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Johnson, L., and G. H. Galal, "KBS methodologies: principles and misconceptions", Systems Research and Information Science, vol. 6: GORDON & BREACH SCIENCE PUBLISHERS SA, pp. 69–69, 1993. Abstract
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Johnson, L., and N. E. Johnson, "Knowledge {Elicitation} {Involving} {Teachback} {Interviewing}", Knowlege {Acquisition} for {Expert} {Systems}: {A} {Practical} {Handbook}, London, Plenum Press, 1987. Abstract
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Johnson, P. C., H. Ammar, W. Zohdy, R. Fouda, and R. Govindu, "Yield of diagnostic tests and its impact on cost in adult patients with syncope presenting to a community hospital.", Southern medical journal, vol. 107, issue 11, pp. 707-14, 2014 Nov. Abstract

OBJECTIVES: Total annual costs for syncope-related hospitalizations were $2.4 billion in 2000. The aim of this study was to examine the type and number of tests ordered for patients admitted with syncope and whether these tests helped establish the cause.

METHODS: We studied the records of 1038 patients coded as "syncope" in billing records, and 167 fulfilled the eligibility criteria. The main outcome measures were the diagnostic yield of the ordered tests, the incremental cost/incremental benefit, and the number of admissions that can be averted if risk stratification were used in the evaluation.

RESULTS: The etiology of the syncope was identified in 48.3% of the patients. Postural blood pressure measurement has the highest diagnostic yield at 58.7%, whereas history taking diagnosed 19.7% of cases. The diagnostic yields of telemetry, electrocardiogram, radionuclide stress test, echocardiography, and troponin measurement were 4.76%, 4.24%, 3.44%, 0.94%, and 0.62%, respectively. Chest x-ray, carotid ultrasonography, 24-hour Holter monitoring, brain computed tomography, and brain magnetic resonance imaging did not yield the diagnosis in any of the patients. Only 1.9% of the money spent in the evaluation of syncope was effective in leading to a definitive diagnosis. The orthostatic blood pressure measurement was ranked first in the incremental cost/incremental benefit ratio and the radionuclide stress test was ranked last (17.03 vs 42,369.0, respectively). Approximately 6% of the patients did not meet the admission criteria.

CONCLUSIONS: Physicians ordered unnecessary tests that have a low yield and are not cost-effective. A standardized algorithmic approach should be the cornerstone in the evaluation of syncope.

Jolly, R. D., K. G. Thompson, and B. G. Winchester, "Bovine mannosidosis--a model lysosomal storage disease.", Birth defects original article series, vol. 11, issue 6, pp. 273-8, 1975. Abstract
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Joly, F., J. McAlpine, R. Nout, E. {\AA}vall-Lundqvist, E. Shash, M. Friedlander, and others, "Quality of life and patient-reported outcomes in endometrial cancer clinical trials: a call for action!", International Journal of Gynecological Cancer, vol. 24, no. 9: LWW, pp. 1693–1699, 2014. Abstract
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Jonaszik, A., T. Severin-Selz, M. Langer, A. Kharabish, and others, Wind sock sing in CT-aortography: A rare case of acute type A aortic dissection with left ventricular intimointimal flap intussusception, : European Congress of Radiology-ESCR 2017, 2017. Abstract
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Jonaszik, A., T. Severin-Selz, M. Langer, A. Kharabish, and others, Wind sock sing in CT-aortography: A rare case of acute type A aortic dissection with left ventricular intimointimal flap intussusception, : European Congress of Radiology-ESCR 2017, 2017. Abstract
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Jones, K. M., R. Bhattacharjee, R. Krishnamurthi, S. Blanton, A. Theadom, S. Barker-Collo, A. Thrift, P. Parmar, A. Maujean, A. Ranta, et al., "Methodology of the Stroke Self-Management Rehabilitation Trial: an international, multisite pilot trial.", Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, vol. 24, issue 2, pp. 297-303, 2015 Feb. Abstract

RATIONALE: Stroke is a major cause of long-term adult disability with many survivors living in the community relying on family members for on-going support. However, reports of inadequate understanding of rehabilitation techniques are common. A self-management DVD-based observational learning tool may help improve functional outcomes for survivors of stroke and reduce caregivers' burden.

AIMS: This article describes the methodology of the stroke self-management rehabilitation trial. The overall aim of this pilot trial is to assess the feasibility and preliminary efficacy of a DVD-based intervention for improving functional outcomes of survivors of stroke 2 months postrandomization to inform the design of a full-scale randomized clinical trial.

