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Ibrahim, M. A. E., and H. D. Kalfallah, "Effect of Instructions for Mothers Regarding Weaning on Their Infants Complains", IOSR Journal of Nursing and Health Science (IOSR-JNHS) e- ISSN: 2320–1959.p- ISSN: 2320–1940 Volume 7, Issue 3 Ver. III (May-June .2018), PP 31-42 www.iosrjournals.org, Submitted. e0703033142_3.pdf
Ibrahim, I. M., G. Yu, L. Chen, and Y. Wang, "Enhancing the convex analysis of mixtures technique for estimating DCE-MRI pharmacokinetic parameters.", Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2014, pp. 6434-7, 2014. Abstract

Dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI) is a useful noninvasive tool for monitoring tumor angiogenesis and assessing therapeutic response. One major problem that prevents an accurate estimation of pharmacokinetic parameters is partial-volume effect (PVE). A multi-tissue compartmental modeling (CM) technique supported by convex analysis of mixtures (CAM) is used to overcome the PVE by clustering pixels and constructing a simplex whose vertices are of a single compartment type. CAM uses the identified pure-volume pixels to estimate the kinetics of the tissues under investigation. This paper reports an enhanced version of CAM-CM to identify pure-volume pixels more accurately. This includes the consideration of the neighborhood effect on each pixel and the use of a barycentric coordinate system to identify more pure-volume pixels and to test those identified by CAM. The enhanced CAM achieved root mean square error (RMSE) of 0.00348 ± 0.000019, lower than the RMSE of 0.05409 ± 0.00496 achieved by CAM.

Ibrahim, I., S. D. da Silva, B. Segal, and A. Zeitouni, "Effect of cochlear implant surgery on vestibular function: meta-analysis study.", Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, vol. 46, issue 1, pp. 44, 2017. Abstract

IMPORTANCE: Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the effect of CI before and after surgery on the outcomes of vestibular tests, postural stability, and subjective perception of dizziness.

OBJECTIVE: To evaluate the effects of CI surgery on vestibular function in adult patients (≥18 years) with sensorineural hearing loss who underwent unilateral or bilateral implantation.

DATA SOURCES: MEDLINE, PubMed, Web of Science and Cochrane Library from January 1, 1995, through July 12, 2016.

STUDY SELECTION: Published studies of adult patients who received unilateral or bilateral CIs and whose vestibular function or postural stability was assessed before and after surgery.

DATA EXTRACTION: From each study, test results before and after surgery were compared, for the following five tests: clinical head impulse test (HIT); bi-thermal caloric irrigation of the horizontal semicircular canal; vestibular evoked myogenic potential (VEMP); dizziness handicap inventory (DHI); and computerized dynamic posturography (CDP).

RESULTS: Twenty-seven studies met all inclusion criteria. Most studies performed either bi-thermal caloric irrigation and/or VEMP, with fewer studies investigating changes in HIT, posturography or DHI. CI surgery significantly affected the results of caloric and VEMP testing. However, HIT results, posturography, and DHI, scores were not significantly affected after CI surgery.

CONCLUSIONS AND RELEVANCE: CI surgery has a significant negative effect on the results of caloric as well as VEMP tests. No significant effect of CI surgery was detected in HIT, posturography, or DHI scores. Overall, the clinical effect of CI surgery on the vestibular function was found to be insignificant. Nonetheless, the potential effects of surgery on the vestibular system should be discussed with CI candidates before surgery.

Ibrahim, G. M., A. S. Hassan, E. M. Almetwally, and H. M. Almongy, "Parameter Estimation of Alpha Power Inverted Topp-Leone Distribution with Applications", Intelligent Automation & Soft Computing, vol. 29, issue 2, pp. 353-371, 2021. 18_alpha_power_inverted_topp-leone_distribution.pdf
Ibrahim, A. M., A. Bilsland, S. Rickelt, J. S. Morris, and T. Stein, "A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans.", Breast cancer research : BCR, vol. 23, issue 1, pp. 90, 2021. Abstract

BACKGROUND: During pregnancy, the mouse mammary ductal epithelium branches and grows into the surrounding stroma, requiring extensive extracellular matrix (ECM) and tissue remodelling. It therefore shows parallels to cancer invasion. We hypothesised that similar molecular mechanisms may be utilised in both processes, and that assessment of the stromal changes during pregnancy-associated branching may depict the stromal involvement during human breast cancer progression.

