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Eissa, I. H., H. Mohammad, O. A. Qassem, W. Younis, T. M. Abdelghany, A. Elshafeey, M. A. R. M. Moustafa, M. N. Seleem, and A. S. Mayhoub, "{Diphenylurea derivatives for combating methicillin-and vancomycinresistant Staphylococcus aureus}", {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, vol. {130}, {23 RUE LINOIS, 75724 PARIS, FRANCE}, {ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER}, pp. {73-85}, {APR 21}, Submitted. Abstract

{A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin-and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structureactivity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics. (C) 2017 Elsevier Masson SAS. All rights reserved.}

Mattar, A., "nutrition in mechanically ventilated patients", critical care summit, Cairo ,Grand Hyatt hotel, 8 January 2015, Submitted.
Mohamed, A. W., A. A. Hadi, A. M. Fattouh, and K. M. Jambi, "LSHADE with semi-parameter adaptation hybrid with CMA-ES for solving CEC 2017 benchmark problems", 2017 IEEE Congress on Evolutionary Computation (CEC), pp. 145 - 152, 5-8 June 2017, Submitted. Abstract
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Moustafa, H., M. K. Kamel, A. M. Abdel Hakim, and S. Hantar, "99mTc-HIG and 99mTc-infecton in assessment of disease activity in tuberculosis", European Congress Nuclear Medicine, Berlin, 29 Aug- 4 Sept, Submitted.
Victoria, S., H. Amaral, I. Mulamitsi, S. Bhatnagar, H. Moustafa, H. Kartunihardja, F. Sundram, and K. Britton, "CRF on in vivo imaging for infection (sepsis) and inflammation", European Congress Nuclear Medicine, Berlin, 29 Aug- 4 Sept, Submitted.
Moustafa, H., A. Zaher, S. Eissa, and H. Abd El Dayem, "Role of Q12 as a tumour imaging agent in different malignant tumours", European Congress Nuclear Medicine, Berlin, 29 Aug- 4 Sept, Submitted.
Hassanein Walid1, 2, G. Fabienne1, J. Etienne1, R. Emmanuel3, M. M. 4, A. Mohamed2, and H. Mohamed2, "Paleoenvironmental conditions during the Late Aptian-Early Albian in the Essaouira-Agadir Basin (Morocco): evidence from sedimentology, calcareous nannofossils and stable isotope records ", RST PAU, FRANCE, PAU , FRANCE, 27th -31 Octobre, Submitted. paufrance_2014.docx
nehal hamdy elsaid, N. S. Ghanem, R. S. Mohamed, and N. A. E. G. M. Mohamed Aly Salem, "THE RELATIONSHIP BETWEEN SERUM OSTEOPROTEGRIN LEVEL AND CORONARY ARTERY CALCIFICATION IN TYPE 2 DIABETES MELLITUS PATIENTS", meditarrean group for the study of diabetes, Athens(Greece), 27-29 april 2017, Submitted.
Mattar, A., "weight loss resistance during obesity management (non responders)", EMASO conference for obesity management, Cairo intercontinental hotel , 26 February 2015, Submitted.
Khalafallah, K., H. Moustafa, S. Wagih, and F. H, "99mTc MIBI, Tl201 and 131I whole body scanning in the follow up of patients with differentiated thyroid cancer", First Egyptian International Nuclear Medicine meeting, Hurghada , 25-27 February, Submitted.
Zaher, A., H. Moustafa, W. Omar, H. Farag, and I. Ezzat, "Assessment of treatment response and tumour viability using Tl201, Tc-MIBI and Tc-MDP in bone and soft tissue sarcoma", First Egyptian International Nuclear Medicine Meeting, Hurghada , 25-27 February, Submitted.
