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2022
Helal, M., M. A. Ali, A. H. Nadrin, Y. I. Awad, N. K. Younis, B. M. Alasyed, M. Jamal, D. H. Eid, H. A. Soliman, S. A. Eissa, et al., "Association between IRS-1, PPAR-$\gamma$ and LEP genes polymorphisms and growth traits in rabbits", Animal Biotechnology: Taylor & Francis, pp. 1–9, 2022. Abstract
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Jacob, R. H., A. S. Afify, S. M. M. Shanab, E. A. Shalaby, and R. M. Hafez, "Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate", Biomass Conversion and Biorefinery, vol. 7, pp. 1-23, 2022. s13399-022-03473-2.pdf
Jacob, R. H., A. S. Afify, S. M. M. Shanab, E. A. Shalaby, and R. M. Hafez, "Biotechnological studies on Arthrospira platensis biomass cultivated in enriched culture with chelated leather waste and chelated glycinate", Biomass Conversion and Biorefinery, vol. 7, pp. 1-23, 2022. s13399-022-03473-2.pdf
Biancari, F., A. Kaserer, A. Perrotti, V. G. Ruggieri, S. - M. Cho, J. K. Kang, M. Dalén, H. Welp, K. Jónsson, S. Ragnarsson, et al., "Central versus Peripheral Postcardiotomy Veno-Arterial Extracorporeal Membrane Oxygenation: Systematic Review and Individual Patient Data Meta-Analysis.", Journal of clinical medicine, vol. 11, issue 24, 2022. Abstractjcm-11-07406.pdf

BACKGROUND: It is unclear whether peripheral arterial cannulation is superior to central arterial cannulation for postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

METHODS: A systematic review was conducted using PubMed, Scopus, and Google Scholar to identify studies on postcardiotomy VA-ECMO for the present individual patient data (IPD) meta-analysis. Analysis was performed according to the intention-to-treat principle.

RESULTS: The investigators of 10 studies agreed to participate in the present IPD meta-analysis. Overall, 1269 patients were included in the analysis. Crude rates of in-hospital mortality after central versus peripheral arterial cannulation for VA-ECMO were 70.7% vs. 63.7%, respectively (adjusted OR 1.38, 95% CI 1.08-1.75). Propensity score matching yielded 538 pairs of patients with balanced baseline characteristics and operative variables. Among these matched cohorts, central arterial cannulation VA-ECMO was associated with significantly higher in-hospital mortality compared to peripheral arterial cannulation VA-ECMO (64.5% vs. 70.8%, = 0.027). These findings were confirmed by aggregate data meta-analysis, which showed that central arterial cannulation was associated with an increased risk of in-hospital mortality compared to peripheral arterial cannulation (OR 1.35, 95% CI 1.04-1.76, I 21%).

CONCLUSIONS: Among patients requiring postcardiotomy VA-ECMO, central arterial cannulation was associated with an increased risk of in-hospital mortality compared to peripheral arterial cannulation. This increased risk is of limited magnitude, and further studies are needed to confirm the present findings and to identify the mechanisms underlying the potential beneficial effects of peripheral VA-ECMO.

Jacob, R. H., A. S. Afify, S. M. Shanab, and E. A. Shalaby, "Chelated amino acids: biomass sources, preparation, properties, and biological activities", Biomass Conv. Bioref. , 2022. 56783072-3037-478e-9cbc-5740a7ad3e1d.pdf
Alengebawy, A., B. A. Mohamed, K. Jin, T. Liu, N. Ghimire, M. Samer, and P. Ai, "A comparative life cycle assessment of biofertilizer production towards sustainable utilization of anaerobic digestate", Sustainable Production and Consumption, vol. 33, issue 2022, pp. 875–889, 2022.
MA, Y., A. Salem, and A. Jester, "Complications of Peripheral Arterial Access in Preterm and Term Neonates: A Systematic Review", Pediatric Intensive care, issue s-0042-1757476, 2022.
Rizk, R., T. Juzsakova, M. B. Ali, M. A. Rawash, E. Domokos, A. Hedfi, M. Almalki, F. Boufahja, H. M. Shafik, and Á. Rédey, "Comprehensive environmental assessment of heavy metal contamination of surface water, sediments and Nile Tilapia in Lake Nasser, Egypt", Journal of King Saud University – Science, vol. 34 , issue 2022, pp. 101748, 2022.
Salminen, J., C. Kandpal, A. M. Kamel, S. - G. Jung, and B. J. Jansen, "Creating and detecting fake reviews of online products", Journal of Retailing and Consumer Services, vol. 64: Elsevier Ltd, 2022. AbstractWebsite

