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Rehman, H. U., X. Yan, M. U. Jan, M. A. Abdelbaky, S. Iqbal, T. Egamnazarova, and S. A. A. A. Rizvi, "Wind Turbine System based Virtual Synchronous Generator Control for Microgrid Frequency Regulation", 2021 7th International Conference on Energy Materials and Environment Engineering (ICEMEE 2021), Zhangjaijie, China, pp. 1-5, 2021.
Jonaszik, A., T. Severin-Selz, M. Langer, A. Kharabish, and others, Wind sock sing in CT-aortography: A rare case of acute type A aortic dissection with left ventricular intimointimal flap intussusception, : European Congress of Radiology-ESCR 2017, 2017. Abstract
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Jonaszik, A., T. Severin-Selz, M. Langer, A. Kharabish, and others, Wind sock sing in CT-aortography: A rare case of acute type A aortic dissection with left ventricular intimointimal flap intussusception, : European Congress of Radiology-ESCR 2017, 2017. Abstract
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Nahrstedt, A., M. Schmidt, R. Jäggi, J. Metz, and M. T. Khayyal, "Willow bark extract: the contribution of polyphenols to the overall effect.", Wiener medizinische Wochenschrift (1946), vol. 157, issue 13-14, pp. 348-51, 2007. Abstract

The efficacy of willow bark extract in the treatment of painful mobility disorders, such as back pain and arthritis, has been attributed to the content of salicin and its derivatives as pro-drugs of salicylates. However, based on clinical experience and the evidence of experimental pharmacological studies, the fraction of total salicin cannot satisfactorily explain the clinical efficacy of willow bark. In addition, salicins and their metabolites lack the acetylating potential of ASA and must therefore possess a different mechanism of action. A detailed pharmacological screening of the aqueous willow bark extract STW 33-I addressed the question of the identification of fractions contributing to the overall effect. All in vivo and in vitro models studied pointed to relevant contributions of the fraction of polyphenols and flavonoids. The single compounds or their combinations responsible for the effect remain to be elucidated.

Nahrstedt, A., M. Schmidt, R. Jäggi, J. Metz, and M. T. Khayyal, "Willow bark extract: the contribution of polyphenols to the overall effect.", Wiener medizinische Wochenschrift (1946), vol. 157, issue 13-14, pp. 348-51, 2007. Abstract

The efficacy of willow bark extract in the treatment of painful mobility disorders, such as back pain and arthritis, has been attributed to the content of salicin and its derivatives as pro-drugs of salicylates. However, based on clinical experience and the evidence of experimental pharmacological studies, the fraction of total salicin cannot satisfactorily explain the clinical efficacy of willow bark. In addition, salicins and their metabolites lack the acetylating potential of ASA and must therefore possess a different mechanism of action. A detailed pharmacological screening of the aqueous willow bark extract STW 33-I addressed the question of the identification of fractions contributing to the overall effect. All in vivo and in vitro models studied pointed to relevant contributions of the fraction of polyphenols and flavonoids. The single compounds or their combinations responsible for the effect remain to be elucidated.

Nahrstedt, A., M. Schmidt, R. Jäggi, J. Metz, and M. T. Khayyal, "Willow bark extract: the contribution of polyphenols to the overall effect.", Wiener medizinische Wochenschrift (1946), vol. 157, issue 13-14, pp. 348-51, 2007. Abstract

The efficacy of willow bark extract in the treatment of painful mobility disorders, such as back pain and arthritis, has been attributed to the content of salicin and its derivatives as pro-drugs of salicylates. However, based on clinical experience and the evidence of experimental pharmacological studies, the fraction of total salicin cannot satisfactorily explain the clinical efficacy of willow bark. In addition, salicins and their metabolites lack the acetylating potential of ASA and must therefore possess a different mechanism of action. A detailed pharmacological screening of the aqueous willow bark extract STW 33-I addressed the question of the identification of fractions contributing to the overall effect. All in vivo and in vitro models studied pointed to relevant contributions of the fraction of polyphenols and flavonoids. The single compounds or their combinations responsible for the effect remain to be elucidated.

