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Laimoud, M., E. Hakami, M. J. Maghirang, and T. Mohamed, "Impact of diastolic pulmonary gradient and pulmonary vascular remodeling on survival after left ventricular assist device implantation and heart transplantation.", The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, vol. 75, issue 1, pp. 102, 2023. Abstracts43044-023-00428-4.pdf

BACKGROUND: The left ventricular assist devices (LVADs) are increasingly used for advanced heart failure as a bridge to heart transplantation or as a destination therapy. The aim of this study was to investigate the changes of diastolic pulmonary gradient (DPG), pulmonary vascular resistance (PVR) and transpulmonary gradient (TPG) after LVAD implantation and their impact on survival after LVAD and heart transplantation.

RESULTS: A total of 73 patients who underwent LVAD (HeartMate III) implantation between 2016 and 2022 were retrospectively studied. According to pre-LVAD catheterization, 49 (67.1%) patients had DPG < 7 mmHg and 24 (32.9%) patients had DPG ≥ 7 mmHg. The patients with a pre-VAD DPG ≥ 7 mmHg had higher frequencies of right ventricular (RV) failure (p < 0.001), RVAD insertion (p < 0.001), need for renal replacement therapy (p = 0.002), total mortality (p = 0.036) and on-VAD mortality (p = 0.04) with a longer ICU stay (p = 0.001) compared to the patients with DPG < 7 mmHg. During the follow-up period of 38 (12-60) months, 24 (32.9%) patients died. Pre-LVAD DPG ≥ 7 mmHg (adjusted HR 1.83, 95% CI 1.21-6.341, p = 0.039) and post-LVAD DPG ≥ 7 mmHg (adjusted HR 3.824, 95% CI 1.482-14.648, p = 0.002) were associated with increased risks of mortality. Neither pre-LVAD TPG ≥ 12 (p = 0.505) nor post-LVAD TPG ≥ 12 mmHg (p = 0.122) was associated with an increased risk of death. Pre-LVAD PVR ≥ 3 WU had a statistically insignificant risk of mortality (HR 2.35, 95% CI 0.803-6.848, p = 0.119) while post-LVAD PVR ≥ 3 WU had an increased risk of death (adjusted HR 2.37, 95% CI 1.241-7.254, p = 0.038). For post-transplantation mortality, post-LVAD DPG ≥ 7 mmHg (p = 0.55), post-LVAD TPG ≥ 12 mmHg (p = 0.85) and PVR ≥ 3 WU (p = 0.54) did not have statistically increased risks. The logistic multivariable regression showed that post-LVAD PVR ≥ 3 WU (p = 0.013), post-LVAD DPG ≥ 7 mmHg (p = 0.026) and RVF (p = 0.018) were the predictors of mortality after LVAD implantation. Pre-LVAD DPG ≥ 7 mmHg (p < 0.001) and pre-LVAD PVR ≥ 3 WU (p = 0.036) were the predictors of RVF after LVAD implantation.

CONCLUSIONS: Persistently high DPG was associated with right ventricular failure and mortality after LVAD implantation rather than after heart transplantation. DPG is a better predictor of pulmonary vascular remodeling compared to TPG and PVR. Further larger prospective studies are required in this field due to the growing numbers of patients with advanced heart failure, as possible candidates for LVAD implantation, and limitations of heart transplantation.

Laimoud, M., M. N. Alanazi, M. J. Maghirang, S. M. Al-Mutlaq, S. Althibait, R. Ghamry, R. Qureshi, B. Alanazi, M. Alomran, Z. Bakheet, et al., "Impact of Chronic Kidney Disease on Clinical Outcomes during Hospitalization and Five-Year Follow-Up after Coronary Artery Bypass Grafting.", Critical care research and practice, vol. 2023, pp. 9364913, 2023. Abstract

BACKGROUND: Chronic kidney disease (CKD) is often associated with multiple comorbidities including diabetes mellitus, and each has its own complications and impact after cardiac surgery including coronary revascularization. The objective of this work was to study the impact of CKD on clinical outcomes after coronary artery bypass grafting (CABG) and to compare outcomes in patients with different grades of renal functions. We retrospectively reviewed all patients who underwent CABG from January 2016 to August 2020 at our tertiary care hospital using electronic medical records.

