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Ibrahim, M., N. A. Saleh, W. M. Elshemey, and A. A. Elsayed, "Computational notes on fullerene based system as HIV-1 protease inhibitors", Journal of Computational and Theoretical Nanoscience, vol. 7, no. 1, pp. 224-227, 2010. AbstractWebsite
Ibrahim, E. M., A. A. Zeeneldin, A. M. Al-Gahmi, Y. A. Sallam, E. E. Fawzi, and Y. A. Bahadur, "Safety and efficacy of cetuximab-chemotherapy combination in Saudi patients with metastatic colorectal cancer", Indian journal of cancer, vol. 44, issue 2: Medknow Publications, pp. 56, 2007. Abstract
Ibrahim, M. S. H., and A. oussama himid, جغرافية العالم الجديد, , giza, cairo, 2017. جغرافية العالم الجديد.pdf
Ibrahim, H., Y. M. Issa, and O. R. Shehab, "New selenite ion-selective electrodes based on 5,10,15,20-tetrakis-(4-methoxyphenyl)-21H,23H-porphyrin-Co(II)", Journal of Hazardous Materials, vol. 181, pp. 857–867, 2010. Abstract
Ibrahim, M., A. Eltaliawy, H. Mostafa, and Y. Ismail, "A New Digital Current Sensing Technique Suitable for Low Power Energy Harvesting Systems", IEEE International Conference on Energy Aware Computing Systems and Applications (ICEAC 2015), Cairo Egypt, IEEE, pp. 1-4, 2015. [PDF]
Ibrahim, Y. A., A. H. M. Elwahy, B. N. Barsoum, A. A. Abbas, and S. K. Khella, "Seventeen new 14-and 15-crown formazans: their synthesis and evaluation in spectrophotometric determination of lithium (vol 47, pg 1199, 1998)", TALANTA, vol. 53, no. 6: ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, pp. 1261–1261, 2001. Abstract
Ibrahim, N. S., M. O. F. Hanna, R. J. Farid, N. A. Zayed, S. S. Hunter, and G. Esmat, "Detection of bcl-2 Translocation in Patients with Chronic Hepatitis C and its Possible Relation to Antiviral Therapy: Preliminary Study", Journal of the Egyptian Nat. Cancer Inst, vol. 19, issue 3, pp. 211-218, 2007. detection_of_bcl-2.pdf
Ibrahim, B. B., M. M. Salem, R. A. Khairy, and R. A. R. Al Gunaid, "Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia", J Clin Diagn Res, vol. 11, issue 5, pp. 31-35, 2017.
Ibrahim, D. K., E. S. T. E. Din, E. M. Aboul-Zahab, and S. M. Saleh, "Real time evaluation of DWT-based high impedance fault detection in EHV transmission", Electric Power Systems Research, vol. 80, issue 8: Elsevier, pp. 907 - 914, 2010. Abstract


Ibrahim, A. B., H. F. Zaki, W. Wadie, M. M. Omran, and S. A. Shouman, "Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells.", Cancer management and research, vol. 11, pp. 10011-10028, 2019. Abstract

Purpose: Tamoxifen (TAM) is a non-steroidal antiestrogen drug, used in the prevention and treatment of all stages of hormone-responsive breast cancer. Simvastatin (SIM) is a lipid-lowering agent and has been shown to inhibit cancer cell growth. The study aimed to investigate the effect of the combination of TAM and SIM in the treatment of estrogen receptor positive (ER+) breast cancer cell line, MCF-7, and in mice-bearing Ehrlich solid tumors.

Methods: MCF-7 cells were treated with different concentrations of TAM or/and SIM for 72 hours and the effects of the combination treatment on cytotoxicity, oxidative stress markers, apoptosis, angiogenesis, and metastasis were investigated using different techniques. In addition, tumor volume, oxidative markers, and inflammatory markers of the combined therapy were explored in mice bearing solid EAC tumors.

Results: The results showed that treatment of MCF-7 cells with the combination of 10 µM TAM, and 2 µM SIM significantly inhibited the increase in oxidative stress markers, LDH, and NF-kB induced by TAM. In addition, there was a significant decrease in the total apoptotic ratio, caspase-3 activity, and glucose uptake, while there was a non-significant change in Bax/bcl-2 ratio compared to the TAM-treated group. Using the isobologram equation, the drug interaction was antagonistic with combination index, CI=1.18. On the other hand, the combination regimen decreased VEGF, and matrix metalloproteinases, MMP 2&9 compared to TAM-treated cells. Additionally, in vivo, the combination regimen resulted in a non-significant decrease in the tumor volume, decreased oxidative markers, and the protein expression of TNF-α, and NF-B compared to the TAM treated group.

Conclusion: Although the combination regimen of TAM and SIM showed an antagonistic drug interaction in MCF-7 breast cancer, it displayed favorable antiangiogenic, anti-metastatic, and anti-inflammatory effects.

