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Hussein, H. A., S. M. Abdelmawella, E. H. Esmail, A. H. Ragab, R. Roshdy, and N. Kishk, Grief Versus Depression in Multiple Sclerosis Patients, , 2017. grief-versus-depression-in-multiple-sclerosis-patients.pdf_final_publication.pdf
Hussein, A., H. Fathy, S. Amin, and N. Elsisy, "Oral steroids alone or followed by intranasal steroids versus watchful waiting in the management of otitis media with effusion", The Journal of Laryngology & Otology, vol. 131, pp. 907-913, 2017. printed_paper.pdf
Hussein, A. M. S., and E. - S. A. El-Sherpieny, Quasi-Bayesian Estimation, , Egypt, Cairo University, 2012. ahlam_mohamed_saad_hussein.pdf
Hussein, E., "Non-myeloablative bone marrow transplant and platelet infusion can transiently improve the clinical outcome of mitochondrial neurogastrointestinal encephalopathy: a case report.", Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, vol. 49, issue 2, pp. 208-11, 2013 Oct. Abstract

Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is caused by deficiency in thymidine phosphorylase (TP), that regulates thymidine (dThd) and deoxyuridine (dUrd). Toxic levels of dThd and dUrd can lead to mitochondrial dysfunction by impairing mitochondrial DNA replication, causing GI and neurologic deterioration. We studied the impact of bone marrow transplant (BMT) and platelets, as a source of TP on the clinical outcome of MNGIE. We report a case of MNGIE, who presented with severe vomiting. Over time, he was non-ambulatory and his GI symptoms got progressively worse with severe dysphagia, abdominal pain episodes, persistent vomiting and diarrhea. Being unfit for intense conditioning regimen, he received a mini BMT, with mild conditioning regimen. Bone marrow was obtained from his HLA fully matched brother. One month after transplantation, donor chimerism in peripheral blood was 33%. Excellent clinical responses were achieved 3 months after transplantation and circulating donor cell chimerism decreased to 24% with a significant increase in platelet TP activity. Ten months post transplant the patient's symptoms recurred and fresh single donor platelets were infused, with a significant increase in platelet TP activity. Mini BMT and platelet transfusion can transiently increase circulating TP activity and might prevent progress of this fatal disease.

Hussein, R. E., E. d Laila Ahmed RASHED, B. E. Aboulhoda, G. M. A. Aziz, E. G. Abdelhady, Sarah A Ab-AAL, A. Shamseldeen, M. M. Khalifa, and H. Morsi, "The Role of Thymoquinone in Mitigating Carbon Tetrachloride-Induced Hepatocellular Carcinoma in Rats: Targeting the CHOP-1/JNK/P38 MAPK, NFêB/TNF-á/IL-10, and Bax/Bcl-2/Caspase-3 Signalling Pathways", Folia Biologica, vol. 69, issue 1, pp. 1-9, 2021.
Hussein, O. S., and S. B. Mulani, "Multi-dimensional optimization of functionally graded material composition using polynomial expansion of the volume fraction", Structural and Multidisciplinary Optimization, vol. 56, no. 2, pp. 271–284, Aug, 2017. AbstractWebsite

The work of this paper proposes a method for multi-dimensional optimization of functionally graded materials (FGMs) composition. The method is based on using polynomial expansion of the volume fraction of the constituent materials. In this approach, the design variables are the coefficients of the polynomial expansion which to be determined through the optimization process. This method provides much more flexibility in the design compared to the methods based on the power-law, or the exponential-law which will in turn lead to more optimal designs. Also it requires much less number of design variables compared to the grid based approaches which is also utilized for two-dimensional optimization of FGMs structures. As an application of the proposed method, the optimization of a simply supported Aluminum plate reinforced with Silicon Carbide nano-particles is considered. Cost plays a very important role for this type of structures, since the cost of the reinforcements such as Silicon Carbide nano-particles, or carbon nano-tubes is too high. So the aim of the optimization process is to minimize the amount of the reinforcement required to satisfy certain performance criteria. Both static, and dynamic cases are considered in this work; a plate under a transverse pressure distribution is considered as the static case, and the panel flutter problem as the dynamic case.

