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de Joode, K., D. W. Dumoulin, J. Tol, H. M. Westgeest, L. V. Beerepoot, F. W. P. J. van den Berkmortel, P. G. N. J. Mutsaers, N. G. J. van Diemen, O. J. Visser, E. Oomen-de Hoop, et al., "Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study.", European journal of cancer (Oxford, England : 1990), vol. 141, pp. 171-184, 2020. Abstract

AIM OF THE STUDY: Patients with cancer might have an increased risk for severe outcome of coronavirus disease 2019 (COVID-19). To identify risk factors associated with a worse outcome of COVID-19, a nationwide registry was developed for patients with cancer and COVID-19.

METHODS: This observational cohort study has been designed as a quality of care registry and is executed by the Dutch Oncology COVID-19 Consortium (DOCC), a nationwide collaboration of oncology physicians in the Netherlands. A questionnaire has been developed to collect pseudonymised patient data on patients' characteristics, cancer diagnosis and treatment. All patients with COVID-19 and a cancer diagnosis or treatment in the past 5 years are eligible.

RESULTS: Between March 27th and May 4th, 442 patients were registered. For this first analysis, 351 patients were included of whom 114 patients died. In multivariable analyses, age ≥65 years (p < 0.001), male gender (p = 0.035), prior or other malignancy (p = 0.045) and active diagnosis of haematological malignancy (p = 0.046) or lung cancer (p = 0.003) were independent risk factors for a fatal outcome of COVID-19. In a subgroup analysis of patients with active malignancy, the risk for a fatal outcome was mainly determined by tumour type (haematological malignancy or lung cancer) and age (≥65 years).

CONCLUSION: The findings in this registry indicate that patients with a haematological malignancy or lung cancer have an increased risk of a worse outcome of COVID-19. During the ongoing COVID-19 pandemic, these vulnerable patients should avoid exposure to severe acute respiratory syndrome coronavirus 2, whereas treatment adjustments and prioritising vaccination, when available, should also be considered.

Jordaens, L., V. Van Hoeck, J. De Bie, M. Berth, W. F. A. Marei, K. L. J. Desmet, P. E. J. Bols, and J. Leroy, "Non-esterified fatty acids in early luteal bovine oviduct fluid mirror plasma concentrations: An ex vivo approach", Reprod Biol, 2017/05/30, vol. 17, no. 3, pp. 281-284, Sep, 2017. AbstractWebsite

We investigated whether and to which extent plasma non-esterified fatty acids (NEFAs) are reflected in oviduct fluid (OF) using an improved ex vivo flushing method. OF and plasma NEFA concentrations were respectively 0.29+/-0.19 and 0.31+/-0.14mmol/L, they didn't differ significantly (P=0.13) and tended to be positively correlated (Pearson correlation coefficient=0.56; P=0.07). Results suggest that OF NEFAs mirror the concentrations seen in plasma of healthy cattle.

Jordaens, L., V. Van Hoeck, V. Maillo, A. Gutierrez-Adan, W. F. A. Marei, B. Vlaeminck, S. Thys, R. G. Sturmey, P. E. J. Bols, and J. Leroy, "Maternal metabolic stress may affect oviduct gatekeeper function", Reproduction, 2017/03/05, vol. 153, no. 6, pp. 759-773, Jun, 2017. AbstractWebsite