Cheng, H. - L., S. C. Lam, J. Cruz, J. Almazan, F. Machuca-Contreras, D. H. S. John Cecily, H. Rady, I. Papathanasiou, F. Ghrayeb, M. Qtait, et al., Willingness to care for older people and associated factors in pre-registered student nurses: A multi-country survey study, , vol. 110, pp. 105279, 2022/01/26. Abstract

Background: Addressing nursing students' lack of interest in providing care for the aged population is a global challenge for nursing educators. Despite global interest in student nurses' readiness for older people care, almost all the literature has been identified from single countries, predominantly with high income per capita. At present, no study has been conducted to provide evidence-based data related to this topic from a multi-country perspective.Objective: The study's purpose was to examine the willingness to work with older persons and associated factors among student nurses from nine countries (or regions).
Design: This study utilized correlational and cross-sectional designs.
Settings: This was a multi-country survey study conducted in China, Chile, Egypt, Hong Kong, India, Greece, the State of Palestine (henceforth Palestine), the Philippines, and Saudi Arabia.
Participants: 2250 baccalaureate nursing students were recruited from nine universities in this study.
Methods: The survey that was used to collect data comprised four parts: socio-demographic data, attitude toward aging, older persons care perception, and willingness to work with such group.
Results: Respondents in five regions (including Mainland China, Greece, Hong Kong, Palestine, and Saudi Arabia) stated that older persons were the least favored group for future career choices. In comparison with mainland China, respondents in Chile, India, and the Philippines were significantly more likely to be willing to care for older patients, but those in Egypt and Greece indicated a lower tendency to choose this option. Favorable attitudes toward aging and older person care perception were significantly associated with having the willingness to provide care to gerontologic patients in the future.
Conclusions: Although attitudes toward aging and older person care perceptions have long been confirmed as important factors that are linked with willingness in caring for older people, this study adds that location is a more influential factor. Additional research in other countries is needed to advance the knowledge in this important area.

van der Ven, A. T., D. M. Connaughton, H. Ityel, N. Mann, M. Nakayama, J. Chen, A. Vivante, D. - Y. Hwang, J. Schulz, D. A. Braun, et al., "Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract.", Journal of the American Society of Nephrology : JASN, vol. 29, issue 9, pp. 2348-2361, 2018 Sep. Abstract

BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most prevalent cause of kidney disease in the first three decades of life. Previous gene panel studies showed monogenic causation in up to 12% of patients with CAKUT.

METHODS: We applied whole-exome sequencing to analyze the genotypes of individuals from 232 families with CAKUT, evaluating for mutations in single genes known to cause human CAKUT and genes known to cause CAKUT in mice. In consanguineous or multiplex families, we additionally performed a search for novel monogenic causes of CAKUT.

RESULTS: In 29 families (13%), we detected a causative mutation in a known gene for isolated or syndromic CAKUT that sufficiently explained the patient's CAKUT phenotype. In three families (1%), we detected a mutation in a gene reported to cause a phenocopy of CAKUT. In 15 of 155 families with isolated CAKUT, we detected deleterious mutations in syndromic CAKUT genes. Our additional search for novel monogenic causes of CAKUT in consanguineous and multiplex families revealed a potential single, novel monogenic CAKUT gene in 19 of 232 families (8%).

CONCLUSIONS: We identified monogenic mutations in a known human CAKUT gene or CAKUT phenocopy gene as the cause of disease in 14% of the CAKUT families in this study. Whole-exome sequencing provides an etiologic diagnosis in a high fraction of patients with CAKUT and will provide a new basis for the mechanistic understanding of CAKUT.

Warejko, J. K., W. Tan, A. Daga, D. Schapiro, J. A. Lawson, S. Shril, S. Lovric, S. Ashraf, J. Rao, T. Hermle, et al., "Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome.", Clinical journal of the American Society of Nephrology : CJASN, vol. 13, issue 1, pp. 53-62, 2018 Jan 06. Abstract

BACKGROUND AND OBJECTIVES: Steroid-resistant nephrotic syndrome overwhelmingly progresses to ESRD. More than 30 monogenic genes have been identified to cause steroid-resistant nephrotic syndrome. We previously detected causative mutations using targeted panel sequencing in 30% of patients with steroid-resistant nephrotic syndrome. Panel sequencing has a number of limitations when compared with whole exome sequencing. We employed whole exome sequencing to detect monogenic causes of steroid-resistant nephrotic syndrome in an international cohort of 300 families.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Three hundred thirty-five individuals with steroid-resistant nephrotic syndrome from 300 families were recruited from April of 1998 to June of 2016. Age of onset was restricted to <25 years of age. Exome data were evaluated for 33 known monogenic steroid-resistant nephrotic syndrome genes.