Hussein, E. R. M. A., E. A. A. Gihad, R. A. M. Ali, and S. M. Allam, "Chloride retention in sheep.", Egyptian Journal of Animal Production, 1974. Abstract
Hussein, H., H. alzan, P. Lacy, J. laughery, and C. Suarez, "long term culturing of Babesia bovis results in reduction of virulence and abrogates tick transmission ", Washington state VMP Research symposium, Pullman, WA, USA, 31 October 2017.
Hussein, M. F., N. A. Ahmed, and M. M. ‎ Fathi, "Action of heat stress on the total brain acetylcholine level in ‎some Egyptian rodents. ‎", Proc. Zool. Soc. A.R.E. , vol. 8, , pp. 75-114, 1985.
Hussein, W. A., E. M. Hassan, A. Mahmoud, and M. H. Abd-El-Kader, "Characteristics of wheat flour cakes as influenced by substitution of maize fractions", Egyptian Journal of Agricultural Research, vol. 74, 1996. Abstract
Hussein, H. E., F. K. Adham, G. A. Scoles, M. W. Ueti, C. E. Suarez, F. D. Guerrero, and R. G. Bastos, "Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness", Parasites & vectors, vol. 8, issue doi:10.1186/s13071-015-1226-2, pp. 618-630, 2015. aquaporin2_full_text.pdf
Hussein, H. T., H. A. Hassan, H. H. R. Madkor, A. A. Abdel-Ghany, and K. A. Ahmed, "THE ROLE OF VISFATIN AND CYTOGLOBIN IN OBESE DIABETIC RATS: THE MODULATORY EFFECTS OF RASPBERRY KETONE", Bulletin of Pharmaceutical Sciences Assiut University, vol. 43, issue 1, pp. 53-72, 2020.
Hussein, A. H., A. El-Sanousi, A. A. Youssif, M. A. Shalaby, M. S. Saber, and I. M. Reda, "Sequence Analysis of Fusion and Matrix Protein Genes of the Velogenic Viscerotropic Newcastle Disease Virus Egyptian Strain sr/76", In the First International Conference of Virology "Towards A Better Strategy for Control of Viral Diseases", Cairo, Egypt, pp. 65, 2004.
Hussein, H. A., OM Khattab, S. M. Aly, and M. A. Rohaim, "Role of ixodid (Hard) tick in the transmission of lumpy skin disease", Hosts Viruses, vol. 4, pp. 46-53, 2017.
Hussein, A. S., M. A. Rashwan, and A. F. Atiya, "Arabic Full Text Diacritization using Light Layered Approach", Artificial Intelligence and Machine Learning Journal, vol. 16, issue 1, pp. 31-41, 1975 Sep, 2016. Abstractp1121636514.pdf

Effects of sodium nitrate were compared with sodium chloride loading on transport of electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron, the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1%, urinary sodium excretion (UNaV) of 1,126 mueq/min, and urinary chloride excretion (UClV) of 848 mueq/min during nitrate loading compared with an increase in CNa/GFR of 37.6%, UNaV of 2,362 mueq/min, and UClV of 2,397 mueq/min during saline loading. The smaller diuretic-induced increment in Na and Cl excretion in the nitrate studies suggests, as do the hydrated studies, that less Cl and Na are reabsorbed in the distal nephron during nitrate than saline loading. At every level of UNaV, fractional bicarbonate reabsorption was higher, urine pH was lower, and urinary potassium excretion (UKV) was higher in the nitrate studies. Thus, compared with saline loading, sodium nitrate decreases chloride and sodium reabsorption in the distal nephron. The higher hydrogen and potassium secretion in the nitrate studies may be consequent to the decreased ability of the distal nephron to reabsorb chloride.

Hussein, A., V. Gaudet, H. Mostafa, and M. Elmasry, "A 16-bit High Speed Low Power Hybrid Adder", IEEE International Conference on Microelectronics (ICM 2016), Cairo, Egypt, IEEE, pp. 313-316, 2016. [PDF]
Hussein, A. A., S. B. Shafiei, M. Sharif, E. Esfahani, B. Ahmad, J. D. Kozlowski, Z. Hashmi, and K. A. Guru, "Technical mentorship during robot-assisted surgery: a cognitive analysis.", BJU international, vol. 118, issue 3, pp. 429-36, 2016 Sep. Abstract

OBJECTIVE: To investigate cognitive and mental workload assessments, which may play a critical role in defining successful mentorship.

MATERIALS AND METHODS: The 'Mind Maps' project aimed at evaluating cognitive function with regard to surgeon's expertise and trainee's skills. The study included electroencephalogram (EEG) recordings of a mentor observing trainee surgeons in 20 procedures involving extended lymph node dissection (eLND) or urethrovesical anastomosis (UVA), with simultaneous assessment of trainees using the National Aeronautics and Space Administration Task Load index (NASA-TLX) questionnaire. We also compared the brain activity of the mentor during this study with his own brain activity while actually performing the same surgical steps from previous procedures populated in the 'Mind Maps' project.

RESULTS: During eLND and UVA, when the mentor thought the trainee's mental demand and effort were low based on his NASA-TLX questionnaire (not satisfied with his performance), his EEG-based mental workload increased (reflecting more concern and attention). The mentor was mentally engaged and concerned while he was engrossed in observing the surgery. This was further supported by the finding that there was no significant difference in the mental demands and workload between observing and operating for the expert surgeon.

CONCLUSIONS: This study objectively evaluated the cognitive engagement of a surgical mentor teaching technical skills during surgery. The study provides a deeper understanding of how surgical teaching actually works and opens new horizons for assessment and teaching of surgery. Further research is needed to study the feasibility of this novel concept in assessment and guidance of surgical performance.

Hussein, H. M., A. Abdel Moneim, T. Emara, Y. A. Abd-Elhamid, H. H. Salem, F. Abd-Allah, M. A. Farrag, A. M. Tork, A. S. Shalash, K. H. Ezz El Dein, et al., "Arabic cross cultural adaptation and validation of the National Institutes of Health Stroke Scale.", Journal of the neurological sciences, vol. 357, issue 1-2, pp. 152-6, 2015 Oct 15. