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Lopez-Orozco, J., N. Fayad, J. Q. Khan, A. Felix-Lopez, M. Elaish, M. Rohamare, M. Sharma, D. Falzarano, J. Pelletier, and J. Wilson, The RNA interference effector protein argonaute 2 functions as a restriction factor against SARS-CoV-2, , vol. 435, issue 16: Academic Press, pp. 168170, 2023. Abstract
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López-Medina, C., S. Chevret, A. Molto, J. Sieper, T. Duruöz, U. Kiltz, B. E. Zorkany, N. Hajjaj-Hassouni, R. Burgos-Vargas, J. Maldonado-Cocco, et al., "Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study", Rheumatic & Musculoskeletal Disease (RMD), vol. 7 , issue 3, pp. 1 - 12, 2021.
López-Medina, C., A. Molto, J. Sieper, T. Duruöz, U. Kiltz, B. E. Zorkany, N. Hajjaj-Hassouni, R. Burgos-Vargas, J. Maldonado-Cocco, N. Ziade, et al., "Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASASPerSpA study", Rheumatic & Musculoskeletal Disease (RMD), vol. 7 , issue 1, pp. 1 - 12, 2021.
López-Medina, C., A. Molto, J. Sieper, T. Duruöz, U. Kiltz, B. E. Zorkany, N. Hajjaj-Hassouni, R. Burgos-Vargas, J. Maldonado-Cocco, N. Ziade, et al., "Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study.", RMD open, vol. 7, issue 1, 2021. Abstract

OBJECTIVES: To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world.

METHODS: Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive arthritis or juvenile SpA (Juv-SpA)) fitted the patient best. Peripheral manifestations (ie, peripheral joint disease, enthesitis, dactylitis and root joint disease), their localisation and treatments were evaluated.

RESULTS: A total of 4465 patients were included (61% men, mean age 44.5 years) from four geographic areas: Latin America (n=538), Europe plus North America (n=1677), Asia (n=975) and the Middle East plus North Africa (n=1275). Of those, 78% had ever suffered from at least one peripheral musculoskeletal manifestation; 57% had peripheral joint disease, 44% had enthesitis and 15% had dactylitis. Latin American had far more often peripheral joint disease (80%) than patients from other areas. Patients with PsA had predominantly upper limb and small joint involvement (52%).Hip and shoulder involvement was found in 34% of patients. The prevalence of enthesitis ranged between 41% in patients with axSpA and 65% in patients with Juv-SpA. Dactylitis was most frequent among patients with PsA (37%).

CONCLUSION: These results suggest that all peripheral features can be found in all subtypes of SpA, and that differences are quantitative rather than qualitative. In a high proportion of patients, axial and peripheral manifestations coincided. These findings reconfirm SpA clinical subtypes are descendants of the same underlying disease, called SpA.

Lopez-Garcia, S. C., F. Emma, S. B. Walsh, M. Fila, N. Hooman, M. Zaniew, A. Bertholet-Thomas, G. Colussi, K. Burgmaier, E. Levtchenko, et al., "Treatment and long-term outcome in primary distal renal tubular acidosis.", Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, vol. 34, issue 6, pp. 981-991, 2019. Abstract

BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome.

METHODS: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form.

RESULTS: Adequate data were collected on 340 patients (29 countries, female 52%). Mutation testing had been performed on 206 patients (61%); pathogenic mutations were identified in 170 patients (83%). The median (range) presentation age was 0.5 (0-54) years and age at last follow-up was 11.0 (0-70.0) years. Adult height was slightly below average with a mean (SD score) of -0.57 (±1.16). There was an increased prevalence of chronic kidney disease (CKD) Stage ≥2 in children (35%) and adults (82%). Nephrocalcinosis was reported in 88%. Nephrolithiasis was more common with SLC4A1 mutations (42% versus 21%). Thirty-six percent had hearing loss, particularly in ATP6V1B1 (88%). The median (interquartile range) prescribed dose of alkali (mEq/kg/day) was 1.9 (1.2-3.3). Adequate metabolic control (normal plasma bicarbonate and normocalciuria) was achieved in 158 patients (51%), more commonly in countries with higher gross domestic product (67% versus 23%), and was associated with higher height and estimated glomerular filtration rate.