RESULTS: In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a mutation in a gene that causes a phenocopy of steroid-resistant nephrotic syndrome. This is consistent with our previously published identification of mutations using a panel approach. We detected a causative mutation in a known steroid-resistant nephrotic syndrome gene in 38% of consanguineous families and in 13% of nonconsanguineous families, and 48% of children with congenital nephrotic syndrome. A total of 68 different mutations were detected in 20 of 33 steroid-resistant nephrotic syndrome genes. Fifteen of these mutations were novel.,,, andwere the most common genes in which we detected a mutation. In another 28% of families, we detected mutations in one or more candidate genes for steroid-resistant nephrotic syndrome.

CONCLUSIONS: Whole exome sequencing is a sensitive approach toward diagnosis of monogenic causes of steroid-resistant nephrotic syndrome. A molecular genetic diagnosis of steroid-resistant nephrotic syndrome may have important consequences for the management of treatment and kidney transplantation in steroid-resistant nephrotic syndrome.

Daga, A., A. J. Majmundar, D. A. Braun, H. Y. Gee, J. A. Lawson, S. Shril, T. Jobst-Schwan, A. Vivante, D. Schapiro, W. Tan, et al., "Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis.", Kidney international, vol. 93, issue 1, pp. 204-213, 2018 Jan. Abstract

The incidence of nephrolithiasis continues to rise. Previously, we showed that a monogenic cause could be detected in 11.4% of individuals with adult-onset nephrolithiasis or nephrocalcinosis and in 16.7-20.8% of individuals with onset before 18 years of age, using gene panel sequencing of 30 genes known to cause nephrolithiasis/nephrocalcinosis. To overcome the limitations of panel sequencing, we utilized whole exome sequencing in 51 families, who presented before age 25 years with at least one renal stone or with a renal ultrasound finding of nephrocalcinosis to identify the underlying molecular genetic cause of disease. In 15 of 51 families, we detected a monogenic causative mutation by whole exome sequencing. A mutation in seven recessive genes (AGXT, ATP6V1B1, CLDN16, CLDN19, GRHPR, SLC3A1, SLC12A1), in one dominant gene (SLC9A3R1), and in one gene (SLC34A1) with both recessive and dominant inheritance was detected. Seven of the 19 different mutations were not previously described as disease-causing. In one family, a causative mutation in one of 117 genes that may represent phenocopies of nephrolithiasis-causing genes was detected. In nine of 15 families, the genetic diagnosis may have specific implications for stone management and prevention. Several factors that correlated with the higher detection rate in our cohort were younger age at onset of nephrolithiasis/nephrocalcinosis, presence of multiple affected members in a family, and presence of consanguinity. Thus, we established whole exome sequencing as an efficient approach toward a molecular genetic diagnosis in individuals with nephrolithiasis/nephrocalcinosis who manifest before age 25 years.

Darwish, E., S. U. Rehman, X. Mao, and R. Jing, "A wheat stress induced WRKY transcription factor TaWRKY32 confers drought stress tolerance in Oryza sativa", Asian Journal of Agriculture and Biology, vol. 1, pp. 1-7, 2021.
Massah, S. E., S. Bacheer, and R. James, "What shapes students’ perceptions of group work: personality or past experience?", International Journal of Educational Management, vol. 34, issue 9, pp. 1457-1473, 2020. 2-_2020-student_perception_1108_ijem-11-2019-0401.pdf
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JL, A., A. N, P. JE, K. R, and K. NA, "VWD type 2N (Normandy) in two sisters.", Haemophilia. 2015 May;21(3):e223-5. doi: 10.1111/hae.12595. Epub 2015 Feb 4. , vol. 3, issue 10, pp. 223-5, 2015.
J.J.A. v.d. Dungen, O. Gabriel, W. Soliman, and C. S. D. R. and Engeln., "VUV-LIF spectroscopy of Ro-vibrationally excited HD molecules produced in hydrogen-deuterium plasmas", 10th EUREGIONAL WELTPP, Workshop on the Exploration of Low Temperature Plasma Physics, Kerkrade, The Netherlands, The Netherland, 2007.
Xiao, S., S. Wang, D. Jiang, X. Cheng, X. Zhu, F. Lin, B. Yu, H. Dong, X. Wang, M. Munir, et al., "VP2 virus-like particles elicit protective immunity against duckling short beak and dwarfism syndrome in ducks.", Transboundary and emerging diseases, vol. 69, issue 2, pp. 570-578, 2022. Abstract

