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2021
Cuahutenango-Barro, B., M. A. Taneco-Hernández, Y. - P. Lv, J. F. Gómez-Aguilar, M. S. Osman, H. Jahanshahi, and A. A. Aly, "Analytical solutions of fractional wave equation with memory effect using the fractional derivative with exponential kernel", Results in Physics, vol. 25: Elsevier, pp. 104148, 2021. Abstract
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M.T., K., M. S. Uddin, P. Jeandet, T. B. Emran, S. Mitra, G. M. Albadrani, A. A. SAYED, and M. M. Abdel-Daim, Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential, , 2021.
Al-Surhanee, A. A., M. Afzal, N. A. Bouqellah, S. A. Ouf, S. Muhammad, M. Jan, S. Kaleem, M. Hashem, S. Alamri, A. A. H. A. Latef, et al., "The Antifungal Activity of Ag/CHI NPs against Rhizoctonia solani Linked with Tomato Plant Health", Plants, vol. 10, no. 11, 2021. AbstractWebsite

Pathogenic infestations are significant threats to vegetable yield, and have become an urgent problem to be solved. Rhizoctonia solani is one of the worst fungi affecting tomato crops, reducing yield in some regions. It is a known fact that plants have their own defense against such infestations; however, it is unclear whether any exogenous material can help plants against infestation. Therefore, we performed greenhouse experiments to evaluate the impacts of R. solani on 15- and 30-day old tomato plants after fungal infestation, and estimated the antifungal activity of nanoparticles (NPs) against the pathogen. We observed severe pathogenic impacts on the above-ground tissues of tomato plants which would affect plant physiology and crop production. Pathogenic infection reduced total chlorophyll and anthocyanin contents, which subsequently disturbed plant physiology. Further, total phenolic contents (TPC), total flavonoid contents (TFC), and malondialdehyde (MDA) contents were significantly increased in pathogen treatments. Constitutively, enhanced activities were estimated for catalase (CAT), superoxide dismutase (SOD), and ascorbate peroxidase (APX) in response to reactive oxygen species (ROS)in pathogen-treated plants. Moreover, pathogenesis-related genes, namely, chitinase, plant glutathione S-transferase (GST), phenylalanine ammonia-lyase (PAL1), pathogenesis-related protein (PR12), and pathogenesis-related protein (PR1) were evaluated, with significant differences between treated and control plants. In vitro and greenhouse antifungal activity of silver nanoparticles (Ag NPs), chitosan nanoparticles, and Ag NPs/CHI NPs composites and plant health was studied using transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectrophotometry. We found astonishing results, namely, that Ag and CHI have antifungal activities against R. solani. Overall, plant health was much improved following treatment with Ag NPs/CHI NPs composites. In order to manage R. solani pathogenicity and improve tomato health, Ag/CHI NPs composites could be used infield as well as on commercial levels based on recommendations. However, there is an urgent need to first evaluate whether these NP composites have any secondary impacts on human health or the environment.

Grace, S. R., H. Adıgüzel, J. Alzabut, and J. M. Jonnalagadda, "Asymptotic Behavior of Positive Solutions for Three Types of Fractional Difference Equations with Forcing Term", Vietnam Journal of Mathematics, vol. 49, issue 4: Springer, pp. 1151-1164, 2021. Abstract
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Stuart, D., M. Sandström, H. M. Youssef, S. Zakhrabekova, P. E. Jensen, D. Bollivar, and M. Hansson, "Barley Viridis-k links an evolutionarily conserved C-type ferredoxin to chlorophyll biosynthesis", The Plant Cell, 2021.
Bantan, R., A. S. Hassan, E. Almetwally, M. Elgarhy, F. A. R. R. U. K. H. JAMAL, C. H. R. I. S. T. O. P. H. E. CHESNEAU, and M. ELSEHETRY, Bayesian Analysis in Partially Accelerated Life Tests for Weighted Lomax Distribution, , 2021.
Taranta, A., M. A. Elmonem, F. Bellomo, E. D. Leo, S. Boenzi, M. J. Janssen, A. Jamalpoor, S. Cairoli, A. Pastore, C. De Stefanis, et al., "Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis.", Cells, vol. 10, issue 12, 2021. Abstract