DESIGN: Recruitment of a minimum of 20 survivors of stroke and their informal caregivers (where available) in each of the participating centers will occur across multiple international sites. After baseline assessments, participants will be randomly assigned to an intervention or standard care group. The intervention comprises a structured DVD observation and practice schedule over 8 weeks. All participants will complete follow-up assessments.

STUDY OUTCOMES: The outcome measures will include a global shift in the Rankin Scale scores and dichotomized scores, changes in quality of life, general health, depression, and caregiver burden at 2 months postrandomization. A qualitative analysis of the effects of the intervention will also be undertaken.

DISCUSSION: The results of the pilot study will provide knowledge of whether observational learning techniques delivered via DVD can effectively improve recovery after stroke and reduce caregiver burden.

Jonsdottir, S., E. Hamza, J. Janda, C. Rhyner, A. Meinked, E. L. Marti, V. Svansson, and S. Torsteinsdottir, "Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study", Veterinary Immunology and Immunopathology , vol. 166, pp. 8-21, 2015.
Jonsdottir, S., E. Hamza, J. Janda, C. Rhyner, A. Meinke, E. Marti, W. Svanson, and S. Torsteinsdottir, "Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: a pilot study. ", Vet Immunol Immunopathol, vol. 166, issue 1-2, pp. 8-21, 2015.
de Joode, K., D. W. Dumoulin, J. Tol, H. M. Westgeest, L. V. Beerepoot, F. W. P. J. van den Berkmortel, P. G. N. J. Mutsaers, N. G. J. van Diemen, O. J. Visser, E. Oomen-de Hoop, et al., "Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study.", European journal of cancer (Oxford, England : 1990), vol. 141, pp. 171-184, 2020. Abstract

AIM OF THE STUDY: Patients with cancer might have an increased risk for severe outcome of coronavirus disease 2019 (COVID-19). To identify risk factors associated with a worse outcome of COVID-19, a nationwide registry was developed for patients with cancer and COVID-19.

METHODS: This observational cohort study has been designed as a quality of care registry and is executed by the Dutch Oncology COVID-19 Consortium (DOCC), a nationwide collaboration of oncology physicians in the Netherlands. A questionnaire has been developed to collect pseudonymised patient data on patients' characteristics, cancer diagnosis and treatment. All patients with COVID-19 and a cancer diagnosis or treatment in the past 5 years are eligible.

RESULTS: Between March 27th and May 4th, 442 patients were registered. For this first analysis, 351 patients were included of whom 114 patients died. In multivariable analyses, age ≥65 years (p < 0.001), male gender (p = 0.035), prior or other malignancy (p = 0.045) and active diagnosis of haematological malignancy (p = 0.046) or lung cancer (p = 0.003) were independent risk factors for a fatal outcome of COVID-19. In a subgroup analysis of patients with active malignancy, the risk for a fatal outcome was mainly determined by tumour type (haematological malignancy or lung cancer) and age (≥65 years).

CONCLUSION: The findings in this registry indicate that patients with a haematological malignancy or lung cancer have an increased risk of a worse outcome of COVID-19. During the ongoing COVID-19 pandemic, these vulnerable patients should avoid exposure to severe acute respiratory syndrome coronavirus 2, whereas treatment adjustments and prioritising vaccination, when available, should also be considered.

Jordaens, L., V. Van Hoeck, I. Pintelon, S. Thys, P. E. J. Bols, W. F. A. Marei, and J. Leroy, "Altered embryotrophic capacities of the bovine oviduct under elevated free fatty acid conditions: an in vitro embryo--oviduct co-culture model", Reprod Fertil Dev, 2020/02/11, vol. 32, no. 6, pp. 553-563, Mar, 2020. AbstractWebsite

Maternal metabolic stress conditions are of growing importance in both human and dairy cattle settings as they can have significant repercussions on fertility. Upregulated lipolysis is a common trait associated with metabolic disorders and results in systemically elevated concentrations of non-esterified fatty acids (NEFAs). The effects of high NEFA concentrations on the follicular environment, oocyte and embryo development is well documented. However, knowledge on the effects of NEFAs within the oviduct, representing the initial embryonic growth environment, is currently lacking. Therefore, the experiments outlined here were designed to obtain fundamental insights into both the direct and indirect interactions between NEFAs, bovine oviductal cells and developing zygotes. Hence, zygotes were co-cultured with NEFA-pre-exposed bovine oviductal cells or subjected to simultaneous NEFA exposure during the co-culture period. The outcome parameters assessed were embryo development with cleavage (48h post insemination (pi)), morula (120-126h pi) and blastocyst (192h pi) rates, as well as morula intracellular lipid content and blastocyst quality using Bodipy and differential staining respectively. Our data suggest a direct embryotoxicity of NEFAs as well as impaired embryo development through a reduced oviductal ability to support and protect early embryo development.

