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Shaheen, A. A. M., M. T. A. Omar, and O. I. Ali, "Normative values of handgrip and pinch strengths in healthy female college students in Riyadh, Saudi Arabia: a crosssectional study", Bulletin of Faculty of Physical Therapy, vol. 26, issue 1, 2021.
Osman, M., B. Zaitchik, H. Badr, and S. Hameed, "North Atlantic centers of action and seasonal to subseasonal temperature variability in Europe and eastern North America", International Journal of Climatology, vol. 41: John Wiley & Sons, Ltd. Chichester, UK, pp. E1775–E1790, 2021. Abstract
Aboushady, D., S. S. Rasheed, J. Herrmann, A. Maher, E. M. El-Hossary, E. S. Ibrahim, A. H. Abadi, M. Engel, R. Müller, M. Abdel-Halim, et al., "Novel 2, 4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2, 4-substituents", Bioorganic Chemistry, vol. 117: Academic Press, pp. 105422, 2021. Abstract
Nisar, K. S., O. A. Ilhan, S. T. Abdulazeez, J. Manafian, S. A. Mohammed, and M. S. Osman, "Novel multiple soliton solutions for some nonlinear PDEs via multiple Exp-function method", Results in Physics, vol. 21: Elsevier, pp. 103769, 2021. Abstract
Fathy, G. M., H. A. Hassan, W. A. L. A. A. SHETA, F. A. Omara, and E. Nabil, "A novel no-sensors 3D model reconstruction from monocular video frames for a dynamic environment", PeerJ Computer Science, vol. 7: PeerJ Inc., pp. e529, 2021. Abstract
Zayed, A. A., R. A. Abdelghafar, A. I. Hegazy, S. Orabi, and M. S. El-Mesidy, "Novel subcision technique combined with either microneedling or trichloroacetic acid 35% peeling for acne scars: a comparative study", Journal of the Egyptian Women's Dermatologic Society, vol. 18, pp. 109-118, 2021.
Youssef, N., M. Elbadry, A. A. Shafie, A. Abdalazeem, S. Hasan, M. Tahoon, D. Omran, and M. El Kassas, "Nutritional status associated with clinical outcomes among patients hospitalized with COVID‐19: A multicenter prospective study in Egypt", Nursing & Health Sciences, vol. 24, issue 1, pp. 204-213, 2021.
Umek, T., T. Olsson, O. Gissberg, O. Saher, E. M. Zaghloul, K. E. Lundin, J. Wengel, E. Hanse, H. Zetterberg, D. Vizlin-Hodzic, et al., "Oligonucleotides Targeting DNA Repeats Downregulate Gene Expression in Huntington's Patient-Derived Neural Model System.", Nucleic acid therapeutics, vol. 31, issue 6, pp. 443-456, 2021. Abstract

Huntington's disease (HD) is one of the most common, dominantly inherited neurodegenerative disorders. It affects the striatum, cerebral cortex, and other subcortical structures leading to involuntary movement abnormalities, emotional disturbances, and cognitive impairments. HD is caused by a CAG•CTG trinucleotide-repeat expansion in exon 1 of the () gene leading to the formation of mutant HTT (mtHTT) protein aggregates. Besides the toxicity of the mutated protein, there is also evidence that mt transcripts contribute to the disease. Thus, the reduction of both mutated mRNA and protein would be most beneficial as a treatment. Previously, we designed a novel anti-gene oligonucleotide (AGO)-based strategy directly targeting the trinucleotide-repeats in DNA and reported downregulation of mRNA and protein in HD patient fibroblasts. In this study, we differentiate HD patient-derived induced pluripotent stem cells to investigate the efficacy of the AGO, a DNA/Locked Nucleic Acid mixmer with phosphorothioate backbone, to modulate transcription during neural development. For the first time, we demonstrate downregulation of mRNA following both naked and magnetofected delivery into neural stem cells (NSCs) and show that neither emergence of neural rosette structures nor self-renewal of NSCs is compromised. Furthermore, the inhibition potency of both mRNA and protein without off-target effects is confirmed in neurons. These results further validate an anti-gene approach for the treatment of HD.