METHODS: Immunohistochemistry (IHC) was employed to assess the alterations within the mouse mammary gland extracellular matrix during early pregnancy when lateral branching of the primary ductal epithelium is initiated. Primary mouse mammary fibroblasts from three-day pregnant and age-matched non-pregnant control mice, respectively, were 3D co-cultured with mammary epithelial cells to assess differences in their abilities to induce branching morphogenesis in vitro. Transcriptome analysis was performed to identify the underlying molecular changes. A signature of the human orthologues of the differentially expressed matrisome RNAs was analysed by Kaplan-Meier and multi-variate analysis in two large breast cancer RNA datasets (Gene expression-based Outcome for Breast cancer Online (GOBO) und Kaplan-Meier Plotter), respectively, to test for similarities in expression between early-pregnancy mouse mammary gland development and breast cancer progression.

RESULTS: The ECM surrounding the primary ductal network showed significant differences in collagen and basement membrane protein distribution early during pregnancy. Pregnancy-associated fibroblasts (PAFs) significantly enhanced branching initiation compared to age-matched control fibroblast. A combined signature of 64 differentially expressed RNAs, encoding matrisome proteins, was a strong prognostic indicator of distant metastasis-free survival (DMFS) independent of other clinical parameters. The prognostic power could be significantly strengthened by using only a subset of 18 RNAs (LogRank P ≤ 1.00e-13; Hazard ratio (HR) = 2.42 (1.8-3.26); p = 5.61e-09). The prognostic power was confirmed in a second breast cancer dataset, as well as in datasets from ovarian and lung cancer patients.

CONCLUSIONS: Our results describe for the first time the early stromal changes that accompany pregnancy-associated branching morphogenesis in mice, specify the early pregnancy-associated molecular alterations in mouse mammary fibroblasts, and identify a matrisome signature as a strong prognostic indicator of human breast cancer progression, with particular strength in oestrogen receptor (ER)-negative breast cancers.

Ibrahim, Y., and R. Hassan, " A revolutionary crowd model: Implemented to contrast oscillating to consistent media influence on crowd behavior", Simul. Trans. Soc. Model. Simul. Int., vol. 93, issue 11, pp. 951–971, 2017.
Ibrahim, S. A. A., H. Hassan, R. Reinbold, N. A. Espinoza-Sanchez, B. Greve, and M. Götte, "Role of Syndecan-1 in Cancer Stem Cells", Proteoglycans in Stem Cells: Springer link, 2021.
IBRAHIM, M. K., and Y. Nakamura, "Correlation Between Linear Stability Theory and Transition of Compressible Jet Shear Layer", Transaction of The Japan Society for Aeronautical and Space Sciences, vol. 45, issue 147, pp. 35-44, 2002. PDF
Ibrahim, A., T. ElGhazaly, and M. Gheith, "A Novel Arabic Text Summarization Model Based on Rhetorical Structure Theory and Vector Space Model", International Journal of Computational Linguistics and Natural Language Processing (IJCLNLP), vol. 2, issue 8, pp. 480-484, 2013. Abstract

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Ibrahim, W. F., Japanes For beginners, , Cairo, العالمية, 2015. glf_lybny_llmbtdyyn.jpg
Ibrahim, M. S., A. G. Mattar, and S. M. Elhafez, "Efficacy of virtual reality-based balance training versus the Biodex balance system training on the body balance of adults.", Journal of physical therapy science, vol. 28, issue 1, pp. 20-6, 2016. Abstract

[Purpose] This study investigated efficacy of virtual reality (VR)-based balance training on enhancing balance and postural reactions of adults as a low-cost new modality compared to the established Biodex Balance System (BBS). [Subjects] Thirty normal adults of both genders were divided randomly into two equal-sized experimental groups of 15: BBS balance training and VR balance training. [Methods] The training programmes were conducted in 12 sessions, three 15-min sessions per week. The Nintendo(®) Wii Fit Plus (NWFP) and its balance board were used to train of the VR group. Each participant answered a questionnaire concerning usability, enjoyment, balance improvement, and fatigue at the end of the training programs. [Results] The study found a significant increase the measure of mean overall balance (OLB) in both groups. No significant difference was found between the groups, but a significant decrease in the mean balance-test time was found for both groups, with no significant difference between the two training methods. The VR programme was rated highly enjoyable by 81.8% of the group. [Conclusion] The Wii Fit Plus system with the balance board as a new VR balance-training technique, can be considered an effective and enjoyable tool for the training of adults' body balance.

