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Noor, N. A., H. S. Mohammed, I. M. Mourad, Y. A. Khadrawy, and H. A. S. ezz, "A promising therapeutic potential of cerebrolysin in 6-OHDA rat model of Parkinson's disease", Life Sciences, vol. 155, pp. 174-179, 2016.
Noor, N. E., K. A. Olama, and R. S. Abdul-Rahman, "Effect of Body Mass Index on Plantar Pressure Distribution in Children During Standing", International journal of health sciences, vol. 6, issue S1, pp. 373-381, 2022.
Noor, N. A., H. M. Fahmy, and I. M. Mourad, "Evaluation of the Potential Neurotoxicity of Gold Nanoparticles in the Different Rat Brain Regions", International Journal of Sciences: Basic and Applied Research (IJSBAR), vol. 30, issue 5, pp. 114-129, 2016. nano.pdf
Noor, N. A., "EFFECT OF KAVA EXTRACT ON SOME AMINO ACID NEUROTRANSMITTERS IN CERTAIN BRAIN AREAS OF ADULT MALE ALBINO RATS", African Journal of Pharmacy and Pharmacology, vol. 4, issue 11, pp. 823-828, 2008.
Noor, N. A., H. S. Mohammed, I. M. Mourad, Y. A. Khadrawy, and H. A. S. ezz, "A promising therapeutic potential of cerebrolysin in 6-OHDA ratmodel of Parkinson's disease", Life Sciences , vol. 155, pp. 174–179, 2016. a_promising_therapeutic_potential_of_cerebrolysin_in_6-ohda_rat_model_of.pdf
Noor, N. A., H. S. Mohammed, N. A. Ahmed, and N. M. Radwan, "Variations in Amino Acid Neurotransmitters in some Brain Areas of Adult and Young Male Albino Rats Due to Exposure to Mobile Phone Radiation", European Review for Medical and Pharmacological Sciences, vol. 15, pp. 729-742, 2011. AbstractCU-PDF.pdf

Background and Objectives: Mobile phone radiation and health concerns have been raised, especially following the enormous increase in the use of wireless mobile telephony throughout the world. The present study aims to investigate the effect of one hour daily exposure to electromagnetic radiation (EMR) with frequency of 900 Mz (SAR 1.165 w/kg, power density 0.02 mW/cm2) on the levels of amino acid neurotransmitters in the midbrain, cerebellum and medulla of adult and young male albino rats.

Noor, S. O., D. A. Al-Zahrani, R. M. Hussein, M. N. Baeshen, T. A. A. Moussa, S. M. Abo-Aba, A. M. Al-Hejin, N. A. Baeshen, and J. P. Huelsenbeck, "Assessment of fungal diversity in soil rhizosphere associated with Rhazya stricta and some desert plants using metagenomics", Arch. Microbiol., 2020, 2021. Abstract2020-_arch_microbiol.pdfWebsite

This study aimed to compare the fungal rhizosphere communities of Rhazya stricta, Enneapogon desvauxii, Citrullus colocynthis, Senna italica, and Zygophyllum simplex, and the gut mycobiota of Poekilocerus bufonius (Orthoptera, Pyrgomorphidae, “Usherhopper”). A total of 164,485 fungal reads were observed from the five plant rhizospheres and Usherhopper gut. The highest reads were in S. italica rhizosphere (29,883 reads). Species richness in the P. bufonius gut was the highest among the six samples. Ascomycota was dominant in all samples, with the highest reads in E. desvauxii (26,734 reads) rhizosphere. Sordariomycetes and Dothideomycetes were the dominant classes detected with the highest abundance in C. colocynthis and E. desvauxii rhizospheres. Aspergillus and Ceratobasidium were the most abundant genera in the R. stricta rhizosphere, Fusarium and Penicillium in the E. desvauxii rhizosphere and P. bufonius gut, Ceratobasidium and Myrothecium in the C. colocynthis rhizosphere, Aspergillus and Fusarium in the S. italica rhizosphere, and Cochliobolus in the Z. simplex rhizosphere. Aspergillus terreus was the most abundant species in the R. stricta and S. italica rhizospheres, Fusarium sp. in E. desvauxii rhizosphere, Ceratobasidium sp. in C. colocynthis rhizosphere, Cochliobolus sp. in Z. simplex rhizosphere, and Penicillium sp. in P. bufonius gut. The phylogenetic results revealed the unclassified species were related closely to Ascomycota and the species in E. desvauxii, S. italica and Z. simplex rhizospheres were closely related, where the species in the P. bufonius gut, were closely related to the species in the R. stricta, and C. colocynthis rhizospheres.