Nephropathic cystinosis is a rare disease caused by mutations of the CTNS gene that encodes for cystinosin, a lysosomal cystine/H+ symporter. The disease is characterized by early-onset chronic kidney failure and progressive development of extra-renal complications related to cystine accumulation in all tissues. At the cellular level, several alterations have been demonstrated, including enhanced apoptosis, altered autophagy, defective intracellular trafficking, and cell oxidation, among others. Current therapy with cysteamine only partially reverts some of these changes, highlighting the need to develop additional treatments. Among compounds that were identified in a previous drug-repositioning study, disulfiram (DSF) was selected for in vivo studies. The cystine depleting and anti-apoptotic properties of DSF were confirmed by secondary in vitro assays and after treating mice with 200 mg/kg/day of DSF for 3 months. However, at this dosage, growth impairment was observed. Long-term treatment with a lower dose (100 mg/kg/day) did not inhibit growth, but failed to reduce cystine accumulation, caused premature death, and did not prevent the development of renal lesions. In addition, DSF also caused adverse effects in cystinotic zebrafish larvae. DSF toxicity was significantly more pronounced in mice and zebrafish compared to wild-type animals, suggesting higher cell toxicity of DSF in cystinotic cells.

teaima, M., M. A. Elnabarawi, M. A. M. Hamid, N. A. Shoman, B. R. Jasti, and M. Yasser, "BINGE EATING DISORDERS; UPDATED AND EMERGING APPROACHES", International Journal of Applied Pharmaceutics, vol. 13, issue 2, 2021. 2021-binge_eating_disorders_updated_and_emerging_approaches.pdf
Abusanad, A., A. Bensalem, E. Shash, L. Mula-Hussain, Z. Benbrahim, S. Khatib, N. Abdelhafiz, J. Ansari, H. Jradi, K. Alkattan, et al., "Burnout in oncology: Magnitude, risk factors and screening among professionals from Middle East and North Africa (BOMENA study).", Psycho-oncology, 2021. Abstract

BACKGROUND: Burnout (BO) among oncology professionals (OP) is increasingly being recognized. Early recognition and intervention can positively affect the quality of care and patient safety. This study investigated the prevalence, work and lifestyle factors affecting BO among OPs in the Middle East and North Africa (MENA).

METHODS: An online survey was conducted among MENA OPs between 10 February and 15 March 2020, using the validated Maslach Burnout Inventory of emotional exhaustion (EE), depersonalization (DP) and personal accomplishment (PA), including questions regarding demography/work-related factors and attitudes towards oncology. Data were analysed to measure BO prevalence and risk factors and explore a screening question for BO.

RESULTS: Of 1054 respondents, 1017 participants (64% medical oncologists, 77% aged less than 45 years, 55% female, 74% married, 67% with children and 40% practiced a hobby) were eligible. The BO prevalence was 68% with high levels of EE and DP (35% and 57% of participants, respectively) and low PA scores (49%). BO was significantly associated with age less than 44 years, administrative work greater than 25% per day and the thought of quitting oncology (TQ). Practising a hobby, enjoying oncology communication and appreciating oncology work-life balance were associated with a reduced BO score and prevalence. North African countries reported the highest BO prevalence. Lack of BO education/support was identified among 72% of participants and TQ-predicted burnout in 77%.

CONCLUSIONS: This is the largest BO study in MENA. The BO prevalence was high and several modifiable risk factors were identified, requiring urgent action. TQ is a simple and reliable screening tool for BO.