Customers increasingly rely on reviews for product information. However, the usefulness of online reviews is impeded by fake reviews that give an untruthful picture of product quality. Therefore, detection of fake reviews is needed. Unfortunately, so far, automatic detection has only had partial success in this challenging task. In this research, we address the creation and detection of fake reviews. First, we experiment with two language models, ULMFiT and GPT-2, to generate fake product reviews based on an Amazon e-commerce dataset. Using the better model, GPT-2, we create a dataset for a classification task of fake review detection. We show that a machine classifier can accomplish this goal near-perfectly, whereas human raters exhibit significantly lower accuracy and agreement than the tested algorithms. The model was also effective on detected human generated fake reviews. The results imply that, while fake review detection is challenging for humans, “machines can fight machines” in the task of detecting fake reviews. Our findings have implications for consumer protection, defense of firms from unfair competition, and responsibility of review platforms. © 2021 The Authors

Elbaz, A. M., M. S. MANSOUR, B. M. Akoush, M. Juddoo, A. M. Khedr, H. M. Al-Bulqini, M. F. Zayed, M. M. A. Ahmed, W. L. Roberts, and A. R. Masri, "Detailed investigation of the mixing field and stability of natural gas and propane in highly turbulent planar flames", Fuel, vol. 309, pp. 122222, 2022. AbstractWebsite

In most practical combustion devices, the actual combustion process occurs within different mixture inhomogeneity levels. Investigating the mixture fraction field upstream of the reaction zones of these flames is an essential step toward understanding their structure, stability, and emission formation. In this study, the mixture fraction fields were measured for turbulent non-reacting inhomogeneous mixtures immediately downstream from the slot burner exit, using Rayleigh scattering imaging. The slot burner had two concentric slots. The inner air slot can be recessed at distances upstream from the exit of the outer fuel slot, allowing various degrees of mixture inhomogeneity. Mixture fraction field statistics and the two-dimensional gradient were utilized to characterize the impact of the air-to-fuel velocity ratio, global equivalence ratio, fuel composition, Reynolds number, and the premixing length on the mixture mixing field, and thus flame stability. These impacts were evaluated by tracking the normalized mean mixture fraction and mixture fraction fluctuation transition across the regime diagram for partially premixed flames. The results showed that the air-to-fuel velocity ratio was the critical parameter affecting the mixture fraction field for the short premixing length. Stability results showed that the level of mixture inhomogeneity mainly influenced the flame stability. High flame stability is achieved if a large portion of the inhomogeneous mixture fraction is within the fuel flammability limits.

Elbaz, A. M., M. S. MANSOUR, B. M. Akoush, M. Juddoo, A. M. Khedr, H. M. Al-Bulqini, M. F. Zayed, M. M. A. Ahmed, W. L. Roberts, and A. R. Masri, "Detailed investigation of the mixing field and stability of natural gas and propane in highly turbulent planar flames", Fuel, vol. 309: Elsevier, pp. 122222, 2022. Abstract
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Elbaz, A. M., M. S. MANSOUR, B. M. Akoush, M. Juddoo, A. M. Khedr, H. M. Al-Bulqini, M. F. Zayed, M. M. A. Ahmed, W. L. Roberts, and A. R. Masri, "Detailed investigation of the mixing field and stability of natural gas and propane in highly turbulent planar flames", Fuel, vol. 309, pp. 122222, 2022.
Aronson, S. J., N. Junge, M. Trabelsi, W. Kelmemi, A. Hubert, K. W. Brigatti, M. D. Fox, R. J. de Knegt, J. C. Escher, V. M. Ginocchio, et al., "Disease burden and management of Crigler-Najjar syndrome: Report of a world registry.", Liver international : official journal of the International Association for the Study of the Liver, vol. 42, issue 7, pp. 1593-1604, 2022.
Javed, R., T. Usman, S. Niaz, N. Ali, H. Baneh, K. Ullah, I. Khattak, M. Kamal, S. Bahadar, N. U. Khan, et al., "Effects of Genetic and Environmental Factors on Mastitis and Performance Traits in Various Breeds of Dairy Cattle Maintained at Khyber Pakhtunkhwa, Pakistan", Pakistan Journal of Zoology, 2022. Abstract

