismeijer, I. H. Aartman, and R. B. Osman, "A Systematic Review on Immediate Loading of Implants Used to Support Overdentures Opposed by Conventional Prostheses: Factors That Might Influence Clinical Outcomes.", The International journal of oral & maxillofacial implants, vol. 31, issue 1, pp. 63-72, 2016. Abstract

PURPOSE: Different treatment protocols in terms of number, diameter, and suprastructure design have been proposed for immediately loaded implants that are used to support mandibular overdentures opposed by maxillary conventional dentures. The aim of this study was to investigate the influence of these protocols on survival rates as well as clinical and prosthodontic outcomes.

MATERIALS AND METHODS: Several electronic databases were searched for all relevant articles published from 1966 to June 2014. Only randomized controlled trials and prospective studies with a minimum follow-up of 12 months were selected. The primary outcomes of interest were the success and survival rates of the implants. Prosthodontic complications were also evaluated.

RESULTS: Fourteen studies fulfilled the inclusion criteria. Of the studies identified, nine were randomized controlled trials and five were prospective studies. The mean follow-up period was 3 years or less for the vast majority of the studies. The reported survival and success rates were comparable to that of conventional loading for most of the included studies. No specific immediate loading protocol seemed to perform better in terms of clinical and prosthodontic outcomes.

CONCLUSION: Immediate loading protocols of mandibular overdentures seem to be a viable alternative to conventional loading. It was not possible to recommend a specific treatment protocol related to the number, diameter of the implants, and attachment system used. Long-term, well-designed studies comparing different immediate loading modalities could help to establish a protocol that delivers the most clinically predictable, efficient, and cost-effective outcome for edentulous patients in need of implant overdentures.

Omar, M. T. A., A. A. M. Shaheen, and H. Zafar, "Systematischer Review über den Effekt der Low-Level-Lasertherapie bei der Behandlung des brustkrebsbedingten Lympödems", VasoMed, vol. 25, issue 10, pp. 138-140, 2013.
Eesa, N. N., H. Abdel Nabi, R. E. Owaidy, I. Khalifa, A. R. Radwan, A. M. NourEl-Din, M. A. Amer, R. R. El Shereef, E. Hassan, F. Ismail, et al., "Systemic lupus erythematosus children in Egypt: Homeland spectrum amid the global situation.", Lupus, vol. 30, issue 13, pp. 2135-2143, 2021. Abstract

OBJECTIVES: This study aims to present the manifestations of juvenile systemic lupus erythematosus (JSLE) across Egypt, to focus on age at onset and gender-driven influence on disease characteristics, and to compare findings to other countries.

METHODS: The study included 404 Egyptian children with systemic lupus erythematosus (SLE) presenting to one of the specialized rheumatology centers corresponding to 13 major governorates. Juvenile cases age was ≤ 16°years at the time of recruitment. The SLE Disease Activity Index (SLEDAI) and damage index (DI) were assessed.

RESULTS: The mean age was 13.2 ± 2.4°years; 355 females and 49 males (7.2:1), and the disease duration was 2.3 ± 1.6 years, while age at disease onset was 11.1 ± 2.5°years. Their SLEDAI was 13.5 ± 12.3, and DI, 0.36 ± 0.78. The overall estimated prevalence of childhood-SLE patients in the recruited cohort in Egypt was 1/100,000 population (0.24/100000 males and 1.8/100000 females). 7.4% developed pre-pubertal SLE (≤ 7 years); 73.3%, peri-pubertal; and 19.3% during early adolescence. The differences according to age group were equal for gender and clinical manifestations except skin lesions present in 59.3% of pre-pubertal onset, 74.6% of peri-pubertal, and 84.2% of adolescents ( = 0.029), and renal involvement in 73.8% of peripubertal, 62.1% of pre-pubertal and 58.9% of adolescents ( = 0.03). Laboratory investigations, SLEDAI, and DI were similar among age categories. Lupus nephritis was more common in Egypt compared to JSLE from other countries.

CONCLUSION: Our large multicenter study identified that female gender influenced disease characteristics with more frequent skin involvement. Skin lesions were significantly higher in adolescents, while renal involvement in peri-pubertal children.

Osman, A. A., and A.A. Farahat, "Systemic nematicides controlling Meloidogyne spp. Infecting cucurbitaceous crops in newly reclaimed sandy soil.", Bull. Fac. of Agric., Cairo Univ., vol. 34, issue 2, pp. 751-761, 1983.
Chandrasekar, S. S., Y. Phanse, M. Riel, R. E. Hildebrand, M. Hanafy, J. E. Osorio, S. S. Abdelgayed, and A. M. Talaat, "Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2", Viruses, vol. 14, issue 1262, pp. 1-20, 2022. viruses-14-01262-v2.pdf
Chandrasekar, S. S., Y. Phanse, M. Riel, R. E. Hildebrand, M. Hanafy, J. E. Osorio, S. S. Abdelgayed, and A. M. Talaat, "Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2", Viruses, vol. 14, no. 6, 2022. AbstractWebsite

Antibody measurements are primarily used to evaluate experimental and approved COVID-19 vaccines, which is unilateral considering our immune responses’ complex nature. Previously, we showed that nanoparticle plasmid DNA adjuvant system, QAC, and MVA based vaccines were immunogenic against SARS-CoV-2. Here, we report on the protective efficacy of systemic humoral and mucosal cell-mediated immune responses in transgenic mice models against SARS-CoV-2 following nanoparticle immunization. Parenteral, intramuscular administration of QAC-based plasmid DNA vaccine-encoding SARS-CoV-2 S and N led to the induction of significant serum neutralizing humoral responses, which reduced viral burden in the lungs and prevented viral dissemination to the brain. In contrast, the mucosal, intranasal administration of a heterologous vaccine elicited significant mucosal cell-mediated immune responses in the lungs that limited lung viral replication. The presented results demonstrate that serum neutralizing humoral and local lung T-cell immune responses are critical for the control of SARS-CoV-2 replication.