Noor, N. A., H. S. Mohammed, N. A. Ahmed, and N. M. Radwan, "Variations in amino acid neurotransmitters in some brain areas of adult and young male albino rats due to exposure to mobile phone radiation", Eur Rev Med Pharmacol Sci, vol. 15, no. 7, pp. 729–742, 2011. Abstract
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Noor, N. A., H. S. Mohammed, N. A. Ahmed, and N. M. Radwan, "Variations in amino acid neurotransmitters in some brain areas of adult and young male albino rats due to exposure to mobile phone radiation", Eur Rev Med Pharmacol Sci, vol. 15, no. 7, pp. 729–742, 2011. Abstract
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Noor, N. A., H. S. Mohammed, N. A. Ahmed, and N. M. Radwan, "Variations in amino acid neurotransmitters in some brain areas of adult and young male albino rats due to exposure to mobile phone radiation", European Review for Medical and Pharmacological Sciences, vol. 15, pp. 729-742, 2011.
Noor, N. A., H. M. Fahmy, and I. M. Mouradc, "Evaluation of the Potential Neurotoxicity of Gold Nanoparticles in the Different Rat Brain Regions", International Journal of Sciences: Basic and Applied Research (IJSBAR, vol. 30, issue 5, pp. 114-129, 2016. nano.pdf
Noor, N. A., and A. F. ELKARMOTY, "Anatomical, Radiographical and Magnetic Resonance Imaging features of normal Temporomandibular Joint (TMJ) in camels (Camelus dromedarius): A special reference to TMJ surgical approach", International Journal of Advanced Research in Biological Sciences, vol. 5, issue 2, pp. 34-43, 2018.
Nooh, H. A., M. S. Abdellateif, L. Refaat, E. Z. Kandeel, A. Bayoumi, M. Samra, and medhat khafagy, "The role of inflammatory indices in the outcome of COVID-19 cancer patients.", Medical oncology (Northwood, London, England), vol. 39, issue 1, pp. 6, 2022. Abstract

To assess the prognostic role of different inflammatory indices on the outcome of cancer patients with COVID-19. Sixty-two adults and 22 pediatric cancer patients with COVID-19 infection were assessed for the prognostic value of certain inflammatory indices including the neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), derived NLR (dNLR), systemic inflammation index (SII), mean platelet volume to platelet ratio (MPR), C-reactive protein to lymphocyte ratio (CRP/L), aggregate index of systemic inflammation (AISI), systemic inflammation response index (SIRI), and neutrophil to lymphocyte, platelet ratio (NLPR). Data were correlated to patients' outcome regarding ICU admission, and incidence of mortality. Increased CRP/L ratio in adult COVID-19 cancer patients was significantly associated with inferior survival [152 (19-2253) in non-survivors, compared to 27.4 (0.8-681) in survivors (P = 0.033)]. It achieved a sensitivity (60%) and a specificity (90.2%) at a cut-off 152, while it achieved a sensitivity of 60% and specificity 95.1% at a cut-off 252 (AUC 0.795, P = 0.033). When combining both CRP/L and NLPR for the prediction of poor outcome in adult cancer patients with COVID19, the sensitivity increased to 80% and the specificity was 70.7% (AUC 0.805, P = 0.027). Increased incidence of ICU admission in pediatric cancer patients associated significantly with the severity of covid19 infection, decreased mean corpuscular hemoglobin (MCH) < 28.3, increased red cell distribution width (RDW) > 16, lymphopenia < 1.04, pseudo Pelger-Huet appearance, and PLR < 196.4 (P = 0.004, P = 0.040, P = 0.029, P = 0. 0.039, P = 0.050, and P = 0.040; respectively). The mean corpuscular volume (MCV), MCH, and RDW could be useful prognostic markers for poor outcome in COVID-19 pediatric cancer patients (P < 0.05 for all). Increased both CRP/L and NLPR associated significantly with poor survival in adult COVID-19 cancer patients, while PLR associated significantly with ICU admission in pediatric COVID-19 cancer patients.

