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5
Nassar, Y. S., M. Magdy, L. Hamed, and T. E. Gohary, "A 5-year registry of mechanically ventilated patients comprising epidemiology, initial settings, and clinical outcome", Egyptian Journal of Chest Diseases and Tuberculosis, vol. 67, issue 2018, pp. 250-263, 2018. mena_paper.pdf
Srinivas, U. S., J. Dyczkowski, T. Beißbarth, J. Gaedcke, W. Y. Mansour, K. Borgmann, and M. Dobbelstein, "5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.", Oncotarget, vol. 6, issue 14, pp. 12574-86, 2015 May 20. Abstractsrinivas-2015.pdf

Malignant tumors of the rectum are treated by neoadjuvant radiochemotherapy. This involves a combination of 5-fluorouracil (5-FU) and double stranded DNA-break (DSB)-inducing radiotherapy. Here we explored how 5-FU cooperates with DSB-induction to achieve sustainable DNA damage in colorectal cancer (CRC) cells. After DSB induction by neocarzinostatin, phosphorylated histone 2AX (γ-H2AX) rapidly accumulated but then largely vanished within a few hours. In contrast, when CRC cells were pre-treated with 5-FU, gammaH2AX remained for at least 24 hours. GFP-reporter assays revealed that 5-FU decreases the efficiency of homologous recombination (HR) repair. However, 5-FU did not prevent the initial steps of HR repair, such as the accumulation of RPA and Rad51 at nuclear foci. Thus, we propose that 5-FU interferes with the continuation of HR repair, e. g. the synthesis of new DNA strands. Two key mediators of HR, Rad51 and BRCA2, were found upregulated in CRC biopsies as compared to normal mucosa. Inhibition of HR by targeting Rad51 enhanced DNA damage upon DSB-inducing treatment, outlining an alternative way of enhancing therapeutic efficacy. Taken together, our results strongly suggest that interfering with HR represents a key mechanism to enhance the efficacy when treating CRC with DNA-damaging therapy.

Srinivas, U. S., J. Dyczkowski, T. Beißbarth, J. Gaedcke, W. Y. Mansour, K. Borgmann, and M. Dobbelstein, "5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.", Oncotarget, vol. 6, issue 14, pp. 12574-86, 2015 May 20. Abstract

Malignant tumors of the rectum are treated by neoadjuvant radiochemotherapy. This involves a combination of 5-fluorouracil (5-FU) and double stranded DNA-break (DSB)-inducing radiotherapy. Here we explored how 5-FU cooperates with DSB-induction to achieve sustainable DNA damage in colorectal cancer (CRC) cells. After DSB induction by neocarzinostatin, phosphorylated histone 2AX (γ-H2AX) rapidly accumulated but then largely vanished within a few hours. In contrast, when CRC cells were pre-treated with 5-FU, gammaH2AX remained for at least 24 hours. GFP-reporter assays revealed that 5-FU decreases the efficiency of homologous recombination (HR) repair. However, 5-FU did not prevent the initial steps of HR repair, such as the accumulation of RPA and Rad51 at nuclear foci. Thus, we propose that 5-FU interferes with the continuation of HR repair, e. g. the synthesis of new DNA strands. Two key mediators of HR, Rad51 and BRCA2, were found upregulated in CRC biopsies as compared to normal mucosa. Inhibition of HR by targeting Rad51 enhanced DNA damage upon DSB-inducing treatment, outlining an alternative way of enhancing therapeutic efficacy. Taken together, our results strongly suggest that interfering with HR represents a key mechanism to enhance the efficacy when treating CRC with DNA-damaging therapy.