Ibrahim, A. F., E. O. Abusteit, and E. El‐Metwally, "Response of rapeseed (Brassica napus L.) growth, yield, oil content and its fatty acids to nitrogen rates and application times", Journal of Agronomy and Crop Science, vol. 162, issue 2: Wiley Online Library, pp. 107-112, 1989. Abstract
Ibrahim, K. A., H. A. Abdelgaid, M. A. El-Desouky, A. A. Fahmi, and M. M. Abdel-Daim, "Modulation of Paraoxonase-1 and Apoptotic Gene Expression Involves in the Cardioprotective Role of Flaxseed Following Gestational Exposure to Diesel Exhaust Particles and/or Fenitrothion Insecticide", Cardiovascular Toxicology, vol. 20, issue 6, pp. 604–617, 2020.
Ibrahim, M. M., G. A. M. Mersal, N. El-Shafai, M. M. Youssef, and H. Shoukry, "Synthesis, spectroscopy, electrochemistry, and methylation reaction of the dithiolate-based cobalt(II) complex derived from tert-butyl N-(2-mercaptoethyl)carbamate", Comptes Rendus Chimie, vol. 17, issue 5, pp. 1013-1022, 2014. 2014-comptes.rendu_.chem_.pdf
Ibrahim, M. M., "Influence of soil moisture content on soil solarization efficiency", Misr J. Ag. Eng., vol. 29 , issue 4, pp. 1125- 1148, 2012. influence.pdf
Ibrahim, M. K., M. H. Ismail, and W. M. El-Kharashi, "A Novel Scheduling Algorithm for mmWave Mesh Networks Using Packet Aggregation", In Proc. 2015 IEEE Int. Conference on Electronics, Circuits, & Systems, Cairo, Egypt, 2015.
Ibrahim, W. S., B. B. Ibrahim, M. A. A. Hamid, and A. B. ElZahed, "Immunohistochemical evaluation of EGFR and HER-2/NEU expression in renal cell carcinomas and their prognostic significance.", Med. J. Cairo Univ., vol. 80, issue 2, pp. 211-218, 2012.
Ibrahim, H., S. Mehanny, L. Darwish, and M. Farag, "A Comparative Study on the Mechanical and Biodegradation Characteristics of Starch-Based Composites Reinforced with Different Lignocellulosic Fibers", Journal of Polymers and the Environment, vol. 25, issue 99, pp. 1-14, 2017.
Ibrahim, I. H., H. T. Dorrah, and M. Aboelela, Development of Improved On-Line Control Technique of The Autopilot For Flight ‎Vehicle, , Cairo, Cairo University, 2011.
Ibrahim, A. A., H. M. Soliman, D. El-Lebedy, M. Hassan, N. A. Helmy, T. A. A. Hamid, and N. Abdelhamid, "Expression of exosomal miR-21 and miR-29 in serum of children and adolescents with T1DM and persistent microalbuminuria", Gene Reports, vol. 16, pp. 100461, 2019.
Ibrahim, M., and S. Reveliotis, "Maximal Linear Deadlock Avoidance Policies for Complex Resource Allocation Systems", 2018 IEEE Conference on Decision and Control (CDC): IEEE, pp. 3968–3974, 2018. Abstract
Ibrahim, M. R. M., H. M. A. El-Banna, M. A. F. El-Manylawi, M. M. B. Azza, and A. A. M. Ahmed, "Replacement of okara for soybean, meal protein without or with avizyme in growing rabbit diets.", Egyptian Journal of Rabbit Science, vol. 20, issue 1: Egyptian Rabbit Science Association, pp. 1-14, 2010. Abstract
Ibrahim, A. M., T. Alahawany, M. Mossaad, and H. S. Ashmawy, Induction of Controlled Ovarian Hyperstimulation in Poor Responders, , Cairo, Faculty of Medicine - Cairo University, 2007. induction.pdf
Ibrahim, N. S., M. F. Mohamed, A. H. M. Elwahy, and I. A. Abdelhamid, Biological Activities and Docking Studies on Novel Bis 1,4-DHPS Linked to Arene Core via Ether or Ester Linkage, , vol. 15, issue 10, pp. 1036 - 1045, 2018. Abstract

Background: Novel bis(1,4-dihydropyridine) derivatives linked to arene core via ester 5-7 as well as ether linkages 10-12 were prepared, and their structures were confirmed by several
spectral tools. They were evaluated as anticancer agents on A549 and MCF7 cell lines by SRB assay
and as antibacterial agents on two gram-positive and two gram-negative bacterial strains by disc
diffusion method.
Methods: SRB assay shows that the novel compounds are more effective against lung carcinoma
than human breast cancer. Compound 7 was found to be the most active compound toward A549
cell line with an IC50 value (30.7µM), while compound 12 showed great efficiency against MCF7
cell line recording an IC50 value (46.3µM). The computational studies enabled us to understand the
mechanism of action of these compounds. Compound 7 was chosen for molecular docking studies
on xIAP and cIAP1 proteins using MOE-2009.10 software, and the results obtained show that
compound 7 bound to xIAP and cIAP1 with good energy score (S = -22.0356 Kcal/mol
and -21.3381Kcal/mol), respectively.
Results: With respect to the antibacterial activity, compound 12 exhibited great efficiency against
the bacterial strains and hence it was used in the docking study on β-ketoacyl-ACPsynthaseIII
Conclusion: The results showed good interaction of compound 12 with fabH (with energy score
S = -22.8975 kcal/mol).