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Galal, A., H. K. Hassan, N. F. Atta, A. M. Abdel-Mageed, and T. Jacob, "Synthesis, structural and morphological characterizations of nano-Ru-based perovskites/RGO composites", Scientific reports, vol. 9, issue 7948, pp. 1-13, 2019.
Galal, A., H. K. Hassan, N. F. Atta, A. M. Abdel-Mageed, and T. Jacob, "Synthesis, structural and morphological characterizations of nano-Ru-based perovskites/RGO composites", Scientific Reports, vol. 9, pp. 7948, 2019.
Galal, A., H. K. Hassan, N. F. Atta, A. M. Abdel-Mageed, and T. Jacob, "Synthesis, structural and morphological characterizations of nano-Ru-based perovskites/RGO composites", Scientific reports, vol. 9, issue 1: Nature Publishing Group, pp. 1-13, 2019. Abstract
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Abdelrazek, F. M., N. H. Metwally, N. A. Kassab, N. A. Sobhy, P. Metz, and A. Jaeger, "Synthesis of some novel polyaza fused heterocyclic compounds. ", J. Heterocyclic Chem., vol. 47, issue ---, pp. 384-388, 2010.
Abdelrazek, F. M., N. H. Metwally, N. A. Kassab, N. A. Sobhy, P. Metz, and A. Jaeger, "Synthesis of Some Novel Polyaza Fused Heterocyclic Compounds.", ChemInform, vol. 41, no. 34: Wiley Online Library, pp. i, 2010. Abstract
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Dawood, D. H., R. S. Jasass, M. M. Amin, T. A. Farghaly, and E. M. H. and Abbas, "Synthesis of some new azoloazines with potent Anti-inflammatory and analgesic activity", Journal of Heterocyclic Chemistry , pp. 1578-1589, 2017.
Khalil, K. D., S. M. Riyadh, M. Jaremko, T. A. Farghaly, and M. Hagar, "Synthesis of Chitosan-La2O3 Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles", Molecules, 2021.
Khalil, K. D., S. M. Riyadh, M. Jaremko, T. A. Farghaly, and M. Hagar, "Synthesis of Chitosan-La2O3 Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles", Molecules, vol. 26, pp. 3689-3699, 2021.
Khalil, K. D., S. M. Riyadh, M. Jaremko, T. A. Farghaly, and M. Hagar, "Synthesis of Chitosan-La2O3 Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles", Molecules, vol. 26, pp. 3689, 2021.
El Gaafary, M., A. M. Fouda, H. M. Mohamed, A. Hamed, H. K. A. El-Mawgoud, L. Jin, J. Ulrich, T. Simmet, T. Syrovets, and A. M. El-Agrody, "Synthesis of $\beta$-Enaminonitrile-Linked 8-Methoxy-1H-Benzo [f] Chromene Moieties and Analysis of Their Antitumor Mechanisms", Frontiers in chemistry, vol. 9: Frontiers Media SA, 2021. Abstract
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Abdelrazek, F. M., P. Metz, O. Kataeva, A. Jaeger, and S. F. El-Mahrouky, "Synthesis and molluscicidal activity of some new chromene, pyrano[2,3-c]pyrazole derivatives. ", Arch. Pharm. Chem. Life Sciences (Weinheim), vol. 340, issue 10, pp. 543-548., 2007.
Shawali, A. S., S. M. Sherif, E. L. - M. M. M., and D. M. A. A. J., "Synthesis and atntiumor screening of new 3-(J,3-disubstituted-IH-pyrazole-4-carbonyl)-1,7-diphenyl[l,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones", Heterocycl. Chem. , 2008.
Patrick, D. A., M. A. Ismail, R. K. Arafa, T. Wenzler, X. Zhu, T. Pandharkar, S. K. Jones, K. A. Werbovetz, R. Brun, D. W. Boykin, et al., "Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.", Journal of medicinal chemistry, vol. 56, issue 13, pp. 5473-94, 2013 Jul 11. Abstract

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. rhodesiense, and dimethyltetrahydropyrimidinyl analogues 4 and 9 with IC50 values of ≤ 3 nM against P. falciparum. Bis-pyridylimidamide derivative 31 was 25 times more potent than benznidazole against T. cruzi and slightly more potent than amphotericin B against L. amazonensis. Terphenyldiamidine 1 and dipyridylbenzene analogues 23 and 25 each cured 4/4 mice infected with T. b. rhodesiense STIB900 with four daily 5 mg/kg intraperitoneal doses, as well as with single doses of ≤ 10 mg/kg. Derivatives 5 and 28 (prodrugs of 1 and 25) each cured 3/4 mice with four daily 25 mg/kg oral doses.