We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24-h treatments at Day 9: (1) control (0 microM NEFA + 0% EtOH), (2) solvent control (0 microM NEFA + 0.45% EtOH), (3) basal NEFA (720 microM NEFA + 0.45% EtOH in the basal compartment) and (4) apical NEFA (720 microM NEFA + 0.45% EtOH in the apical compartment). FITC-albumin was used for monolayer permeability assessment and related to transepithelial electric resistance (TER). Fatty acid (FA), glucose, lactate and pyruvate concentrations were measured in spent medium. Intracellular lipid droplets (LD) and FA uptake were studied using Bodipy 493/503 and immunolabelling of FA transporters (FAT/CD36, FABP3 and CAV1). BOEC-mRNA was retrieved for qRT-PCR. Results revealed that apical NEFA reduced relative TER increase (46.85%) during treatment and increased FITC-albumin flux (27.59%) compared to other treatments. In basal NEFA, FAs were transferred to the apical compartment as free FAs: mostly palmitic and oleic acid increased respectively 56.0 and 33.5% of initial FA concentrations. Apical NEFA allowed no FA transfer, but induced LD accumulation and upregulated FA transporter expression ( upward arrowCD36, upward arrowFABP3 and upward arrowCAV1). Gene expression in apical NEFA indicated increased anti-apoptotic ( upward arrowBCL2) and anti-oxidative ( upward arrowSOD1) capacity, upregulated lipid metabolism ( upward arrowCPT1, upward arrowACSL1 and downward arrowACACA) and FA uptake ( upward arrowCAV1). All treatments had similar carbohydrate metabolism and oviduct function-specific gene expression (OVGP1, ESR1 and FOXJ1). Overall, elevated NEFAs affected BOEC metabolism and barrier function differently depending on NEFA exposure side. Data substantiate the concept of the oviduct as a gatekeeper that may actively alter early embryonic developmental conditions.

Jordaens, L., V. Van Hoeck, I. Pintelon, S. Thys, P. E. J. Bols, W. F. A. Marei, and J. Leroy, "Altered embryotrophic capacities of the bovine oviduct under elevated free fatty acid conditions: an in vitro embryo--oviduct co-culture model", Reprod Fertil Dev, 2020/02/11, vol. 32, no. 6, pp. 553-563, Mar, 2020. AbstractWebsite

Maternal metabolic stress conditions are of growing importance in both human and dairy cattle settings as they can have significant repercussions on fertility. Upregulated lipolysis is a common trait associated with metabolic disorders and results in systemically elevated concentrations of non-esterified fatty acids (NEFAs). The effects of high NEFA concentrations on the follicular environment, oocyte and embryo development is well documented. However, knowledge on the effects of NEFAs within the oviduct, representing the initial embryonic growth environment, is currently lacking. Therefore, the experiments outlined here were designed to obtain fundamental insights into both the direct and indirect interactions between NEFAs, bovine oviductal cells and developing zygotes. Hence, zygotes were co-cultured with NEFA-pre-exposed bovine oviductal cells or subjected to simultaneous NEFA exposure during the co-culture period. The outcome parameters assessed were embryo development with cleavage (48h post insemination (pi)), morula (120-126h pi) and blastocyst (192h pi) rates, as well as morula intracellular lipid content and blastocyst quality using Bodipy and differential staining respectively. Our data suggest a direct embryotoxicity of NEFAs as well as impaired embryo development through a reduced oviductal ability to support and protect early embryo development.

Jori, G., and J. D. Spikes, "Photobiochemistry of porphyrins", Topics in photomedicine: Plenum Press New York, pp. 183-318, 1984. Abstract
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Jori, G., E. Reddi, R. C. Straight, J. D. Spikes, T. Sicuro, P. Carlini, V. Scarcelli, E. Domenici, and I. Cozzani, "Molecular and cellular mechanisms in photomedicine: porphyrins in microheterogeneous environments", Primary Photo-Processes in Biology and Medicine: Springer, Boston, MA, pp. 349-369, 1985. Abstract
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Jori, G., "Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy", Journal of Photochemistry and photobiology B: Biology, vol. 36, issue 2: Elsevier, pp. 87-93, 1996. Abstract
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Jorssen, E. P., A. Langbeen, W. F. Marei, E. Fransen, H. F. De porte, J. L. Leroy, and P. E. Bols, "Morphologic characterization of isolated bovine early preantral follicles during short-term individual in vitro culture", Theriogenology, 2015/04/22, vol. 84, no. 2, pp. 301-11, Jul 15, 2015. AbstractWebsite

