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Kotb, M. M. W., "Endoscopic Lumbar Microdiscectomy: Pitfalls & Complications", International Conference of Minimal Invasive Neurosurgery, Cairo, Egypt, 25 March, 2001.
Kotb, H., and E. E. Khalil, "Sneeze and Cough Pathogens Migration inside Aircraft Cabins", ,REHVA Journal,April,, vol. 57, issue 2, pp. 35,45, 2020.
prof. dr. mostafa wagih kotb, prof. dr. helmy abdel-halim el-desouky, and prof. dr. sherif gamal el-deen al-mekkawy, usefulness of spine navigation in transpedicular screw placement versus the conventional surgery, , cairo, cairo, 2012.
Kotb, M. A., A. F. Hamza, H. Abd El Kader, M. El Monayeri, D. S. Mosallam, N. Ali, C. W. S. Basanti, H. Bazaraa, H. A. Rahman, M. M. Nabhan, et al., "Combined liver-kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience.", Pediatric transplantation, pp. e13313, 2018 Nov 26. Abstract

Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid-ity, end stage kidney disease (ESKD), and mortality if left untreated. Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). This study aimed to report outcome of CLKT in a pediatric cohort of PH1 patients, through retrospective analysis of data of 8 children (2 girls and 6 boys) who presented by PH1 to Wadi El Nil Pediatric Living Related Liver Transplant Unit during 2001-2017. Mean age at transplant was 8.2 ± 4 years. Only three of the children underwent confirmatory genotyping. Three patients died prior to surgery on waiting list. The first attempt at CLKT was consecutive, and despite initial successful liver transplant, the girl died of biliary peritonitis prior to scheduled renal transplant. Of the four who underwent simultaneous CLKT, only two survived and are well, one with insignificant complications, and other suffered from abdominal Burkitt lymphoma managed by excision and resection anastomosis, four cycles of rituximab, cyclophosphamide, vincristine, and prednisone. The other two died, one due to uncontrollable bleeding within 36 hours of procedure, while the other died awaiting renal transplant after loss of renal graft to recurrent renal oxalosis 6 months post-transplant. PH1 with ESKD is a rare disease; simultaneous CLKT offers good quality of life for afflicted children. Graft shortage and renal graft loss to oxalosis challenge the outcome.

Kotb, M. A., "Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia.", Journal of pediatric surgery, vol. 43, issue 7, pp. 1321-7, 2008 Jul. Abstract

BACKGROUND: Ursodeoxycholic acid is a bile acid that was found to increase bile flow, protect hepatocytes, and dissolve gallstones.

PURPOSE: The objective of this study is to review ursodeoxycholic acid in infants and children with extrahepatic biliary atresia.

METHODS: We used a statistical analysis of data of records of infants and children having extrahepatic biliary atresia who underwent Kasai portoenterostomy and attended Hepatology Clinic, New Children's Hospital, Cairo University, Egypt, from May 1985 until June 2005.

RESULTS: Of 141 infants with extrahepatic biliary atresia, 108 received ursodeoxycholic acid for mean duration +/- SD of 252.6 +/- 544.9 days in a dosage of 20 mg/kg per day. The outcome of infants who did not receive ursodeoxycholic acid and those who did was the following: 8 (24.2%) and 11 (10.18%) had a successful outcome (P = .043), 0 (0%) and 7 (6.4%) improved (P = .148), 25 (75.7%) and 84 (77.7%) had a failed outcome (P = .489), and none vs 5 died (4.6%) (P = .135), respectively. The predictors of successful outcomes were age less than 65 days at portoenterostomy (P = .008) and absence of ursodeoxycholic acid intake (P = .04) with a likelihood of a successful outcome that was 2.8, that associated with ursodeoxycholic acid intake.

CONCLUSION: In this cohort of infants with extrahepatic biliary atresia, ursodeoxycholic acid was not shown to be effective, and its use was associated with a plethora of hepatic and extrahepatic complications.

Kotb, M. S., R. R. Shahin, Y. A. Nasr, and M. Abdel-Tawab, "Charge characteristics of clay separates in some soils of Egypt.", Bull. Fac. of Agric., Cairo Univ., Conference of New Technologies in Agriculture (Special Issue), 2006. Abstract
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Kotb, S., M. S. Elsheemy, H. A. Morsi, T. Zakaria, M. Salah, and M. A. Eissa, "Renal recoverability in infants with obstructive calcular anuria: Is it better than in older children?", J Pediatr Urol, vol. 9, issue 6, pp. 1178-1182, 2013.
Kotb, S., M. S. Elsheemy, H. A. Morsi, T. Zakaria, M. Salah, and M. A. Eissa, "Renal recoverability in infants with obstructive calcular anuria: Is it better than in older children?", Journal of pediatric urology, vol. 9, no. 6: Elsevier, pp. 1178–1182, 2013. Abstract