Duckling short beak and dwarfism syndrome virus (SBDSV), an emerging goose parvovirus, has caused short beak and dwarfism syndrome (SBDS) in Chinese duck flocks since 2015. Presently, there is no commercial vaccine against SBDS. In the present study, a virus-like particle (VLP)-based candidate vaccine was developed against this disease. A baculovirus expression system was used to express the SBDSV VP2 protein in Sf9 cells. Immunofluorescence assay, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting were used to confirm protein expression. Furthermore, transmission electron microscopy was used to observe the formation of VLPs. VLPs were formulated into an oil-adjuvanted maternal vaccine to evaluate humoral responses in breeding ducks via latex particle agglutination inhibition assay (LPAI) and microneutralization assay. The offspring were challenged with SBDSV to test the protective efficacy. A single dose of SBDSV was able to induce the high level of LPAI antibodies in ducks, with LPAI and neutralization peak titres of 4.9 ± 1.20 log2 and 7.1 ± 1.20 log2, respectively, at 4 weeks post-vaccination (wpv). The average LPAI titre of yolk antibodies in duck eggs receiving 2 doses (first and boost doses) of the vaccine was 5.3 ± 1.09 log2 at 4 weeks post-boost. The protective efficacy of the maternal vaccine was 87.5%-100%. These results indicate that SBDSV VLPs can be a promising vaccine candidate for controlling SBDS.

Nada, R. M., B. van Loon, J.G.Schols, T. J. Maal, Y. A. Mostafa, and A. M. Kuijpers-Jagtman, "Volumetric changes of the nose and nasal airway 2 years after tooth-borne and bone-borne surgically assisted rapid maxillary expansion.", Eur J Oral Sci, vol. 121, issue 5, pp. 450-456, 2013. Abstract

Abstract
This study aimed to assess the effects of bone-borne and tooth-borne surgically assisted rapid maxillary expansion on the volumes of the nose and nasal airway 2 yr after maxillary expansion. This prospective cohort study included 32 patients with transverse maxillary hypoplasia. Expansion was performed with a tooth-borne distractor (Hyrax) in 19 patients and with a bone-borne distractor [transpalatal distractor (TPD)] in the remaining 13. Cone beam computed tomography scans and three-dimensional (3D) photographs of the face were acquired before treatment and 22 ± 7 months later, and were used to evaluate the volumes of the nose and nasal airway. Nasal volume increased by 1.01 ± 1.6% in the Hyrax group and by 2.39 ± 2.4% in the TPD group. Nasal airway volume increased by 9.7 ± 5.6% in the Hyrax group and by 12.9 ± 12.7% in the TPD group. Changes in the nasal volume and in the nasal airway volume between the pre- and post-treatment measurements were statistically significant, whereas differences between the treatment groups were not; 22 months after surgically assisted rapid maxillary expansion, the increases in the nasal volume and in the nasal airway volume were comparable between tooth-borne and bone-borne devices.

© 2013 Eur J Oral Sci.

Avramovic-Cingara, G., C. A. R. Saleh, M. Jain, and D. Wilkinson, "Void Nucleation and Growth in Dual-Phase Steel 600 during Uniaxial Tensile Testing", Metallurgical and Material transactions A, , vol. 40, , issue 13, 2009, pp. 3117-3127, 2009.
El-Ghandour, N. M. F., A. A. M. Ezzat, M. A. Zaazoue, P. Gonzalez-Lopez, B. S. Jhawar, and M. A. R. Soliman, "Virtual learning during the COVID-19 pandemic: a turning point in neurosurgical education.", Neurosurgical focus, vol. 49, issue 6, pp. E18, 2020. Abstract

OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has caused dramatic changes in medical education. Social distancing policies have resulted in the rapid adoption of virtual learning (VL) by neurosurgeons as a method to exchange knowledge, but it has been met with variable acceptance. The authors surveyed neurosurgeons from around the world regarding their opinions about VL and how they see the future of neurosurgical conferences.