To provide new insights in the molecular mechanism controlling preantral follicular development and to unravel the needs to support in vitro follicular development of early-stage preantral follicles (PAFs), there is a need for alternative in vitro bovine follicle culture methods. In this study, we aimed to characterize follicular dynamics using an IVC system of isolated and individually cultured bovine early PAFs during 10 days to generate individual follicle follow-up data. Preantral follicles (<50 mum) were isolated from slaughterhouse ovaries and cultured individually for 10 days. Individual follicle morphology, growth, survival, quality, and cell proliferation were evaluated in time by combining noninvasive and invasive assessment methods. The PAFs were light microscopically evaluated during culture to assess follicular dynamics, stained with neutral red to determine follicle viability, stained with 4',6-diamidino-2-phenylindole and terminal deoxynucleotidyl transferase dUTP nick end labeling to evaluate cell proliferation and follicle quality, and processed for histologic evaluation to assess follicle morphology. On the basis of their morphology, follicles were subdivided in three categories, with category 1 follicles showing the best morphologic features. On Day 0, only category 1 follicles were selected, but follicle categories were reassigned on evaluation Days 1, 2, 4, 7, or 10. Although 67% of the follicles survived 10 days of IVC, the number of follicles exhibiting a normal morphology decreased significantly from Day 7 onward and the apoptotic index increased significantly from Day 10. Both category 1 and 2 follicles showed a significant increase in follicular diameter (Day 10: 21.80 +/- 0.86 and 11.82 +/- 0.80, respectively). This increase in follicular diameter showed to be correlated with an increase in the total cell number. In conclusion, this culture system showed to support follicular development until Day 10, although the proportion of follicles showing normal morphologic features and the follicular quality decreased after 10 days of IVC. Follicles maintaining their category 1 morphologic features over time seem to be of a better quality and show a higher developmental competence as compared to category 2 and 3 follicles.

Jorssen, E. P., A. Langbeen, W. F. Marei, E. Fransen, H. F. De porte, J. L. Leroy, and P. E. Bols, "Morphologic characterization of isolated bovine early preantral follicles during short-term individual in vitro culture", Theriogenology, vol. 84, no. 2, pp. 301-11, Jul 15, 2015. AbstractWebsite

To provide new insights in the molecular mechanism controlling preantral follicular development and to unravel the needs to support in vitro follicular development of early-stage preantral follicles (PAFs), there is a need for alternative in vitro bovine follicle culture methods. In this study, we aimed to characterize follicular dynamics using an IVC system of isolated and individually cultured bovine early PAFs during 10 days to generate individual follicle follow-up data. Preantral follicles (<50 mum) were isolated from slaughterhouse ovaries and cultured individually for 10 days. Individual follicle morphology, growth, survival, quality, and cell proliferation were evaluated in time by combining noninvasive and invasive assessment methods. The PAFs were light microscopically evaluated during culture to assess follicular dynamics, stained with neutral red to determine follicle viability, stained with 4',6-diamidino-2-phenylindole and terminal deoxynucleotidyl transferase dUTP nick end labeling to evaluate cell proliferation and follicle quality, and processed for histologic evaluation to assess follicle morphology. On the basis of their morphology, follicles were subdivided in three categories, with category 1 follicles showing the best morphologic features. On Day 0, only category 1 follicles were selected, but follicle categories were reassigned on evaluation Days 1, 2, 4, 7, or 10. Although 67% of the follicles survived 10 days of IVC, the number of follicles exhibiting a normal morphology decreased significantly from Day 7 onward and the apoptotic index increased significantly from Day 10. Both category 1 and 2 follicles showed a significant increase in follicular diameter (Day 10: 21.80 +/- 0.86 and 11.82 +/- 0.80, respectively). This increase in follicular diameter showed to be correlated with an increase in the total cell number. In conclusion, this culture system showed to support follicular development until Day 10, although the proportion of follicles showing normal morphologic features and the follicular quality decreased after 10 days of IVC. Follicles maintaining their category 1 morphologic features over time seem to be of a better quality and show a higher developmental competence as compared to category 2 and 3 follicles.