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Kotb, M. M. W., "Endoscopic percutaneous lumbar discectomy in Kasr Al-Aini: a preliminary report", E. J. N. S., vol. 12, issue 2, pp. 317*321, 1997.
Kotb, M. A., "Ursodeoxycholic acid in neonatal hepatitis and infantile paucity of intrahepatic bile ducts: review of a historical cohort.", Digestive diseases and sciences, vol. 54, issue 10, pp. 2231-41, 2009 Oct. Abstract

We retrospectively reviewed the role of ursodeoxycholic acid in infants having nonsurgical cholestasis attending the Hepatology Clinic, New Children Hospital, Cairo University, Egypt, from 1985 until 2005. Files of 496 infants with neonatal hepatitis and 97 with intrahepatic bile duct paucity were included; of them 241 (48.6%) and 52 (46.4%) received 20-40 mg/kg/day ursodeoxycholic acid for 319.2 +/- 506.9 days and 480.3 +/- 583.3 days, respectively. The outcome of infants with neonatal hepatitis with intake of ursodeoxycholic acid and those without was: 108 (44.8%) and 179 (70.2%) successful (P = 0.000), 11 (4.6%) and 13 (5.1%) improved (P = 0. 474), 112 (46.5%) and 61 (23.9%) suffered failed outcome (P = 0.000), and 10 (4.1%) and 2 (0.78%) died (P = 0.014), respectively. Likelihood of successful outcome with ursodeoxycholic acid intake was 0.345 (P = 0.000), and that of deterioration was 2.76 (P = 0.000). For those having intrahepatic bile duct paucity likelihood of successful outcome with ursodeoxycholic acid intake was 0.418 (P = 0.040) and that of deterioration was 2.64 (P = 0.028). Ursodeoxycholic acid failed in management of this cohort of infants with nonsurgical cholestasis.

Kotb, M. A., Abd El Satar I, Badr AM, A. N, Ismail HA, Hamza AF, and A. E. K. H. M, "Pulmonary Hypertension and Cardiac Hypertrophy in Children Recipients of Orthotopic Living Related Liver Transplantation", Journal of Advanced Research, vol. 8, pp. 663-668, 2017. pulmonary_hypertension_post_liver_transplant_.pdf
Kotb, A., S. Hassan, and H. Hassan, "A Comparative Study Among Various Algorithms for Lossless Airborne LiDAR Data Compression", 2018 14th International Computer Engineering Conference (ICENCO): IEEE, pp. 17–21, 2018. Abstract
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Kotb, M. A., L. Mansour, C. W. S. Basanti, W. Elgarf, G. I. Z. Ali, S. T. Mostafa El Sorogy, I. E. M. Kamel, and N. M. Kamal, "Pilot study of classic galactosemia: Neurodevelopmental impact and other complications urge neonatal screening in Egypt.", Journal of advanced research, vol. 12, pp. 39-45, 2018 Jul. Abstract

Classic galactosemia is caused by deficiency of galactose-1-phosphate uridylyltransferase (GALT). It causes serious morbidity and mortality if left untreated. Screening for galactosemia is not included in Egyptian neonatal screening program. The study aimed to define clinical presentation and complications of galactosemia at Pediatric Hepatology Clinic, Cairo University, Egypt. Thus, the clinical presentation, course and outcome of 37 children with documented galactosemia was studied. Jaundice was the main presentation (67.6%). Other presentations included; convulsions (29.7%), motor retardation (24.3%), mental retardation (5.4%), microcephaly (5.4%), failure to thrive (16.2%), hepatomegaly (62.2%), splenomegaly (35.1%), vomiting (16.2%), diarrhea (8.1%), liver cell failure (10.8%), renal tubular acidosis (5.4%), cataract (5.4%), autoimmune hepatitis (2.7%), self-mutilation (2.7%), combined immune deficiency (2.7%) and kernicterus (2.7%). There was no correlation of residual enzyme activity to severity, clinical presentation, liver function tests, liver biopsy findings or outcome apart from highly significant correlation with repeated chest infections ( = 0.001). Duration to diagnosis and exposure to galactose in diet correlated with liver pathology severity i.e. hepatocyte necrosis ( = 0.003) and cytoskeleton damage ( = 0.003), but not to outcome. Galactosemia should be suspected in any child with liver, neurologic disease and/or immunodeficiency. Its complications are potentially preventable. Early detection is mandatory to prevent serious morbidity and mortality. Initiation of neonatal screening for galactosemia in Egypt is recommended.

