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Kuznetsov, V. A., M. Szulik, T. M. Katova, M. P. P. Michalis, C. H. A. Jost, M. S. V. Del Castillo, Y. Y. Lam, A. Mazzone, S. Herrmann, Z. Y. Yong, et al., "", European Heart Journal-Cardiovascular Imaging, vol. 11, no. suppl 2: The Oxford University Press, pp. ii12–ii41, 2010. Abstract
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Kuznetsov, V. A., M. Szulik, T. M. Katova, M. P. P. Michalis, C. H. A. Jost, M. S. V. Del Castillo, Y. Y. Lam, A. Mazzone, S. Herrmann, Z. Y. Yong, et al., "", European Heart Journal-Cardiovascular Imaging, vol. 11, no. suppl 2: The Oxford University Press, pp. ii12–ii41, 2010. Abstract
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Abdelhamid, M., F. J. Fortes, M. A. Harith, and J. J. Laserna, " Analysis of explosive residues in human fingerprints using optical catapulting–laser-induced breakdown spectroscopy", J. Anal. At. Spectrom., vol. 26 , pp. 1445-1450. ., 2011.
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Labib JR, A. - H. H, I. SK, and A. E. F. S. A. M. S. M. R. A. A. A. Ismail MM, Sleem HM, " Diagnostic indicator of acute lung injury for pediatric critically ill patients at a tertiary pediatric hospital. ", Medicine, vol. 97, issue 10, 2018.
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Latif, N. A. E., N. M. Garib, and S. M. Adel, " Efficacy of Spinal Manipulation As A Part Of Physical Therapy Program In Patients With Lumbar Disc Herniation: A Randomized Controlled Trial", Journal of Medical Science and clinical Research, vol. 3, issue 5, pp. 5768-5779, 2015.
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Ghaleb, A. F., E. K. Rawy, and L..ISKANDAR, " Numerical Solution for a nonlinear one dimensional problem of thermoelasticity ,", Journal of computational and applied Mathematics 100, pp. 53- 76, 1998.
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L, G., L. ME, Z. HS, A. - G. N, A. AA, A. AS, and A. NA., " Boosting isoprene production via heterologous expression of the Kudzu isoprene synthase gene (kIspS) into Bacillus spp. cell factory", AMB Express, vol. 7, issue 1, pp. 161-181, 2017.
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Gomella, L.G., Lotfi, Z., Milam, D., Albala, D.M., and D.: Reagan, " Contact Laser Vaporisation of the Prostate for Benign Prostatic Hypertrophy.", Proceedings SPIE – The International Society for Optical Engineering, Los Angeles, CA, vol. January, 1994.
Hirsch, I.H., Lotfi, Z., Moreno, J., and L. G. Gomella, " Controlled balloon dilatation of the retroperitoneal space for laparoscopic surgery.", Journal of Laparoendoscopic Surgery, vol. 4, pp. 247-251, 1994.
Refai, M., Gad El Said, W., Lotfi, Z., E. Safwat, and M. Saad, " Correlation between bacteriological and serological examination for the detection of salmonella carriers in buffalo calves.", J. Egypt. Vet. Med. Ass. , vol. 45, 2, , pp. 37-45 , 1985. correlation_between_bact_and_serol_...of_salmonella_carriers.pdf
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Canales Vergara, A. M., V. Landi, J. V. Delgado Bermejo, A. M. Martínez, P. Cervantes Acosta, A. P. Barros, D. Bigi, P. Sponenberg, M. Helal, M. Hossein Banabazi, et al., " Design and development of a multiplex microsatellite panel for the genetic characterisation and diversity assessment of domestic turkey (Meleagris gallopavo gallopavo)", Italian Journal of Animal Science , vol. 19, issue 1, pp. 392-398, 2020.
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NH, E. - E., K. D, H. RA, and R. L, " Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients", Journal of the European Academy of Dermatology and Venereology, vol. 27, issue 3, pp. 351–355, 2013. Abstract

BACKGROUND:

Several lines of evidences support a major role for Th1 cells in psoriasis. Treatment of psoriasis with cyclosporine, methotrexate and psoralen plus ultraviolet A (PUVA) is associated with clinical improvement and decrease in epidermal hyperplasia. Osteopontin (OPN) exerts a T-helper type 1 (Th1) cytokine function, regulating inflammatory cell accumulation and function.
OBJECTIVE:

To detect the effects of methotrexate, cyclosporine and PUVA on OPN expression in psoriatic plaques, and whether these changes correlate with clinical response.
METHODS:

For three groups of psoriatic patients (each including 12 patients), the Psoriasis Area Severity Index (PASI) and levels of lesional skin OPN were determined using enzyme-linked immunosorbent assays before and after treatment with methotrexate, cyclosporine or PUVA. Skin biopsies from 20 healthy volunteers served as control for OPN levels in normal skin.
RESULTS:

