Refaat, S., A. A. Mawgood, M. A. Sonbaty, A. Ahmed, and M. Gamal,
Multi-Modal Analgesic Technique for Pain Control in Patients Undergoing Diagnostic Gynecological Laparoscopy: Randomized Controlled Clinical Trial,
, Cairo, Cairo University, 2019.
Arafa, W. A. A., R. A. M. Faty, and A. K. Mourad,
A New Sustainable Strategy for Synthesis of Novel Series of Bis‐imidazole and Bis‐1,3‐thiazine Derivatives,
, Cairo, Cairo University, Giza,Egypt, Submitted.
Mokhtar, S. H.,
NICORANDIL AND PROPOLIS, A LOOK AT BOTH SIDES EFFECT OF NICORANDIL USED SEPARATELY OR COUPLED WITH PROPOLIS ON THE PERIDONTIUM OF THE RAT,
, Giza, Cairo University, 2015.
AbstractObjective:
This study evaluated the effect of Nicorandil used separately or coupled with Propolis on the gingival and periodontal ligament of the rat through:
Microscopic examination of the above mentioned structures using Haematoxylin and Eosin and Masson's trichrome stains to detect any possible histopathological findings.
MATERIALS AND METHODS: Forty adult male albino rats weighing 120-150gm were used in this investigation. The animals were divided into 4 equal groups, 10 animals each .Group I animals served as controls Group II animals were treated with Nicorandil in a daily oral dose of 0.1mg/kg body weight (Raveaud et al., 2009) using curved metallic oro-pharyngeal tube Group III animals were treated with Propolis in a daily oral dose of 50mg/kg body weight (ElMasry et al., 2011) using curved metallic oro-pharyngeal tube.
Group IV animals were treated with Nicorandil coupled with Propolis in the same doses and route of adminsration as groups II and III.
At the end of the experiment, the rats of the different groups were sacrificed by carbon dioxide inhalation. The upper and lower jaws dissected out. Specimens from the gingiva were taken from the region of the upper and lower first molars of the left sides of the upper and lower jaws, fixed in 10% neutral buffered formalin, processed, embedded in paraffin and sectioned.
RESULTS: Nicorandil caused severe destructive histological changes in the surface epithelium and lamina propria of the gingival and in the PDL fibers. There was no histological changes in the structure of the gingival and PDL after application of Propolis alone. Application of Propolis with Nicorandil helped in reversing the condition from the Nicorandil induced destructive changes towards the healing and regeneration processes
CONCLUSION: Propolis plays a natural goal in overcoming the side effects of many drugs one of which is nicorandil.
Mokhtar, S. H.,
NICORANDIL AND PROPOLIS, A LOOK AT BOTH SIDES EFFECT OF NICORANDIL USED SEPARATELY OR COUPLED WITH PROPOLIS ON THE PERIDONTIUM OF THE RAT,
, Giza, Cairo University, 2015.
AbstractObjective:
This study evaluated the effect of Nicorandil used separately or coupled with Propolis on the gingival and periodontal ligament of the rat through:
Microscopic examination of the above mentioned structures using Haematoxylin and Eosin and Masson's trichrome stains to detect any possible histopathological findings.
MATERIALS AND METHODS: Forty adult male albino rats weighing 120-150gm were used in this investigation. The animals were divided into 4 equal groups, 10 animals each .Group I animals served as controls Group II animals were treated with Nicorandil in a daily oral dose of 0.1mg/kg body weight (Raveaud et al., 2009) using curved metallic oro-pharyngeal tube Group III animals were treated with Propolis in a daily oral dose of 50mg/kg body weight (ElMasry et al., 2011) using curved metallic oro-pharyngeal tube.
Group IV animals were treated with Nicorandil coupled with Propolis in the same doses and route of adminsration as groups II and III.
At the end of the experiment, the rats of the different groups were sacrificed by carbon dioxide inhalation. The upper and lower jaws dissected out. Specimens from the gingiva were taken from the region of the upper and lower first molars of the left sides of the upper and lower jaws, fixed in 10% neutral buffered formalin, processed, embedded in paraffin and sectioned.
RESULTS: Nicorandil caused severe destructive histological changes in the surface epithelium and lamina propria of the gingival and in the PDL fibers. There was no histological changes in the structure of the gingival and PDL after application of Propolis alone. Application of Propolis with Nicorandil helped in reversing the condition from the Nicorandil induced destructive changes towards the healing and regeneration processes
CONCLUSION: Propolis plays a natural goal in overcoming the side effects of many drugs one of which is nicorandil.
] 