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2023
Fadaly, W. A. A., M. T. M. Nemr, T. H. Zidan, F. E. A. Mohamed, M. M. Abdelhakeem, N. A. N. Jayab, H. A. Omar, and K. R. A. Abdellatif, "New1,2,3triazole/1,2,4triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2,aromatase,B-RAFV600E and EGFR inhibitors celecoxib analogs:design,synthesis,antiinflammatory/antiproliferative activities,apoptosis and molecular modeling", Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, issue 1, pp. 2290461, 2023.
van der Sluis, T. C., G. Beyrend, E. T. I. van der Gracht, T. Abdelaal, S. P. Jochems, R. A. Belderbos, T. H. Wesselink, S. van Duikeren, F. J. van Haften, A. Redeker, et al., "OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.", Cell reports. Medicine, vol. 4, issue 3, pp. 100939, 2023. Abstract

Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting of the OX40 costimulatory and PD-1 inhibitory pathways. Single-cell RNA sequencing and mass cytometry expose systemic and dynamic activation states of therapy-responsive CD4 and CD8 T cells in tumor-bearing mice with expression of distinct natural killer (NK) cell receptors, granzymes, and chemokines/chemokine receptors. Moreover, similar NK cell receptor-expressing CD8 T cells are also detected in the blood of immunotherapy-responsive cancer patients. Targeting the NK cell and chemokine receptors in tumor-bearing mice shows the functional importance of these receptors for therapy-induced anti-tumor immunity. These findings provide a better understanding of ICT and highlight the use and targeting of dynamic biomarkers on T cells to improve cancer immunotherapy.

Meili, C. H., A. L. Jones, A. X. Arreola, J. Habel, C. J. Pratt, R. A. Hanafy, Y. Wang, A. S. Yassin, M. A. Tag ElDein, C. D. Moon, et al., "Patterns and determinants of the global herbivorous mycobiome.", Nature communications, vol. 14, issue 1, pp. 3798, 2023. Abstract

Despite their role in host nutrition, the anaerobic gut fungal (AGF) component of the herbivorous gut microbiome remains poorly characterized. Here, to examine global patterns and determinants of AGF diversity, we generate and analyze an amplicon dataset from 661 fecal samples from 34 mammalian species, 9 families, and 6 continents. We identify 56 novel genera, greatly expanding AGF diversity beyond current estimates (31 genera and candidate genera). Community structure analysis indicates that host phylogenetic affiliation, not domestication status and biogeography, shapes the community rather than. Fungal-host associations are stronger and more specific in hindgut fermenters than in foregut fermenters. Transcriptomics-enabled phylogenomic and molecular clock analyses of 52 strains from 14 genera indicate that most genera with preferences for hindgut hosts evolved earlier (44-58 Mya) than those with preferences for foregut hosts (22-32 Mya). Our results greatly expand the documented scope of AGF diversity and provide an ecologically and evolutionary-grounded model to explain the observed patterns of AGF diversity in extant animal hosts.

Al-Ata, J. A., G. A. Abdelmohsen, S. A. Bahaidarah, N. A. Alkhushi, M. H. Abdelsalam, S. B. Bekheet, O. O. Al-Radi, A. A. Jamjoom, A. F. Elmahrouk, A. J. Alata, et al., "Percutaneous coronary stent implantation in children and young infants following surgical repair of congenital heart disease.", Cardiovascular diagnosis and therapy, vol. 13, issue 4, pp. 638-649, 2023. Abstractpercutaneous_coronary_stent_implantation_in_children.pdf

BACKGROUND: Coronary artery stent implantation (CSI) in the pediatric population is rare. Only a few reports were published on managing postoperative coronary artery obstruction using coronary stents following surgical repair of congenital heart diseases (CHD). This study aimed to analyze the feasibility, indications, procedural technique, risk factors, and short-term outcomes of CSI after pediatric cardiac surgery.

METHODS: In this retrospective cohort study, we reviewed all pediatric patients who underwent surgical repair of CHD requiring postoperative CSI in two cardiac centers (King Abdulaziz University Hospital and King Faisal Specialist Hospital and Research Center) between 2012 and 2022. Survival to hospital discharge was the study's primary outcome. The secondary outcomes included procedural success, duration of mechanical ventilation, intensive care unit (ICU) stay, hospital stay, need for coronary reintervention, and late mortality. A descriptive analysis was performed for the collected data from the patients' medical records.

RESULTS: Eleven patients who underwent postoperative CSI were identified. The most common anatomic diagnosis was congenital aortic valve stenosis. All patients underwent cardiac catheterization on extracorporeal membrane oxygenation support except one patient, who presented with chest pain after cardiac surgery. Procedural success was achieved in all patients with excellent revascularization documented by post-procedural angiograms. Both patients who had late coronary events after cardiac surgery survived hospital discharge. There was no in-hospital mortality among the two patients who required stenting of only the right coronary artery. The four patients who required more than 120 minutes to complete the procedure had early mortality. After CSI, the median duration of mechanical ventilation and ICU stay was 12 and 17 days, respectively. Six patients (54.5%) survived hospital discharge post-CSI; they did not require re-intervention during the follow-up period (38-1,695 days).

