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2023
Abdel-Aal, S. K., M. Souhassou, P. Durand, C. Lecomte, A. S. Abdel-Rahmana, and N. Claiserc, "Synthesis, crystal structure and phase transitions of novel hybrid perovskite: bis(1,2diaminepropane) dil-chloro-bis[diaquadichloromanganate(II)] dichloride", Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, vol. 79, pp. 314-319, 2023. acta-b2023.pdf
Naveen, R., D. R. Thakare, M. Kuwana, J. D. Pauling, J. Day, M. Joshi, I. Parodis, P. Sen, K. Jagtap, E. Nikiphorou, et al., "Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey.", Rheumatology international, vol. 43, issue 7, pp. 1265-1275, 2023. Abstract

The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumatic (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). The COVID-19 Vaccination in autoimmune diseases (COVAD) self-reporting e-survey was circulated by a group of > 110 collaborators in 94 countries from March to December 2021. AEs were analyzed between different groups using regression models. Of 10,679 complete respondents [73.8% females, mean age 43 years, 53% Caucasians], 478 had SSc. 83% had completed two vaccine doses, Pfizer-BioNTech (BNT162b2) (51%) was the most common. Minor and major AEs were reported by 81.2% and 3.3% SSc patients, respectively, and did not differ significantly with disease activity or different vaccine types, though with minor symptom differences. Frequencies of AEs were not affected by background immunosuppression, though SSc patients receiving hydroxychloroquine experienced fatigue less commonly (OR 0.4; 95% CI 0.2-0.8). Frequency of AEs and hospitalisations were similar to other AIRDs, nrAIDs, and HC except a higher risk of chills (OR 1.3; 95% CI 1.0-1.7) and fatigue (OR 1.3; 95% CI 1.0-1.6) compared to other AIRDs. COVID-19 vaccines were largely safe and well tolerated in SSc patients in the short term. Background immunosuppression and disease activity did not influence the vaccination-related short-term AEs.

Lukyanova, V. K., E. V. Zemlyanaya, K. V. Lukyanova, and I. Abdul-Magead, "Theoretical Analysis of Pion–Nucleus Scattering at Energies of the (3,3) Pion–Nucleon Resonance", Physics of Particles and Nuclei, vol. 54, issue 4, pp. 734–755, 2023. physics_of_particles_and_nuclei_2023_vol._54_734-755.pdf
Gouda, O. E., A. E. Z. Dein, E. Tag‐Eldin, M. A. T. T. I. LEHTONEN, and M. O. H. A. M. E. D. M. F. DARWISH, "Thermal analysis of the influence of harmonics on the current capacity of medium‐voltage underground power cables", Energy Sci Eng. , vol. 11, issue 1, pp. 3471–3485, 2023.
Abd El-Rahman, Y., M. Ramzey, L. - G. Wu, X. - H. Li, M. El-Shafeiy, and A. Said, "Tonian-Cryogenian bimodal volcanism and related sulfide ores in the Arabian-Nubian Shield: An example from the Dendekan prospect in the Eastern Desert of Egypt", Geochemistry, vol. paper No. 125986, 2023.
Otify, A. M., R. M. Ibrahim, B. Abib, A. Laub, L. A. Wessjohann, Y. Jiang, and M. A. Farag, "Unveiling metabolome heterogeneity and new chemicals in 7 tomato varieties via multiplex approach of UHPLC-MS/MS, GC–MS, and UV–Vis in relation to antioxidant effects as analyzed using molecular networking and chemometrics", Food Chemistry, vol. 417: Elsevier Ltd, 2023. AbstractWebsite

Tomatoes show diverse phytochemical attributes that contribute to their nutritive and health values. This study comprehensively dissects primary and secondary metabolite profiles of seven tomato varieties. UHPLC-qTOF-MS assisted molecular networking was used to monitor 206 metabolites, 30 of which were first-time to be reported. Flavonoids, as valuable antioxidants, were enriched in light-colored tomatoes (golden sweet, sun gold, and yellow plum) versus high tomatoside A, an antihyperglycemic saponin, in cherry bomb and red plum varieties. UV–Vis analysis revealed similar results with a strong absorbance corresponding to rich phenolic content in light varieties. GC–MS unveiled monosaccharides as the main contributors to samples’ segregation, found abundant in San Marzano tomato accounting for its sweet flavor. Fruits also demonstrated potential antioxidant activities in correlation to their flavonoids and phospholipids. This work provides a complete map of tomatoes’ metabolome heterogeneity for future breeding programs and a comparative approach utilizing different metabolomic platforms for tomato analysis. © 2023 Elsevier Ltd

