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Lu, D., K. U. Tariq, M. S. Osman, D. Baleanu, M. Younis, and M. M. A. Khater, "New analytical wave structures for the (3+ 1)-dimensional Kadomtsev-Petviashvili and the generalized Boussinesq models and their applications", Results in Physics, vol. 14, pp. 102491, 2019.
Lozon, L., E. Saleh, V. Menon, W. S. Ramadan, A. Amin, and R. El-Awady, "Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter?", frontiers in pharmacology, vol. 13, issue 1663-9812, pp. 938471, 2022. safranal.pdf
Lozano, R., N. Fullman, D. Abate, S. M. Abay, C. Abbafati, N. Abbasi, H. Abbastabar, F. Abd-Allah, J. Abdela, and A. Abdelalim, "Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017", The Lancet, vol. 392, issue 10159: Elsevier, pp. 2091-2138, 2018. Abstract
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Lowry, O. H., N. J. Rosebrough, L. A. Farr, and R. J. Randall, "Protein measurement with the Folin phenol reagent", Journal of biological chemistry, vol. 193, issue 1: Elsevier, pp. 265-275, 1951. Abstract
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Lownik, J. C., A. J. Luker, S. R. Damle, L. F. Cooley, R. E. Sayed, A. Hutloff, C. Pitzalis, R. K. Martin, M. E. E. M. Shikh, and D. H. Conrad, "ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses", Journal of Immunology, vol. 199, issue 7, pp. 2305-2315 , 2017.
Lownes, N. E., Q. Wang, S. Ibrahim, R. A. Ammar, S. Rajasekaran, and D. Sharma, "Many-to-Many Game-Theoretic Approach for the Measurement of Transportation Network Vulnerability", Transportation Research Record: Journal of the Transportation Research Board, vol. 2263, no. 1: Trans Res Board, pp. 1–8, 2011. Abstract
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Lowenthal, D. H., A. W. Gertler, M. Labib, and M. H. Khalil, "Comparison between the Cairo Lead Inventory and Source Attribution Results", AWMA paper, vol. 42962, 2002. Abstract
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Low, K. R., Z. P. Berger, S. Kostka, B. Elhadidi, S. Gogineni, and M. N. Glauser, "A low-dimensional approach to closed-loop control of a Mach 0.6 jet", Experiments in Fluids, vol. 54, no. 4: Springer-Verlag, pp. 1–17, 2013. Abstract
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Lovice, D. B., M. D. Mingrone, and D. M. Toriumi, "Grafts and implants in rhinoplasty and nasal reconstruction", Otolaryngologic Clinics of North America, vol. 32, issue 1: Elsevier, pp. 113-141, 1999. Abstract
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Loutfy1, S. A., H. MM, M. WA, A. F. NM, M. MM, and S. Z. H, "SEN Virus Infection in Egyptian Patients on Maintenance Hemodialysis: Prevalence and Clinical Importance", Journal of Microbiology Immunology and infectrion, vol. 42, pp. 464-470, 2009.
loutfy, S. A., "Cytomegalovirus in Paediatric lymphoma", Pediatric Cancer: Diagnosis , Therapy and Prognosis, USA, MA Hayat (editor), 2013.
Loutfy, S. A., Z. F. Abdallah, M. Shaalan, M. Moneer, A. Karam, M. M. Moneer, I. M. Sayed, A. A. Abd El-Hafeez, P. Ghosh, and A. - R. N. Zekri, "Prevalence of MMTV-Like Sequences and Its Association with BRCA1/2 Genes Mutations Among Egyptian Breast Cancer Patients.", Cancer management and research, vol. 13, pp. 2835-2848, 2021. Abstract

BACKGROUND: Mouse mammary tumor virus (MMTV) is thought to have a role in human breast cancer (BC) pathogenesis. BRCA1 and 2 genes mutations are well-established risk factors for BC. The purpose of this study was to evaluate the presence of MMTV in familial and non-familial Egyptian breast cancer patients. We also aimed to establish a correlation between BRCAs genes mutations and MMTV infection in those patients.

PATIENTS AND METHODS: The study was included 80 BC patients and 10 healthy women were included as a control group. We used PCR to amplify a 250-bp MMTV-like env sequence. We also used PCR followed by direct sequencing to identify the genetic variation of exons 2, 13, 19 of BRCA1 gene and exon 9 and region f of exon 11 of BRCA2 gene. High resolution melting (HRM) analysis was used to screen the selected exons of BRCA1/2 genes in order to detect different variants.