RESULTS: The study included 410 patients with a median age of 60 years, and 28.6% of them had CKD and hospital mortality of 2.7%. About 71.4% of the patients had GFR > 60 mL/min per 1.73 m, 18.1% had early CKD (GFR 30-60), 2.7% had late CKD (GFR < 30), and 7.8% of them had end-stage renal disease (ESRD) requiring dialysis. The CKD group had significantly more frequent hospital mortality ( = 0.04), acute cerebrovascular stroke ( = 0.03), acute kidney injury (AKI) ( < 0.001), longer ICU stay ( = 0.002), post-ICU stay ( = 0.001), and sternotomy wound debridement ( = 0.03) compared to the non-CKD group. The frequencies of new need for dialysis were 2.4% vs. 14.9% vs. 45.5% ( < 0.001) in the patients with GFR > 60 mL/min per 1.73 m, early CKD, and late CKD, respectively. Acute cerebral stroke (OR: 10.29, 95% CI: 1.82-58.08, and  = 0.008), new need for dialysis (OR: 25.617, 95% CI: 13.78-85.47, and  < 0.001), and emergency surgery (OR: 3.1, 95% CI: 1.82-12.37, and  = 0.036) were the independent predictors of hospital mortality after CABG. The patients with CKD had an increased risk of strokes (HR: 2.14, 95% CI: 1.20-3.81, and  = 0.01) but insignificant mortality increase (HR: 1.44, 95% CI: 0.42-4.92, and  = 0.56) during follow-up.

CONCLUSION: The patients with CKD, especially the late grade, had worse postoperative early and late outcomes compared to non-CKD patients after CABG. Patients with dialysis-independent CKD had increased risks of needing dialysis, hospital mortality, and permanent dialysis after CABG.

Laimud, M., Y. Nassar, W. Omar, A. Abdelbary, and H. Elghawaby, "Quantitative Coronary Analysis Compared to Intravascular Ultrasound in the Assessment of Coronary Lesions and Evaluation of Stent Expansion during Elective Percutaneous Coronary Interventions", The Medical journal of Cairo University, vol. 85, issue 3, June, pp. 879-884, 2017.
Laithy, H. M. E. -, D. I. Nesseem, A. A. El-Adly, and M. Shoukry, "Moxifloxacin -Gelrite in-Situ Ophthalmic Gelling System against Photodynamic Therapy for Treatment of Bacterial Corneal Inflammation.", Arch Pharm Res., , vol. 34, issue 10, pp. 1663-1678 , 2011.
Laithy, H. M. E. -, O. Shoukry, and L. G. Mahran, "Novel Sugar Esters Proniosomes for Transdermal Delivery of Vinpocetine: Preclinical and Clinical studies", European Journal of Pharmaceutics and Biopharmaceutics, vol. 77, pp. 43-55, 2011.
Lakowicz, J. R., Topics in fluorescence spectroscopy: volume 4: probe design and chemical sensing, : Springer Science & Business Media, 1994. Abstract
LakshmiNarayanan, B., A. Yosri, M. Ezzeldin, W. El-Dakhakhni, and S. Dickson-Anderson, "A complex network theoretic approach for interdependence investigation: An application to radionuclide behavior in the subsurface", Computers & Geosciences, vol. 157, issue December 2021, pp. 104913, 2021.
Lalli, B. S., and S. R. Grace, "Asymptotic and oscillatory behavior of a class of second order functional differential equations", The Rocky Mountain Journal of Mathematics: JSTOR, pp. 1063-1077, 1990. Abstract
Lalli, B. S., and S. R. Grace, "Some oscillation criteria for delay differential equations of even order", Journal of mathematical analysis and applications, vol. 119, issue 1-2: Elsevier, pp. 164-170, 1986. Abstract
Lalli, B. S., and S. R. Grace, "Oscillations of second order general nonlinear differential equations", Recent Trends in Differential Equations: World Scientific, pp. 413-429, 1992. Abstract
Lalli, B. S., and S. R. Grace, "Oscillation theorems for second order neutral difference equations", Applied Mathematics and Computation, vol. 62, issue 1: Elsevier, pp. 47-60, 1994. Abstract
Lalli, B. S., and S. R. Grace, "G) World Scientific Publishing Company 413", Recent Trends In Differential Equations, vol. 1: World Scientific, pp. 413, 1992. Abstract
Lalwani, N., R. F. El Sayed, A. Kamath, S. Lewis, H. Arif, and V. Chernyak, "Imaging and clinical assessment of functional defecatory disorders with emphasis on defecography.", Abdominal radiology (New York), vol. 46, issue 4, pp. 1323-1333, 2021. Abstract