GaserAbdelmohsen, J. Al-Ata, N. Alkhushi, S. Bahaidarah, H. Baho, M. Abdelsalam, S. Bekheet, W. Ba-Atiyah, A. Alghamdi, A. Fawzy, et al., "Cardiac Catheterization During Extracorporeal Membrane Oxygenation After Congenital Cardiac Surgery: A Multi-Center Retrospective Study.", Pediatric cardiology, 2021. Abstract

Cardiac catheterization can affect clinical outcomes in patients on extracorporeal membrane oxygenation (ECMO) after congenital heart surgery; however, its effect in this group of patients remains unclear. This study aimed to evaluate the safety and outcome of cardiac catheterization in patients undergoing ECMO after congenital cardiac surgery and determine predictors that influence successful weaning. This retrospective cohort study included pediatric patients who underwent cardiac catheterization while on ECMO after congenital heart surgery in two cardiac centers between November 2012 and February 2020. Predictors of successful weaning from ECMO were studied using univariate and multivariate logistic regression analyses. Of 123 patients on ECMO support after congenital cardiac surgery, 60 patients underwent 60 cardiac catheterizations (31 diagnostic and 29 interventional). Thirty-four (56.7%) and 22 patients (36.7%) underwent successful decannulation from ECMO support and survived after hospital discharge, respectively. Patients who underwent earlier catheterization (within 24 h of ECMO initiation) had more successful weaning from ECMO and survival compared to others. Patients who underwent an interventional procedure (interventional catheterization or redo cardiac surgery after cardiac catheterization) had better survival than those who underwent only diagnostic catheterization (P = 0.038). Shorter durations of ECMO was the most important predictor of successful weaning from ECMO. Early cardiac catheterization greatly impacts successful weaning from ECMO and survival. Patients with correctable lesions amenable either by catheterization or redo surgery are more likely to survive. Shorter durations of ECMO could have a significant influence on successful weaning from ECMO and survival.

Roel, E., A. Pistillo, M. Recalde, A. G. Sena, S. Fernández-Bertolín, M. Aragón, D. Puente, W. - U. - R. Ahmed, H. Alghoul, O. Alser, et al., "Characteristics and Outcomes of Over 300,000 Patients with COVID-19 and History of Cancer in the United States and Spain.", Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 30, issue 10, pp. 1884-1894, 2021. Abstract

BACKGROUND: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and coronavirus disease 2019 (COVID-19). Second, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza.

METHODS: We conducted a cohort study using eight routinely collected health care databases from Spain and the United States, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: (i) diagnosed with COVID-19, (ii) hospitalized with COVID-19, and (iii) hospitalized with influenza in 2017 to 2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes.

RESULTS: We included 366,050 and 119,597 patients diagnosed and hospitalized with COVID-19, respectively. Prostate and breast cancers were the most frequent cancers (range: 5%-18% and 1%-14% in the diagnosed cohort, respectively). Hematologic malignancies were also frequent, with non-Hodgkin's lymphoma being among the five most common cancer subtypes in the diagnosed cohort. Overall, patients were aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 2% to 14% and from 6% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza ( = 67,743) had a similar distribution of cancer subtypes, sex, age, and comorbidities but lower occurrence of adverse events.

CONCLUSIONS: Patients with a history of cancer and COVID-19 had multiple comorbidities and a high occurrence of COVID-19-related events. Hematologic malignancies were frequent.

IMPACT: This study provides epidemiologic characteristics that can inform clinical care and etiologic studies.

Adnan Awad, S., D. Kim, H. Hohtari, K. K. Javarappa, T. Brandstoetter, I. Mayer, S. Potdar, C. A. Heckman, S. Kytölä, K. Porkka, et al., "Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets", Leukemia, vol. 35, no. 4: Nature Publishing Group, pp. 1964–1975, 2021. Abstract

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Elmahrouk, A. F., M. F. Ismail, A. A. Arafat, A. M. Dohain, A. M. Edrees, A. A. Jamjoom, and O. O. Al-Radi, "Combined Norwood and Cavopulmonary Shunt as the first palliation in Late Presenters with Hypoplastic Left Heart Syndrome and Single Ventricle Lesions", The Journal of Thoracic and Cardiovascular Surgery, 2021.
Reslan, M. R., E. Osman, L. Segaan, M. Rayyan, C. Joukhadar, and M. Fattouh, "Comparison between Integrated and Parallel Interlock Designs of an Extracoronal Attachment-retained Distal Extension Removable Partial Dentures: A Clinical Trial", Journal of International Society of Preventive and Community Dentistry, vol. 11, issue 1, pp. 41-49, 2021.
Bakry, I. A., L. Yang, M. A. Farag, S. A. Korma, I. Khalifa, I. Cacciotti, N. I. Ziedan, J. Jin, Q. Jin, W. Wei, et al., "A Comprehensive Review of the Composition, Nutritional Value, and Functional Properties of Camel Milk Fat.", Foods (Basel, Switzerland), vol. 10, issue 9, 2021. Abstract

