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NOURA S. EL NASSERY, M. D., M. R. C. O. G. EMAN A. EL KATTAN, M.D., M. D. MONA A. FOUAD, and M. S. TOKKA M. AFFIFI, "Unengaged Head in Primigravidas, Will it Affect the Chance of Having a Vaginal Birth?", Med. J. Cairo Univ, vol. VoL 81, issue 1, pp. 221-225, 2013.
NOURA S. EL NASSERY, M. D., M. R. C. O. G. EMAN A. EL KATTAN, M.D., M. D. MONA A. FOUAD, and M. S. TOKKA M. AFFIFI, "Unengaged Head in Primigravidas, Will it Affect the Chance of Having a Vaginal Birth?", Med. J. Cairo Univ., vol. 81, issue 1, pp. 221-225, 2013.
Nour-Eldin, N. - E. A., M. Alsubhi, T. Gruber-Rouh, T. J. Vogl, B. Kaltenbach, H. H. Soliman, W. E. Hassan, S. M. Abolyazid, and N. N. Naguib, "CT-Guided Drainage of Pericardial Effusion after Open Cardiac Surgery.", Cardiovascular and interventional radiology, vol. 40, issue 8, pp. 1223-1228, 2017 Aug. Abstract

PURPOSE: This study was designed to evaluate the safety and efficacy of CT-guided drainage of the pericardial effusion in patients after cardiac surgery.

MATERIALS AND METHODS: The study included 128 consecutive patients (82 males, 46 females; mean age 66.6 years, SD: 4.2) complicated by pericardial effusion or hemopericardium after cardiac surgeries between June 2008 and June 2016. The medical indication for therapeutic pericardiocentesis in all patients was hemodynamic instability caused by pericardial effusion. The treatment criteria for intervention were evidence of pericardial tamponade with ejection fraction (EF) <50%. The preintervention ejection fraction was determined echocardiographically with value between 30 and 40%. Exclusion criteria for drainage were hemodynamically unstable patients or impaired coagulation profile (INR <1.8 or platelet count <75,000). Drains (8F-10F) were applied using Seldinger's technique under CT guidance.

RESULTS: Pericardiocentesis and placement of a percutaneous pericardial drain was technically successful in all patients. The mean volume of evacuated pericardial effusion was 260 ml (range 80-900 ml; standard deviation [SD]: ±70). Directly after pericardiocentesis, there was a significant improvement of the ejection fraction to 40-55% (mean: 45%; SD: ±5; p < 0.05). The mean percentage increase of the EF following pericardial effusion drainage was 10%. The drainage was applied anteriorly (preventricular) in 39 of 128 (30.5%), retroventricularly in 33 of 128 (25.8%), and infracardiac in 56 of 128 (43.8%). Recurrence rate of pericardial effusion after removal of drains was 4.7% (67/128). Complete drainage was achieved in retroventricular and infracardiac positioning of the catheter (p < 0.05) in comparison to the preventricular position of the catheter. Recorded complications included minimal asymptomatic pneumothorax and pneumomediastinum 2.3% (3/128) and sinus tachycardia 3.9% (5/128).

CONCLUSION: CT-guided drainage of postoperative pericardial effusion is a minimally invasive technique for the release of the tamponade effect of the effusion and improvement of cardiac output.

Nour-Eldin, E. M., Y. E. Hamza, and H. H. Zedan, "Solubilization and antimicrobial effect of chloramphenicol. ", Bull. Fac. Pharm. Cairo Univ. , vol. 12, pp. 48-54, 1975.
Nour-Eldin, N. N. N. Naguib, A. M. Tawfik, K. Koitka, A. S. Saeed, and T. J. Vog, "Outcomes of an Algorithmic Approach to Management of Pneumothorax Complicating Thermal Ablation of Pulmonary Neoplasms", J. Vasc Interv Radiol, 2011. Abstract

Purpose: To investigate the outcomes of an algorithm for treatment of pneumothorax in association with radiofrequency (RF) and microwave (MW) ablation of pulmonary neoplasms.

Nour-Eldin, M., A. Kamel, and O. Hegazy, "Capture-recapture techniques in software verification", International Conference on Computer Engineering & Systems, (ICCES08), Cairo, Egypt, November 25-27, 2008.
Nour-Eldin, N. - E. A., S. Exner, M. Al-Subhi, N. N. N. Naguib, B. Kaltenbach, A. Roman, and T. J. Vogl, "Ablation therapy of non-colorectal cancer lung metastases: retrospective analysis of tumour response post-laser-induced interstitial thermotherapy (LITT), radiofrequency ablation (RFA) and microwave ablation (MWA).", International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, vol. 33, issue 7, pp. 820-829, 2017 11. Abstract

PURPOSE: To retrospectively compare the local tumour response and survival rates in patients with non-colorectal cancer lung metastases post-ablation therapy using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA) and microwave ablation (MWA).