CONCLUSIONS: CSI in pediatric patients can be performed with excellent procedural success for treating coronary artery stenosis after cardiac surgery. It could be considered a potential treatment strategy for this population.

Shama, S., H. Jang, X. Wang, Y. Zhang, N. N. Shahin, T. K. Motawi, S. Kim, S. Gawrieh, and W. Liu, "Phosphatidylethanolamines Are Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Adults and Induce Liver Cell Metabolic Perturbations and Hepatic Stellate Cell Activation.", International journal of molecular sciences, vol. 24, issue 2, 2023. Abstract

Pathogenesis roles of phospholipids (PLs) in nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This study investigated the role of PLs in the progression of NAFLD among obese individuals via studying the alterations in serum PL composition throughout the spectrum of disease progression and evaluating the effects of specific phosphatidylethanolamines (PEs) on FLD development in vitro. A total of 203 obese subjects, who were undergoing bariatric surgery, were included in this study. They were histologically classified into 80 controls (C) with normal liver histology, 93 patients with simple hepatic steatosis (SS), 16 with borderline nonalcoholic steatohepatitis (B-NASH) and 14 with progressive NASH (NASH). Serum PLs were profiled by automated electrospray ionization tandem mass spectrometry (ESI-MS/MS). HepG2 (hepatoma cells) and LX2 (immortalized hepatic stellate cells or HSCs) were used to explore the roles of PL in NAFLD/NASH development. Several PLs and their relative ratios were significantly associated with NAFLD progression, especially those involving PE. Incubation of HepG2 cells with two phosphatidylethanolamines (PEs), PE (34:1) and PE (36:2), resulted in significant inhibition of cell proliferation, reduction of mitochondrial mass and membrane potential, induction of lipid accumulation and mitochondrial ROS production. Meanwhile, treatment of LX2 cells with both PEs markedly increased cell activation and migration. These effects were associated with a significant change in the expression levels of genes involved in lipogenesis, lipid oxidation, autophagy, apoptosis, inflammation, and fibrosis. Thus, our study demonstrated that elevated level of PEs increases susceptibility to the disease progression of obesity associated NAFLD, likely through a causal cascade of impacts on the function of different liver cells.

Mansouri, S., S. O. Mezan, F. M. A. Altalbawy, A. K. Kareem, F. R. Alhachami, A. ´ A. es Ramírez-Coronel, A. M. Gatea, R. M. Romero-Parra, Y. F. Mustafa, and Z. H. Jawhar, "Recent advances in assembly strategies of new advanced materials-based analytical methods for the detection of cardiac biomarkers as a diagnosis tool", Microchemical Journal, vol. 191, pp. 108827, 2023. 13-microchemical_journal.pdf
Al-Gazally, M. E., R. Khan, M. Imran, A. A. Ramírez-Coronel, S. H. Alshahrani, F. M. A. Altalbawy, A. T. Jalil, R. M. Romero-Parra, R. S. Zabibah, M. S. Iqba, et al., "The role and mechanism of action of microRNA-122 in cancer: Focusing on the liver", International Immunopharmacology, vol. 123, pp. 110713, 2023.
Ramírez-Coronel, A. A., A. A. Alameri, F. Altalbawy, H. S. Jabbar, G. R. L. Al-Awsi, A. H. Iswanto, A. S. Altamimi, K. S. Mohsen, A. F. Almulla, and Y. F. Mustafa, "Smartphone-Facilitated Mobile Colorimetric Probes for Rapid Monitoring of Chemical Contaminations in Food: Advances and Outlook", Critical Reviews in Analytical Chemistry, 2023. 11-_critical_reviews_in_analytical_chemistry.pdf
Jawad, S. F., F. M. A. Altalbawy, R. M. Hussein, A. A. Fadhil, M. A. Jawad, R. S. Zabibah, T. Y. Taraki, C. D. Mohan, and K. S. Rangappa, "The strict regulation of HIF‑1α by non‑coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies", Cancer and Metastasis Reviews, 2023.
J.-L.Godet, and M.S.A.El-Kader, "Study of the weakly bound pair Helium–Krypton: Interatomic potential, interaction hyperpolarizabilities and hyperRayleigh spectra", Journal of Quantitative Spectroscopy and Radiative Transfer, vol. 306, pp. 108641, 2023.
Mohr, B., O. J, Souilem, A. B. M. Abdussamad, Abelouafi;Bugnon, C. Phillippe, S. Fahmy, T. R;Fourie, and K.; Gaafar, "Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward", Laboratory Animals,, vol. 57, issue 2, pp. 136–148, 2023.
Mohr, B., O. J, Souilem, A. B. M. Abdussamad, Abelouafi;Bugnon, C. Phillippe, S. Fahmy, T. R;Fourie, and K.; Gaafar, "Sustainable education and training in laboratory animal science and ethics in low- and middle-income countries in Africa – challenges, successes, and the way forward", Laboratory Animals,, vol. 57, issue 2, pp. 136–148, 2023.
Chen, J., M. K. Khabaz, M. M. Ghasemian, F. M. A. Altalbawy, A. T. Jali, A. S. Eftekhari, M. Hashemian, D. Toghraie, and Z. F. Albahash, "Transverse vibration analysis of double-walled carbon nanotubes in an elastic medium under temperature gradients and electrical fields based on nonlocal Reddy beam theory", Materials Science and Engineering B, vol. 291, pp. 116220, 2023.
Fu, J., A. T. Jalil, F. M. A. Altalbawy, T. Aljawahiry, H. Babur, I. M. Mohammed, R. S. Zabibah, L. Y. Qassem, and L. Baharinikoo, "Ultrasound-assisted dispersive solid-phase extraction for the preconcentration of dyes in water samples", Arabian Journal of Chemistry, vol. 16, pp. 105126, 2023.
2022
Cheng, H. - L., S. C. Lam, J. Cruz, J. Almazan, F. Machuca-Contreras, D. H. S. John Cecily, H. Rady, I. Papathanasiou, F. Ghrayeb, M. Qtait, et al., Willingness to care for older people and associated factors in pre-registered student nurses: A multi-country survey study, , vol. 110, pp. 105279, 2022/01/26. Abstract