Recently, camel milk (CM) has been considered as a health-promoting icon due to its medicinal and nutritional benefits. CM fat globule membrane has numerous health-promoting properties, such as anti-adhesion and anti-bacterial properties, which are suitable for people who are allergic to cow's milk. CM contains milk fat globules with a small size, which accounts for their rapid digestion. Moreover, it also comprises lower amounts of cholesterol and saturated fatty acids concurrent with higher levels of essential fatty acids than cow milk, with an improved lipid profile manifested by reducing cholesterol levels in the blood. In addition, it is rich in phospholipids, especially plasmalogens and sphingomyelin, suggesting that CM fat may meet the daily nutritional requirements of adults and infants. Thus, CM and its dairy products have become more attractive for consumers. In view of this, we performed a comprehensive review of CM fat's composition and nutritional properties. The overall goal is to increase knowledge related to CM fat characteristics and modify its unfavorable perception. Future studies are expected to be directed toward a better understanding of CM fat, which appears to be promising in the design and formulation of new products with significant health-promoting benefits.

Zaky, A., G. Saxena, and C. Jayawardhena, "Conceptualising the role of marketing strategies of tourism providers in inducing risk-taking behaviour", International Journal of Tourism Research, vol. 23, issue 5, pp. 942-957, 2021.
Gurland, B. H., G. Khatri, R. Ram, T. L. Hull, E. Kocjancic, L. H. Quiroz, R. F. El Sayed, K. R. Jambhekar, V. Chernyak, R. M. Paspulati, et al., "Consensus definitions and interpretation templates for magnetic resonance imaging of Defecatory pelvic floor disorders : Proceedings of the consensus meeting of the pelvic floor disorders consortium of the American Society of Colon and Rectal Surgeons,", International urogynecology journal, vol. 32, issue 10, pp. 2561-2574, 2021.
Gurland, B. H., G. Khatri, R. Ram, T. L. Hull, E. Kocjancic, L. H. Quiroz, R. F. El Sayed, K. R. Jambhekar, V. Chernyak, R. M. Paspulati, et al., "Consensus Definitions and Interpretation Templates for Magnetic Resonance Imaging of Defecatory Pelvic Floor Disorders: Proceedings of the Consensus Meeting of the Pelvic Floor Disorders Consortium of the American Society of Colon and Rectal Surgeons", Female pelvic medicine & reconstructive surgery, vol. 27, issue 10, pp. e645-e656, 2021.
Gurland, B. H., G. Khatri, R. Ram, T. L. Hull, E. Kocjancic, L. H. Quiroz, R. E. F. Sayed, K. R. Jambhekar, V. Chernyak, R. M. Paspulati, et al., "Consensus Definitions and Interpretation Templates for Magnetic Resonance Imaging of Defecatory Pelvic Floor Disorders: Proceedings of the Consensus Meeting of the Pelvic Floor Disorders Consortium of the American Society of Colon and Rectal Surgeons,.", AJR. American journal of roentgenology, vol. 217, issue 4, pp. 800-812, 2021. Abstract

The Pelvic Floor Disorders Consortium (PFDC) is a multidisciplinary organization of colorectal surgeons, urogynecologists, urologists, gynecologists, gastroenterologists, radiologists, physiotherapists, and other advanced care practitioners. Specialists from these fields are all dedicated to the diagnosis and management of patients with pelvic floor conditions, but they approach, evaluate, and treat such patients with their own unique perspectives given the differences in their respective training. The PFDC was formed to bridge gaps and enable collaboration between these specialties. The goal of the PFDC is to develop and evaluate educational programs, create clinical guidelines and algorithms, and promote high quality of care in this unique patient population. The recommendations included in this article represent the work of the PFDC Working Group on Magnetic Resonance Imaging of Pelvic Floor Disorders (members listed alphabetically in Table 1). The objective was to generate inclusive, rather than prescriptive, guidance for all practitioners, irrespective of discipline, involved in the evaluation and treatment of patients with pelvic floor disorders.