Metwally, N. H., F. M. Abdelrazek, and M. T. Jaafer, "Synthesis and antimicrobial activity of some novel bis-pyridones, pyrazoles and thiazole derivatives", J. Heterocyclic Chem., vol. 52, issue 2, pp. 358-365, 2015.
Tyo, K. M., A. B. Lasnik, L. Zhang, M. Mahmoud, A. B. Jenson, J. L. Fuqua, K. E. Palmer, and J. M. Steinbach-Rankins, "Sustained-release Griffithsin nanoparticle-fiber composites against HIV-1 and HSV-2 infections.", Journal of controlled release : official journal of the Controlled Release Society, vol. 321, pp. 84-99, 2020. Abstract

Human immunodeficiency virus (HIV-1) and herpes simplex virus 2 (HSV-2) affect hundreds of millions of people worldwide. The antiviral lectin, Griffithsin (GRFT), has been shown to be both safe and efficacious against HSV-2 and HIV-1 infections in vivo. The goal of this work was to develop a multilayered nanoparticle (NP)-electrospun fiber (EF) composite to provide sustained-release of GRFT, and to examine its safety and efficacy in a murine model of lethal HSV-2 infection. Composites were fabricated from polycaprolactone (PCL) fibers surrounding polyethylene oxide (PEO) fibers that incorporated methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (mPEG-PLGA) GRFT NPs. GRFT loading and release were determined via ELISA, showing that NP-EF composites achieved high GRFT loading, and provided sustained-release of GRFT for up to 90 d. The in vitro efficacy of GRFT NP-EFs was assessed using HIV-1 pseudovirus assays, demonstrating complete in vitro protection against HIV-1 infection. Additionally, sustained-release NP-EFs, administered 24 h prior to infection, prevented against a lethal dose of HSV-2 infection in a murine model. In parallel, histology and cytokine expression from murine reproductive tracts and vaginal lavages collected 24 and 72 h post-administration were similar to untreated mice, suggesting that NP-EF composites may be a promising and safe sustained-delivery platform to prevent HSV-2 infection. Future work will evaluate the ability to provide prolonged protection against multiple virus challenges, and different administration times with respect to infection.

Mohr, B., O. J, Souilem, A. B. M. Abdussamad, Abelouafi;Bugnon, C. Phillippe, S. Fahmy, T. R;Fourie, and K.; Gaafar, "Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward", Laboratory Animals,, vol. 57, issue 2, pp. 136–148, 2023.
Mohr, B., O. J, Souilem, A. B. M. Abdussamad, Abelouafi;Bugnon, C. Phillippe, S. Fahmy, T. R;Fourie, and K.; Gaafar, "Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward", Laboratory Animals,, vol. 57, issue 2, pp. 136–148, 2023.
Alzabut, J., R. P. Agarwal, S. R. Grace, J. M. Jonnalagadda, G. M. A. Selvam, and C. Wang, "A Survey on the Oscillation of Solutions for Fractional Difference Equations", Mathematics, vol. 10, issue 6: MDPI, pp. 894, 2022. Abstract
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Herz, A., S. A. Hassan, E. Hegazi, B. Hafez, F. Nasr, A. Youssef, E. Agamy, T. Jardak, M. Ksantini, and T. Broumas, Survey of native Trichogramma-species in the olive grove ecosystem., : DGaaE-meeting, German Society for General and Applied Entomology, 2005. Abstract
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Herz, A., S. A. Hassan, E. Hegazi, B. Hafez, F. Nasr, A. Youssef, E. A. Agamy, T. Jardak, M. Ksantini, and M. Konstantopoulou, "Survey of native Trichogramma species in the olive grove ecosystem.", DgaaE-Tagung, Dresden, 23-26 March, Germany, 2005. Abstract
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Ansari, W. K., M. S. Parvej, M. E. El Zowalaty, S. Jackson, S. A. Bustin, A. K. Ibrahim, A. E. El Zowalaty, M. T. Rahman, H. Zhang, M. F. R. Khan, et al., "Surveillance, epidemiological, and virological detection of highly pathogenic H5N1 avian influenza viruses in duck and poultry from Bangladesh.", Veterinary microbiology, vol. 193, pp. 49-59, 2016. Abstract

