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Labib, D. A., D. Koptan, S. Ghoniem, S. H. Salah, R. [E. Shazly], and R. [E. M. Refai], "Dysregulation of microRNA146a-5p expression in systemic lupus erythematosus females: Diagnostic potential and association with ocular manifestations", The Egyptian Rheumatologist, vol. 42, no. 2, pp. 117 - 121, 2020. AbstractWebsite

Background Micro-ribonucleic acids (miRNA) are key regulators for the expression of related target genes and their aberrant expression has a substantial role across many pathways within autoimmunity. Aim of the work To evaluate the expression of miRNA-146a-5p in systemic lupus erythematosus (SLE) patients and to assess its relation to the disease activity and various disease parameters with specific focus on the ocular manifestations. Patients and methods 42 female SLE patients and 39 matched healthy individuals were enrolled in this study. The serum level of miRNA146a-5p was evaluated by a quantitative real-time polymerase chain reaction (PCR) (Taqman technology). Results The mean age of the patients was 29 ± 9.1 years. The serum level of miRNA146a-5p was significantly higher in SLE cases (3.21 ± 4.47 fold change) compared to the controls (1.54 ± 1.66 fold change) (p = 0.001). A significant negative association was found between the serum level of miRNA146a-5p and C4 level (p = 0.018). Expression levels of miRNA146a-5p were significantly decreased in patients with photosensitivity (p = 0.006). Regarding ocular manifestations, a lower level of miRNA146a-5p was detected in patients suffering from dry eyes, cataract, keratitis and drusen compared to patients without and a higher level was found in those suffering from retinopathy. Serum miRNA146a-5p at a cut off value of 1.36 could discriminate patients from controls (95%CI: 0.61–0.84; p = 0.001) at a sensitivity of 69% and specificity of 64.1%. Conclusion These findings suggest that miR-146a-5p could be a potential diagnostic biomarker in SLE and may implicate a functional role in the pathophysiology of the ocular manifestations in the disease.

Labib, M. W., A. Saleh, and M. H. Khalil, "Ambient PM10, PM2.5, inorganic elements and polycyclic aromatic hydrocarbons concentrations at a traffic impacted site in Cairo", Proceedings of the Air and Waste Management Association's Annual Conference and Exhibition, AWMA, 2007. Abstract
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Labib, M. B., A. M. Fayez, E. L. - S. H. A. Y. M. A. A. EL-NAHASS, M. Awadallah, and P. A. Halim, "Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study", Bioorg. Chem., vol. 104, pp. 104308, 2020. bioorganic_cox_paper.pdf
Labib, C., E. Hasanein, and O. Hegazy, "Early development of graphical user interface (GUI) in agile methodologies", Journal of Computational Methods in Sciences and Engineering, vol. 9, issue 1, 2S2: IOS Press, pp. 239-249, 2009. Abstract
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Labib, J. R., S. K. Ibrahem, M. M. Ismail, S. A. M. A. ElFatah, A. S. Sedrak, M. A. S. Attia, H. M. El-Hanafi, and M. H. Kamel, "Vitamin D supplementation and improvement of pneumonic children at a tertiary pediatric hospital in Egypt A randomized controlled trial", Medicine, vol. 100, issue 13, pp. 1-10, 2021.
Labib, D. M., M. Hegazy, S. M. Esmat, E. A. H. Ali, and foraysa talaat, "Retinal nerve fiber layer and ganglion cell layer changes using optical coherence tomography in patients with chronic migraine: a case-control study", The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, vol. 56, issue 1, pp. 1-6, 2020.
Labib, D., H. Heshmat, A. Gaafar, T. Marei, M.Salah, and S. Gharieb, "VALIDATION OF A NEW MITRAL VALVE SCORING SYSTEM BY REAL-TIME THREE-DIMENSIONAL ECHOCARDIOGRAPHY AGAINST OPERATIVE FINDINGS IN PATIENTS WITH RHEUMATIC HEART DISEASE.", 24th Annual Scientific Sessions of The American Society of Echocardiography., Minneapolis, MN., Journal of The American Society of Echocardiography., pp. B75, 2013.
Labib, J. R., S. K. Ibrahem, H. M. Sleem, M. M. Ismail, S. A. M. Abd El Fatah, M. R. Salem, A. A. Abdelaal, and H. Al-Hanafi, "Diagnostic indicator of acute lung injury for pediatric critically ill patients at a tertiary pediatric hospital.", Medicine, vol. 97, issue 10, pp. e9929, 2018 Mar. Abstract

Early identification of acute lung injury (ALI) in pediatric patients at risk of mortality is important for improving outcome.Assessment of soluble form of receptor for advanced glycation end products (sRAGE) as a valid biomarker for diagnosis of ALI among critically ill, pediatric patients in addition to correlating levels of sRAGE and different outcomes of those patients.A Hospital-based case-control study was conducted in pediatric intensive care units (PICUs) at Cairo University Hospital, along a period of 6 months. Total of 68 pediatric patients following inclusion criteria were classified into: patients with ALI; with both ALI and sepsis; with sepsis and control patients. They were prospectively followed and their laboratory and immunological workup (at days 1 and 9) was done to measure serum sRAGE levels and detect (sRAGE) genotypes.The age of the included children ranged from 8 to 84 months. Plasma level of sRAGE was significantly higher in plasma from patients with ALI regardless of associated sepsis. Plasma sRAGE levels were positively correlated with lung injury score. When assessing sRAGE genotypes, TA and TT genotypes were significant in most of the ALI with and without sepsis patients.Monitoring levels of sRAGE and genotypes can significantly affect the survival of ALI children.