Nooh, M. M., A. Kale, and S. W. Bahouth, "Involvement of PDZ-SAP97 interactions in regulating AQP2 translocation in response to vasopressin in LLC-PK cells.", American journal of physiology. Renal physiology, vol. 317, issue 2, pp. F375-F387, 2019 Aug 01. Abstract

Arginine-vasopressin (AVP)-mediated translocation of aquaporin-2 (AQP2) protein-forming water channels from storage vesicles to the membrane of renal collecting ducts is critical for the renal conservation of water. The type-1 PDZ-binding motif (PBM) in AQP2, "GTKA," is a critical barcode for its translocation, but its precise role and that of its interacting protein partners in this process remain obscure. We determined that synapse-associated protein-97 (SAP97), a membrane-associated guanylate kinase protein involved in establishing epithelial cell polarity, was an avid binding partner to the PBM of AQP2. The role of PBM and SAP97 on AQP2 redistribution in response to AVP was assessed in LLC-PK renal collecting cells by confocal microscopy and cell surface biotinylation techniques. These experiments indicated that distribution of AQP2 and SAP97 overlapped in the kidneys and LLC-PK cells and that knockdown of SAP97 inhibited the translocation of AQP2 in response to AVP. Binding between AQP2 and SAP97 was mediated by specific interactions between the second PDZ of SAP97 and PBM of AQP2. Mechanistically, inactivation of the PBM of AQP2, global delocalization of PKA, or knockdown of SAP97 inhibited AQP2 translocation as well as AVP- and forskolin-mediated phosphorylation of Ser in AQP2, which serves as the major translocation barcode of AQP2. These results suggest that the targeting of PKA to the microdomain of AQP2 via SAP97-AQP2 interactions in association with cross-talk between two barcodes in AQP2, namely, the PBM and phospho-Ser, plays an important role in the translocation of AQP2 in the kidney.

Nooh, M. M., S. Mancarella, and S. W. Bahouth, "Novel Paradigms Governing -Adrenergic Receptor Trafficking in Primary Adult Rat Cardiac Myocytes.", Molecular pharmacology, vol. 94, issue 2, pp. 862-875, 2018 Aug. Abstract

The -adrenergic receptor (-AR) is a major cardiac G protein-coupled receptor, which mediates cardiac actions of catecholamines and is involved in genesis and treatment of numerous cardiovascular disorders. In mammalian cells, catecholamines induce the internalization of the -AR into endosomes and their removal promotes the recycling of the endosomal -AR back to the plasma membrane; however, whether these redistributive processes occur in terminally differentiated cells is unknown. Compartmentalization of the -AR in response to -agonists and antagonists was determined by confocal microscopy in primary adult rat ventricular myocytes (ARVMs), which are terminally differentiated myocytes with unique structures such as transverse tubules (T-tubules) and contractile sarcomeres. In unstimulated ARVMs, the fluorescently labeled -AR was expressed on the external membrane (the sarcolemma) of cardiomyocytes. Exposing ARVMs to isoproterenol redistributed surface -ARs into small (∼225-250 nm) regularly spaced internal punctate structures that overlapped with puncta stained by Di-8 ANEPPS, a membrane-impermeant T-tubule-specific dye. Replacing the -agonist with the -blocker alprenolol, induced the translocation of the wild-type -AR from these punctate structures back to the plasma membrane. This step was dependent on two barcodes, namely, the type-1 PDZ binding motif and serine at position 312 of the -AR, which is phosphorylated by a pool of cAMP-dependent protein kinases anchored at the type-1 PDZ of the -AR. These data show that redistribution of the -AR in ARVMs from internal structures back to the plasma membrane was mediated by a novel sorting mechanism, which might explain unique aspects of cardiac -AR signaling under normal or pathologic conditions.