Gurland, B. H., G. Khatri, R. Ram, T. L. Hull, E. Kocjancic, L. H. Quiroz, R. F. El Sayed, K. R. Jambhekar, V. Chernyak, R. M. Paspulati, et al., "Consensus Definitions and Interpretation Templates for Magnetic Resonance Imaging of Defecatory Pelvic Floor Disorders: Proceedings of the Consensus Meeting of the Pelvic Floor Disorders Consortium of the American Society of Colon and Rectal Surgeons.", Diseases of the colon and rectum, vol. 64, issue 10, pp. 1184-1197, 2021.
Tan, E. H., A. G. Sena, A. Prats-Uribe, S. C. You, W. - U. - R. Ahmed, K. Kostka, C. Reich, S. L. DuVall, K. E. Lynch, M. E. Matheny, et al., "COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.", Rheumatology (Oxford, England), vol. 60, issue SI, pp. SI37-SI50, 2021. Abstract

OBJECTIVE: Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.

METHODS: A multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30 days of hospitalization.

RESULTS: We studied 133 589 patients diagnosed and 48 418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged ≥50 years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70 660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%).

CONCLUSION: Compared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.

Jalal, D., M. G. Elzayat, A. A. Diab, H. E. El-Shqanqery, O. Samir, U. Bakry, R. Hassan, M. El anany, L. Shalaby, and A. A. Sayed, "Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt", mSphere, vol. 6, issue 6: American Society for Microbiology (ASM), 2021. Abstract
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Ballesté, C., R. Valero, M. Istrate, P. Peralta, A. A. Mosharafa, A. A. Morsy, M. A. Bakr, A. I. Kamal Abdelkader, H. Sheashaa, G. S. Juvelekian, et al., "Design and implementation of the European-Mediterranean Postgraduate Programme on Organ Donation and Transplantation (EMPODaT) for Middle East/North Africa countries.", Transplant international : official journal of the European Society for Organ Transplantation, 2021. Abstract

This prospective study reports the design and results obtained after the EMPODaT project implementation. This project was funded by the Tempus programme of the European Commission with the objective to implement a common postgraduate programme on organ donation and transplantation (ODT) in six selected universities from Middle East/North Africa (MENA) countries (Egypt, Lebanon and Morocco). The consortium, coordinated by the University of Barcelona, included universities from Spain, Germany, Sweden and France. The first phase of the project was to perform an analysis of the current situation in the beneficiary countries, including existing training programmes on ODT, Internet connection, digital facilities and competences, training needs, and ODT activity and accreditation requirements. A total of 90 healthcare postgraduate students participated in the 1-year training programme (30 ECTS academic credits). The methodology was based on e-learning modules and face-to-face courses in English and French. Training activities were evaluated through pre- and post-tests, self-assessment activities and evaluation charts. Quality was assessed through questionnaires and semi-structured interviews. The project results on a reproducible and innovative international postgraduate programme, improvement of knowledge, satisfaction of the participants and confirms the need on professionalizing the activity as the cornerstone to ensure organ transplantation self-sufficiency in MENA countries.

Polychronopoulou, K., A. A. AlKhoori, A. M. Efstathiou, M. A. Jaoude, C. M. Damaskinos, M. A. Baker, A. Almutawa, D. H. Anjum, M. A. Vasiliades, A. Belabbes, et al., "Design aspects of doped CeO2 for low-temperature catalytic CO oxidation: transient kinetics and DFT approach", ACS applied materials & interfaces, vol. 13, no. 19: American Chemical Society, pp. 22391–22415, 2021. Abstract
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