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Abubakr, M., N. Sirag, I. Osman, M. Osman, S. Abakar, and A. M. Aboul-Enein, Anticancer and antioxidant activities of Guiera senegalensis, , 2013. Abstract

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Ezzat, S. M., S. A. Shouman, A. ElKhoely, Y. M. Attia, M. S. Elsesy, A. S. El Senousy, M. A. Choucry, S. H. Elgayed, A. A. El Sayed, E. Abdelsattar, et al., Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars, : Nature Publishing Group, 2018. Abstract
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Ezzat, S. M., S. A. Shouman, A. ElKhoely, Y. M. Attia, M. S. Elsesy, A. S. El Senousy, M. A. Choucry, S. H. Elgayed, A. A. El Sayed, E. Abdelsattar, et al., "Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars", Scientific Reports, vol. 8, no. 1: Nature Publishing Group, pp. 1–16, 2018. Abstract
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A.Ouf, S., S. M.Gomha, M. Eweis, A. S. Ouf, I. A. A. Sharawy, and SulaimanA.Alharbi, "Antidermatophytic activity of some newly synthesized arylhydrazonothiazoles conjugated with monoclonal antibody", scientific reports, vol. 10, pp. 20863, 2020. s41598-020-77829-x.pdf
Ouf, S. A., S. M. Gomha, M. Eweis, A. S. Ouf, I. A. A. Sharawy, and S. A. Alharbi, Antidermatophytic activity of some newly synthesized arylhydrazonothiazoles conjugated with monoclonal antibody, , vol. 10, issue 1, pp. 20863, 2020. AbstractWebsite

A new series of 5-arylhydrazonothiazole derivatives 5a–d has been synthesized, elucidated, and evaluated for their antidermatophytic activity. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the newly synthesized products were investigated against 18 dermatophyte fungal isolates related to Epidermophyton floccosum, Microsporum canis, and Trichophyton rubrum. The morphological alterations induced by the synthesized derivatives singly or conjugated with the monoclonal antibody were examined on spores of T. rubrum using a scanning electron microscope. The efficacy of synthesized derivative 5a applied at its respective MFC alone or conjugated with anti-dermatophyte monoclonal antibody 0014 in skin infection treatment of guinea pigs due to inoculation with one of the examined dermatophytes, in comparison with fluconazole as standard reference drug was evaluated. In an in vivo experiment, the efficiency of 5a derivative conjugated with the antibody induced 100% healing after 45 days in the case of T. rubrum and M. canis-infected guinea pigs.

Ouf, S. A., S. M. Gomha, M. Eweis, A. S. Ouf, I. A. A. Sharawy, and S. A. Alharbi, "Antidermatophytic activity of some newly synthesized arylhydrazonothiazoles conjugated with monoclonal antibody.", Scientific reports, vol. 10, issue 1, pp. 20863, 2020. Abstract

A new series of 5-arylhydrazonothiazole derivatives 5a-d has been synthesized, elucidated, and evaluated for their antidermatophytic activity. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the newly synthesized products were investigated against 18 dermatophyte fungal isolates related to Epidermophyton floccosum, Microsporum canis, and Trichophyton rubrum. The morphological alterations induced by the synthesized derivatives singly or conjugated with the monoclonal antibody were examined on spores of T. rubrum using a scanning electron microscope. The efficacy of synthesized derivative 5a applied at its respective MFC alone or conjugated with anti-dermatophyte monoclonal antibody 0014 in skin infection treatment of guinea pigs due to inoculation with one of the examined dermatophytes, in comparison with fluconazole as standard reference drug was evaluated. In an in vivo experiment, the efficiency of 5a derivative conjugated with the antibody induced 100% healing after 45 days in the case of T. rubrum and M. canis-infected guinea pigs.