Elfeky, S. A., N Qenawi, W. Tawfik, S. A. Loutfy, and T. D. Subash, "Utilization of Nanographene Oxide–Folic Acid–Metal Chalcogen in Cancer Theranostics", NanoWorld J, vol. 9, issue S5, pp. S206-S214, 2023.
Elfeky, S. A., N Qenawi, W. Tawfik, S. A. Loutfy, and T. D. Subash, "Utilization of Nanographene Oxide–Folic Acid–Metal Chalcogen in Cancer Theranostics", NanoWorld J, vol. 9, no. S5, pp. S206–S214, 2023. Abstract
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Sen, P., N. R, N. Houshmand, S. Moghadam Kia, M. Joshi, S. Saha, K. Jagtap, V. Agarwal, A. Nune, E. Nikiphorou, et al., "Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys.", Rheumatology (Oxford, England), vol. 62, issue 10, pp. 3291-3301, 2023. Abstract

OBJECTIVE: COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys.

METHODS: The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups.

RESULTS: We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)].

CONCLUSION: Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.

Maged, A. M., A. El-Mazny, N. Kamal, S. I. Mahmoud, M. Fouad, N. El‑Nassery, amal Kotb, W. S. Ragab, A. I. Ogila, A. A. Metwally, et al., "The value of platelet‑rich plasma in women with previous implantation failure: a systematic review and meta‑analysis", Journal of Assisted Reproduction and Genetics, 2023.
Shehata, M. M. A., A. Maged, amal Kotb, A. I. Ogila, Y. Lasheen, N. Salah, R. A. Mohsen, M. Fouad, and A. S. Abd-elazeim, "Whole-body vibration versus supervised aerobic exercise on hormonal parameters and inflammatory status in women with premenstrual syndrome: A randomized controlled trial", International journal of Gynecology and Obstetrics, 2023.
Hela, M. I. D., H. A. Khater, M. M. El-Mogy, M. A. Fathy, F. E. Ibrahim, Y. C. Li, Z. Tong, and K. F. Abelgawad, "[HTML] from mdpi.com A controlled-release nanofertilizer improves tomato growth and minimizes nitrogen consumption", plants, vol. 12, issue 10, pp. 1978, 2023. 5.pdf
Mohamed, T. G., A. A. El-Midany, M. a Ismail, M. G. ElSamrah, E. A. Lotfy, and M. A. Hassan, "Effect of Incorporating Black Sands (Magnetite and Ilmenite) into Concrete Mixtures on their Mechanical Properties", 5th Novel Intelligent and Leading Emerging Sciences Conference, 2023.
Bui, D. T., J. Favell, E. N. Kitova, Z. Li, K. A. McCord, E. N. Schmidt, F. Mozaneh, M. Elaish, A. El-Hawiet, and Y. St-Pierre, Absolute affinities from quantitative shotgun glycomics using concentration-independent (COIN) native mass spectrometry, , vol. 9, issue 7: American Chemical Society, pp. 1374 - 1387, 2023. Abstract
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Yan, J., P. Wang, L. Wang, Q. Jin, A. S. Ali, Y. He, Y. Wang, Y. Sun, A. Li, W. Adwy, et al., Bio-decolorization of synthetic dyes by a novel endophytic fungus Penicillium janthinellum LM5 from blueberry pulp, , vol. 195, pp. 108909, 2023. AbstractWebsite