H, M., A. Fawzy, and A. Moneim, "The value of 99mTc -HIG and 99mTc-MDP in the evaluation of patients with Rheumatoid arthritis", First Egyptian International Nuclear Medicine meeting,, Hurghada , 25-27 February, Submitted.
asmaa hamoda, samah semary, E. Moussa, and omnia hassanien, Burkitts lymphoma is second preinduction phase in critically ill patients important, , dublin, 24/5/2016, Submitted.
Mohamed, A. K., A. A. Hadi, and A. W. Mohamed, "Generalized Adaptive Differential Evolution algorithm for Solving CEC 2020 Benchmark Problems", 2020 2nd Novel Intelligent and Leading Emerging Sciences Conference (NILES), pp. 391 - 396, 24-26 Oct. 2020, Submitted. Abstract
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Moustafa, H., A. Fawzy, S. El-Tobgi, and M. Abd El Ghani, "201Tl-reinjection-NTG as a predictor of myocardial viability", European Congress Nuclear Medicine, Glasgow, 23 - 27 August, Submitted.
Moustafa, H., K. Khallafallah, H. Farag, and I. Ezzat, "99mTc-MIBI, 201Tl and 131I whole body scanning in the follow up of patients with differentiated thyroid cancer", . European Congress Nuclear Medicine, Glasgow, 23 - 27 August, Submitted.
Moustafa, H., A. Zaher, I. Ezzat, and H. Farag, "Assessment of residual and recurrent viable bone and soft tissue sarcoma using 201Tl, 99mTc-MIBI and 99mTcMDP", European Congress Nuclear Medicine, Glasgow, 23 - 27 August, Submitted.
nehal hamdy, R. A. N. D. A. F.SALAM, E. L. S. A. Y. E. D. MAHMOUD, and S. Ahmed, "EFFECT OF BRANCHED CHAIN AMINO ACIDSON TYPE 2 DIABETIC PATIENTS CONTROL", ACCE-E POSTER, 22-23 N0VEMBER , Submitted.
Britton, K., S. Solanki, H. Ameral, A. Bhatangar, J. Katamihadja, J. Malamits, M. H, V. Soroa, F. Sundram, D. Warehan, et al., "Imaging of bacterial infection", European congress Nuclear Medicine, Paris , 2-6 September, Submitted.
Agrawal, P., T. Ganesh, and A. W. Mohamed, "Solution of Uncertain Solid Transportation Problem by Integer Gaining Sharing Knowledge Based Optimization Algorithm", 2020 International Conference on Computational Performance Evaluation (ComPE), pp. 158 - 162, 2-4 July 2020, Submitted. Abstract
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Moustafa, H., M. Mekawy, M. Said, H. Rabiee, E. Hamada, and H. Zawam, ".: 99mTc -antigranulocyte bone marrow scintigraphy in malignant lymphoma", European congress Nuclear Medicine, Paris , 2 – 6 September, Submitted.
H, M., S. El-Refai, M. Mahfouz, S. Nasr, and A. E. Mahmoud, "Evaluation of multidrug resistance using 99mTc -MIBI and in-vitro MDR expression using PCR in bronchial cancer", European congress Nuclear Medicine, Paris , 2 – 6 September, Submitted.
Mohamed, A. W., A. A. Hadi, A. K. Mohamed, and N. H. Awad, "Evaluating the Performance of Adaptive GainingSharing Knowledge Based Algorithm on CEC 2020 Benchmark Problems", 2020 IEEE Congress on Evolutionary Computation (CEC), pp. 1 - 8, 19-24 July 2020, Submitted. Abstract
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Mattar, A., "Enteral nutrition in cancer patient", Nutrition & Cancer, Cairo ,Grand Hyatt hotel, 19 March 2015, Submitted.
asmaa hamoda, L. Shalaby, W. Zekry, hany hussien, and A. mostafa, "INCIDENCE AND OUTCOME OF SEPTIC SHOCK IN PEDIATRIC CANCER PATIENTS", EHA, MILAN,ITALY, 12 JUNE, Submitted.
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