Osman, M. A., R. M. Romeilah, G. I. Mahmoud, and S. S. Shoman, "ANTIDIABETIC ACTIVITY OF Ficus carica L. LEAF EXTRACTS IN STREPTOZOTOCIN-DIABETIC RATS", Desert Technology,12 th International Conference, vol. 66, issue 5, pp. 33-41, 2015.
Marzouk, M., T. Y. Omar, and A. M. Soliman, "Antidiabetic and hyperinsulinemic effects of Fenugreek and Termis seeds aqueous extracts in experimental rats. ", The Third International Conference On Basic Sciences & Their Applications, 2019.
Ogaly, H. A., N. A. Eltablawy, and R. M. Abd-Elsalam, "Antifibrogenic Influence of Mentha piperita L. Essential Oil against CCl4-Induced Liver Fibrosis in Rats", Oxidative Medicine and Cellular Longevity, vol. 4039753, pp. 1-15, 2018.
Al-Surhanee, A. A., M. Afzal, N. A. Bouqellah, S. A. Ouf, S. Muhammad, M. Jan, S. Kaleem, M. Hashem, S. Alamri, A. A. H. A. Latef, et al., "The Antifungal Activity of Ag/CHI NPs against Rhizoctonia solani Linked with Tomato Plant Health", Plants, vol. 10, issue 11, pp. 2283, 2021. AbstractWebsite

Pathogenic infestations are significant threats to vegetable yield, and have become an urgent problem to be solved. Rhizoctonia solani is one of the worst fungi affecting tomato crops, reducing yield in some regions. It is a known fact that plants have their own defense against such infestations; however, it is unclear whether any exogenous material can help plants against infestation. Therefore, we performed greenhouse experiments to evaluate the impacts of R. solani on 15- and 30-day old tomato plants after fungal infestation, and estimated the antifungal activity of nanoparticles (NPs) against the pathogen. We observed severe pathogenic impacts on the above-ground tissues of tomato plants which would affect plant physiology and crop production. Pathogenic infection reduced total chlorophyll and anthocyanin contents, which subsequently disturbed plant physiology. Further, total phenolic contents (TPC), total flavonoid contents (TFC), and malondialdehyde (MDA) contents were significantly increased in pathogen treatments. Constitutively, enhanced activities were estimated for catalase (CAT), superoxide dismutase (SOD), and ascorbate peroxidase (APX) in response to reactive oxygen species (ROS)in pathogen-treated plants. Moreover, pathogenesis-related genes, namely, chitinase, plant glutathione S-transferase (GST), phenylalanine ammonia-lyase (PAL1), pathogenesis-related protein (PR12), and pathogenesis-related protein (PR1) were evaluated, with significant differences between treated and control plants. In vitro and greenhouse antifungal activity of silver nanoparticles (Ag NPs), chitosan nanoparticles, and Ag NPs/CHI NPs composites and plant health was studied using transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectrophotometry. We found astonishing results, namely, that Ag and CHI have antifungal activities against R. solani. Overall, plant health was much improved following treatment with Ag NPs/CHI NPs composites. In order to manage R. solani pathogenicity and improve tomato health, Ag/CHI NPs composites could be used infield as well as on commercial levels based on recommendations. However, there is an urgent need to first evaluate whether these NP composites have any secondary impacts on human health or the environment.

Al-Surhanee, A. A., M. Afzal, N. A. Bouqellah, S. A. Ouf, S. Muhammad, M. Jan, S. Kaleem, M. Hashem, S. Alamri, A. A. H. A. Latef, et al., "The Antifungal Activity of Ag/CHI NPs against Rhizoctonia solani Linked with Tomato Plant Health", Plants, vol. 10, no. 11, 2021. AbstractWebsite