CONCLUSION: Long-term follow-up from this large dRTA cohort shows an overall favourable outcome with normal adult height for most and no patient with CKD Stage 5. However, 82% of adult patients have CKD Stages 2-4. Importance of adequate metabolic control was highlighted by better growth and renal function but was achieved in only half of patients.

Lopez del Amo, J. M., U. Langer, V. Torres, M. Pietrzak, G. Buntkowsky, H. - M. Vieth, M. F. Shibl, O. Kühn, M. Bröring, and H. - H. Limbach, "Isotope and phase effects on the proton tautomerism in polycrystalline porphycene revealed by NMR", The Journal of Physical Chemistry A, vol. 113, issue 10: American Chemical Society, pp. 2193-2206, 2009. Abstract
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Lopes-Oliveira, V., L. K. S. Herval, O. V. Gordo, D. F. Cesar, M. P. F. de Godoy, G. Y. Gobato, M. Henini, and A. Khatab, "Strain and localization effects in InGaAs (N) quantum wells: Tuning the magnetic response", Journal of Applied Physics, vol. 116, issue 23, pp. 233703, 2014.
Lopes, P. D., O. C. Freitas Neto, D. F. A. Batista, J. Denadai, M. F. F. Alarcon, A. M. Almeida, R. O. Vasconcelos, A. Setta, P. A. Barrow, and A. Berchieri, "Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum.", Veterinary journal (London, England : 1997), vol. 214, pp. 40-6, 2016 Aug. Abstract

Salmonella enterica subsp. enterica serovar Gallinarum biovar Gallinarum (SG) causes fowl typhoid (FT), a septicaemic disease which can result in high mortality in poultry flocks. The absence of flagella in SG is thought to favour systemic invasion, since bacterial recognition via Toll-like receptor (TLR)-5 does not take place during the early stages of FT. In the present study, chicks susceptible to FT were inoculated with a wild type SG (SG) or its flagellated motile derivative (SG Fla(+)). In experiment 1, mortality and clinical signs were assessed, whereas in experiment 2, gross pathology, histopathology, systemic invasion and immune responses were evaluated. SG Fla(+) infection resulted in later development of clinical signs, lower mortality, lower bacterial numbers in the liver and spleen, and less severe pathological changes compared to SG. The CD8(+) T lymphocyte population was higher in the livers of chicks infected with SG at 4 days post-inoculation (dpi). Chicks infected with SG had increased expression of interleukin (IL)-6 mRNA in the caecal tonsil at 1 dpi and increased expression of IL-18 mRNA in the spleen at 4 dpi. In contrast, the CD4(+) T lymphocyte population was higher at 6 dpi in the livers of birds infected with SG Fla(+). Therefore, flagella appeared to modulate the chicken immune response towards a CD4(+) T profile, resulting in more efficient bacterial clearance from systemic sites and milder infection.

Lone, Z., A. A. Hussein, Z. Jing, A. S. Elsayed, N. A. Aldhaam, K. Sniadecki, and K. A. Guru, "Optimizing the Financial Burden of the Approach to Robot-Assisted Radical Prostatectomy", J Endourol, 2020/01/25, vol. 34, no. 4, pp. 456-460, Apr, 2020. AbstractWebsite

Objectives: The robot-assisted approach to radical prostatectomy (RARP) has been adopted worldwide as an acceptable alternative to open prostatectomy owing to improved visualization and dexterity for surgeons, with improved recovery and convalescence for patients. However, the associated cost of installation of robot as well as running costs may hamper its utilization. We sought to investigate and identify the drivers of cost at our institution and implement changes that could reduce costs. Methods: We retrospectively reviewed the annual cost data of all RARPs performed by a single surgeon between April 1, 2017 and March 31, 2018. A cost analysis was performed investigating the variable costs associated with RARP: anesthesia related, operative time, and medical supplies. We then prospectively implemented a cost reduction plan that included reducing the number of robotic instruments used per surgery, surgical supplies, and changing the type of trocars. We also investigated whether these changes impacted cost as well as operative outcomes. Results: Forty retrospective procedures were compared with 32 prospective procedures after implementation of cost reduction plan. There were no differences in clinical characteristics. Cost savings per case were $705 for variable costs (95% CI $662, $748, p < 0.01): $36 for anesthesia related (95% CI $5, $67, p = 0.03), $198 for operative time (95% CI $145, $251, p < 0.01), and $471 for medical supplies (95% CI $438, $504, p < 0.01). There was no statistically significant difference in operative time or estimated blood loss between the two groups. Conclusion: Cost reduction plan can reduce total cost associated with RARP without compromising patient safety or operating room efficiency.