Youssif, B. G. M., A. M. Mohamed, E. E. A. Osman, O. F. Abou-Ghadir, D. H. Elnaggar, M. H. Abdelrahman, L. Treamblu, and H. A. M. Gomaa, 5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents, , vol. 177, pp. 1 - 11, 2019. AbstractWebsite

Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators as the 5-chloroindole-2-carboxamide derivatives and their furan congeners. Based on the antiproliferative activity of two 5-chlorobenzofuran-2-carboxamide allosteric CB1 modulators, a series of novel derivatives was designed and synthesized. The synthesized compounds were tested in a cell viability assay using human mammary gland epithelial cell line (MCF-10A) where all the compounds exhibited no cytotoxic effects and more than 85% cell viability at a concentration of 50 μM. Some derivatives showed good antiproliferative activities against tumor cells as compounds 8, 15, 21 and 22. The most active compound 15 showed equipotent activity to doxorubicin. Compounds 7, 9, 15, 16, 21 and 22 increased the level of active caspase 3 by 4–8 folds, compared to the control cells in MCF-7 cell line and doxorubicin as a reference drug. Compounds 15 and 21, the most activecaspase-3 inducers, increase the levels of caspase 8 and 9 indicating activation of both intrinsic and extrinsic pathways and showed potent induction of Bax, down-regulation of Bcl-2 protein levels and over-expression of Cytochrome C levels in MCF-7 cell lines. Compound 15 exhibited cell cycle arrest at the Pre-G1 and G2/M phases in the cell cycle analysis of MCF-7 cell line. The drug Likeness profile of the synthesized compounds showed that all the compounds were predicted to have high oral absorption complying with different pharmacokinetics filters.

Oing, C., I. Verem, W. Y. Mansour, C. Bokemeyer, S. Dyshlovoy, and F. Honecker, "5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells.", International journal of molecular sciences, vol. 20, issue 1, pp. 21-32, 2018 Dec 21, 2019. Abstract

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two embryonal carcinoma cell lines (NCCIT, 2102Ep) and their cisplatin-resistant isogenic derivatives. Effects on cell viability and cisplatin sensitivity were assessed by the trypan blue exclusion method. Western blotting was used to examine induction of apoptosis 5-aza and results were validated by flow cytometry. Single agent treatment with 5-aza strongly impacted viability and induced apoptosis at low nanomolar concentrations, both in cisplatin-sensitive and -resistant cell lines. 5-aza exerted an immediate apoptotic response, followed by a prolonged inhibitory effect on cell viability and cell-cycle progression. Sequential treatment with 5-aza and cisplatin reduced cellular survival of the cisplatin-resistant sublines already at nanomolar concentrations, suggesting a partial restoration of cisplatin sensitivity by the compound. 5-aza demonstrated anti-tumor activity as a single agent at low nanomolar concentrations in GCT cells, irrespective of cisplatin-sensitivity. 5-aza may also have the potential at least to partially restore cisplatin-sensitivity in non-seminoma cells, supporting the hypothesis that combining DNA demethylating agents with cisplatin-based chemotherapy may be a valid therapeutic approach in patients with refractory GCTs.

Gomha, S. M., M. M. Edrees, Z. A. Muhammad, and A. A. M. El-Reedy, "5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents", Drug Design, Development and Therapy, 2018.
Abdelrazek, F. M., and N. H. Metwally, "5 The reaction of substituted pyrazolin-5-ones with het-arylidene-melononitriles", Egyptian Journal of Chemistry, vol. 50, pp. 69, 2007. Abstract
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Ateia, E. E., A. T. Mohamed, and M. Morsy, "5 - Functionalized multimetal oxide–carbon nanotube-based nanocomposites and their properties", Metal Oxide-Carbon Hybrid MaterialsMetal Oxides: Elsevier, pp. 103 - 130, 2022. Abstract

Water is the supreme critical material for living organisms on Earth. As a result, the decontamination of undesirable heavy metals from water has become a foremost environmental issue. At the same time, the basic requirements are cost-wise efficiency, effortless setup and operation, high competence in heavy metal elimination, and restoration after use. A combined citrate autocombustion and chemical vapor deposition for fabricating double perovskite/carbon nanotube La2Fe2O6/multiwalled carbon nanotube (MWCNT) nanostructures is introduced. The crystal structure of the synthesized nanoparticles was tested by X-ray diffraction, high-resolution electron microscopy, atomic force microscopy, Raman spectroscopy, and Brunauer–Emmett–Teller analyses. The analyses confirmed that the carbon nanotubes were attached to the external surfaces of the La2Fe2O6. The obtained data show that fabricated MWCNT/La2Fe2O6 nanostructures are more effective than La2Fe2O6 for the Cr III adsorption process, thus exhibiting good adsorption performance and recyclability. The Freundlich model is more convenient for the adsorption system. The maximum adsorption capacity (qm) of Cr III on the nanocomposite was 149 mg/g, which is higher than for other adsorbents analyzed in the literature. The motivation of the present chapter is to summarize the physical properties of double perovskite La2Fe2O6/MWCNTs, find potential applications in material science, and discuss the trends of upcoming works.