Synthetic dyes from textile, paper, leather, and plastic processing, etc. are the majority of the colored effluents and have a harmful impact on human health and environment. Dye biosorption through endophytic fungi will be a challenge. A new fungus isolated from blueberry pulp was identified morphologically and genetically as Penicillium janthinellum LM5. It was utilized for the biosorption of synthetic dyes by forming mycelium particles with efficient decolorization properties in the dye solution. The results of decolorization experiments exhibited that dye type, pH, temperature and time were the important factors and the best decolorization condition on Congo red was pH 6.0, 30 ℃ and 48 h. Moreover, LM5 can achieve 90% decolorization rate even under the high salt concentrations of 200 mg/mL. Based on spectral analysis, the decolorization of Congo red was mainly attributed to the biosorption of mycelium and its pellet structure. Additionally, the fungus adsorbed Congo red can be as an excellent electrode material with a long-cycle performance and stable capacitance property, being a good way for recycling. In summary, this research employed a novel dye treatment method with simultaneous culture and decolorization through an endophytic fungus LM5, being a promising biomaterial in the application of dye wastewater treatment.

Cheng, L., J. - R. Liu, J. - M. Liu, D. Guo, F. Deng, Q. Bian, H. Zhang, X. Han, A. S. Ali, W. - H. Zhang, et al., "Design, synthesis, antifungal activity and molecular docking of ring-opened pimprinine derivative containing (thio)amide structure", Pest Management Science, vol. 79, issue 6, pp. 2220 - 2229, 2023. AbstractWebsite
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Liu, J. - R., Y. Gao, B. Jin, D. Guo, F. Deng, Q. Bian, H. - F. Zhang, X. - Y. Han, A. S. Ali, M. - Z. Zhang, et al., "Design, Synthesis, Antifungal Activity, and Molecular Docking of Streptochlorin Derivatives Containing the Nitrile Group", Marine Drugs, vol. 21, issue 2, 2023. AbstractWebsite
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Abdelaziem, A., A. M. Mohamed, Y. M. Yousry, R. Borayek, A. S. Razeen, N. Zhang, S. Chen, L. Zhang, K. Lin, and Z. Liu, "Effect of poling on the dielectric properties of synthesized β-poly (vinylidene fluoride) foam", Journal of Applied PhysicsJournal of Applied Physics, vol. 133, issue 12: American Institute of Physics, pp. 124101, 2023. AbstractWebsite
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Turner, J. D., A. J. Schupper, P. V. Mummaneni, J. S. Uribe, R. K. Eastlack, G. M. Mundis, P. G. Passias, J. D. DiDomenico, S. Harrison Farber, M. A. R. Soliman, et al., "Evolving concepts in pelvic fixation in adult spinal deformity surgery", Adult Spinal Deformity Surgery, vol. 35, issue 4, pp. 101060, 2023. AbstractWebsite

Long-segment adult spinal deformity (ASD) constructs carry a high risk of mechanical complications. Pelvic fixation was introduced to improve distal construct mechanics and has since become the standard for long constructs spanning the lumbosacral junction. Pelvic fixation strategies have evolved substantially over the years. Numerous techniques now use a variety of entry points, screw trajectories, and construct configurations. We review the various strategies for pelvic fixation in ASD in a systematic review of the literature and update the techniques employed in the International Spine Study Group Complex Adult Deformity Surgery database.

Zhang, J., A. M. Senousi, P. Zhao, S. Law, and X. Liu, Exploring 3D spatial morphology using multilayered space syntax, network science and wi-fi log data, , vol. 2, issue 1, pp. 1, 2023. AbstractWebsite

Spatial morphology of 2D space has been well studied at the scales of building, community, and city in space syntax literature. Space syntax decomposes continuous geographic space into a set of unique axial lines and represents them as a spatial network to analyze spatial morphology. However, 3D spatial morphology remains largely unexplored, partially due to limited data access and methodological constraints. Motivated by the multilayered network literature in network science, this work extends the conventional 2D space syntax axial network into a multilayered axial network to explore the spatial morphology of a university campus. Scaling properties are discovered from several aspects of the constructed spatial network (e.g., degree, local integration). The relationship between spatial morphology and route-based pedestrian flow is evaluated using a large Wi-Fi log dataset and multiple regression analysis. We found a significant correlation between the two, with a correlation coefficient of 0.756 and r2 of 0.571. Four network features (i.e., local depth, geometric length, eigenvector, and betweenness), are found to significantly shape the pedestrian flow. The results of community detection show the effectiveness of multilayered space syntax analysis in depicting functional areas of campus, despite the complex nature of 3D space. Whilst a limitation of this research is the need to account for the 3D angular route preferences when characterizing the morphology of campus and the flow estimated based on the shortest routes using the Dijkstra algorithm.