Avian influenza viruses (AIVs) continue to pose a global threat. Waterfowl are the main reservoir and are responsible for the spillover of AIVs to other hosts. This study was conducted as part of routine surveillance activities in Bangladesh and it reports on the serological and molecular detection of H5N1 AIV subtype. A total of 2169 cloacal and 2191 oropharyngeal swabs as well as 1725 sera samples were collected from live birds including duck and chicken in different locations in Bangladesh between the years of 2013 and 2014. Samples were tested using virus isolation, serological tests and molecular methods of RT-PCR. Influenza A viruses were detected using reverse transcription PCR targeting the virus matrix (M) gene in 41/4360 (0.94%) samples including both cloacal and oropharyngeal swab samples, 31 of which were subtyped as H5N1 using subtype-specific primers. Twenty-one live H5N1 virus isolates were recovered from those 31 samples. Screening of 1,868 blood samples collected from the same birds using H5-specific ELISA identified 545/1603 (34%) positive samples. Disconcertingly, an analysis of 221 serum samples collected from vaccinated layer chicken in four districts revealed that only 18 samples (8.1%) were seropositive for anti H5 antibodies, compared to unvaccinated birds (n=105), where 8 samples (7.6%) were seropositive. Our result indicates that the vaccination program as currently implemented should be reviewed and updated. In addition, surveillance programs are crucial for monitoring the efficacy of the current poultry vaccinations programs, and to monitor the circulating AIV strains and emergence of AIV subtypes in Bangladesh.

Bhangu, A., A. O. Ademuyiwa, M. L. Aguilera, P. Alexander, S. W. Al-Saqqa, G. Borda-Luque, A. Costas-Chavarri, T. M. Drake, F. Ntirenganya, E. J. Fitzgerald, et al., "Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study", The Lancet Infectious DiseasesThe Lancet Infectious Diseases, vol. 18, issue 5: Elsevier, pp. 516 - 525, 2018. AbstractWebsite

BackgroundSurgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.BackgroundSurgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.

Collaborative, G. S., "Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study", BMJ Global Health, vol. 5, no. 12: BMJ Specialist Journals, 2020. AbstractWebsite

Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).Results Of 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.

Alamri, R. M., A. M. Dohain, A. A. Arafat, A. F. Elmahrouk, A. H. Ghunaim, A. A. Elassal, A. A. Jamjoom, and O. O. Al-Radi, "Surgical repair for persistent truncus arteriosus in neonates and older children.", Journal of cardiothoracic surgery, vol. 15, issue 1, pp. 83, 2020. Abstracttruncus_artriosus.pdf

OBJECTIVES: Persistent truncus arteriosus represents less than 3% of all congenital heart defects. We aim to analyze mid-term outcomes after primary Truncus arteriosus repair at different ages and to identify the risk factors contributing to mortality and the need for intervention after surgical repair.

METHODS: This retrospective cohort study included 36 children, underwent repair of Truncus arteriosus in the period from January 2011 to December 2018 in two institutions. We recorded the clinical and echocardiographic data for the patients preoperatively, early postoperative, 6 months postoperative, then every year until their last documented follow-up appointment.

RESULTS: Thirty-six patients had truncus arteriosus repair during the study period. Thirty-one patients had open sternum post-repair, and two patients required extracorporeal membrane oxygenation. Bleeding occurred in 15 patients (41.67%), and operative mortality occurred in 5 patients (14.7%). Patients with truncus arteriosus type 2 (p = 0.008) and 3 (p = 0.001) and who were ventilated preoperatively (p < 0.001) had a longer hospital stay. Surgical re-intervention was required in 8 patients (22.86%), and 11 patients (30.56%) had catheter-based reintervention. Freedom from reintervention was 86% at 1 year, 75% at 2 years and 65% at 3 years. Survival at 1 year was 81% and at 3 years was 76%. High postoperative inotropic score predicted mortality (p = 0.013).

CONCLUSION: Repair of the truncus arteriosus can be performed safely with low morbidity and mortality, both in neonates, infants, and older children. Re-intervention is common, preferably through a transcatheter approach.

Elassal, A. A., O. O. Al-Radi, H. H. Jabbad, Z. F. Zaher, M. H. Abdelsalam, A. M. Dohain, G. A. Abdelmohsen, and K. E. Al-Ebrahim, "Surgery for Pericardial Syndromes in Adults and Children: Clarification of Questionable Aspects", World Journal of Cardiovascular Surgery, vol. 10, issue 11, pp. 213-225, 2020. surgery_for_pericardial_syndromes.pdf