Lok, K. Y. - W., D. Y. T. Fong, J. Y. H. Wong, M. Ho, E. P. H. Choi, V. Pandian, P. M. Davidson, W. Duan, M. Tarrant, J. J. Lee, et al., "International survey for assessing COVID-19’s impact on fear and health: study protocol", BMJ open, vol. 11, no. 5: British Medical Journal Publishing Group, pp. e048720, 2021. Abstract
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Lohr, F., M. El-Haddad, B. Dobler, R. Grau, H. - J. Wertz, U. Kraus-Tiefenbacher, V. Steil, Y. Abo-Madyan, and F. Wenz, "Potential effect of robust and simple IMRT approach for left-sided breast cancer on cardiac mortality", International Journal of Radiation Oncology* Biology* Physics, vol. 74, issue 1, no. 1: Elsevier, pp. 73–80, 2009. AbstractWebsite

Purpose

Three-dimensional (3D) treatment planning has reduced the cardiac dose in postoperative radiotherapy for breast cancer; however, the overall cardiac toxicity is still an issue because of more aggressive adjuvant treatment. Toxicity models have suggested that a reduction of the heart volume treated to high doses might be particularly advantageous. We compared aperture-based multifield intensity-modulated radiotherapy (IMRT) plans to 3D-planned tangent fields using dose–volume histograms, cardiac toxicity risk, and the robustness to positioning errors.
Methods and Materials

For 14 computed tomography data sets of patients with left-sided breast cancer (unfavorable thoracic geometry), a 3D treatment plan and an IMRT plan were created. The dose–volume histograms were evaluated for the target and risk organs. Excess risk of cardiac mortality was calculated for both approaches using a relative seriality model. Positioning errors were simulated by moving the isocenter.
Results

IMRT reduced the maximal dose to the left ventricle by a mean of 30.9% (49.14 vs. 33.97 Gy). The average heart volume exposed to >30 Gy was reduced from 45 cm3 to 5.84 cm3. The mean dose to the left ventricle was reduced by an average of 10.7% (10.86 vs. 9.7 Gy), and the mean heart dose increased by an average of 24% (from 6.85 to 8.52 Gy). The model-based reduction of the probability for excess therapy-associated cardiac death risk was from 6.03% for the 3D plans to 0.25% for the IMRT plans.
Conclusion

Aperture-based IMRT for left-sided breast cancer significantly reduces the maximal dose to the left ventricle, which might translate into reduced cardiac mortality. Biological modeling might aid in deciding to treat with IMRT but has to be validated prospectively.
Author Keywords

Breast cancer;
Breast-conserving therapy;
Adjuvant chemotherapy;
Intensity-modulated radiotherapy;
IMRT;
Cardiac toxicity;
Heart sparing;
Aperture-based optimization

Note—An online CME test for this article can be taken at http://asro.astro.org under Continuing Education.