ahmed labib, D., N. M. H. Shaheen, N. Zayed, M. nermine Riad, H. H.Tamim, R. M. H. Shahin, S. M. ELsheikh, and R. A. Moneim, "Role of circulating miR-182 and miR-150 as biomarkers for cirrhosis and hepatocellular carcinoma post HCV infection in Egyptian patients", virus research, vol. 255, pp. 77-84, 2018.
Labib, J. R., N. M. K. Elden, A. A. Hegazy, and N. A. Labib, "Incident Reporting System in Pediatric Intensive Care Units of Cairo Tertiary Hospitals: An Intervention Study", Archives of Pediatric Infectious Diseases, vol. 7, issue 4, 2019.
Labib, R., M. Mostafa, A. Samir, S. E. Alfaar, and S. Abouelnaga., "Omics-Ready Bio/Data Repository For Childhood Cancers in Egypt.", The International Society for Biological and Environmental Repositories Annual Meeting., Orlando, International Society for Biological and Environmental Repositories Annual Meeting, 2014. Abstract
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Labib, N. A., M. El-Lawindi, S. B. Abdelaziz, and Y. S. Abdelhamid, "Incidence and predictors of surgical site infections at Cairo University Hospitals", The Egyptian Journal of Community Medicine, vol. 30, issue 1, pp. 39-58, 2012.
Labib, M. W., M. H. Khalil, and A. W. Gertler, "MTBE and hazardous chemicals in the greater Cairo (GC) area", Proceedings of the Air and Waste Management Association's Annual Conference and Exhibition, AWMA, 2007. Abstract
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Labib, G. S., H. M. Aldawsari, and S. M. Badr-Eldin, "Metronidazole and Pentoxifylline films for the local treatment of chronic periodontal pockets: preparation, in vitro evaluation and clinical assessment", Expert Opin. Drug Del., vol. 11, issue 6, pp. 855-865, 2014. Abstract3._metronidazole_and_pentoxifylline.pdfWebsite

OBJECTIVE:
Periodontitis is one of the most important chronic inflammatory dental diseases arising from the destructive actions caused by a variety of pathogenic organisms presented in the oral cavity. The aim of this study is the preparation and in vitro evaluation of films for the local treatment of periodontal pockets.
METHODS:
The prepared films contained either metronidazole (Mtr), for its antimicrobial effect in periodontal diseases, using a mixture of polymers namely hydroxypropyl methyl cellulose, Carbopol 934 or locally applied Pentoxifylline (PTX), for its anti-inflammatory activity, using chitosan. All films were prepared using solvent casting technique and were evaluated for their physical characteristics, drug content uniformity, surface pH, swelling behavior, mechanical properties and in vitro release. Further characterization was done on the selected formulations using differential scanning calorimetry and scanning electron microscopy for surface structure. Clinical evaluation tests were also performed.
RESULT:
Appropriate physical characteristics and mechanical properties for most formulations and their suitability for periodontal application were observed. In vitro drug release from most films showed a burst release rate for both Mtr and PTX during the first 2 h after which the release rate was markedly decreased. Clinical trials on patients revealed the advantageous use of Mtr and PTX as an adjunct treatment with traditionally used dental techniques.

Labib, N. A., G. N. Radwan, R. Aziz, E. Israel, M. K. Mohamed, N. E. Sherbiny, and C. A. Loffredo, women smoking, , 2009.
Labib, M. W., Z. Safar, and M. H. Khalil, "Lead Emission Inventory in the Greater Cairo Area During the Life Time of CAIP", AWMA paper, vol. 70137, 2003. Abstract
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Labib, D. A., O. G. Shaker, R. M. ElRefai, S. A. Ghoniem, and A. Elmazny, "Association between miRNA-146a and Polymorphisms of its Target Gene, IRAK1, Regarding Susceptibility to and Clinical Features of Systemic Lupus Erythematous and Multiple Sclerosis.", Laboratory medicine, vol. 50, issue 1, pp. 34-41, 2019 Jan 01. Abstract

Single-nucleotide polymorphisms (SNPs) in microRNA-146a (miRNA-146a) can be associated with the development of immune-system dysfunctions.The aim of this work is to correlate SNPs of miRNA-146a and its target gene, IRAK1, with susceptibility, clinical manifestations, and diseases progression in patients with systemic lupus erythematous (SLE) and multiple sclerosis (MS). Genotyping for miRNA-146a (rs2910164) and its target gene IRAK1 (rs3027898) was performed using real-time polymerase chain reaction (RT-PCR) in 80 patients with SLE and 70 patients with MS, as well as 120 healthy control individuals. A statistically significant difference was found between the frequencies of the genotypes and alleles of miRNA-146a (rs2910164) and IRAK1 (rs3027898), compared with the control group. Also, whereas the mutant allele G of miRNA-146a may be a factor in the pathogenesis of lupus nephritis, the mutant allele C of IRAK1 may play a role in lupus arthritis. Both genes may contribute to the susceptibility of patients to SLE and MS.

Labib, M. W., Z. Safar, and M. H. Khalil, "Estimation of the health risk from ambient lead pollution in the greater Cairo (GC) area in Egypt", Proceedings of the Air and Waste Management Association's Annual Conference and Exhibition, AWMA, 2007. Abstract
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Labib, J. R., S. Kamal, M. R. Salem, E. D. ElDesouky, and A. T. Mahmoud, "Hospital Preparedness for Critical Care during COVID-19 Pandemic: Exploratory Cross-sectional Study", Open Access Macedonian Journal of Medical Sciences, vol. 8, no. T1, pp. 429–432, Oct., 2020. AbstractWebsite
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