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Hegazy Zaher, M. El-Sherbieny, N. R. Saied, and E. Oun, "An Alternative Bat Algorithm", Journal of Multidisciplinary Engineering Science and Technology, vol. 4, issue 2, pp. 6736-6746, 2017. jmestn42352072.pdf
Khalil, M. N. A., M. A. Choucry, A. S. El Senousy, A. Hassan, S. A. El-Marasy, S. A. El Awdan, and F. A. Omar, "Ambrosin, a potent NF-$ąppa$$\beta$ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin", PloS one, vol. 14, no. 7: Public Library of Science San Francisco, CA USA, pp. e0219378, 2019. Abstract
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Khalil, M. N. A., M. A. Choucry, A. S. El Senousy, A. Hassan, S. A. El-Marasy, S. A. El Awdan, and F. A. Omar, "Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin.", PloS one, vol. 14, issue 7, pp. e0219378, 2019. Abstract

Despite its poor bioavailability, curcumin is a promising natural polyphenol targeting NF-κβ. NF-κβ is a target for new therapeutics because it plays a pivotal role in the pathophysiology of Alzheimer disease (AD). In contrast, ambrsoin, a sesquiterpene lactone which is a potent NF-κβ inhibitor, is scarcely studied in AD models. The current work aims to assess the efficacy of ambrosin as a possible remedy for AD. In silico studies showed that bioavailability and BBB permeability could be favorable for ambrosin over curcumin. Memory impairment was induced in mice by single intraperitoneal injection of LPS (0.4 mg/kg). Treated groups received curcumin (100 mg/kg) or ambrosin at doses (5 or 10 mg/kg) for 7 days. Mice in treated groups showed a significant improvement in memory functions during Morris water maze and object recognition tests. Curcumin and ambrosin (10 mg/kg) inhibited the upsurge of NF-κβp65 transcript and protein levels. Consequently, downstream pro-inflammatory and nitrosative mediators were inhibited, namely, TNF-α, IL-1β, COX-2 and iNOS. BACE1 was inhibited, thereby reducing amyloid plaques (Aβ) deposition and eventually reducing inflammation and apoptosis of neurons as revealed by immunohistopathological examination. In conclusion, ambrosin can be repurposed as AD remedy after further pharmacokinetic/pharamacodynamic assessments. It could serve as an additional lead drug for AD therapeutics.

Oraby, M. A., M. F. El-Yamany, M. M. Safar, N. A. G. L. A. A. ASSAF, and H. A. Ghoneim, "Amelioration of Early Markers of Diabetic Nephropathy by Linagliptin in Fructose-Streptozotocin-Induced Type 2 Diabetic Rats ", Nephron, vol. 141, issue 4, pp. 273-286. , 2019. linagliptin_mamdouh.pdf
Elkhatib, M. A. W., A. Mroueh, R. W. Rafeh, F. Sleiman, H. Fouad, E. I. Saad, M. A. Fouda, O. Elgaddar, K. Issa, A. H. Eid, et al., "Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs", Translational Research, vol. 214: Mosby, pp. 121–143, 2019. Abstract
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Alsherbiny, M. A., W. H. Abd-Elsalam, E. Taher, M. Fares, A. Torres, D. Chang, C. G. Li, and others, "Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: a comprehensive review", Food and Chemical Toxicology, vol. 123: Pergamon, pp. 72–97, 2019. Abstract
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El-Mahdi, M. M., W. A. Mansour, H. Olfat, N. A. Mehana, and M. H. Taghreed, "The ameliorative effect of bone marrow-derived stem cells on injured liver of mice infected with Schistosoma mansoni.", Korean J Parasitol, vol. 52, issue 2, pp. 1-12, 2014. Abstract
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Abd-El-Hafez, M. A., M. D. El-Shafee, S. H. Omar, A. A. Aburahma, and S. S. Kamar, "The ameliorative effect of curcumin on cryptorchid and non-cryptorchid testes in induced unilateral cryptorchidism in albino rat: histological evaluation.", Folia morphologica, vol. 80, issue 3, pp. 596-604, 2021. Abstract

BACKGROUND: Cryptorchidism, one or both hidden testes, is the most common abnormality of male sexual development. Subfertility or infertility is associated with both unilateral and bilateral cryptorchidism. In this study, we investigate the possible ameliorative effect of curcumin (Cur) on the induced-unilateral cryptorchidism testicular injury in both cryptorchid (Cryp) and non-cryptorchid (non-Cryp) scrotal testes through histological, immunohistochemical and morphometrics.