F. Lohr, M.D., and M. El-Haddad, M.D., F.R.C.R., contributed equally to this work

Lohr, F., D. Georg, L. Cozzi, H. T. Eich, D. C. Weber, J. Koeck, B. Knäusl, K. Dieckmann, Y. Abo-Madyan, C. Fiandra, et al., "Novel radiotherapy techniques for involved-field and involved-node treatment of mediastinal Hodgkin lymphoma", Strahlentherapie und Onkologie, vol. 190, no. 10: Springer Berlin Heidelberg, pp. 864–871, 2014. Abstract
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Lohnert, G., B. Esteve, H. F. Abdalla, M. M. Megahed, M. Y. A. Younan, J. Arros, N. Doumbalski, W. Gerstle, N. Sau, S. Silling, et al., GUEST EDITOR: G. Lohnert, , 2005. Abstract
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Loghin, C. K. - M. M. E., A. M. Paker, Linda Chi, A. Youssef, S. Tummala, and M. E. Loghin, "Posterior reversible encephalopathy syndrome in cancer patients: a single institution retrospective study", neuro-oncology, 2016.
Lofty M, I. I. M., S. S, A. B, and T. A, "Successful Separation Of Craniopagus Parasiticus in Egyptian Buffalo Calf ", Global Veterinaria, vol. 3, issue 3, pp. 183-188, 2009.
Lofty, H. M., A. - A. A. - B. Abdel-Aleem, and H. H. Monir, "NOVEL SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF ITS OXIDATIVE DEGRADATION PRODUCT", J. Chil. Chem. Soc., vol. 57, issue 4, pp. 1199-1207, 2012. flz-spc_chilean.pdf
Lofty, H. M., huda marzouk, yomna farag, M. Nabih, I. A. S. Khalifa, N. Mostafa, A. Salah, L. Rashed, and K. E. Garf, "Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever.", International journal of rheumatology, vol. 2016, pp. 7354018, 2016. Abstract

Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.

Lofty, H. M., huda marzouk, yomna farag, M. Nabih, I. A. S. Khalifa, N. Mostafa, A. Salah, L. Rashed, and K. E. Garf, "Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever.", International journal of rheumatology, vol. 2016, pp. 7354018, 2016. Abstract

. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. . The study enrolled seventy-one children with FMF. . SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. . High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.

Lofty, H. M., A. E. - A. A. - B. A. El-Aleem, and H. H. Monir, "Determination of insecticides malathion and lambda-cyhalothrin residues in zucchini by gas chromatography", Bulletin of Faculty of Pharmacy, Cairo University, vol. 51, pp. 255-260, 2013. Abstractbfopcu_final.pdfWebsite

A sensitive gas chromatographic method has been developed for the determination of
malathion and lambda-cyhalothrin (k-cyhalothrin) insecticide residues in zucchini. The developed
method consists of extraction with acetone, purification and partitioning with methylene chloride,
column chromatographic clean-up, and finally capillary gas chromatographic determination of the
insecticides. The recoveries of method were greater than 90% and limit of determination was
0.001 ppm for both insecticides. The method was applied to determine residues and the rate of disappearance
of malathion and k-cyhalothrin from fruits of zucchini (open field treatment, 50 cc of
Malason/Cormandel 57% EC (emulsifiable concentrate) for 100 L of water, 20 cc of LAMBDA
SUPER FOG 5% liquid for 100 L of water). The insecticide incorporated into the plants decreased
rapidly with a half-life time around 0.77 day (18.5h) for malathion and 4 days for k-cyhalothrin. It
is not recommended to use zucchini before 12 h of malathion application. For k-cyhalothrin, the
preharvest interval is 5 days. Four market samples were chosen from different regions from
A.R.E. and all of them showed no residues of malathion or k-cyhalothrin.

Lofty, H. M., huda marzouk, yomna farag, M. Nabih, I. A. S. Khalifa, N. Mostafa, A. Salah, L. Rashed, and K. E. Garf, "Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever.", International journal of rheumatology, vol. 2016, pp. 7354018, 2016. Abstract

Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.

Lofty, H. M., A. - A. A. - B. Abdel-Aleem, and H. H. Monir, "Determination of diniconazole fungicide residues in grapes and zucchini by capillary gas chromatography", Analytical Chemistry - An Indian Journal, vol. 11, issue 4, pp. 131-136, 2012. dini_indian.pdf
Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Protzer U, Busch DH, Layland LE, and P. da Costa, "Schistosome infection aggravates HCV related liver disease and induces changes in theregulatory T-cell phenotype. ", Parasite Immunol., vol. Feb;37, issue (2), pp. 97-104, Submitted.
Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Protzer U, Busch DH, Layland LE, and P. da Costa, "Schistosome infection aggravates HCV related liver disease and induces changes in theregulatory T-cell phenotype. ", Parasite Immunol., vol. Feb;37, issue (2), pp. 97-104, Submitted.
Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Protzer U, Busch DH, Layland LE, and P. da Costa, "Schistosome infection aggravates HCV related liver disease and induces changes in theregulatory T-cell phenotype.", Parasite Immunol., vol. Feb;37, issue (2), pp. 97-104, 2015. pai_hcv_schisto_1lbhth_lthny.pdf
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