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Jabbar, A., A. Iqbal, M. A. Iqbal, U. A. A. Sheikh, J. Rahim, S. Khalid, R. M. Hafez, A. -ul- H. Shah, A. A. Khan, M. S. A. Bazmi, et al., "Egyptian Clover Genotypic Divergence and Last Cutting Management Augment Nutritive Quality, Seed Yield and Milk Productivity", Sustainability (MDPI), vol. 14, pp. 5833, 2022. sustainability-14-05833.pdf
Adnan Awad, S., O. Brück, N. Shanmuganathan, T. Jarvinen, H. Lähteenmäki, J. Klievink, H. Ibrahim, S. Kytölä, P. Koskenvesa, T. P. Hughes, et al., "Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation", Blood cancer journal, vol. 12, no. 4: Nature Publishing Group, pp. 1–4, 2022. Abstract
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Hasanain, A. A., M. A. R. Soliman, R. Elwy, A. A. M. Ezzat, S. H. Abdel-Bari, S. Marx, A. Jenkins, E. E. L. Refaee, and A. Zohdi, "An eye on the future for defeating hydrocephalus, ciliary dyskinesia-related hydrocephalus: review article.", British journal of neurosurgery, pp. 1-11, 2022. Abstract

Congenital hydrocephalus affects approximately one in 1000 newborn children and is fatal in approximately 50% of untreated cases. The currently known management protocols usually necessitate multiple interventions and long-term use of healthcare resources due to a relatively high incidence of complications, and many of them mostly provide a treatment of the effect rather than the cause of cerebrospinal fluid flow reduction or outflow obstruction. Future studies discussing etiology specific hydrocephalus alternative treatments are needed. We systematically reviewed the available literature on the effect of ciliary abnormality on congenital hydrocephalus pathogenesis, to open a discussion on the feasibility of factoring ciliary abnormality in future research on hydrocephalus treatment modalities. Although there are different forms of ciliopathies, we focused in this review on primary ciliary dyskinesia. There is growing evidence of association of other ciliary syndromes and hydrocephalus, such as the reduced generation of multiple motile cilia, which is distinct from primary ciliary dyskinesia. Data for this review were identified by searching PubMed using the search terms 'hydrocephalus,' 'Kartagener syndrome,' 'primary ciliary dyskinesia,' and 'immotile cilia syndrome.' Only articles published in English and reporting human patients were included. Seven studies met our inclusion criteria, reporting 12 cases of hydrocephalus associated with primary ciliary dyskinesia. The patients had variable clinical presentations, genetic backgrounds, and ciliary defects. The ependymal water propelling cilia differ in structure and function from the mucus propelling cilia, and there is a possibility of isolated non-syndromic ependymal ciliopathy causing only hydrocephalus with growing evidence in the literature for the association ependymal ciliary abnormality and hydrocephalus. Abdominal and thoracic situs in children with hydrocephalus can be evaluated, and secondary damage of ependymal cilia causing hydrocephalus in cases with generalized ciliary abnormality can be considered.

Arif, A., A. A. Alameri, U. B. Tariq, S. A. Ansari, H. I. Sakr, M. T. Qasim, F. F. M. Aljoborae, A. A. Ramírez-Coronel, H. S. Jabbar, G. A. Gabr, et al., "The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.", International immunopharmacology, vol. 114, pp. 109581, 2022. Abstract

Currently, cancer ranks as the second leading cause of death worldwide, and at the same time, the burden of cancer continues to increase. The underlying molecular pathways involved in the initiation and development of cancer are the subject of considerable research worldwide. Further understanding of these pathways may lead to new cancer treatments. Growing data suggest that Tribble's homolog 3 (TRIB3) is essential in oncogenesis in many types of cancer. The mammalian tribbles family's proteins regulate various cellular and physiological functions, such as the cell cycle, stress response, signal transduction, propagation, development, differentiation, immunity, inflammatory processes, and metabolism. To exert their activities, Tribbles proteins must alter key signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/AKT pathways. Recent evidence supports that TRIB3 dysregulation has been linked to various diseases, including tumor development and chemoresistance. It has been speculated that TRIB3 may either promote or inhibit the onset and development of cancer. However, it is still unclear how TRIB3 performs this dual function in cancer. In this review, we present and discuss the most recent data on the role of TRIB3 in cancer pathophysiology and chemoresistance. Furthermore, we describe in detail the molecular mechanism TRIB3 regulates in cancer.

Said, A. A., A. H. MacQueen, H. Shawky, M. Reynolds, T. E. Juenger, and M. El-Soda, "Genome-wide association mapping of genotype-environment interactions affecting yield-related traits of spring wheat grown in three watering regimes", Environmental and Experimental Botany, vol. 194: Elsevier, pp. 104740, 2022. Abstract
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Xueming Ren, S. Cao, M. Akami, A. Mansour, Y. Yang, N. Jiang, H. Wang, G. Zhang, X. Qi, P. Xu, et al., "Gut symbiotic bacteria are involved in nitrogen recycling in the tephritid fruit fly Bactrocera dorsalis.", BMC biology, vol. 20, issue 1, pp. 201, 2022. Abstract

BACKGROUND: Nitrogen is considered the most limiting nutrient element for herbivorous insects. To alleviate nitrogen limitation, insects have evolved various symbiotically mediated strategies that enable them to colonize nitrogen-poor habitats or exploit nitrogen-poor diets. In frugivorous tephritid larvae developing in fruit pulp under nitrogen stress, it remains largely unknown how nitrogen is obtained and larval development is completed.