Kotb, S., M. S. Elsheemy, H. A. Morsi, T. Zakaria, M. Salah, and M. A. Eissa, "Renal recoverability in infants with obstructive calcular anuria: Is it better than in older children?", J Pediatr Urol, vol. 9, pp. 1178-1182, 2013. Abstract
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Kotb, M., L. Hassan, A. Tamer, H. Abushady, E. Mohamed, and A. Aly, "Sarcoidosis in a Toddler: A Rare Presentation", Pediatric Sciences Journal, vol. 2, issue 1, pp. 108-111, 2022. cupsj_volume_2_issue_1_pages_108-111.pdf
Kotb, A. M., M. M. El-Far, and M. W. El-Kerdawy, "Accuracy Of Implant Placement Using Maxillary And Mandibular Tissue Supported Computer Aided Surgical Guides.", Cairo Dental Journal, vol. II, 2015.
Kotb, M. A., D. Mosallam, H. A. Ragab;, A. E. H. Baky, E. A. Hatw, A. F. Hamza, A. E. H. Kader, E. G. Tagy, H. Esmat, S. Shehata, et al., " Management and Outcome of Chylous Ascites in Children: A CARE compliant Case Series", Pediatric Sciences Journal, vol. 1, issue 1, pp. 34-40, 2021.
Kotb, M. M. M., A. G. M. A. Hassan, and A. M. A. AwadAllah, "Does dehydroepiandrosterone improve pregnancy rate in women undergoing IVF/ICSI with expected poor ovarian response according to the Bologna criteria? A randomized controlled trial.", European journal of obstetrics, gynecology, and reproductive biology, vol. 200, pp. 11-5, 2016 May. Abstract

OBJECTIVE: To provide the best available evidence on the role of dehydroepiandrosterone (DHEA) treatment in improving the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in women with poor ovarian response (POR).

STUDY DESIGN: A randomized controlled trial conducted in Cairo University hospitals and Dar Al-Teb subfertility and assisted conception centre, Giza, Egypt. 140 women undergoing IVF/ICSI with POR according to the Bologna criteria were randomly divided into 2 equal groups. The study group received DHEA 25mg three times daily for 12 weeks before the IVF/ICSI cycles and the control group did not receive DHEA. Controlled ovarian stimulation (COH) was started on the second day of menstruation using human menopausal gonadotropins, cetrotide 0.25mg was started when the leading follicle reached 14mm. The main outcome measures were the clinical pregnancy rate, ongoing pregnancy rate, retrieved oocytes, fertilization rate, gonadotropins doses and COH days.

RESULTS: The DHEA group had significantly higher clinical pregnancy rate (32.8% vs 15.7%, p=0.029), ongoing pregnancy rate (28.5% vs 12.8%), retrieved oocytes (6.9±3 vs 5.8±3.1, p=0.03), fertilization rate (62.3±27.4 vs 52.2±29.8, p=0.039), significantly less gonadotropins doses (3383±717.5IU vs 3653.5±856IU, p=0.045) and COH days (11.6±1.8 vs 12.6±1.06, p=0.001).

CONCLUSION: DHEA increases the number of oocytes, fertilization rate, fertilized oocytes, and clinical pregnancy rate and ongoing pregnancy rate in women with POR according to the Bologna criteria. DHEA was well tolerated by the patients and was associated with less COH days and gonadotropins doses.

REGISTRATION NUMBER: www.clinicaltrials.govNCT02151006.

Kotb, M. A., M. Sheba, N. El Koofy, S. Mansour, H. M. E. Karaksy, N. M. Dessouki, W. Mostafa, M. El Barbary, H. E. El-Tantawy, and S. Kaddah, "Post-portoenterostomy triangular cord sign prognostic value in biliary atresia: a prospective study.", The British journal of radiology, vol. 78, issue 934, pp. 884-7, 2005 Oct. Abstract

The triangular cord sign (TC sign) is a sensitive and specific tool in prompt diagnosis of extrahepatic biliary atresia. The objective of this study is to evaluate post-operative TC sign presence in outcome prediction of infants with biliary atresia after Kasai hepato-portoenterostomy 27 infants and children with biliary atresia underwent 122 ultrasound examinations using both 5 MHz and 7 MHz convex linear transducers in 33 months follow up. For all infants TC sign identification was included pre-operatively, ultrasound was done 2 weeks post-operatively then bimonthly for 3 months, monthly for 2 months and every 3 months thereafter. 14 (53.8%) had post-operative TC sign. Once post-operatively positive, it remained positive throughout the study. It did not reappear in an initially post-operatively TC sign negative infant. Those having post-operative TC sign had statistically worse outcomes (0 became anicteric, 2 improved, 7 had progressive disease and 6 died) than those with a negative TC sign (p = 0.04) (3 became anicteric, 5 improved, 2 progressed and 1 died). Presence of TC sign post-operatively correlated with measure of removal of all fibrous cone at porta-hepatis during portoenterostomy (p = 0.026). Post-portoenterostomy TC sign is associated with more morbidity and mortality; and reflects inadequate surgical technique.