Osman, M. S., J. A. T. Machado, D. Baleanu, A. Zafar, and M. Raheel, "On distinctive solitons type solutions for some important nonlinear Schrödinger equations", Optical and Quantum Electronics, vol. 53, issue 2: Springer, pp. 1-24, 2021. Abstract
Baskonus, H. M., M. S. Osman, M. Ramzan, M. Tahir, and S. Ashraf, "On pulse propagation of soliton wave solutions related to the perturbed Chen–Lee–Liu equation in an optical fiber", Optical and Quantum Electronics, vol. 53, issue 10: Springer, pp. 1-17, 2021. Abstract
Akbulut, A., H. Almusawa, M. Kaplan, and M. S. Osman, "On the conservation laws and exact solutions to the (3+ 1)-dimensional modified kdv-zakharov-kuznetsov equation", Symmetry, vol. 13, issue 5: MDPI, pp. 765, 2021. Abstract
Abdel-Gawad, H. I., M. Tantawy, T. N. Nkomom, and J. B. Okaly, "On the dynamics of DNA molecules with an-harmonics potential in the normal and damaged states", Physica Scripta, vol. 96, issue 12, pp. 125246, 2021.
Kaabar, M. K. A., S. R. Grace, J. Alzabut, A. Özbekler, and Z. Siri, "On the oscillation of even-order nonlinear differential equations with mixed neutral terms", Journal of Function Spaces, vol. 2021: Hindawi, 2021. Abstract
Kayum, M. A., S. Ara, M. S. Osman, A. M. Akbar, and K. A. Gepreel, "Onset of the broad-ranging general stable soliton solutions of nonlinear equations in physics and gas dynamics", Results in Physics, vol. 20: Elsevier, pp. 103762, 2021. Abstract
Kallel, W., H. Almusawa, S. M. Mirhosseini-Alizamini, M. Eslami, H. Rezazadeh, and M. S. Osman, "Optical soliton solutions for the coupled conformable Fokas–Lenells equation with spatio-temporal dispersion", Results in Physics, vol. 26, pp. 104388, 2021.
Gómez-Aguilar, J. F., M. S. Osman, N. Raza, A. Zubair, S. Arshed, M. E. Ghoneim, E. E. Mahmoud, and A. - H. Abdel-Aty, "Optical solitons in birefringent fibers with quadratic-cubic nonlinearity using three integration architectures", AIP Advances, vol. 11, issue 2: AIP Publishing LLC, pp. 025121, 2021. Abstract
Mahmoud, W. S., A. Osailan, A. S. Ahmed, R. K. Elnaggar, and N. L. Radwan, "Optimal parameters of blood flow restriction and resistance training on quadriceps strength and cross-sectional area and pain in knee osteoarthritis", Isokinetics and Exercise Science , vol. 29, issue 4, pp. 393-402, 2021.
Badr-Eldin, S. M., U. A. Fahmy, H. M. Aldawsari, O. A. A. Ahmed, N. A. Alhakamy, S. Z. Okbazghi, M. A El-Moselhy, A. F. Alghaith, A. Anter, A. I. Matouk, et al., "Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions.", Dose-response : a publication of International Hormesis Society, vol. 19, issue 1, pp. 15593258211001259, 2021. Abstract

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict its therapeutic efficacy. This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the pumpkin oil (X1, 10-30%), the surfactant tween 80 (X2, 20-50%), and the co-surfactant polyethylene glycol 200 (X3, 30-60%). The experimental design for the proposed mixture produced 16 formulations with varying ALA-SNEDDS formulation component percentages. The optimized ALA-SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized ALA-SNEDDS achieved significant improvement in gastric ulcer index in comparison with raw ALA. Histopathological findings confirmed the protective effect of the formulated optimized ALASNEDDS in comparison with raw ALA. These findings suggest that formulation of ALA in SNEDDS form would be more effective in gastric ulcer protection compared to pure ALA.