Background: Addressing nursing students' lack of interest in providing care for the aged population is a global challenge for nursing educators. Despite global interest in student nurses' readiness for older people care, almost all the literature has been identified from single countries, predominantly with high income per capita. At present, no study has been conducted to provide evidence-based data related to this topic from a multi-country perspective.Objective: The study's purpose was to examine the willingness to work with older persons and associated factors among student nurses from nine countries (or regions).
Design: This study utilized correlational and cross-sectional designs.
Settings: This was a multi-country survey study conducted in China, Chile, Egypt, Hong Kong, India, Greece, the State of Palestine (henceforth Palestine), the Philippines, and Saudi Arabia.
Participants: 2250 baccalaureate nursing students were recruited from nine universities in this study.
Methods: The survey that was used to collect data comprised four parts: socio-demographic data, attitude toward aging, older persons care perception, and willingness to work with such group.
Results: Respondents in five regions (including Mainland China, Greece, Hong Kong, Palestine, and Saudi Arabia) stated that older persons were the least favored group for future career choices. In comparison with mainland China, respondents in Chile, India, and the Philippines were significantly more likely to be willing to care for older patients, but those in Egypt and Greece indicated a lower tendency to choose this option. Favorable attitudes toward aging and older person care perception were significantly associated with having the willingness to provide care to gerontologic patients in the future.
Conclusions: Although attitudes toward aging and older person care perceptions have long been confirmed as important factors that are linked with willingness in caring for older people, this study adds that location is a more influential factor. Additional research in other countries is needed to advance the knowledge in this important area.

Della Casa, F., A. Vitale, G. Lopalco, P. Ruscitti, F. Ciccia, G. Emmi, M. Cattalini, E. Wiesik-Szewczyk, M. C. Maggio, B. Ogunjimi, et al., "Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases", Frontiers in Medicine, vol. 9: Frontiers Media S.A., 2022. AbstractWebsite
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Glasbey, J. C., T. E. F. Abbott, A. Ademuyiwa, A. Adisa, E. Alameer, S. Alshryda, A. P. Arnaud, B. Bankhead-Kendall, M. K. Abou Chaar, D. Chaudhry, et al., Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries, , vol. 400, issue 10363, pp. 1607 - 1617, 2022. AbstractWebsite