Pathogenic infestations are significant threats to vegetable yield, and have become an urgent problem to be solved. Rhizoctonia solani is one of the worst fungi affecting tomato crops, reducing yield in some regions. It is a known fact that plants have their own defense against such infestations; however, it is unclear whether any exogenous material can help plants against infestation. Therefore, we performed greenhouse experiments to evaluate the impacts of R. solani on 15- and 30-day old tomato plants after fungal infestation, and estimated the antifungal activity of nanoparticles (NPs) against the pathogen. We observed severe pathogenic impacts on the above-ground tissues of tomato plants which would affect plant physiology and crop production. Pathogenic infection reduced total chlorophyll and anthocyanin contents, which subsequently disturbed plant physiology. Further, total phenolic contents (TPC), total flavonoid contents (TFC), and malondialdehyde (MDA) contents were significantly increased in pathogen treatments. Constitutively, enhanced activities were estimated for catalase (CAT), superoxide dismutase (SOD), and ascorbate peroxidase (APX) in response to reactive oxygen species (ROS)in pathogen-treated plants. Moreover, pathogenesis-related genes, namely, chitinase, plant glutathione S-transferase (GST), phenylalanine ammonia-lyase (PAL1), pathogenesis-related protein (PR12), and pathogenesis-related protein (PR1) were evaluated, with significant differences between treated and control plants. In vitro and greenhouse antifungal activity of silver nanoparticles (Ag NPs), chitosan nanoparticles, and Ag NPs/CHI NPs composites and plant health was studied using transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectrophotometry. We found astonishing results, namely, that Ag and CHI have antifungal activities against R. solani. Overall, plant health was much improved following treatment with Ag NPs/CHI NPs composites. In order to manage R. solani pathogenicity and improve tomato health, Ag/CHI NPs composites could be used infield as well as on commercial levels based on recommendations. However, there is an urgent need to first evaluate whether these NP composites have any secondary impacts on human health or the environment.

Alhilal, M., Y. Y. or Sulaiman, S. Alhilal, S. Gomha, and S. A. Ouf, Antifungal Activity of New Diterpenoid Alkaloids Isolated by Different Chromatographic Methods from Delphinium peregrinum L. var. eriocarpum Boiss, , vol. 26, pp. 1 - 10, 2021/03/04. Abstract
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Alhilal, M., Y. A. M. Sulaiman, S. Alhilal, S. M. Gomha, and S. A. Ouf, "Antifungal Activity of New Diterpenoid Alkaloids Isolated by Different Chromatographic Methods from Delphinium peregrinum L. var. eriocarpum Boiss", Molecules, vol. 26, no. 5, 2021. AbstractWebsite

This paper aimed to investigate the potential antifungal influences of new alkaloids from Delphinium peregrinum L. var. eriocarpum Boiss. New Diterpenoid alkaloids Delcarpum (1), Hydrodavisine (4) and known alkaloids Peregrine (2), Delphitisine (3) were isolated by different chromatographic methods from the aerial parts of D. Peregrinum eriocarpum Boiss, which grows in Syria. The structures of alkaloids were proposed based on 1D NMR spectroscopy 1H-NMR, 13C-NMR, DEPT-135, DEPT-90, 2D NMR spectroscopy DQF-COSY, HMQC, EI-Ms mass spectrum, and IR spectroscopic measurements. The antifungal activity of the isolated alkaloids was evaluated against different dermatophyte fungal isolates compared with fluconazole. In the case of Peregrine (2) the minimum inhibitory concentrations(MICs) recorded 128–256, 32–64, and 32 for Epidermophyton floccosum, Microsporum canis, and Trichophyton rubrum, respectively, compared to 32–64, 16, and 32 μg/mL in the case of fluconazole, respectively. The MICs recorded on application of the four alkaloids mixture were 64, 32, and 16 in the case of E. floccosum, M. canis, and T. rubrum, respectively, which were significantly lower than that measured for each of the individual alkaloid and were compatible for fluconazole. In conclusion, MICs of the tested alkaloids showed a variable potential effect on the investigated fungal isolates. Peregrine (2) was the most effective alkaloid, however, the application of the mixture of alkaloids induced significant synergistic activity that was more pronounced than the application of individual ones.

