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Nossair, A. A., W. A. Ewais, and S. A. Eissa, "Chandelier-assisted scleral buckling using wide angle viewing contact lens for pseudophakic retinal detachment repair.", International Journal of Ophthalmology , vol. 12, issue 4, pp. 627-633, 2019.
Nosier, M., T. Darwich., M. H. Sayyouh, and M. El-Salaly, "A Mathematical Simulation for Optimizing Production Multiphase flow Systems", 2nd Computer Conference of SPE, , Cairo, Egypt, 1995.
NOSHYUTTA, W., E. OSMAN, and M. MANSOUR, "AN INVESTIGATION OF THE BIOLOGICAL FUNGICIDAL ACTIVITY OF SOME ESSENTIAL OILS USED AS PRESERVATIVES FOR A 19TH CENTURY EGYPTIAN COPTIC CELLULOSIC MANUSCRIPT", INTERNATIONAL JOURNAL OF CONSERVATION SCIENCE , vol. 7, issue 1, pp. 41-56 , 2016. Abstract

The main goal of this work was to investigate the biological fungicidal activity of some commercial essential oils of tea tree, lavender and thyme, which were to be applied as alternative preservatives for ancient manuscripts. To achieve our goal, model samples of cellulosic paper were made to mimic the original manuscript, which was a Coptic manuscript known as Pascha (the sacred week), dated 1812. Twenty-three microorganism strains were isolated representing twelve fungal taxa and one bacterial taxa which were identified in all collected and analyzed in samples, which included Trichoderma viride, Penicillium roqueforti, Eurotium chevalieri, Aspergillus flavus and Bacillus subtilis. A scanning electron microscope (SEM) was used to investigate the growth of the associated microorganisms and their effect on the sample paper structure. Different concentrations of the aforementioned essential oils were applied on the mimic samples, which were then subjected to accelerated ageing corresponding to 25 or 50 years of a natural one. To characterize the applied oils on the samples, we made records by using FTIR-ATR, color measurements according to CIELAB system, and analyzed the mechanical properties of the tested samples. The results revealed that the samples treated with either tea tree oil or lavender oil, had ΔE values that decreased as the oil concentration increased. However, when samples were treated with thyme oil the reverse was obtained. For the treated samples exposed to 25 years of light ageing, we noticed that the higher obtained tensile strength and % elongation of treated samples followed the ranking order: thyme > lavender > tea tree oils. For the treated samples that were exposed to 50 years of natural light ageing, we observed that almost all tensile strength and elongation values of the treated samples were higher than that of the untreated ones. Moreover, we noticed that the inhibition of growth of the microorganisms was obtained at a low concentration of tea tree oil (0.25% v/v). This treatment was esthetically acceptable for archaeological objects, because it was colorless, transparent and safe. Based on the results we obtained, the optimized essential oil, which is the oil with an appropriate concentration, was selected to be added to the cellulosic pulp used for the leaf casting. Moreover, the same optimized essential oil was applied on the paper samples to be used as separators between the ancient manuscript pages. After dismantling, cleaning, leaf casting and rebinding of the damaged parts, the manuscript is then preserved.

Noshy W., T. Nazel, R. R. A. Hassan, and A. Hosni, "THE USE OF DIGITAL TECHNOLOGY (2.5D) IN THE AUTHENTICITY OF A MANUSCRIPT FROM THE ISLAMIC ERA", Egyptian Journal of Archaeological and Restoration Studies, vol. Vol. 10 , issue (1) - , pp. June 2020: 1-7, 2020. 1.pdf
Noshy, M. M., A. Saad-Hussein, E. M. Shahy, H. A. I. D. A. N. M. EL-SHORBAGY, M. M. Taha, and E. A. Abdel-Shafy, "Assessment of anticholinesterase toxicity, oxidative stress and antioxidant status in carbamate and organophosphorus pesticides-exposed agricultural workers", International Journal of Pharmaceutical and Clinical Research, vol. 9, issue 3, pp. 205-209, 2017.
Noshy, P. A., M. A. Elhady, A. A. A. Khalaf, M. M. Kamel, and E. I. Hassanen, "Ameliorative effect of carvacrol against propiconazole-induced neurobehavioral toxicity in rats.", Neurotoxicology, vol. 67, pp. 141-149, 2018 07. Abstract

Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of acetylcholinesterase enzyme in neural tissue was also observed in PCZ-exposed rats. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, co-administration of CAR ameliorated most of the undesirable effects of PCZ.