MATERIALS AND METHODS: Forty adult male albino rats were divided into: control group, Cur control group, Cryp group, and Cryp+Cur group. The rat model was surgically established by fixing the left testis in the abdomen. The treated groups were subjected to surgically induced-unilateral cryptorchidism on the left side then were given Cur (80 mg/kg) orally, for 20 days. Histological analysis using haematoxylin and eosin and periodic acid Schiff's reaction was done. Immunohistochemistry was performed for proliferating cell nuclear antigen (PCNA); to estimate the proliferation in the germinal epithelium, and vimentin; to evaluate Sertoli cells. The results were confirmed by statistical evaluation of the spermatogenic epithelium height, the seminiferous tubules diameter, the basement membrane thickness, the number of PCNA immunostained cells and the area per cent of vimentin immunostaining.

RESULTS: Distorted seminiferous tubules, substantial degeneration of the germinal epithelium, thickening of the basement membrane with a significant decrease in PCNA and vimentin immunostaining were observed in Cryp group; mainly in the cryptorchid testis. These structural changes were significantly reversed in Crypt+Cur group.

CONCLUSIONS: Curcumin proved to be an important and effective medical line for protecting against the unfavourable sequels of cryptorchidism in a rat model.

Morgan, A. M., Mona K Galal, Marwa A Ibrahim, A. M. Hussien, E. I. Hassanen, H. A. Ogaly, S. A. A. Dulmani, F. A. M. Al‐Zahrani, S. Kamel, and undefined, "The ameliorative effect of N‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats", J Biochem Mol Toxicol. 2021;e22884: 1-11, vol. e22884:, pp. 1-11, 2021.
Osama Abdel-Ghaffar, S. T. Mahmoud, A. A. Said, and F. A. Y. Sanad, "Ameliorative effect of rutin against isoniazid-induced alterations in certain hematological and biochemical parameters of albino rats.", International Journal of Pharmacology , vol. 14, issue 1, pp. 39-51, 2018.
Marwa A Ibrahim, A. A. Khalaf, Mona K Galal, H. A. Ogaly, and A. H M Hassan, "Ameliorative Influence of Green Tea Extract on Copper Nanoparticle-Induced Hepatotoxicity in Rats.", Nanoscale research letters, vol. 10, issue 1, pp. 363, 2015 Dec. Abstract

The potential toxicity of copper nanoparticles (CNPs) to the human health and environment remains a critical issue. In the present study, we investigated the protective influence of an aqueous extract of green tea leaves (GTE) against CNPs-induced (20-30 nm) hepatotoxicity. Four different groups of rats were used: group I was the control, group II received CNPs (40 mg/kg BW), group III received CNPs plus GTE, and group IV received GTE alone. We highlighted the hepatoprotective effect of GTE against CNPs toxicity through monitoring the alteration of liver enzyme activity, antioxidant defense mechanism, histopathological alterations, and DNA damage evaluation. The rats that were given CNPs only had a highly significant elevation in liver enzymes, alteration in oxidant-antioxidant balance, and severe pathological changes. In addition, we detected a significant elevation of DNA fragmentation percentage, marked DNA laddering, and significance over expression of both caspase-3 and Bax proteins. The findings for group III clarify the efficacy of GTE as a hepatoprotectant on CNPs through improving the liver enzyme activity, antioxidant status, as well as suppressing DNA fragmentation and the expression of the caspase-3 and Bax proteins. In conclusion, GTE was proved to be a potential hepatoprotective additive as it significantly ameliorates the hepatotoxicity and apoptosis induced by CNPs.