Nooh, M. M., S. M. Rizk, N. M. Saied, and S. M. Abdelazim, "Carnosine Remedial Effect on Fertility of Male Rats Receiving Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisone (CHOP)", Andrologia , vol. 53, issue 11, pp. e14233, 2021.
Nooh, M. M., S. Nookala, R. Kansal, and M. Kotb, "Individual genetic variations directly effect polarization of cytokine responses to superantigens associated with streptococcal sepsis: implications for customized patient care", The Journal of Immunology, vol. 186, no. 5: Am Assoc Immnol, pp. 3156–3163, 2011. Abstract
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Nooh, M. M., M. M. Chumpia, T. B. Hamilton, and S. W. Bahouth, "Sorting of $\beta$1-adrenergic receptors is mediated by pathways that are either dependent on or independent of type I PDZ, protein kinase A (PKA), and SAP97", Journal of Biological Chemistry, vol. 289, no. 4: American Society for Biochemistry and Molecular Biology, pp. 2277–2294, 2014. Abstract
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Nooh, M. M., A. P. Naren, S. - J. Kim, Y. K. Xiang, and S. W. Bahouth, "SAP97 Controls the Trafficking and Resensitization of the Beta-1-Adrenergic Receptor through Its PDZ2 and I3 Domains", PloS one, vol. 8, no. 5: Public Library of Science, pp. e63379, 2013. Abstract
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Nooh, M. M., N. El-Gengehi, R. Kansal, C. S. David, and M. Kotb, "HLA transgenic mice provide evidence for a direct and dominant role of HLA class II variation in modulating the severity of streptococcal sepsis", The Journal of Immunology, vol. 178, no. 5: Am Assoc Immnol, pp. 3076–3083, 2007. Abstract
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Nooh, M. M., R. G. Kansal, C. S. David, and M. Y. Kotb, "146-P: HLA class II plays a key role in modulating the severity of invasive streptococcal infections: In vivo and in vitro studies using HLA transgenic mice", Human Immunology, vol. 67: Elsevier, pp. S146, 2006. Abstract
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Nooh, M. M., S. Mancarella, and S. W. Bahouth, "Identification of novel transplantable GPCR recycling motif for drug discovery.", Biochemical pharmacology, vol. 120, pp. 22-32, 2016 Nov 15. Abstract

β1-Adrenergic receptor (β1-AR) agonists and antagonists are widely used in the treatment of major cardiovascular diseases such as heart failure and hypertension. The β1-AR like other G protein-coupled receptors (GPCRs) are endocytosed in response to intense agonist activation. Recycling of the agonist-internalized β1-AR is dependent on its carboxy-terminal type-1 PSD-95/DLG/ZO1 (PDZ) and on phospho-serine(312) in the third intracellular loop of the β1-AR. Progressive elongation of the β1-AR at its C-tail inactivated the PDZ-biding domain and inhibited the recycling of the β1-AR. However, fusing a twenty amino acid peptide derived from the multiple cloning region of the mammalian expression vector pCDNA3 to the C-tail of the β1-AR (β1-AR[+20]) produced a chimeric β1-AR that recycled rapidly and efficiently. The β1-AR[+20] recycled in a type-1 PDZ and phospho-Ser(312)-independent manner, indicating that this peptide provided a general GPCR recycling signal. Fusing the enhanced yellow fluorescent protein (EYFP) down-stream of β1-AR[+20] generated a β1-AR-EYFP chimera that was expressed on the membrane and recycled efficiently after agonist-induced internalization. This construct trafficked in a PDZ-SNX27/retromer-independent manner. We also fused EYFP to the N-terminus of the β1-AR to created EYFP-WT β1-AR. This construct recycled in PDZ and SNX27/retromer dependent manner. These β1-AR-EYFP constructs would be useful for high throughput screening (HTS) programs to identify new entities that would interfere with the recycling of agonist internalized GPCR that traffic in PDZ-dependent vs. PDZ-independent roadmaps.

Nooh, M. M., and S. W. Bahouth, "Visualization and quantification of GPCR trafficking in mammalian cells by confocal microscopy.", Methods in cell biology, vol. 142, pp. 67-78, 2017. Abstract

G protein-coupled receptors (GPCRs) are recognized as one of the most fruitful group of therapeutic targets, accounting for more than 40% of all approved pharmaceuticals on the market. Therefore, the search for selective agents that affect GPCR function is of major interest to the pharmaceutical industry. This chapter describes methods for measuring agonist-promoted GPCR trafficking, which involves the internalization of the GPCR and its subsequent recycling back to the plasma membrane or retention and eventual degradation. These pathways will be analyzed by confocal cellular imaging, using the β1-adrenergic receptor (β1-AR) as a primary model. A major problem encountered in studying GPCR trafficking is the unavailability of antibodies that would recognize the native receptor in cells or tissues. Therefore, wild-type, point mutants, and β1-AR chimeras are generated as epitope-tagged proteins, which are stably- or transiently expressed in mammalian cells. GPCR are labeled with a fluorophore-conjugated antibody directed against the N-terminal epitope tag. The trafficking of the fluorophore-tagged GPCR between divergent trafficking pathways that result in retention and eventual degradation or recycling and reinsertion into the plasma membrane can be followed by confocal immunofluorescence microscopy techniques outlined in this review.

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