Noshy, P. A., A. A. A. Khalaf, Marwa A Ibrahim, A. M. Mekkawy, R. E. Abdelrahman, A. Farghali, A. A. - E. Tammam, and A. R. Zaki, "Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin.", Toxicology, vol. 473, pp. 153208, 2022. Abstract

With recent progress in the manufacture and applications of nickel oxide nanoparticles (NiO NPs), concerns about their adverse effects are increasing. Hesperidin (HSP) is a citrus flavonoid that has a potent anti-inflammatory, antioxidant and free radical scavenging activities. This study aims to investigate the protective effect of HSP against testicular and spermatological damages induced by NiO NPs in male rats. Forty rats were randomly and equally divided into four groups: control, NiO NPs, HSP and NiO NPs + HSP. NiO NPs (100 mg/kg) and/or HSP (100 mg/kg) were given daily by gavage for 60 days. Exposure to NiO NPs induced marked reproductive toxicity in male rats that was manifested by increased sperm abnormalities and deterioration of sperm motility, count and viability. NiO NPs also increased lipid peroxidation and negatively affected the cellular antioxidant defense system in the testis of rats. The level of serum testosterone hormone was increased in NiO NPs-exposed rats. qPCR showed a marked downregulation in expression of steroidogenesis-related genes (CYP11A1, HSD3B and STAR) and a significant upregulation in expression of apoptosis-related gene (caspase-9) in testicular tissue of rats. Various pathological lesions and an increase in the number of PCNA-positive immune-reactive cells were also noticed in the testis of NiO NPs-exposed rats. Co-administration of HSP significantly ameliorated most of the NiO NPs-induced testicular damages and improved male fertility in rats.

Noshy, M. M., H. M. EL-SHORBAGY, and A. A. ElGhor, "Investigation of sensitivity of the cytogenetic and molecular biomarkers to asses the genotoxicity of cadmium and lead", Egypt. J. Zool, vol. 58, pp. 339-358, 2012.
Noshy, M. M., N. A. Hussien, and A. A. El-Ghor, Evaluation of the role of the antioxidant silymarin in modulating the in vivo genotoxicity of the antiviral drug ribavirin in mice, : Mutation Research 752,14– 20, 2013.
NOSHY, W., R. R. A. Hassan, and N. M., "Using biopolymers to strengthen the historical printed paper: mechanical and optical characters", Pigment & Resin Technology,, vol. Vol. 51 pp. 212-226., issue No. 2,, pp. pp. 212-226., 2022.
Noshy, M., A. Hussein, E. Shahy, H. El-Shorbagy, M. Taha, and E. Abdel-Shafy, "Assessment of Anticholinesterase Toxicity, Oxidative Stress and Antioxidant Status in Carbamate and Organophosphorus Pesticides-Exposed Agricultural Workers", International Journal of Pharmaceutical and Clinical Research , vol. 9, issue (3), pp. 205-209, 2017.
Noshy, P. A., M. A. Elhady, A. A. A. Khalaf, M. M. Kamel, and E. I. Hassanen, "Ameliorative effect of carvacrol against propiconazole-induced neurobehavioral toxicity in rats.", Neurotoxicology, vol. 67, pp. 141-149, 2018 07. Abstract

Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of acetylcholinesterase enzyme in neural tissue was also observed in PCZ-exposed rats. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, co-administration of CAR ameliorated most of the undesirable effects of PCZ.