RESULTS: MMTV DNA-like env sequences were detected in 70%, 76% of familial and non-familial BC patients, respectively, and it was not detected in any of the control subjects. The presence of viral sequences was associated with larger tumor size in the sporadic patients. Seventy BC patients showed variations in BRCA1/2 genes according to HRM analysis and sequencing analysis showed two different sequences of polymorphism among 22 familial and non-familial BC patients.

CONCLUSION: MMTV DNA was present among BC patients and it was associated with increased tumor growth. This indicates a potential role for MMTV in BC patients with and without deleterious mutation in BRCA1/2 genes.

loutfy, S. A., M. A. Abo-Shadi, M. O. H. A. M. E. D. FAWZY, M. El-Wakil, S. A. Metwally, M. M. Moneer, N. A. F. Fattah, S. Kassem, and A. Elgebaly, "Epstein-Barr virus and cytomegalovirus infections and their clinical relevance in Egyptian leukemic pediatric patients", Virology Journal, vol. 14, issue 1, pp. 46, 2017. Abstract

BACKGROUND: Epstein-Barr virus (EBV) and human cytomegalovirus (CMV) infections are environmental risk factors affecting the outcome of cancer due to an impairment in the cell-mediated immunity. Therefore, this study aimed to detect the frequency of EBV and CMV DNA and their association with clinical characteristics and outcome of pediatric leukemic patients.METHODS: Samples of 50 immunocompromised pediatric leukemic patients and 30 apparently healthy children were subjected to the amplification of EBV DNA by one version of PCR targeting the Bam H1 W region of the genomic region of EBV, and the amplification of CMV DNA by targeting the CMV UL97 genomic region by a second round PCR. All investigations were performed on WBCs and sera. Results were correlated with the clinical and laboratory characteristics of the disease, and with overall survival.
RESULTS: EBV and CMV DNA were detected in 20 and 54% of leukemic patients, respectively. Nine out of ten patients with EBV DNA (90%) were positive for CMV DNA in their sera. The presence of EBV DNA or CMV DNA was associated with neutropenia and a low total leukocyte count (TLC) (p = 0.02, 0.03, respectively). The presence of severe CMV disease, longer duration of febrile neutropenia, neutropenia, lymphopenia, thrombocytopenia and the presence of EBV DNA in patients' sera were significantly associated with worse overall survival.
CONCLUSION: The detection of CMV disease and EBV DNA is relatively common in leukemic children and is significantly associated with a decline in the overall survival.

loutfy, S. A., M. A. Abo-Shadi, M. O. H. A. M. E. D. FAWZY, M. El-Wakil4, S. A. Metwally, N. A. F. Fattah, S. Kassem, and A. Elgebaly, "Epstein-Barr virus and cytomegalovirus infections and their clinical relevance in Egyptian leukemic pediatric patients", virology, vol. 14, issue 1, pp. 46, 2017.
loutfy, S. A., M. F. Ibrahim, M. El-Wakil, and M. M. Moneer, "Detection of Human Herpes virus 6 (HHV6) in Pediatric Lymphomas: Impact on Clinical Course and Association with Cytomegalovirus Infection", Virology Journal, vol. 7, pp. 287, 2010.
Loutfy, S. A., N. A. Al-Ansary, N. T. Abdel-Ghani, A. R. Hamed, M. B. Mohamed, J. D. Craik, T. S. A. Eldin, A. M. Abdellah, Y. Hussein, M. T. M. Hasanin, et al., "Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model", Asian Pac J Cancer Prev, vol. 16, issue 14, pp. 6039-6046, 2015.
loutfy, S. A., M. M. Hafez, W. A. Massoud, N. A. Fotuh, M. M. Moneer, and H. S. Zaghloul, "SEN virus infection in Egyptian patients undergoing maintenance hemodialysis: prevalence and clinical importance.", Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, vol. 42, issue 6, pp. 464-70, 2009 Dec. Abstract

BACKGROUND AND PURPOSE: SEN virus (SENV) is assumed to be responsible for post-transfusion non-A to -E hepatitis. Phylogenetic analysis of SENV has shown 9 different strains. Two strains, SENV-H and SENV-D, were described as possible candidates for post-transfusion hepatitis. This study examined the prevalence of SENV infection and its clinical importance for patients undergoing hemodialysis.