MATERIAL AND METHODS: Retrospective analysis of 175 computed tomography (CT)-guided ablation sessions performed on 109 patients (43 males and 66 females, mean age: 56.6 years). Seventeen patients with 22 lesions underwent LITT treatment (tumour size: 1.2-4.8 cm), 29 patients with 49 lesions underwent RFA (tumour size: 0.8-4.5 cm) and 63 patients with 104 lesions underwent MWA treatment (tumour size: 0.6-5 cm). CT scans were performed 24-h post-therapy and on follow-up at 3, 6, 12, 18 and 24 months.

RESULTS: The overall-survival rates at 1-, 2-, 3- and 4-year were 93.8, 56.3, 50.0 and 31.3% for patients treated with LITT; 81.5, 50.0, 45.5 and 24.2% for patients treated with RFA and 97.6, 79.9, 62.3 and 45.4% for patients treated with MWA, respectively. The mean survival time was 34.14 months for MWA, 34.79 months for RFA and 35.32 months for LITT. In paired comparison, a significant difference could be detected between MWA versus RFA (p = 0.032). The progression-free survival showed a median of 23.49 ± 0.62 months for MWA,19.88 ± 2.17 months for LITT and 16.66 ± 0.66 months for RFA (p = 0.048). The lowest recurrence rate was detected in lesions ablated with MWA (7.7%; 8 of 104 lesions) followed by RFA (20.4%; 10 of 49 lesions) and LITT (27.3%; 6 of 22 lesions) p value of 0.012. Pneumothorax was detected in 22.16% of MWA ablations, 22.73% of LITT ablations and 14.23% of RFA ablations.

CONCLUSION: LITT, RFA and MWA may provide an effective therapeutic option for non-colorectal cancer lung metastases with an advantage for MWA regarding local tumour control and progression-free survival rate.

Nour Mohamed Badr, M. F. Ali, and G. A. N. Nesrin M. N. El Hadidi, "Identification of materials used in a wooden coffin lid covered with composite layers dating back to the Ptolemaic period in Egypt", Conservar Património, pp. 1-13, 2018.
Nour Mohamed Badr, and M. A. E. R. and Nesrin M.N El Hadidi, "Further investigation of a Ptolemaic wooden coffin lid from Abusir el-Meleq in the Egyptian Museum, Cairo", ANCIENT EGYPTIAN COFFINS PAST · PRESENT· FUTURE: OXBOW BOOKS-United Kingdom, 2019.
Nour El-Din, H. T., N. M. Elhosseiny, M. A. El-Gendy, A. A. Mahmoud, M. M. M. Hussein, and A. S. Attia, "A Rapid Lysostaphin Production Approach and a Convenient Novel Lysostaphin Loaded Nano-emulgel; As a Sustainable Low-Cost Methicillin-Resistant Combating Platform.", Biomolecules, vol. 10, issue 3, 2020. Abstractbiomolecules-10-00435-final_published_form.pdf

is a Gram-positive pathogen that is capable of infecting almost every organ in the human body. Alarmingly, the rapid emergence of methicillin-resistant strains (MRSA) jeopardizes the available treatment options. Herein, we propose sustainable, low-cost production of recombinant lysostaphin (rLST), which is a native bacteriocin destroying the staphylococcal cell wall through its endopeptidase activity. We combined the use of BL21(DE3)/pET15b, factorial design, and simple Ni-NTA affinity chromatography to optimize rLST production. The enzyme yield was up to 50 mg/L culture, surpassing reported systems. Our rLST demonstrated superlative biofilm combating ability by inhibiting staphylococcal biofilms formation and detachment of already formed biofilms, compared to vancomycin and linezolid. Furthermore, we aimed at developing a novel rLST topical formula targeting staphylococcal skin infections. The phase inversion composition (PIC) method fulfilled this aim with its simple preparatory steps and affordable components. LST nano-emulgel (LNEG) was able to extend active LST release up to 8 h and cure skin infections in a murine skin model. We are introducing a rapid, convenient rLST production platform with an outcome of pure, active rLST incorporated into an effective LNEG formula with scaling-up potential to satisfy the needs of both research and therapeutic purposes.