Noshy, M. M., A. A. El-Ghor, F. H. Hafez, and H. H. R., "Role of chlorophyllin in the protection of mice bonemarrow chromosomes from damage induced by cisplatin", J. Zool, issue 50, pp. 233-252, 2008.
Noshy, P. A., and R. A. Azouz, "Neuroprotective effect of hesperidin against emamectin benzoate-induced neurobehavioral toxicity in rats.", Neurotoxicology and teratology, vol. 86, pp. 106981, 2021. Abstract

Emamectin Benzoate (EMB) is an avermectin insecticide widely used in agriculture and veterinary medicine. Hesperidin (HSP) is a flavanone glycoside predominantly found in citrus fruits and has various beneficial health effects. The current research was conducted to study the neurobehavioral toxic effects of EMB in rats and also to evaluate the protective effect of HSP against these toxic effects. Sixty Sprague-Dawley rats were randomly divided into 4 equal groups: control group, EMB group, HSP group, and EMB + HSP group. EMB (8.8. mg/kg) and/or HSP (100 mg/kg) were administered daily by gavage for 8 weeks. The behavioral assessment demonstrated the adverse effects of EMB on the behavioral, motor, and cognitive brain functions. Exposure to EMB also decreased the activity of antioxidants (catalase and reduced glutathione) and increased the malondialdehyde level in nervous tissue. Moreover, EMB increased the level of inflammatory cytokines (tumor necrosis factor-α and interleukin-1β) and decreased brain-derived neurotrophic factor (BDNF) levels in rats' brains. On the other hand, concurrent administration of HSP ameliorated the toxic effects of EMB as indicated by improvements in neural functions and reduction of oxidative stress and inflammation. The study concluded that exposure to EMB induces toxic effects in the brain of rats and that HSP has a protective effect against these toxic effects.

Noshy, M. M., N. A. Hussien, and A. A. El-Ghor, "Evaluation of the role of the antioxidant silymarin in modulating the in vivo genotoxicity of the antiviral drug ribavirin in mice.", Mutation research, vol. 752, issue 1-2, pp. 14-20, 2013 Apr 15. Abstract

Ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a widely used broad-spectrum antiviral drug. Recently, several reports revealed genotoxic effects of ribavirin in vivo and in vitro, which were correlated with the production of reactive oxygen species (ROS). This study aimed to evaluate the genotoxicity of ribavirin and to investigate the role of the natural antioxidant silymarin to modulate this genotoxicity. Male albino mice (age, 8-10 weeks) were injected intraperitoneally (i.p.) with ribavirin at three dose levels (20, 75 and 130 mg/kg bw) either in a single injection (acute treatment) or in multiple injections on five consecutive days (sub-acute treatment). Other comparable groups were treated with silymarin (70 mg/kg bw) 1h before the injection with ribavirin. Mice were sacrificed at different sampling times (24, 48 and 72 h) after the last ribavirin treatment. Micronucleus (MN) and single-strand conformation polymorphism (SSCP) assays were used to assess genotoxic and cytotoxic effects of ribavirin and to evaluate the protective effect of the pre-treatment with silymarin. Our results reveal genotoxic and cytotoxic effects of ribavirin in the MN assay. Pre-treatment with silymarin reduced the toxicity of ribavirin. In the SSCP assay, ribavirin treatment did not induce any mutations in the two selected sites in the D-loop of mitochondrial DNA (mtDNA).