Yusufoglu, H. S., G. A. Soliman, R. F. Abdel-Rahman, M. S. Abdel-Kader, M. A. Ganaie, E. Bedir, S. B. Erel, and B. Öztürk, "Antihyperglycemic and Antihyperlipidemic Effects of Ferula assa-foetida and Ferula tenuissima Extracts in Diabetic Rats", Pakistan Journal of Biological Sciences, vol. 18, no. 7: Asian Network for Scientific Information (ANSINET), pp. 314, 2015. Abstract

The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg/kg) and F. tenuissima (400 mg/kg) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kgG1) and F. tenuissima (400 mg kgG1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity.

Abdel-Rahman, R. F., A. F. Hessin, M. Abdelbaset, H. A. Ogaly, R. M. Abd-Elsalam, and S. M. Hassan, "Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats", Oxidative Medicine and Cellular Longevity, vol. 2017, issue 2017, pp. 1-24, Submitted.
Abdel-Rahman, R. F., A. F. Hessin, M. Abdelbaset, H. A. Ogaly, R. M. Abd-Elsalam, and S. M. Hassan, "Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats", Oxidative medicine and cellular longevity, vol. 2017: Hindawi, 2017. Abstract
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Osman, K., A. Alvarez-Ordóñez, L. Ruiz, J. Badr, F. ElHofy, K. S. Al-Maary, I. M. I. Moussa, A. M. Hessain, A. Orabi, A. Saad, et al., "Antimicrobial resistance and virulence characterization of Staphylococcus aureus and coagulase-negative staphylococci from imported beef meat.", Annals of clinical microbiology and antimicrobials, vol. 16, issue 1, pp. 35, 2017 May 10. Abstract

BACKGROUND: The objectives of this study were to characterize the diversity and magnitude of antimicrobial resistance among Staphylococcus species recovered from imported beef meat sold in the Egyptian market and the potential mechanisms underlying the antimicrobial resistance phenotypes including harboring of resistance genes (mecA, cfr, gyrA, gyrB, and grlA) and biofilm formation.

RESULTS: The resistance gene mecA was detected in 50% of methicillin-resistant non-Staphylococcus aureus isolates (4/8). Interestingly, our results showed that: (i) resistance genes mecA, gyrA, gyrB, grlA, and cfr were absent in Staphylococcus hominis and Staphylococcus hemolyticus isolates, although S. hominis was phenotypically resistant to methicillin (MR-non-S. aureus) while S. hemolyticus was resistant to vancomycin only; (ii) S. aureus isolates did not carry the mecA gene (100%) and were phenotypically characterized as methicillin- susceptible S. aureus (MSS); and (iii) the resistance gene mecA was present in one isolate (1/3) of Staphylococcus lugdunensis that was phenotypically characterized as methicillin-susceptible non-S. aureus (MSNSA).

CONCLUSIONS: Our findings highlight the potential risk for consumers, in the absence of actionable risk management information systems, of imported foods and advice a strict implementation of international standards by different venues such as CODEX to avoid the increase in prevalence of coagulase positive and coagulase negative Staphylococcus isolates and their antibiotic resistance genes in imported beef meat at the Egyptian market.