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Mens, T., and G. H. Galal, "4th workshop on object-oriented architectural evolution", Object-{Oriented} {Technology}: Springer, pp. 150–164, 2002. Abstract
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Mens, T., and G. H. Galal, "4th workshop on object-oriented architectural evolution", European Conference on Object-Oriented Programming: Springer, Berlin, Heidelberg, pp. 150–164, 2001. Abstract
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Eissa, A., M. Zaki, M. Moustafa, A. Abdelaziz, and S. Saeid, 4th Sci. Congr. of Egypt. Soc. For Anim. Manag. 25-28 Oct., 2010: 172-188., , 2010. Abstract

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Yassine, I. A., and T. E. Mcgraw, "4th Order Diffusion Tensor Interpolation With Divergence and Curl Constrained Bezier Patches", 6th International Symposium on Biomedical Imaging(ISBI): Macro to Nano, Boston, MS, USA, pp. 634-637, 2009.
Safina, E. - S. M. S. Gheith, S. a. mouas, and O. Z. El-Badry, "497Original Research ArticlePlant Cell Biotechnology and Molecular Biology 22(71&72):497-505; 2021ISSN: 0972-2025RESPONSE OF THEE WHEAT VARIETIES TO NITROGENLEVELS, SEEDING RATES AND THEIR COMBINATION: 3-STRAW YIELD AND ITS COMPONENTS", 497Original Research ArticlePlant Cell Biotechnology and Molecular Biology , vol. 22(71&72), pp. 467-505, 2021. safina_2021.pdf
Ragab, Y., Y. Emad, T. Gheita, O. Moawayh, A. Abou-Zeid, and J. J. Rasker, "474 DIFFERENTIATION OF OSTEOPOROTIC AND NEOPLASTIC VERTEBRAL FRACTURES BY OPPOSED-PHASED IMAGING (CHEMICAL SHIFT MR IMAGING)", European Journal of Pain, vol. 13: No longer published by Elsevier, pp. S141, 2009. Abstract
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Moawad, A. R., J. Zhu, I. Choi, and K. H. S. Campbell, "43. Developmental competence of ovine oocytes vitrified at germinal vesicle stage by two different protocols, Solid Surface Vitrification (SSV) or Cryoloop", Cryobiology, vol. 61, no. 3: Academic Press, pp. 375, 2010. Abstract
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Wentworth, B., M. Wineland, M. Mashaly, J. Proudman, N. Zimmermann, and W. Burke, "4. Status and Importance of Radioimmunoassay in Poultry Research", Poultry Science, vol. 53, issue 4: Poultry Science Association, pp. 1315-1315, 1974. Abstract
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Alem, S. A., A. Elsharkawy, R. Fouad, E. Adel, Z. abdellatif, S. Musa, A. Nagy, M. S. Hussein, A. Yosry, and G. Esmat, "4. Improvement of Glycemic State Among Responders to Sofosbuvir - Based Treatment Regimens: Single Center Experience", J Med Virol, vol. 89, issue 12, pp. 2181-2187, 2017.
M.shehata, S. M. Azab, A. M. Fekry, and M. A. Ameer, "4. Nano-TiO2 modified carbon paste sensor for electrochemical nicotine detection using anionic surfactant, ", Biosensors and Bioelectronics, , vol. 79, pp. 589-592, 2016. bio_1.pdf
Abbas, S. E. - S., E. I. Aly, F. M. Awadallah, and W. R. Mahmoud, "4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity", Chemical Biology and Drug Design, pp. 1-15, 2015. EGFR_paper.pdf
Alaasar, M., M. Prehm, K. May, A. Eremin, and C. Tschierske., "4-Cyanoresorcinol based bent-core mesogens with azobenzene wings – emergence of sterically stabilised polar order in liquid crystalline phases. ", Advanced Functional Materials, vol. Online, 2013.
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