Kotb, M. A., M. Kamal, S. Mansour, E. M. Hawary, W. N. Lotfi, H. Hamdi, M. M. E. Barbary, S. Kaddah, W. Mostafa, and A. Kotb, "Progression of disease in extrahepatic biliary atresia is associated with reduced total hepatic blood flow: descriptive results of a prospective pilot study ", Alexandria Journal of Pediatrics , vol. 20, issue 1, pp. 63-68, 2006.
Kotb, M. A., A. F. Hamza, H. Abd El Kader, M. El Monayeri, D. S. Mosallam, N. Ali, C. W. S. Basanti, H. Bazaraa, H. A. Rahman, M. M. Nabhan, et al., "Combined liver-kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience.", Pediatric transplantation, vol. 23, issue 1, pp. e13313, 2019. Abstractcombined_liver_and_kidney_transplant.pdf

Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid-ity, end stage kidney disease (ESKD), and mortality if left untreated. Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). This study aimed to report outcome of CLKT in a pediatric cohort of PH1 patients, through retrospective analysis of data of 8 children (2 girls and 6 boys) who presented by PH1 to Wadi El Nil Pediatric Living Related Liver Transplant Unit during 2001-2017. Mean age at transplant was 8.2 ± 4 years. Only three of the children underwent confirmatory genotyping. Three patients died prior to surgery on waiting list. The first attempt at CLKT was consecutive, and despite initial successful liver transplant, the girl died of biliary peritonitis prior to scheduled renal transplant. Of the four who underwent simultaneous CLKT, only two survived and are well, one with insignificant complications, and other suffered from abdominal Burkitt lymphoma managed by excision and resection anastomosis, four cycles of rituximab, cyclophosphamide, vincristine, and prednisone. The other two died, one due to uncontrollable bleeding within 36 hours of procedure, while the other died awaiting renal transplant after loss of renal graft to recurrent renal oxalosis 6 months post-transplant. PH1 with ESKD is a rare disease; simultaneous CLKT offers good quality of life for afflicted children. Graft shortage and renal graft loss to oxalosis challenge the outcome.

Kotb, M. A., H. N. Elmahdy, F. E. Z. Mostafa, M. E. Falaki, C. W. Shaker, M. A. Refaey, and K. Rjoob, "Improving the Recognition of Heart Murmur", International Journal of Advanced Computer Science and Applications (IJACSA), vol. 7, no. 7, pp. 283-287, 2016. Abstract

Diagnosis of congenital cardiac defects is challenging, with some being diagnosed during pregnancy while others are diagnosed after birth or later on during childhood. Prompt diagnosis allows early intervention and best prognosis. Contemporary diagnosis relies upon the history, clinical examination, pulse oximetery, chest X-ray, electrocardiogram (ECG), echocardiography (ECHO), computed tomography (CT) and cardiac catheterization. These diagnostic modalities reliable upon recording electrical activity or sound waves or upon radiation. Yet, congenital heart diseases are still liable to misdiagnosis because of level of operator expertise and other multiple factors. In an attempt to minimize effect of operator expertise this paper built a classification model for heart murmur recognition using Hidden Markov Model (HMM). This paper used Mel Frequency Cepestral coefficient (MFCC) as a feature and 13 MFCC coefficients. The machine learning model built by studying 1069 different heart sounds covering normal heart sounds, ventricular septal defect (VSD), mitral regurgitation (MR), aortic stenosis (AS), aortic regurgitation (AR), patent ductus arteriosus (PDA), pulmonary regurgitation (PR), and pulmonary stenosis (PS). MFCC feature used to extract feature matrix for each type of heart sounds after separation according to amplitude threshold. The frequency of normal heart sound (range= 1Hz to 139Hz) was specific without overlap with any of the studied defects (ranged= 156-556Hz). The frequency ranges for each of these defects was typical without overlap according to examined heart area (aortic, pulmonary, tricuspid and mitral area). The overall correct classification rate (CCR) using this model was 96% and sensitivity 98%. This model has great potential for prompt screening and specific defect detection. Effect of cardiac contractility, cardiomegaly or cardiac electrical activity on this novel detection system needs to be verified in future works.

Kotb, M., R. W. Williams, N. Fathey, M. Nooh, S. Rowe, R. Kansal, and R. Aziz, "Biotools for Determining the Genetics of Susceptibility to Infectious Diseases and Expediting Research Translation Into Effective Countermeasures", National Institute of Allergy and Infectious Diseases, NIH: Springer, pp. 13–17, 2008. Abstract
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