Noshy, P. A., A. A. A. Khalaf, Marwa A Ibrahim, A. M. Mekkawy, R. E. Abdelrahman, A. Farghali, A. A. - E. Tammam, and A. R. Zaki, "Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin", Toxicology, vol. 473, pp. 153208, 2022. AbstractWebsite

With recent progress in the manufacture and applications of nickel oxide nanoparticles (NiO NPs), concerns about their adverse effects are increasing. Hesperidin (HSP) is a citrus flavonoid that has a potent anti-inflammatory, antioxidant and free radical scavenging activities. This study aims to investigate the protective effect of HSP against testicular and spermatological damages induced by NiO NPs in male rats. Forty rats were randomly and equally divided into four groups: control, NiO NPs, HSP and NiO NPs + HSP. NiO NPs (100 mg/kg) and/or HSP (100 mg/kg) were given daily by gavage for 60 days. Exposure to NiO NPs induced marked reproductive toxicity in male rats that was manifested by increased sperm abnormalities and deterioration of sperm motility, count and viability. NiO NPs also increased lipid peroxidation and negatively affected the cellular antioxidant defense system in the testis of rats. The level of serum testosterone hormone was increased in NiO NPs-exposed rats. qPCR showed a marked downregulation in expression of steroidogenesis-related genes (CYP11A1, HSD3B and STAR) and a significant upregulation in expression of apoptosis-related gene (caspase-9) in testicular tissue of rats. Various pathological lesions and an increase in the number of PCNA-positive immune-reactive cells were also noticed in the testis of NiO NPs-exposed rats. Co-administration of HSP significantly ameliorated most of the NiO NPs-induced testicular damages and improved male fertility in rats.

NOSHY, W., E. OSMAN, and M. MANSOUR, "AN INVESTIGATION OF THE BIOLOGICAL FUNGICIDAL ACTIVITY OF SOME ESSENTIAL OILS USED AS PRESERVATIVES FOR A 19TH CENTURY EGYPTIAN COPTIC CELLULOSIC MANUSCRIPT ", INTERNATIONAL JOURNAL OF CONSERVATION SCIENCE, vol. 7, issue 4, 2016. AbstractWebsite

The main goal of this work was to investigate the biological fungicidal activity of some
commercial essential oils of tea tree, lavender and thyme, which were to be applied as
alternative preservatives for ancient manuscripts. To achieve our goal, model samples of
cellulosic paper were made to mimic the original manuscript, which was a Coptic manuscript
known as Pascha (the sacred week), dated 1812. Twenty-three microorganism strains were
isolated representing twelve fungal taxa and one bacterial taxa which were identified in all
collected and analyzed in samples, which included Trichoderma viride, Penicillium roqueforti,
Eurotium chevalieri, Aspergillus flavus and Bacillus subtilis. A scanning electron microscope
(SEM) was used to investigate the growth of the associated microorganisms and their effect on
the sample paper structure. Different concentrations of the aforementioned essential oils were
applied on the mimic samples, which were then subjected to accelerated ageing corresponding
to 25 or 50 years of a natural one. To characterize the applied oils on the samples, we made
records by using FTIR-ATR, color measurements according to CIELAB system, and analyzed
the mechanical properties of the tested samples. The results revealed that the samples treated
with either tea tree oil or lavender oil, had ΔE values that decreased as the oil concentration
increased. However, when samples were treated with thyme oil the reverse was obtained. For
the treated samples exposed to 25 years of light ageing, we noticed that the higher obtained
tensile strength and % elongation of treated samples followed the ranking order: thyme >
lavender > tea tree oils. For the treated samples that were exposed to 50 years of natural light
ageing, we observed that almost all tensile strength and elongation values of the treated
samples were higher than that of the untreated ones. Moreover, we noticed that the inhibition
of growth of the microorganisms was obtained at a low concentration of tea tree oil (0.25%
v/v). This treatment was esthetically acceptable for archaeological objects, because it was
colorless, transparent and safe. Based on the results we obtained, the optimized essential oil,
which is the oil with an appropriate concentration, was selected to be added to the cellulosic
pulp used for the leaf casting. Moreover, the same optimized essential oil was applied on the
paper samples to be used as separators between the ancient manuscript pages. After
dismantling, cleaning, leaf casting and rebinding of the damaged parts, the manuscript is then
preserved.