METHODS: Serum samples were obtained from 63 long-term hemodialysis patients, and examined for SENV-H and SENV-D viremia by polymerase chain reaction. Serum samples were also obtained from 20 patients with chronic kidney diseases (CKD) who were not undergoing hemodialysis and from 20 apparently healthy blood donors to act as controls. For SENV screening, a primer pair was used for the conserved ORF1 region among all SENV genotypes from A to I.

RESULTS: SENV infection was significantly more frequent among hemodialysis patients (33/63; 52.4%) and those with CKD (10/20; 50.0%) than among the control participants (2/20; 10.0%) [p = 0.003]. Twenty three of 33 hemodialysis patients had SENV-H or -D, 61% of whom were positive for SENV-H only, 4% were positive for SENV-D only, and 36% were positive for both SENV-H and SENV-D. SENV infection was not associated with age, sex, amount or duration of hemodialysis, or liver function test results. Elevated alanine aminotransferase was significantly associated with HCV viremia, but not with SENV infection.

CONCLUSIONS: Egyptian hemodialysis patients and those with CKD are at higher risk for SENV transmission. SENV-H is more prevalent than SENV-D.

Loutfy, S. A., T. A. salah eldin, M. A. Ramadan, K. Y. Farroh, Z. F. Abdallah, and T. Youssef, "Synthesis, Characterization and Cytotoxic Evaluation of Graphene Oxide Nanosheets: In Vitro Liver Cancer Model.", Asian Pacific journal of cancer prevention : APJCP, vol. 18, issue 4, pp. 955-961, 2017. Abstract

Background: Graphene nanosheets have a broad spectrum of biomedical applications. Hepatocellular cancer (HCC) is a major health problem in the Egyptian population. Currently, treatment strategies are invasive and have several adverse side effects. Thus, other approaches are required for managing this aggressive type of cancer. Our objective here was to prepare and characterize graphene oxide nanosheets and evaluate cytotoxic effect at the molecular level in an in vitro human liver cancer cell model (HepG2). Methods: Graphene oxide nanosheets were generated by chemical oxidation and characterized by transmission electron microscopy and X-ray diffraction. Cytotoxic effects in HepG2 cells were monitored by sulforhodamine B (SRB) colorimetric assay followed by flow cytometric analysis. Molecular investigations of DNA fragmentation and expression of some apoptotic genes at the transcriptional RNA level were also performed. Results: Treatment of HepG2 cells with 400μg/ml graphene oxide nanosheets showed alteration in cell morphology after 24 h. Flow cytometry revealed accumulation of cells in S phase of cell cycle followed by dramatic effects on cellular DNA. Extensive evaluation of the cytotoxic effects of graphene oxide showed increased mRNA Bax apoptotic gene expression with not of P53 and caspase-3 mRNA after 24h, suggesting involvement of an intrinsic apoptotic caspase-independent pathway. Conclusion. Graphene oxide can mediate apoptotic gene signaling in human liver cancer cells opening a novel approach to cancer management. Further analyses at the molecular level are now required to confirm our results and facilitate biomedical applications in vivo.

Loutfy, S. A., M. O. H. A. M. E. D. FAWZY, M. El-Wakil, and M. M. Moneer, "Presence of human herpes virus 6 (HHV6) in pediatric lymphomas: impact on clinical course and association with cytomegalovirus infection", Virology Journal, vol. 7, pp. 287, 2010. Abstract

BACKGROUND: Activation of herpes virus 6 (HHV6) has seen in Hodgkin's and non-Hodgkin's Lymphoma (HL&NHL) as a result of lymphoma associated immunosuppression. Multiple studies have suggested an association between both HHV6 and cytomegalovirus CMV for development of CMV disease affecting the pathogenesis of lymphoma. Therefore, this study investigated the frequency of HHV6, its impact on clinical manifestations of lymphoma and its possible association with risk for development of CMV infection in pediatric lymphoma patients.METHODS: Presence of HHV6 DNA and CMV DNA was investigated by PCR assay in both WBC's and plasma samples from 50 patients diagnosed with HL or NHL. CMV antibody titer was also determined in sera obtained from each patient. Twenty apparently healthy siblings were used as a control group.
RESULTS: In a study group of 50 patients diagnosed with HL or NHL, 23/50 (46%) were found to be positive for herpes virus DNA (HHV6 or CMV) in WBC's or plasma by PCR assay and this was significantly higher than its presence in the pediatric control group 2/20 (10%) (p = 0.005). Ten out of these 23 (43%) were found to have active CMV infection. Fifty six percent of patients with CMV infection were found among NHL cases with B- subtype. The presence of both herpes viruses DNA was significantly associated with more frequent episodes of febrile neutropenia (median 3 episodes), absolute neutrophil count (< 0.8), lymphocytes (< 0.5), and low hemoglobin level (< 9.1), (p < 0.05).
CONCLUSION: The presence of HHV6 can be considered as a predicting indicator of cellular immunosuppression preceding the onset of CMV infection which may result in a severe outcome among pediatric lymphoma patients.