Osman, K. M., S. H. Marouf, and N. AlAtfeehy, "Antimicrobial resistance and virulence-associated genes of Salmonella enterica subsp. enterica serotypes Muenster, Florian, Omuna, and Noya strains isolated from clinically diarrheic humans in Egypt", Microbial Drug Resistance, vol. 19, no. 5: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. 370–377, 2013. Abstract
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Osman, K. M., A. M. Amer, J. M. Badr, N. M. Helmy, R. A. Elhelw, A. Orabi, M. Bakry, and A. S. A. Saad, "Antimicrobial resistance, biofilm formation and mecA characterization of methicillin-susceptible S. aureus and Non-S. aureus of Beef Meat Origin in Egypt", Frontiers in microbiology, vol. 7: Frontiers Media SA, 2016. Abstract
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Osman, K. M., A. M. Amer, J. M. Badr, N. M. Helmy, R. A. Elhelw, A. Orabi, M. Bakry, and A. S., "Antimicrobial Resistance, Biofilm Formation and mecA Characterization of Methicillin-Susceptible S. aureus and Non-S. aureus of Beef Meat Origin in Egypt", Frontiers in Microbiology, vol. 7, pp. 222, 2016. Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) have been found in various farm animal species throughout the world. Yet, methicillin-susceptible S. aureus (MSSA), methicillin-susceptible non-S. aureus (MS-NSA), and methicillin-resistant non-S. aureus (MR-NSA) were not investigated. Therefore, we persued to determine the diversity in their phenotypic virulence assay, phenotypic antimicrobial resistance profile and molecular characterization in one of the food chains in Egypt. Samples were collected during 2013 from beef meat at retail. Twenty seven isolates comprising five species (S. hyicus, S. aureus, S. schleiferi subsp. coagulans, S. intermedius, and S. lentus) were characterized for their antibiotic resistance phenotypic profile and antibiotic resistance genes (mecA, cfr, gyrA, gyrB, and grlA). Out of the 27 Staphylococcus isolates only one isolate was resistant to the 12 antibiotics representing nine classes. Raw beef meat sold across the Great Cairo zone, contains 66.7% of MRS, with highest prevalence was reported in S. aureus (66.7%), while the MRS non-S. aureus strains constituted 66.7% from which S. hyicus (60%), S. intermedius (33.3%), S. schleiferi subsp. coagulans (100%), and S. lentus (100%) were MRS. Seven S. aureus, six S. hyicus, four S. schleiferi subsp. coagulans, three S. intermedius, and one S. lentus isolates although being resistant to oxacillin yet, 11/27 (40.7%) carried the mecA gene. At the same time, the cfr gene was present in 2 of the nine S. aureus isolates, and totally undetectable in S. hyicus, S. schleiferi subsp. coagulans, S. intermedius, and S. lentus. Although, global researches largely focused into MRSA and MR-NSA in animals on pigs, the analysis of our results stipulates, that buffaloes and cattle could be MRSA dispersers and that this theme is not specific to pigs. Detection of MSSA virulence determinants is a must, as although oxacillin resistance may be absent yet, the MSSA may carry the virulence determinants which could be a source of perilous S. aureus for the human community.

Osman, K. M., A. M. Amer, J. M. Badr, N. M. Helmy, R. A. Elhelw, A. Orabi, M. Bakry, and A. S. A. Saad, "Antimicrobial resistance, biofilm formation and mecA characterization of methicillin-susceptible S. aureus and non-S. aureus of beef meat origin in Egypt", Frontiers in microbiology, vol. 7: Frontiers Media SA, 2016. Abstract
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Osman, K. M., Hadia A Ali, J. A. ElJakee, M. M. Gaafar, and H. M. Galal, "Antimicrobial Susceptibility and Molecular Typing of Multiple Chlamydiaceae Species Isolated from Genital Infection of Women in Egypt", MICROBIAL DRUG RESISTANCE 2012, vol. Volume 18, Number 4,, pp. 440 -445, 2012.
Zongo, C., A. Savadogo, L. Ouattara, I. H. N. Bassole, C. A. T. Ouattara, A. S. Ouattara, N. Barro, J. Koudou, A. S. Traore, and B. Aderbauer, "Antioxidant and antibacterial activities of three species of Lannea from burkina faso.", International Journal of Pharmacology, vol. 6, issue 6: orgz, pp. 225-231, 2008. Abstract
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Fayed, S. A., and others, "Antioxidant and anticancer activities of Citrus reticulate (Petitgrain Mandarin) and Pelargonium graveolens (Geranium) essential oils", Research Journal of Agriculture and Biological Sciences, vol. 5, no. 5: INSInet Publications, pp. 740–747, 2009. Abstract
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