Baseline lesional skin of psoriatic patients showed a statistically significant elevation of OPN levels in comparison to controls. Three months after therapy, the three therapeutic modalities were associated with a significant decrease in the mean levels of PASI and tissue OPN, with the PUVA group showing the highest level of reduction in OPN levels and cyclosporine group showing the highest level of reduction in PASI.
CONCLUSION:

Our study points to the possible role played by OPN in the pathogenesis of psoriasis and in reflecting disease severity. These standard therapeutic modalities used in the current study were associated with a significant decrease in PASI and OPN levels. They constitute highly effective therapeutic modalities for psoriasis, which might exert their anti-psoriatic activity partially through altering the expression of OPN.

© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

Thakeb, F., M. El-Serafy, S. Zakaria, B. Monir, S. Lashin, R. Marzaban, and M. El-Awady, " Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia ", World J of Gastroenterology, vol. 11, issue 43, pp. 6853-6857, 2005.
Maryam Mahmood, E. A. Elkattan, Hoda Abdelaal, ahmed el lithy, N. K. Ghamry, and M. Sheta, " Evaluation of the clinical and biochemical effects of medical therapy in women with polycystic ovary syndrome", The medical journal of Cairo University, 2009, vol. 77, issue 2, pp. 59-67, 2009. Medical therapy in women with PCOS
FAhmy, E. S., H. A. Abdusalam, and M. L. Lahlouh, " Exact Traveling Wave Solutions for Cattaneos Reaction Diffusion for Prisoners Dilemma Game", FEJMS, vol. 27, issue 2, pp. 395-400, 2007.
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A.Salim, S., S. A. Loutfy, E. M.El-Fakharany, T. H.Taha, Y. Hussien, and E. A.Kamoun, " Influence of chitosan and hydroxyapatite incorporation on properties of electrospun PVA/HA nanofibrous mats for bone tissue regeneration: Nanofibers optimization and in-vitro assessment", Journal of Drug Delivery Science and Technology, vol. 62, pp. , 2021. Abstract

This study targets to develop curcumin-loaded polyvinyl alcohol/cellulose nanocrystals (PVA/CNCs) membrane as localized delivery system for breast/liver cancer. A novel strategy was developed for enhancing encapsulation capacity and maximizing therapeutic efficiency of curcumin-loaded PVA/CNCs membranes. Membranes were prepared by solution-casting method using citric acid as crosslinker. SEM revealed that PVA/CNCs ratio (80:20) was chosen as the optimum for loading curcumin. FT-IR indicated that, curcumin was incorporated into PVA/CNCs in amorphous-phase via intermolecular hydrogen bond between curcumin and membrane components. Curcumin showed biphasic-release through burst-release of 41% of curcumin during the first hour, followed by sustained-release of 70% and 94% during 24 h and 48 h, respectively. In vitro cytotoxicity of PVA/CNCs/Curcumin membrane exhibited a selective inhibition proliferation of breast and liver cancer cells in a concentration-dependent without any toxic effect on normal cells. At high concentration (8 mg/ml) of PVA/CNCs/Curcumin, reduced viability to 35% and 7% of MCF-7 and Huh-7 cells, respectively; meanwhile high HFB-4 normal cell viability ≥80% was investigated. Antimicrobial activity of PVA/CNCs/Curcumin was investigated by multi-drug-resistant strains, and MIC values. PVA/CNCs/Curcumin membranes with concentration (40 mg/ml) showed broad-spectrum antimicrobial activities, thus inhibited ~96-99% of microbial growth. PVA/CNCs/Curcumin membranes could be as promised anti-infective biomaterials for breast and liver cancer wound healing.

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Alaa E. Hamz, M. H. Abu-Risha, and N. A. Laabi, " Lyapunov Stability for Nonlinear Dynamic control Systems on Time Scales", Applied Mathematical Sciences, vol. 7, issue 71 , pp. 3497-3510, 2013. hamzaams69-72-20131.pdf
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El-Din, H. A. M., S. A. loutfy, H. Abdel-Rahman, N. A. H. Eldin, H. A. A. Madani, and M. Sedky, " Measles, Mumps, Varicella Zoster, Diphtheria and Hepatitis B Surface Antibody Status in Pediatric Acute Leukemic Patients", Blood Disorders & Transfusion, vol. S1, pp. S1-008, 2012.
Pioltelli, P., P. T. Atkinson, M. Mattar, A. Edrees, H. M. A. Ahmad, A. Laymouna, M. R. E. Abdel-Halim, and G. Ragab, Monoclonal gammopathies with miscellaneous associations, , 2022.
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Eid, E. M., H. M. E. Hassaneen, S. A. Loutfy, and T. Salaheldin, " Preparation of pyrimido[4,5-b][1,6]naphthyridin-4(1H)-one derivatives using a zeolite–nanogold catalyst and their in vitro evaluation as anticancer agent", Journal of Chemical Research, vol. 15, pp. , 2021. Abstract