METHODS: The authors conducted a global online survey assessing the experience of neurosurgeons and trainees with VL activities. They also questioned respondents about how they see the future of on-site conferences and scientific meetings. They analyzed responses against demographic data, regions in which the respondents practice, and socioeconomic factors by using frequency histograms and multivariate logistic regression models.

RESULTS: Eight hundred ninety-one responses from 96 countries were received. There has been an increase in VL activities since the start of the COVID-19 pandemic. Most respondents perceive this type of learning as positive. Respondents from lower-income nations and regions such as Europe and Central Asia were more receptive to these changes and wanted to see further movement of educational activities (conferences and scientific meetings) into a VL format. The latter desire may be driven by financial savings from not traveling. Most queried neurosurgeons indicated that virtual events are likely to partially replace on-site events.

CONCLUSIONS: The pandemic has improved perceptions of VL, and despite its limitations, VL has been well received by the majority of neurosurgeons. Lower-income nations in particular are embracing this technology. VL is still evolving, but its integration with traditional in-person meetings seems inevitable.

El-Ghandour, N. M. F., A. A. M. Ezzat, M. A. Zaazoue, P. Gonzalez-Lopez, B. S. Jhawar, and M. A. R. Soliman, "Virtual learning during the COVID-19 pandemic: a turning point in neurosurgical education.", Neurosurgical focus, vol. 49, issue 6, pp. E18, 2020. Abstract

OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has caused dramatic changes in medical education. Social distancing policies have resulted in the rapid adoption of virtual learning (VL) by neurosurgeons as a method to exchange knowledge, but it has been met with variable acceptance. The authors surveyed neurosurgeons from around the world regarding their opinions about VL and how they see the future of neurosurgical conferences.

METHODS: The authors conducted a global online survey assessing the experience of neurosurgeons and trainees with VL activities. They also questioned respondents about how they see the future of on-site conferences and scientific meetings. They analyzed responses against demographic data, regions in which the respondents practice, and socioeconomic factors by using frequency histograms and multivariate logistic regression models.

RESULTS: Eight hundred ninety-one responses from 96 countries were received. There has been an increase in VL activities since the start of the COVID-19 pandemic. Most respondents perceive this type of learning as positive. Respondents from lower-income nations and regions such as Europe and Central Asia were more receptive to these changes and wanted to see further movement of educational activities (conferences and scientific meetings) into a VL format. The latter desire may be driven by financial savings from not traveling. Most queried neurosurgeons indicated that virtual events are likely to partially replace on-site events.

CONCLUSIONS: The pandemic has improved perceptions of VL, and despite its limitations, VL has been well received by the majority of neurosurgeons. Lower-income nations in particular are embracing this technology. VL is still evolving, but its integration with traditional in-person meetings seems inevitable.

El-Ghandour, N. M. F., A. A. M. Ezzat, M. A. Zaazoue, P. Gonzalez-Lopez, B. S. Jhawar, and M. A. R. Soliman, Virtual learning during the COVID-19 pandemic: a turning point in neurosurgical education, , vol. 49, issue 6: American Association of Neurological Surgeons, pp. E18, 2020. AbstractWebsite
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Alorabi, M., A. S. Abdelhafiz, N. Mostafa, A. Ali, H. Elghazawy, A. Mesbah, and A. R. Jazieh, Virtual educational meetings and activities during the COVID-19 pandemic and beyond: Egyptian oncologists' experience, , 2021.
Ezzat, K., M. Pernemalm, S. Pålsson, T. C. Roberts, P. Järver, A. Dondalska, B. Bestas, M. J. Sobkowiak, B. Levänen, M. Sköld, et al., "The viral protein corona directs viral pathogenesis and amyloid aggregation.", Nature communications, vol. 10, issue 1, pp. 2331, 2019. Abstract

Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid β-peptide (Aβ), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.

Jaleel, G. A. A., M. F. Yousif, K. A. D. R. I. Y. A. E. L. S. DEEB, and F. A. T. H. Y. M. SOLIMAN, "Vicia ervilia L. seeds newly explored biological activities", cogent biology, vol. 3, 2017. published_paper.pdf