Joseph Naguib, M., A. Moustafa Kamel, A. Thabet Negmeldin, A. H. Elshafeey, and I. Elsayed, "Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency", Drug Delivery, vol. 27, no. 1, pp. 996-1009, 2020. AbstractWebsite
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Joshi, L. R., A. Tiwari, S. P. Devkota, S. Khatiwada, S. Paudyal, and K. R. Pande, International Journal of Veterinary Science, , 2014. Abstract
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Joshi-Barr, S., C. de Gracia Lux, E. Mahmoud, and A. Almutairi, "Exploiting oxidative microenvironments in the body as triggers for drug delivery systems", Antioxidants & redox signaling, vol. 21, issue 5: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. 730-754, 2014. Abstract

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Joslin, S. N., C. Pybus, M. Labandeira-Rey, A. S. Evans, A. S. Attia, C. A. Brautigam, and E. J. Hansen, "A Moraxella catarrhalis Two-Component Signal Transduction System Necessary for Growth in Liquid Media Affects Production of Two Lysozyme Inhibitors", Infection and immunity, vol. 83, no. 1: American Society for Microbiology, pp. 146–160, 2015. AbstractJoslin et al 2015-IAI-83;146-160.pdf

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Jr, A. H. A., B. RG, S. L, G. S, M. RA, and A. H, "CHOP versus two weekly dose dense regimens in aggressive non-Hodgkin’s lymphoma: a meta-analysis", Annals of Oncology, vol. 19, issue suppl 5, pp. v154, 2008.
Jr, R. A. P., D. A. B. P. M. Daniel B. Carr, M.D., and R. N. Judith A. Paice, Ph.D., "Dar Al Fouad", Approaches to Pain Management: An Essential Guide for Clinical Leaders, Second Edition, Oakbrook Terrace, Illinois 60181 U.S.A., Oak Brook, IL: Joint Commission Resources; , 2010.
JR, V., O. AA, and A. JL, "cataract surgery in the nanophthalmic eye", J cataract Refract Surg, vol. july, issue 27(7), pp. 968, 2001.
Jr, A. H. A., M. RA, E. I, E. D, and A. H, "The relation between hormone receptor status and disease-free survival in adjuvant breast cancer: A multivariate analysis", Journal of Clinical Oncology, vol. 26, issue 15S, pp. 11527, 2008.
JR, V., O. AA, and A. JL, "Cataract surgery in the nanophthalmic eye", J Cataract Refract Surg, vol. july (27), issue 7, pp. 968, 2001.
JR Graef, S. R. Grace, and E. Tunç, Asymptotic behavior of solutions of certain integro-differential equations, : International Publications, 2019. Abstract
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JR Graef, S. R. Grace, and E. Tunc, "Oscillation of second-order nonlinear noncanonical dynamic equations with deviating arguments", Acta Mathematica Universitatis Comenianae , vol. 91, issue 2, pp. 113-120, 2022.
Jr., R. A. Y., A. - I. H. G. Jr., and B. M. Jr., "Multiple i.v. oxytocin injection may yield sperm in azoospermic men scheduled for TESE", Fertility and Sterility, vol. 82, 2004. Abstract
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Jr., A. - I. H. G., A. M. A. Sr., M. R. T. Sr., and S. G. Sr., "Optimizing GnRH antagonist administration: A meta-analaysis of fixed vs flexible protocol", Fertility and Sterility, vol. 82, 2004. Abstract
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JS, C., E. - E. S, L. K, and O. HJ, "Morphologic and functional evaluation of duplicated renal collecting systems with MR urography: A descriptive analysis", Clinical Imaging , issue 57, pp. 69-76, 2019.