SummaryBackground
The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
Methods
First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assessment (surgical preparedness index; SPI). Second, we measured surgical preparedness across a global network of hospitals in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) to explore the distribution of the SPI at national, subnational, and hospital levels. Finally, using COVID-19 as an example of an external system shock, we compared hospitals' SPI to their planned surgical volume ratio (SVR; ie, operations for which the decision for surgery was made before hospital admission), calculated as the ratio of the observed surgical volume over a 1-month assessment period between June 6 and Aug 5, 2021, against the expected surgical volume based on hospital administrative data from the same period in 2019 (ie, a pre-pandemic baseline). A linear mixed-effects regression model was used to determine the effect of increasing SPI score.
Findings
In the first phase, from a longlist of 103 candidate indicators, 23 were prioritised as core indicators of elective surgical system preparedness by 69 clinicians (23 [33%] women; 46 [67%] men; 41 from HICs, 22 from MICs, and six from LICs) from 32 countries. The multidomain SPI included 11 indicators on facilities and consumables, two on staffing, two on prioritisation, and eight on systems. Hospitals were scored from 23 (least prepared) to 115 points (most prepared). In the second phase, surgical preparedness was measured in 1632 hospitals by 4714 clinicians from 119 countries. 745 (45·6%) of 1632 hospitals were in MICs or LICs. The mean SPI score was 84·5 (95% CI 84·1–84·9), which varied between HIC (88·5 [89·0–88·0]), MIC (81·8 [82·5–81·1]), and LIC (66·8 [64·9–68·7]) settings. In the third phase, 1217 (74·6%) hospitals did not maintain their expected SVR during the COVID-19 pandemic, of which 625 (51·4%) were from HIC, 538 (44·2%) from MIC, and 54 (4·4%) from LIC settings. In the mixed-effects model, a 10-point increase in SPI corresponded to a 3·6% (95% CI 3·0–4·1; p<0·0001) increase in SVR. This was consistent in HIC (4·8% [4·1–5·5]; p<0·0001), MIC (2·8 [2·0–3·7]; p<0·0001), and LIC (3·8 [1·3–6·7%]; p<0·0001) settings.
Interpretation
The SPI contains 23 indicators that are globally applicable, relevant across different system stressors, vary at a subnational level, and are collectable by front-line teams. In the case study of COVID-19, a higher SPI was associated with an increased planned surgical volume ratio independent of country income status, COVID-19 burden, and hospital type. Hospitals should perform annual self-assessment of their surgical preparedness to identify areas that can be improved, create resilience in local surgical systems, and upscale capacity to address elective surgery backlogs.
Funding
National Institute for Health Research (NIHR) Global Health Research Unit on Global Surgery, NIHR Academy, Association of Coloproctology of Great Britain and Ireland, Bowel Research UK, British Association of Surgical Oncology, British Gynaecological Cancer Society, and Medtronic.

Méndez-Sánchez, N., E. Bugianesi, R. G. Gish, F. Lammert, H. Tilg, M. H. Nguyen, S. K. Sarin, N. Fabrellas, S. Zelber-Sagi, J. - G. Fan, et al., "Global multi-stakeholder endorsement of the MAFLD definition", The Lancet Gastroenterology & HepatologyThe Lancet Gastroenterology & Hepatology, vol. 7, issue 5: Elsevier, pp. 388 - 390, 2022. AbstractWebsite
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Mohamed, B. A., L. Y. Li, H. Hamid, and M. Jeronimo, Sludge-based activated carbon and its application in the removal of perfluoroalkyl substances: A feasible approach towards a circular economy, , vol. 294, pp. 133707, 2022. AbstractWebsite

This study explores the recovery of resources and energy from sewage sludge through the production of sludge-based activated carbon (SBAC) considering circular economy principles. The SBAC production costs were estimated under three scenarios considering various sludge dewatering/drying schemes to determine the production feasibility and its role in the circular economy. SBAC was tested in the removal of a mixture of nine commonly detected poly- and perfluoroalkyl substances (PFASs) in environmentally relevant concentrations of ∽50 μg/L in comparison to commercially available activated carbon (AC) using 5 mg of sorbent and 5 mL of a nine-PFAS mixture in deionised water. SBAC can be produced at approximately 1.2 US $/kg, which is substantially lower than the average production cost of commercial AC of >3 US $/kg. A net revenue ranging from 2 to 7 US $/kg SBAC was estimated by recycling the produced non-condensable gases and bio-oil to produce energy and selling the SBAC. Batch adsorption tests showed that the PFASs removal of SBAC was superior to that of granular AC and similar to that of powdered AC, reaching >91% to below the detection limit. The kinetics tests revealed that adsorption by SBAC and AC occurred within 15 min. The overall results demonstrate the potential of SBAC as an effective sorbent for PFASs, achieving waste-to-resources circular economy via resource and energy recovery from sewage sludge, eliminating sludge disposal and contaminant-leaching to the environment, and in enhancing the quality of wastewater effluent before discharge.

J.-L.Godet, and M.S.A.El-Kader, "Analysis and Modeling of Spectral Line Shapes of Collision-Induced Light Scattering of Gaseous Xenon", Journal of Molecular Physics, vol. 2, pp. 19-31, 2022.
Haakenstad, A., J. A. Yearwood, N. Fullman, C. Bintz, K. Bienhoff, M. R. Weaver, V. Nandakumar, J. N. Joffe, K. E. LeGrand, M. Knight, et al., "Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019", The Lancet Global Health, vol. 10, no. 12: Elsevier, pp. e1715–e1743, 2022. Abstract
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