RESULTS: In this study, we used metagenomics and metatranscriptomics sequencing technologies as well as in vitro verification tests to uncover the mechanism underlying the nitrogen exploitation in the larvae of Bactrocera dorsalis. Our results showed that nitrogenous waste recycling (NWR) could be successfully driven by symbiotic bacteria, including Enterobacterales, Lactobacillales, Orbales, Pseudomonadales, Flavobacteriales, and Bacteroidales. In this process, urea hydrolysis in the larval gut was mainly mediated by Morganella morganii and Klebsiella oxytoca. In addition, core bacteria mediated essential amino acid (arginine excluded) biosynthesis by ammonium assimilation and transamination.

CONCLUSIONS: Symbiotic bacteria contribute to nitrogen transformation in the larvae of B. dorsalis in fruit pulp. Our findings suggest that the pattern of NWR is more likely to be applied by B. dorsalis, and M. morganii, K. oxytoca, and other urease-positive strains play vital roles in hydrolysing nitrogenous waste and providing metabolizable nitrogen for B. dorsalis.

Sapena, V., M. Enea, F. Torres, C. Celsa, J. Rios, G. E. M. Rizzo, P. Nahon, Z. Mariño, R. Tateishi, T. Minami, et al., "Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis.", Gut, vol. 71, issue 3, pp. 593-604, 2022. Abstract

OBJECTIVE: The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration.

DESIGN: We pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death risk was expressed as HCC recurrence or death per 100 person-years (100PY). Propensity score-matched patients from the ITA.LI.CA. cohort (n=328) served as DAA-unexposed controls (no-DAA group). Risk factors for HCC recurrence were identified using random-effects Poisson.

RESULTS: Recurrence rate and death risk per 100PY in DAA-treated patients were 20 (95% CI 13.9 to 29.8, I=74.6%) and 5.7 (2.5 to 15.3, I=54.3), respectively. Predictive factors for recurrence were alpha-fetoprotein logarithm (relative risk (RR)=1.11, 95% CI 1.03 to 1.19; p=0.01, per 1 log of ng/mL), HCC recurrence history pre-DAA initiation (RR=1.11, 95% CI 1.07 to 1.16; p<0.001), performance status (2 vs 0, RR=4.35, 95% CI 1.54 to 11.11; 2 vs 1, RR=3.7, 95% CI 1.3 to 11.11; p=0.01) and tumour burden pre-HCC treatment (multifocal vs solitary nodule, RR=1.75, 95% CI 1.25 to 2.43; p<0.001). No significant difference was observed in RR between the DAA-exposed and DAA-unexposed groups in propensity score-matched patients (RR=0.64, 95% CI 0.37 to 1.1; p=0.1).

CONCLUSION: Effects of DAA exposure on HCC recurrence risk remain inconclusive. Active clinical and radiological follow-up of patients with HCC after HCV eradication with DAA is justified.

Kissani, N., A. E. Khiat, M. M. Watila, I. E. Aarroumi, H. M. F. Wahba, T. H. Emara, D. Eliashiv, I. Kissani, D. Gams Massi, J. N. Jabang, et al., "How New Technologies Could Help Improve Healthcare, Teaching, and Sensitization During Pandemics Like COVID-19", Public Health and Economic Resiliency in the Post-COVID-19 Era, Hershy, IGI global, 2022. how_new_technologies_could_help_improve_healthcare_teaching_and_sensitization_during_pandemics_like_covid-19.pdf
Sobhi, M., M. A. Fayad, A. A. M. Jubori, and T. Badawy, "Impact of spectators attendance on thermal ambience and water evaporation rate in an expansive competitive indoor swimming pool", Case Studies in Thermal Engineering, vol. 38, issue 102359, 2022.
on Collaborative, G. H. R. G. C. ’s N. - C. D., "Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study", BMJ Open, vol. 12, no. 4: British Medical Journal Publishing Group, 2022. AbstractWebsite

Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs.Design A multicentre, international, collaborative cohort study.Setting 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020.Participants Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin’s lymphoma, Hodgkin lymphoma, Wilms’ tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer.Main outcome measure All-cause mortality at 30 days and 90 days.Results 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001).Conclusions The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally.Data are available on reasonable request. Deidentified date will be shared on request.

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