Nour El-Din, H. T., N. M. Elhosseiny, M. A. El-Gendy, A. A. Mahmoud, M. M. M. Hussein, and A. S. Attia, "A Rapid Lysostaphin Production Approach and a Convenient Novel Lysostaphin Loaded Nano-emulgel; As a Sustainable Low-Cost Methicillin-Resistant Combating Platform.", Biomolecules, vol. 10, issue 3, 2020. Abstract

is a Gram-positive pathogen that is capable of infecting almost every organ in the human body. Alarmingly, the rapid emergence of methicillin-resistant strains (MRSA) jeopardizes the available treatment options. Herein, we propose sustainable, low-cost production of recombinant lysostaphin (rLST), which is a native bacteriocin destroying the staphylococcal cell wall through its endopeptidase activity. We combined the use of BL21(DE3)/pET15b, factorial design, and simple Ni-NTA affinity chromatography to optimize rLST production. The enzyme yield was up to 50 mg/L culture, surpassing reported systems. Our rLST demonstrated superlative biofilm combating ability by inhibiting staphylococcal biofilms formation and detachment of already formed biofilms, compared to vancomycin and linezolid. Furthermore, we aimed at developing a novel rLST topical formula targeting staphylococcal skin infections. The phase inversion composition (PIC) method fulfilled this aim with its simple preparatory steps and affordable components. LST nano-emulgel (LNEG) was able to extend active LST release up to 8 h and cure skin infections in a murine skin model. We are introducing a rapid, convenient rLST production platform with an outcome of pure, active rLST incorporated into an effective LNEG formula with scaling-up potential to satisfy the needs of both research and therapeutic purposes.

Nour El-Din, H. T., M. M. Elsebaie, N. S. Abutaleb, A. M. Kotb, A. S. Attia, M. N. Seleem, and A. S. Mayhoub, "Expanding the structure-activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agents.", RSC medicinal chemistry, vol. 14, issue 2, pp. 367-377, 2023. Abstract

With the continuous and alarming threat of exhausting the current antimicrobial arsenals, efforts are urgently needed to develop new effective ones. In this study, the antibacterial efficacy of a set of structurally related acetylenic-diphenylurea derivatives carrying the aminoguanidine moiety was tested against a panel of multidrug-resistant Gram-positive clinical isolates. Compound 18 was identified with a superior bacteriological profile than the lead compound I. Compound 18 demonstrated an excellent antibacterial profile : low MIC values, extended post-antibiotic effect, refractory ability to resistance development upon extended repeated exposure, and high tolerability towards mammalian cells. Finally, when assessed in a MRSA skin infection animal model, compound 18 showed considerable healing and less inflammation, decrease in the bacterial loads in skin lesions, and it surpassed fusidic acid in controlling the systemic dissemination of . Collectively, compound 18 represents a promising lead anti-MRSA agent that merits further investigation for the development of new anti-staphylococcal therapeutics.

Nour El Din, S., T. El-Tayeb, K. Abou-Aisha, and M. El-Azizi, "In vitro and in vivo antimicrobial activity of combined therapy of silver nanoparticles and visible blue light against Pseudomonas aeruginosa", International Journal of Nanomedicine, vol. 11: Dovepress, pp. 1749–1758, 2016. Abstract
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Nour El Din, S., T. El-Tayeb, K. Abou-Aisha, and M. El-Azizi, "In vitro and in vivo antimicrobial activity of combined therapy of silver nanoparticles and visible blue light against Pseudomonas aeruginosa", International Journal of Nanomedicine, vol. 11: Dovepress, pp. 1749-1758, 2016. Abstract
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Nour, M. K., H. T. Fathelbab, A. H. Mwafy, M. A. Shawky, S. J. C. Fre, L. avier Jiménez, J. R. Garrido, A. E. G. Menchero, Rosa Cardenal Piris2, J. F. D. Fernández, et al., "Angiographically Based Direct Implantation of the Bioresorbable Vascular Scaffold in Non-ST Segment Elevation Acute Coronary Syndrome: Feasibility and Outcome", Journal of Medical Sciences., vol. 15, issue 7, pp. 2419-2423, 2019. Abstract