Jordaens, L., V. Van Hoeck, V. Maillo, A. Gutierrez-Adan, W. F. A. Marei, B. Vlaeminck, S. Thys, R. G. Sturmey, P. E. J. Bols, and J. Leroy, "Maternal metabolic stress may affect oviduct gatekeeper function", Reproduction, 2017/03/05, vol. 153, no. 6, pp. 759-773, Jun, 2017. AbstractWebsite

We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24-h treatments at Day 9: (1) control (0 microM NEFA + 0% EtOH), (2) solvent control (0 microM NEFA + 0.45% EtOH), (3) basal NEFA (720 microM NEFA + 0.45% EtOH in the basal compartment) and (4) apical NEFA (720 microM NEFA + 0.45% EtOH in the apical compartment). FITC-albumin was used for monolayer permeability assessment and related to transepithelial electric resistance (TER). Fatty acid (FA), glucose, lactate and pyruvate concentrations were measured in spent medium. Intracellular lipid droplets (LD) and FA uptake were studied using Bodipy 493/503 and immunolabelling of FA transporters (FAT/CD36, FABP3 and CAV1). BOEC-mRNA was retrieved for qRT-PCR. Results revealed that apical NEFA reduced relative TER increase (46.85%) during treatment and increased FITC-albumin flux (27.59%) compared to other treatments. In basal NEFA, FAs were transferred to the apical compartment as free FAs: mostly palmitic and oleic acid increased respectively 56.0 and 33.5% of initial FA concentrations. Apical NEFA allowed no FA transfer, but induced LD accumulation and upregulated FA transporter expression ( upward arrowCD36, upward arrowFABP3 and upward arrowCAV1). Gene expression in apical NEFA indicated increased anti-apoptotic ( upward arrowBCL2) and anti-oxidative ( upward arrowSOD1) capacity, upregulated lipid metabolism ( upward arrowCPT1, upward arrowACSL1 and downward arrowACACA) and FA uptake ( upward arrowCAV1). All treatments had similar carbohydrate metabolism and oviduct function-specific gene expression (OVGP1, ESR1 and FOXJ1). Overall, elevated NEFAs affected BOEC metabolism and barrier function differently depending on NEFA exposure side. Data substantiate the concept of the oviduct as a gatekeeper that may actively alter early embryonic developmental conditions.

Jordaens, L., V. Van Hoeck, J. De Bie, M. Berth, W. F. A. Marei, K. L. J. Desmet, P. E. J. Bols, and J. Leroy, "Non-esterified fatty acids in early luteal bovine oviduct fluid mirror plasma concentrations: An ex vivo approach", Reprod Biol, 2017/05/30, vol. 17, no. 3, pp. 281-284, Sep, 2017. AbstractWebsite

We investigated whether and to which extent plasma non-esterified fatty acids (NEFAs) are reflected in oviduct fluid (OF) using an improved ex vivo flushing method. OF and plasma NEFA concentrations were respectively 0.29+/-0.19 and 0.31+/-0.14mmol/L, they didn't differ significantly (P=0.13) and tended to be positively correlated (Pearson correlation coefficient=0.56; P=0.07). Results suggest that OF NEFAs mirror the concentrations seen in plasma of healthy cattle.

Jori, G., E. Reddi, R. C. Straight, J. D. Spikes, T. Sicuro, P. Carlini, V. Scarcelli, E. Domenici, and I. Cozzani, "Molecular and cellular mechanisms in photomedicine: porphyrins in microheterogeneous environments", Primary Photo-Processes in Biology and Medicine: Springer, Boston, MA, pp. 349-369, 1985. Abstract
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Jori, G., "Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy", Journal of Photochemistry and photobiology B: Biology, vol. 36, issue 2: Elsevier, pp. 87-93, 1996. Abstract
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Jori, G., and J. D. Spikes, "Photobiochemistry of porphyrins", Topics in photomedicine: Plenum Press New York, pp. 183-318, 1984. Abstract
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Jorssen, E. P., A. Langbeen, W. F. Marei, E. Fransen, H. F. De porte, J. L. Leroy, and P. E. Bols, "Morphologic characterization of isolated bovine early preantral follicles during short-term individual in vitro culture", Theriogenology, vol. 84, no. 2, pp. 301-11, Jul 15, 2015. AbstractWebsite