This study targets to develop curcumin-loaded polyvinyl alcohol/cellulose nanocrystals (PVA/CNCs) membrane as localized delivery system for breast/liver cancer. A novel strategy was developed for enhancing encapsulation capacity and maximizing therapeutic efficiency of curcumin-loaded PVA/CNCs membranes. Membranes were prepared by solution-casting method using citric acid as crosslinker. SEM revealed that PVA/CNCs ratio (80:20) was chosen as the optimum for loading curcumin. FT-IR indicated that, curcumin was incorporated into PVA/CNCs in amorphous-phase via intermolecular hydrogen bond between curcumin and membrane components. Curcumin showed biphasic-release through burst-release of 41% of curcumin during the first hour, followed by sustained-release of 70% and 94% during 24 h and 48 h, respectively. In vitro cytotoxicity of PVA/CNCs/Curcumin membrane exhibited a selective inhibition proliferation of breast and liver cancer cells in a concentration-dependent without any toxic effect on normal cells. At high concentration (8 mg/ml) of PVA/CNCs/Curcumin, reduced viability to 35% and 7% of MCF-7 and Huh-7 cells, respectively; meanwhile high HFB-4 normal cell viability ≥80% was investigated. Antimicrobial activity of PVA/CNCs/Curcumin was investigated by multi-drug-resistant strains, and MIC values. PVA/CNCs/Curcumin membranes with concentration (40 mg/ml) showed broad-spectrum antimicrobial activities, thus inhibited ~96-99% of microbial growth. PVA/CNCs/Curcumin membranes could be as promised anti-infective biomaterials for breast and liver cancer wound healing.

R
Ekulu, P. M., A. B. Nkoy, D. K. Betukumesu, M. N. Aloni, J. R. R. Makulo, E. K. Sumaili, E. M. Mafuta, M. A. Elmonem, F. O. Arcolino, F. N. Kitetele, et al., " Risk Genotypes Are Associated With Early Kidney Damage in Children in Sub-Saharan Africa.", Kidney international reports, vol. 4, issue 7, pp. 930-938, 2019 Jul. Abstract

Introduction: Apolipoprotein-L1 () risk variants G1 and G2 increase the risk of chronic kidney disease (CKD), including HIV-related CKD, among African Americans. However, such data from populations living in Africa, especially children, remain limited. Our research aimed to determine the prevalence of risk variants and to assess the association between these variants and early-stage CKD in the general pediatric population and HIV-infected children.

Methods: In a cross-sectional study, we enrolled 412 children from the general population and 401 HIV-infected children in Kinshasa, Democratic Republic of Congo (DRC). high-risk genotype (HRG) was defined by the presence of 2 risk variants (G1/G1, G2/G2, or G1/G2), and low-risk genotype (LRG) by the presence of 0 or 1 risk variants. The main outcome was elevated albuminuria, defined as a urinary albumin/creatinine ratio ≥30 mg/g.

Results: sequence analysis revealed that in the general population, 29 of 412 participants (7.0%) carried HRG, 84 of 412 (20.4%) carried the G1/G0 genotype, and 61 of 412 (14.8%) carried the G2/G0 genotype. In HIV-infected children, 23 of 401 (5.7%) carried HRG, and the same trend as in the general population was observed in regard to the prevalence of LRG. Univariate analysis showed that in the general population, 5 of 29 participants (17.2%) carrying HRG had elevated albuminuria, compared with 35 of 383 (9.0%) with LRG (odds ratio [OR] 2.1, 95% confidence interval [CI] 0.6-6.0;  = 0.13). In HIV-infected children, participants who carried APOL1 HRG had almost 22-fold increased odds of albuminuria compared to those with LRG.

Conclusion: The risk variants are prevalent in children living in DRC. HRG carriers have increased odds of early kidney disease, and infection with HIV dramatically increases this probability.

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Kamel, M.M., M. Refai, and A. Loot, " Studies on the toxins of A. niger isolated from meat. ", Castellania , vol. 4, , pp. 159-161 , 1976. aspergillus_niger_toxins.pdf
SA, F., Z. NH, and R. LA, " Study of lipid peroxidation and cytogenetic damage in workers exposed to benzene.", Egyptian Journal of occupational medicine., vol. 28, issue 1, pp. 123-129, 2004.