Functional defecation disorders (FDD) encompass causes of constipation associated with anorectal dysfunction, which include dyssynergia or inadequate defecatory propulsion. FDD are frequently encountered in clinical practice and may affect up to 33-50% of patients with chronic constipation. The etiology of FDD is unclear, however, it has been defined as an acquired, but subliminal behavioral disorder. Pathophysiologic mechanisms may include discoordination of rectoanal muscles, paradoxical contraction or insufficient relaxation of puborectalis and/or anal sphincter during defecation, and sluggish colonic transit. A combination of comprehensive clinical assessment, digital rectal examination and a battery of physiologic tests are needed to make an accurate diagnosis of FDD. Defecography may play a crucial role in the evaluation of FDD, especially when a balloon expulsion test (BET) and/or anorectal manometry (ARM) are equivocal or demonstrate contradictory results. In this review, we provide a thorough overview of the epidemiology, pathophysiology, diagnostic criteria, clinical and imaging evaluation, and treatment options for FDD, with an emphasis on available diagnostic imaging tools such as defecography and conventional fluoroscopic methods.

Lalwani, N., G. Khatri, R. F. El Sayed, R. Ram, K. Jambhekar, V. Chernyak, A. Kamath, S. Lewis, M. Flusberg, F. Scholz, et al., "MR defecography technique: recommendations of the society of abdominal radiology's disease-focused panel on pelvic floor imaging.", Abdominal radiology (New York), vol. 46, issue 4, pp. 1351-1361, 2021. Abstract

PURPOSE: To develop recommendations for magnetic resonance (MR) defecography technique based on consensus of expert radiologists on the disease-focused panel of the Society of Abdominal Radiology (SAR).

METHODS: An extensive questionnaire was sent to a group of 20 experts from the disease-focused panel of the SAR. The questionnaire encompassed details of technique and MRI protocol used for evaluating pelvic floor disorders. 75% agreement on questionnaire responses was defined as consensus.

RESULTS: The expert panel reached consensus for 70% of the items and provided the basis of these recommendations for MR defecography technique. There was unanimous agreement that patients should receive coaching and explanation of commands used during MR defecography, the rectum should be distended with contrast agent, and that sagittal T2-weighted images should include the entire pelvis within the field of view. The panel also agreed unanimously that IV contrast should not be used for MR defecography. Additional areas of consensus ranged in agreement from 75 to 92%.

CONCLUSION: We provide a set of consensus recommendations for MR defecography technique based on a survey of expert radiologists in the SAR pelvic floor dysfunction disease-focused panel. These recommendations can be used to develop a standardized imaging protocol.

LAM, S., H. SAH, S. F. Al, and others, "Screening for organic acid disorders among Egyptian children with clinically suspected neurometabolic disorders", Res J Med Med Sci, vol. 4, pp. 369–385, 2009. Abstract
Lam, K., A. S. Anbar, and A. O'Brien, "The Role of Provocative Discography in Total Disc Replacement Surgery: with Minimum 2 Year Follow-up (Abstract).", J Bone Joint Surg Br , vol. 92-B, issue SUPP IV, pp. 566, 2010. Website
Lamberts, J. J. M., and D. C. Neckers, "Rose Bengal derivatives as singlet oxygen sensitizers", Tetrahedron, vol. 41, issue 11: Pergamon, pp. 2183-2190, 1985. Abstract
Lameece Moustafa, M. D., M. D. Sherif Sheta, M. D. Randa Abdel Razek, M. D. Gehan Helmy, and M. D. Dina El Fayoumy, "Evaluation of Fundus Autofluorescence as a Prognostic Factor in Diabetic Macular Edema", The Medical Journal of Cairo University, 2016.
Lameece Moustafa, M., M. D. Marwa Metwally, M. D. Ayman El Shiaty, and M. D. Mohamed el Sayed, "Determining The Correlation Between Axial Length and Macular Thickness in Myopia", The Medical Journal of Cairo University, 2014.
Lamees, Elaraby, H. M., S. A. M. A. K. Nagwa, and D. M. Ibrahiem, "The Impact of Renewable and Non-renewable Energy on Carbon Dioxide Emission: An Empirical Analysis for Euro Mediterranean Countries", International Journal of Energy Economics and Policy, vol. 9), , issue (6), pp. 103-108, 2019. renewable_energe.pdf