Noshy, P. A., "Postmortem expression of apoptosis-related genes in the liver of mice and their use for estimation of the time of death.", International journal of legal medicine, vol. 135, issue 2, pp. 539-545, 2021. Abstract

PURPOSE: A major challenge in forensic medicine is to estimate the postmortem interval (PMI). Several approaches had been tried to determine the time of death, including physical and chemical changes. This study aims to explore the postmortem changes in the expression of apoptosis-related genes in the liver of mice and to use these changes for estimation of the PMI.

METHODS: Hepatic tissue was collected from sacrificed mice immediately after death (the control group) and at 3, 6, 9, 12, 18, and 24 hours after death. Four apoptosisrelated genes were selected as target genes, which are Caspase 3 (Casp3), B cell leukemia/ lymphoma 2 (Bcl2), BCL2-associated X protein (Bax), and Transformation related protein 53 (Trp53), and their relative expression was measured using quantitative PCR. miR-122 was used as a reference gene for normalization of the Ct (threshold cycle) values of the target genes.

RESULTS: The results revealed that the postmortem expression of Casp3 increased in a time-dependent manner; the expression of Bax increased from 3 to 18 hours followed by a decrease at 24 hours after death; the expression of Bcl2 decreased in a time-dependent manner after death; the expression of Trp53 increased from 3 to 6 hours and then started to decrease from 9 to 24 hours after death.

CONCLUSION: Based on the observed changes in the expression level of these genes, mathematical models were established to estimate the PMI. Further research is needed to investigate these markers and mathematical models in human tissues.

Noshy, M. M., F. H. Hafez, A. A. El-Ghor, and H. H. R., "Chlorophyllin ameliorates the nephrotoxicity and oxidative stress induced by cisplatin without affecting its antitumor activity", J. Med. Sci., vol. 1, issue 28, pp. 265-276, 2007.
Noshy, P. A., A. A. A. Khalaf, Marwa A Ibrahim, A. M. Mekkawy, R. E. Abdelrahman, A. Farghali, A. A. - E. Tammam, and A. R. Zaki, "Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin", Toxicology, vol. 473, issue 153208, 2022.
Nosair, A. M., M. Y. Shams, L. M. AbouElmagd, A. E. Hassanein, A. E. Fryar, and H. S. Abu Salem, "Predictive model for progressive salinization in a coastal aquifer using artificial intelligence and hydrogeochemical techniques: a case study of the Nile Delta aquifer, Egypt", Environmental Science and Pollution Research, vol. 29, pp. 9318–9340, 2021.
Norsigian, C. J., H. Attia, R. Szubin, A. S. Yassin, B. Ø. Palsson, R. K. Aziz, and J. M. Monk, "Comparative Genome-Scale Metabolic Modeling of Metallo-Beta-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates", Frontiers in cellular and infection microbiology, vol. 9: Frontiers Media S.A., pp. 161 - 161, 2019/05/24. AbstractWebsite

The emergence and spread of metallo-beta-lactamase-producing multidrug-resistant (MDR) Klebsiella pneumoniae is a serious public health threat, which is further complicated by the increased prevalence of colistin resistance. The link between antimicrobial resistance acquired by strains of Klebsiella and their unique metabolic capabilities has not been determined. Here, we reconstruct genome-scale metabolic models for 22 K. pneumoniae strains with various resistance profiles to different antibiotics, including two strains exhibiting colistin resistance isolated from Cairo, Egypt. We use the models to predict growth capabilities on 265 different sole carbon, nitrogen, sulfur, and phosphorus sources for all 22 strains. Alternate nitrogen source utilization of glutamate, arginine, histidine, and ethanolamine among others provided discriminatory power for identifying resistance to amikacin, tetracycline, and gentamicin. Thus, genome-scale model based predictions of growth capabilities on alternative substrates may lead to construction of classification trees that are indicative of antibiotic resistance in Klebsiella isolates.

Norman, D. A., The {Design} of {Everyday} {Things}, : Basic Books, 2002. Abstract
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Tourism