Badr-Eldin, S. M., H. M. Aldawsari, O. A. A. Ahmed, N. A. Alhakamy, T. Neamatallah, S. Z. Okbazghi, and U. A. Fahmy, "Optimized semisolid self-nanoemulsifying system based on glyceryl behenate: A potential nanoplatform for enhancing antitumor activity of raloxifene hydrochloride in MCF-7 human breast cancer cells.", International journal of pharmaceutics, vol. 600, pp. 120493, 2021. Abstract

Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management of the disease by virtue of its estrogen antagonist action. However, the drug has reduced bioavailability related to low water solubility and first pass metabolism. To surmount these pitfalls, this study aimed at developing and optimizing RLX-loaded semisolid self-nanoemulsifying system (SSNES) with minimized globule size to improve the drug solubility, tumor penetration, and consequently antitumor activity. A simplex lattice mixture design was employed for the formulation and optimization of SSNESs. The mixture components, namely, Compritol® 888 ATO, Tween 20, and polyethylene glycol 200 exhibited significant effect on globule size at P < 0.05. The optimized formulation with globule size of 109.19 ± 2.11 nm showed acceptable thermodynamic stability under stress conditions. Anti-cancer efficacy of the obtained formulation was evaluated in MCF-7 breast cancer cell line. MTT viability assay revealed that RLX-loaded SSNES notably inhibited MCF-7 cell proliferation. Flow cytometry and dual staining with annexin V-FITC/PI were used to assay this anti-proliferative effect and induction of apoptosis, respectively. Cells treated with RLX-loaded SSNES showed significant arrest at G2/M phase associated with significant increase in early/late-stages of apoptotic and necrotic cells. The results exhibited that RLX-loaded SSNES induces apoptosis via the activation of caspase-3 and loss of mitochondrial membrane potential. Accordingly, the proposed SSNES could be regarded as a promising platform for enhancing RLX antitumor activity against breast cancer.

Biccard, B. M., P. D. Gopalan, M. Miller, W. L. Michell, D. Thomson, A. Ademuyiwa, E. Aniteye, G. Calligaro, M. S. Chaibou, H. T. Dhufera, et al., "Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study", The Lancet, vol. 397, no. 10288, pp. 1885-1894, 2021. AbstractWebsite

Summary Background There have been insufficient data for African patients with COVID-19 who are critically ill. The African COVID-19 Critical Care Outcomes Study (ACCCOS) aimed to determine which resources, comorbidities, and critical care interventions are associated with mortality in this patient population. Methods The ACCCOS study was a multicentre, prospective, observational cohort study in adults (aged 18 years or older) with suspected or confirmed COVID-19 infection who were referred to intensive care or high-care units in 64 hospitals in ten African countries (ie, Egypt, Ethiopia, Ghana, Kenya, Libya, Malawi, Mozambique, Niger, Nigeria, and South Africa). The primary outcome was in-hospital mortality censored at 30 days. We studied the factors (ie, human and facility resources, patient comorbidities, and critical care interventions) that were associated with mortality in these adult patients. This study is registered on, NCT04367207. Findings From May to December, 2020, 6779 patients were referred to critical care. Of these, 3752 (55·3%) patients were admitted and 3140 (83·7%) patients from 64 hospitals in ten countries participated (mean age 55·6 years; 1890 [60·6%] of 3118 participants were male). The hospitals had a median of two intensivists (IQR 1–4) and pulse oximetry was available to all patients in 49 (86%) of 57 sites. In-hospital mortality within 30 days of admission was 48·2% (95% CI 46·4–50·0; 1483 of 3077 patients). Factors that were independently associated with mortality were increasing age per year (odds ratio 1·03; 1·02–1·04); HIV/AIDS (1·91; 1·31–2·79); diabetes (1·25; 1·01–1·56); chronic liver disease (3·48; 1·48–8·18); chronic kidney disease (1·89; 1·28–2·78); delay in admission due to a shortage of resources (2·14; 1·42–3·22); quick sequential organ failure assessment score at admission (for one factor [1·44; 1·01–2·04], for two factors [2·0; 1·33–2·99], and for three factors [3·66, 2·12–6·33]); respiratory support (high flow oxygenation [2·72; 1·46–5·08]; continuous positive airway pressure [3·93; 2·13–7·26]; invasive mechanical ventilation [15·27; 8·51–27·37]); cardiorespiratory arrest within 24 h of admission (4·43; 2·25–8·73); and vasopressor requirements (3·67; 2·77–4·86). Steroid therapy was associated with survival (0·55; 0·37–0·81). There was no difference in outcome associated with female sex (0·86; 0·69–1·06). Interpretation Mortality in critically ill patients with COVID-19 is higher in African countries than reported from studies done in Asia, Europe, North America, and South America. Increased mortality was associated with insufficient critical care resources, as well as the comorbidities of HIV/AIDS, diabetes, chronic liver disease, and kidney disease, and severity of organ dysfunction at admission. Funding The ACCCOS was partially supported by a grant from the Critical Care Society of Southern Africa.