El-shamy, F. F., M. T. Omar, F. S. Moghanm, H. El-Shamy, and A. M. El-shamy, "Ameliorative potential of black sand therapy on carpal tunnel syndrome during pregnancy: A case report", Complementary Therapies in Clinical Practice, vol. 39, pp. 101149-101153, 2020.
ElHeneidy, H., E. Omran, A. Halwagy, H. Al-Inany, M. Al-Ansary, and A. Gad, Amniotic membrane can be a valid source for wound healing, , 2016. amniotic_membrane_paper.pdf
Sherif, E. F. A., A. H. Othman, S. Shouman, M. M. Omran, N. Azimt, S. Badr, and A. A. al-Rahman, "Analgesic effect of Morphine Added to Bupivacaine in Serratus Anterior Plane Block Following Modified Radical Mastectomy. Only a Local Effect? Randomized Clinical Trial ", Journal of Pain Research, vol. 13, pp. 661—668, 2020.
Khayyal, M. T., M. A. El-Ghazaly, D. M. Abdallah, S. N. Okpanyi, and O. Kelber, "Analgesics. Anti-inflammatories. Antiphlogistics. Antirheumatic Drugs-Mechanisms Involved in the Anti-inflammatory Effect of a Standardized Willow Bark Extract", Arzneimittelforschung, vol. 55, no. 11: Aulendorf [Germany]: Editio Cantor, pp. 677–687, 2005. Abstract
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Khayyal, M. T., M. A. El-Ghazaly, D. M. Abdallah, S. N. Okpanyi, and O. Kelber, "Analgesics. Anti-inflammatories. Antiphlogistics. Antirheumatic Drugs-Mechanisms Involved in the Anti-inflammatory Effect of a Standardized Willow Bark Extract", Arzneimittelforschung, vol. 55, issue 11: Aulendorf [Germany]: Editio Cantor, pp. 677-687, 2005. Abstract
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Georgy, M., M. Kadry, and H. Osman, "Analogy-based ranking of delay causes: an outlook for future projects", The 19th CIB World Building Congress: Queensland University of Technology, pp. 1–10, 2013. Abstract
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Omara, F. A., M. Amoon, N. A. El-Fishawy, and E. - S. kazaz, "Analysing Anchor Links to Enhance the Web Snippet Clustering Technique", The 8th International Conference on Informatics and Systems (INFOS 2012), Cairo, Egypt, pp. SW-08- SW-12, 2012.
Ogedengbe, E. O., O. Igbekoyi, and E. E. Khalil, "Analysis of Electricity Consumption in the Faculty of Engineering with Integration of Renewable Solar Power System, ", Proceedings, IECEC paper AIAA-2012-4247., USA, July , 2012.
Sawaf, S., W. Tawfik, and others, "Analysis of heavy elements in water with high sensitivity using laser induced breakdown spectroscopy", Optoelectron Adv Mater, vol. 8, pp. 414–417, 2014. Abstract
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El-Bashar, R., M. Hussein, S. F. Hegazy, Y. Badr, M. F. O. Hameed, and S. S. A. Obayya, "Analysis of highly efficient quad-crescent-shaped Si nanowires solar cell", Optics Express, vol. 29, no. 9: Optical Society of America, pp. 13641–13656, 2021. Abstract
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El-Bashar, R., M. Hussein, S. F. Hegazy, Y. Badr, M. F. O. Hameed, and S. S. A. Obayya, "Analysis of highly efficient quad-crescent-shaped Si nanowires solar cell", Optics Express, vol. 29, no. 9: Optica Publishing Group, pp. 13641–13656, 2021. Abstract
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Othman, M. A., T. M. Abuelfadl, and I. A. Eshrah, "Analysis of microwave cavities using an eigenmode projection approach", Antennas and Propagation Society International Symposium (APSURSI), 2012 IEEE: IEEE, pp. 1–2, 2012. Abstract
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Othman, M. A., T. M. Abuelfadl, and I. A. Eshrah, "Analysis of microwave cavities using an eigenmode projection approach", Antennas and Propagation Society International Symposium (APSURSI), 2012 IEEE: IEEE, pp. 1–2, 2012. Abstract
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Yao, S. W., M. E. Islam, M. Ali, M. Inc, M. Adel, and M. S. Osman, "Analysis of parametric effects in the wave profile of the variant Boussinesq equation through two analytical approaches", Open Physics, 2021.