BACKGROUND:Direct implantation of metallic drug-eluting stents is recommended for lesions with high thrombotic burden; however, this can't be applied to bioresorbable scaffold for which adequate lesion preparation is recommended. AIM:We aimed at assessing the feasibility and safety of direct scaffold implantation based only on angiographic assessment in patients presented with non-ST segment elevation acute coronary syndrome.METHODS:The study was a retrospective two-centrestudy conducted over patients diagnosed with NSTE-ACS presented to cardiology department at Juan Ramon Hospital, Spain and critical care department, Cairo University in the period between February 2016 to May 2017. We included patients for whom we depend only on angiographic assessmentfor decision making whether to directly implant the scaffold or predilate the lesion and we excluded patients for whom intracoronary imaging wasused at the index procedure either for pre or post-implantation. The primary outcome of interest was the device-oriented composite endpoints (DOCE) including cardiac death,andMI attributed to the target vessel and TLR.The secondary endpoints were the broader patient-oriented composite outcome (POCE) and scaffold/stent thrombosis. POCE includes all-cause mortality, any MI and any revascularisation (including TLR, TVR and revascularisation of non-target vessel)RESULTS:Among 46 patients with NSTE-ACS treated with BVS,we did direct implantation in 20 patients (group A),and we used predilatation in 26 patients (group B).The two groups havesimilar demographicsand clinical criteria. Procedural success was obtained in all study population. Mean follow up duration was 12 months. We have total of 10% device-oriented composite endpoints in group A versus 15% in group B (p-value = 0.684). We didn’t document any cardiac death in both groups. In group B we had one (3.8%) non-fatal MI while there was no MI in group A (P-value= 1). In group A we had 2 cases (10%) of TLR while in group B there were3 cases (11.5%) TLR (P-value=1). We have two cases (7.7%) of TVR in group B and one in group A p-value=1. All cases were planned staged PCI. Scaffold thrombosis occurred in one case in group A (5%) and two cases in group B (7.7%) p-value =1.CONCLUSION:With proper lesion selection,direct BVS implantation in all-comers NSTE-ACS patients is feasible and safe even without the aid of intracoronary imaging

Nour, E. H., M. A. Hamza, M. Fayez, M. Monib, S. Ruppel, and N. A. Hegazi, "The crude plant juices of desert plants as appropriate culture media for the cultivation of rhizospheric microorganisms", Journal of Advanced Research, vol. 3, issue 1, pp. 35 - 43, 2012. AbstractWebsite

The exclusive use of plant juices, not as a mere supplement to synthetic culture media, for culturing rhizospheric microorganisms (RMO) is introduced here. Juices were prepared from desert (Mesembryanthemum crystallinum L., Zygophyllum album L., Carpobrotus edulis L.) as well as cultivated (Trifolium alexandrinum L., Beta vulgaris L.) plants. Colonies of RMO (Azospirillum brasilense, Enterobacter agglomerans and Klebsiella pneumoniae) nicely developed on surface-inoculated agar plates prepared from crude and diluted juice of M. crystallinum (ice plant). Furthermore, hundreds of RMO colonies developed on various standard culture media were replicated (>90%) on agar plates of different plant juices. RMO cells grew nicely in liquid ice plant juice, with doubling times comparable to those grown in the reference culture medium. RMO populations resident in various host plants were able to develop on culture media prepared from homologous and heterologous juices. The application of a thin semi-solid overlay agar on the surfaces of inoculated agar plates significantly increased the recovery of micro-colonies on agar plates, particularly those prepared from plant juices. © 2011.

Nour, M., A. Ghanem, M. Buchholz, and A. Nassar, "Greenhouse Based Desalination for Sustainable Agriculture in Desert Climate", International Conference on Desalination, Environment and Marine Outfall Systems, Sultan Quabus University, Oman, 4 2014.
Nour, Y., and T. Abuelfadl, "PTCC: New Beam Dynamics Design Code for Linear Accelerators", International Particle Accelerator Conference, IPAC13: IPAC, 2013. Abstract
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Nour, M., and F. A. Omara, "Performance Evaluation of Parallel Task Scheduling Algorithms for Heterogeneous Processors ", The Egyptian Informatics Journal, vol. 6, issue 1, pp. 98-122, 2005.
Nour, S. A., M. M. Salama, M. A. A. kaway, and M. S. Hifnawy, "The impact of seasonal variation on the volatile oil profile of leaves of Severinia buxifolia (Poir.) and its antimicrobial activity", Journal of Pharmacognosy & Phytotherapy, vol. 10, issue 3, pp. 56-63, 2018.
Nour, S. A., A. NS, and N. MJ, "Transferosomes for Trans-Nasal Brain Delivery of Clonazepam: Preparation, Optimization, Ex-Vivo Cytotoxicity and Pharmacodynamic Study", Open Access Journal of Pharmaceutical Research, vol. 1, issue 2, pp. 000107, 2017.
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