Mohammed, A. A., M. M. Soliman, A. A. Osman, and R. T. El-zanaty, "Patterns of uveitis in Egypt", Ocular immunology and inflammation , vol. 5, issue 29, pp. 1007-1016uveitis,, 2021.
Abdelshafi, S., A. Okasha, S. E. Sirgany, A. Khalil, S. El-Dessouky, N. AbdelHakim, S. Elanwary, and A. E. Sheikhah, "Peak systolic velocity of fetal middle cerebral artery to predict anemia in Red Cell Alloimmunization in un-transfused and transfused fetuses.", European journal of obstetrics, gynecology, and reproductive biology, vol. 258, pp. 437-442, 2021. Abstract

OBJECTIVE: To assess the accuracy of middle cerebral artery peak systolic velocity (MCA-PSV) in prediction of severe fetal anemia resulting from Red Cell Alloimmunization (Anti-D) in un-transfused and transfused fetuses. In addition to comparing the accuracy of MCA-PSV and the estimation of the daily decline of fetal hemoglobin (Hb), to determine the appropriate time of subsequent transfusions.

STUDY DESIGN: This was a retrospective study of a series of 84 anaemic fetuses due to Red Cell alloimmunization. During each in-utero transfusion session, measurements of (1)MCA-PSV, (2)pre- and (3)post-transfusion Hb levels were recorded. Receiveroperating characteristics (ROC) curves, negative and positive predictive values of MCA-PSV in predicting severe fetal anemia were calculated. Regression analysis assesses the correlation between fetal HB and MCA-PSV, and between observed and expected fetal hemoglobin levels.

RESULTS: Eighty four anemic fetuses were included in the study and had an in-utero transfusion. The positive predictive value (PPV) of MCAPSV decreased sharply from 86.0 % at the first IUT, to 52.0 % and 52.1 % at the second and third IUTs respectively. According to the ROC curves, setting the cut-off at 1.70 MoM would provide the best performance of MCA-PSV with respect to the timing of the second and third IUT. Setting a higher threshold of 1.70 MoM for the 2nd and 3rd transfusions would increase the PPV from 52.0 % to 96.4 % at the second IUT, and from 52.1%-99.8 % at the third IUT.

CONCLUSION: In this study we suggest that a higher MCA-PSV (MoM 1.7 in compared to 1.5MOM) can accurately predict the recurrence of severe fetal anemia requiring serial IUTs. In transfused fetuses, MCAPSV accuracy to detect severe anemia decline slightly with increase number of IUT. In addition to that, the mean projected daily decrease in fetal hemoglobin has a similar accuracy to MCA-PSV in predicting moderate to severe fetal anemia.

Fathy, M., K. A. Abdel-moein, W. A. Osman, A. H. M. E. D. M. ERFAN, A. Prince, A. A. Hafez, and HossamEldin, "Performance of Different Laboratory Methods for Detection of Clostridium difficile in Animal Samples", Advances in Animal and Veterinary Sciences, vol. 9, issue 1, pp. 132-136, 2021.
Osman, A. A., and S. A. Mourad, "Performance of extended end-plate bolted connections subjected to static and blast-like loads", Journal of Engineering and Applied Science, vol. 68, issue 8, 2021.