Kachapila, M., M. Monahan, A. O. Ademuyiwa, Y. M. Adinoyi, B. M. Biccard, C. George, D. N. Ghosh, J. Glasbey, D. G. Morton, O. Osayomwanbo, et al., Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries, , vol. 7, pp. 100207, 2023. AbstractWebsite

BackgroundThis study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa.
Methods
Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($).
Results
High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was $216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with $195 for low FiO2 leading to a −$11 (95% CI: −$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was $1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs.
Conclusion
High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this.

Elkhodary, H. M., M. H. Abdelnabi, A. A. Swelem, H. J. Sabbagh, O. A. E. S. El Meligy, I. M. Talaat, E. B. Abdellatif, Y. Khader, O. B. Al-Batayneh, N. M. Al-Khanati, et al., "Individual, familial and country-level factors associated with oral hygiene practices in children: an international survey", BMC Oral Health, vol. 23, issue 1, 2023. Abstract

Background: Maintaining good oral hygiene is key to preventing dental caries and periodontal disease. Children and adolescents with good oral hygiene behaviours are likely to grow into adults with the same behaviours. This study assessed the frequency of using various oral hygiene methods among children and adolescents from different countries and individual, familial and country-level factors associated with the use of these methods. Methods: A multi-country online survey collected data from caregivers of children in 2020–21 about children’s use of oral hygiene methods including toothbrush, fluoridated toothpaste, mouthwash, dental floss and miswak using self-administered, close-ended questions. Adjusted multilevel logistic regression models were used to assess the relationship between each of the five oral hygiene methods (dependent variables) and the independent factors: sex, age, and history of dental visits (individual factors), mother's education and area of residence (familial factors) as well as country income and region (country-level factors). Results: A total of 4766 parents/caregivers were included from 20 countries (77.4% Eastern Mediterranean-region and 41.6% lower middle income countries). The most frequent oral hygiene methods were using toothbrush and toothpaste (90% and 60.3%). The use of oral hygiene methods differed by age, sex and history of dental visits as well as mother’s education and area of residence (P < 0.05). In addition, children from low income countries had significantly lower odds of using mouthwashes and dental floss than those from high income countries (AOR = 0.55, 95% CI 0.31, 0.98 and AOR = 0.34, 95% CI 0.12, 0.97) whereas children from the European region had higher odds of using mouthwash (AOR = 2.82, 95% CI 1.27, 6.26) and those from the region of the Americas had higher odds of using dental floss (AOR = 3.84, 95% CI 1.28, 11.52) than those from the Eastern Mediterranean region. Conclusions: The use of various oral hygiene methods is associated with individual, familial and country-level factors. Oral health promotion programs should be developed taking into account these influences.

Li, T., J. Fu, J. Cheng, A. A. Elfiky, C. Wei, and J. Fu, "New progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19", Frontiers in Immunology, vol. 14, 2023. AbstractWebsite

Heat-shock-protein family A (Hsp70) member 5 (HSPA5), aliases GRP78 or BiP, is a protein encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33.3. When the endoplasmic reticulum (ER) was stressed, HSPA5 translocated to the cell surface, the mitochondria, and the nucleus complexed with other proteins to execute its functions. On the cell surface, HSPA5/BiP/GRP78 can play diverse functional roles in cell viability, proliferation, apoptosis, attachments, and innate and adaptive immunity regulations, which lead to various diseases, including cancers and coronavirus disease 2019 (COVID-19). COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which caused the pandemic since the first outbreak in late December 2019. HSPA5, highly expressed in the malignant tumors, likely plays a critical role in SARS-CoV-2 invasion/attack in cancer patients via tumor tissues. In the current study, we review the newest research progresses on cell surface protein HSPA5 expressions, functions, and mechanisms for cancers and SARS-CoV-2 invasion. The therapeutic and prognostic significances and prospects in cancers and COVID-19 disease by targeting HSPA5 are also discussed. Targeting HSPA5 expression by natural products may imply the significance in clinical for both anti-COVID-19 and anti-cancers in the future. Copyright © 2023 Li, Fu, Cheng, Elfiky, Wei and Fu.

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