To provide new insights in the molecular mechanism controlling preantral follicular development and to unravel the needs to support in vitro follicular development of early-stage preantral follicles (PAFs), there is a need for alternative in vitro bovine follicle culture methods. In this study, we aimed to characterize follicular dynamics using an IVC system of isolated and individually cultured bovine early PAFs during 10 days to generate individual follicle follow-up data. Preantral follicles (<50 mum) were isolated from slaughterhouse ovaries and cultured individually for 10 days. Individual follicle morphology, growth, survival, quality, and cell proliferation were evaluated in time by combining noninvasive and invasive assessment methods. The PAFs were light microscopically evaluated during culture to assess follicular dynamics, stained with neutral red to determine follicle viability, stained with 4',6-diamidino-2-phenylindole and terminal deoxynucleotidyl transferase dUTP nick end labeling to evaluate cell proliferation and follicle quality, and processed for histologic evaluation to assess follicle morphology. On the basis of their morphology, follicles were subdivided in three categories, with category 1 follicles showing the best morphologic features. On Day 0, only category 1 follicles were selected, but follicle categories were reassigned on evaluation Days 1, 2, 4, 7, or 10. Although 67% of the follicles survived 10 days of IVC, the number of follicles exhibiting a normal morphology decreased significantly from Day 7 onward and the apoptotic index increased significantly from Day 10. Both category 1 and 2 follicles showed a significant increase in follicular diameter (Day 10: 21.80 +/- 0.86 and 11.82 +/- 0.80, respectively). This increase in follicular diameter showed to be correlated with an increase in the total cell number. In conclusion, this culture system showed to support follicular development until Day 10, although the proportion of follicles showing normal morphologic features and the follicular quality decreased after 10 days of IVC. Follicles maintaining their category 1 morphologic features over time seem to be of a better quality and show a higher developmental competence as compared to category 2 and 3 follicles.

Jorssen, E. P., A. Langbeen, W. F. Marei, E. Fransen, H. F. De porte, J. L. Leroy, and P. E. Bols, "Morphologic characterization of isolated bovine early preantral follicles during short-term individual in vitro culture", Theriogenology, 2015/04/22, vol. 84, no. 2, pp. 301-11, Jul 15, 2015. AbstractWebsite

To provide new insights in the molecular mechanism controlling preantral follicular development and to unravel the needs to support in vitro follicular development of early-stage preantral follicles (PAFs), there is a need for alternative in vitro bovine follicle culture methods. In this study, we aimed to characterize follicular dynamics using an IVC system of isolated and individually cultured bovine early PAFs during 10 days to generate individual follicle follow-up data. Preantral follicles (<50 mum) were isolated from slaughterhouse ovaries and cultured individually for 10 days. Individual follicle morphology, growth, survival, quality, and cell proliferation were evaluated in time by combining noninvasive and invasive assessment methods. The PAFs were light microscopically evaluated during culture to assess follicular dynamics, stained with neutral red to determine follicle viability, stained with 4',6-diamidino-2-phenylindole and terminal deoxynucleotidyl transferase dUTP nick end labeling to evaluate cell proliferation and follicle quality, and processed for histologic evaluation to assess follicle morphology. On the basis of their morphology, follicles were subdivided in three categories, with category 1 follicles showing the best morphologic features. On Day 0, only category 1 follicles were selected, but follicle categories were reassigned on evaluation Days 1, 2, 4, 7, or 10. Although 67% of the follicles survived 10 days of IVC, the number of follicles exhibiting a normal morphology decreased significantly from Day 7 onward and the apoptotic index increased significantly from Day 10. Both category 1 and 2 follicles showed a significant increase in follicular diameter (Day 10: 21.80 +/- 0.86 and 11.82 +/- 0.80, respectively). This increase in follicular diameter showed to be correlated with an increase in the total cell number. In conclusion, this culture system showed to support follicular development until Day 10, although the proportion of follicles showing normal morphologic features and the follicular quality decreased after 10 days of IVC. Follicles maintaining their category 1 morphologic features over time seem to be of a better quality and show a higher developmental competence as compared to category 2 and 3 follicles.

Joseph Naguib, M., A. Moustafa Kamel, A. Thabet Negmeldin, A. H. Elshafeey, and I. Elsayed, "Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency", Drug Delivery, vol. 27, no. 1, pp. 996-1009, 2020. AbstractWebsite
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Joshi, L. R., A. Tiwari, S. P. Devkota, S. Khatiwada, S. Paudyal, and K. R. Pande, International Journal of Veterinary Science, , 2014. Abstract
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