Ibrahim, H. K., and S. Salah, "Formulation of venlafaxine for once daily administration using polymeric material hybrids", JOURNAL OF MICROENCAPSULATION, vol. 33, issue 4, pp. 299–306, 2016.
Ibrahim, N. Y., S. M. Talima, and W. S. Makar, "Clinico-Epidemiological Study of Elderly Breast Cancer in a Developing Country: Egypt", Journal of Cancer Treatment and Research, vol. 7 (1), issue 2376-7790, pp. 23-27, 2019. 10.11648.j.jctr_.20190701.14.pdf
Ibrahim, A. A. M., and S. A. Elariane, Feasibility tools for urban animal husbandry in cities: case of greater Cairo, : Taylor & Francis, pp. 1 - 28, 2017. Abstract
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Ibrahim, I. A. M., and S. A. Shehata, "ffect of GA3 ‎‎‎and IAA on Squash infected with CMV and ZYMV ", J. Agric. Res. Tanta Univ. , vol. 3, pp. 481-490, 1990.
Ibrahim, A., M. Hassan, N. Arafa, and S. A. L. A. H. A. ELDIN, "DIABETIC KETOACIDOSI: CLINICAL FEATURES AND PRECIPITATING FACTORS AT DEMPU ", ESPE 2016, pp. 86 P-P2-310. , 2016.
Ibrahim, N. M., R. M. Khaled, M. A. Ragheb, K. Radacki, A. M. Farag, and A. M. Mansour, "Light-activated cytotoxicity of dicarbonyl Ru(II) complexes with a benzimidazole coligand towards breast cancer", Dalton Transactions, vol. 50, pp. 15389, 2021.
Ibrahim, E. M., A. M. Al-Gahmi, J. M. Zekri, S. S. Awadalla, T. R. Elkhodary, E. E. Fawzy, Y. A. Bahadur, M. E. Elsayed, A. Zeeneldin, R. H. Al-Ahmadi, et al., "Pre-operative systemic therapy in locally advanced breast cancer: a single institution experience.", Ecancermedicalscience, vol. 3, pp. 161, 2009. Abstract

BACKGROUND: Locally advanced breast cancer (LABC) is common in developing countries and it frequently affects younger women. Patients do very poorly when treated by locoregional therapy alone; therefore, pre-operative systemic therapy (PST) is commonly used.

MATERIALS AND METHODS: Medical records of 64 Saudi patients with LABC treated with PST in a single institution were retrospectively reviewed.

RESULTS: At diagnosis, most patients were young (median age 41 years), and had poor clinicopathological characteristics. Following surgery, complete pathologic response (pCR) in the breast was achieved in 13 patients (20%). Of 62 patients with known nodal status, 22 (34%) had negative axillary nodes. Presence of oestrogen receptor (ER) negative tumour was the only dependent variable that predicted pCR in the breast (p = 0.03). At a median follow-up of 42 months, the median progression-free survival (PFS) was 48 months (95% CI, 20-76 months) and the projected five-year overall survival (OS) was 68%. The recently published scoring system (Jeruss et al (2008) J Clin Oncol26 2 246-52), was the only variable that independently influenced PFS, while ER negative tumours and presence of lymphovascular space invasion were the only factors that adversely affected OS.

CONCLUSIONS: despite the use of standard multi-modality approach in the management of patients with LABC, prognosis remains guarded.

Ibrahim, A. B., T. M. Sakr, O. M. A. Khoweysa, M. A. Motaleb, A. A. El-Bary, and M. T. El-Kolaly, "Formulation and preclinical evaluation of 99mTc–gemcitabine as a novel radiopharmaceutical for solid tumor imaging", J Radioanal Nucl Chem, vol. 302, issue 1, pp. 179-186, 2014.
Ibrahim, Y. A., A. A. Abbas, and A. H. M. Elwahy, "New trends in the chemistry of condensed heteromacrocycles part B: Macrocyclic formazans", Journal of heterocyclic chemistry, vol. 41, no. 2: Wiley-Blackwell, pp. 135–149, 2004. Abstract
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