Loutfy, S. A., H. A. M. El-Din, M. El-berry, N. G. Allam, M. T. M. Hasanin, and A. M. Abdallah, "Synthesis, characterization and cytotoxic evaluation of chitosan nanoparticles: In Vitro Liver Cancer Model ", Natural Sciences:Nanoscience and Nanotechnology, vol. 7, pp. 1-9, 2016.
loutfy, S. A., L. Hussein, E. L. - C. B. Mohamed, S. E. S. Mohamed, E. A. E. - M. Abada, E. A. E. - M. Ahmed, and A. H.Soliman, "Detection of Human JC Polyomavirus DNA in Patients with Solid Tumors by Semi-Nested Polymerase Chain Reaction", Life Science , vol. 11, issue 12, pp. 918-927, 2014. 01jnd01-1010_my_jc_article_in_life_science.pdf
Loutfy, Samah A.; Mohamed, M. B.; A. - G. N. T.; A. - A. N.; A. W. E. - B. O. H. A.; M.;, "Metallic Nanomaterials as Drug Carriers to Decrease Side Effects of Chemotherapy (In Vitro: Cytotoxicity Study)", Journal of Nanopharmaceutics and Drug Delivery, vol. 1, issue 2, pp. 138-149, 2013.
Loutfy, S. A., M. B. Mohamed, A. M.Tamim, J. R, M. H. Elberry, H. F. Yousef, E. H. El-din, A. M. Abdellah, S. E. I. Elbehairi, and et al, Antiviral and Cytotoxic Activities of Silver Nanoparticles in an in vitro Liver Cancer Model., , 2015.
Loutfy, S. A., M. M. Moneer, S. E. Salem, E. A. El-Moniem Abada, E. A. El-Moniem Ahmed, L. H. Ibrahim, and E. - C. B. Mohamed, "Polyomavirus infections and its clinical relevance in cancer patients: A Prospective Study.", Journal of infection and public health, vol. 10, issue 1, pp. 22-30, 2017 Jan - Feb. Abstract

BK and JC polyomaviruses (PyV) have been demonstrated to be associated with the pathogenesis of various human cancers. We aimed to investigate the impact of BK and JC polyomavirus infections on several clinical parameters in different human cancers. A total of 150 cancer patients were included in the study (51 patients with solid tumors, 48 patients with lymphomas and 51 patients with leukemias). Amplification of PyV DNA was performed using a semi-nested version of Polymerase chain reaction targeting the T genomic region of PyV. The polyomavirus load was determined using real-time PCR assay. The clinical data were collected. Polyomavirus DNA could be detected in 84 (56%) of 150 of all cancerous patients. The solid tumors had the lowest proportion of JCV (6 (11.8%) of 51), whereas had the highest proportion of JCV (200copies/μl). JCV was more frequent among NHL patients (30%) and absent in HL patients (0%). During follow-up, PyV positivity decreased significantly (p=0.004) in lymphoma patients (n=28). Although PyV positivity decreased significantly from 39% to 7% in 28 of 48 lymphoma patients after treatment, it significantly persisted in leukemic patients after treatment (from 22% to 38%). JC was more frequent among leukemic patients with leukopenia. The presence of JC polyomavirus was more frequent among leukemic patients without any significant impact on their overall survival.

Loutfy, S. A., R. H. Shalaby, A. R. Hamed, M. B.Mohamed, A. Barakat, Z. F. Abdullah, H. Yousef, A. Tamim, H. E. Eldin, and N. H. Hegazy, "Evaluation of cytotoxic effect of metallic nanoparticles in an in vitro liver cancer model. ", Journal of Chemical and Pharmaceutical Research , vol. 7, issue 6, pp. 470-487, 2015.
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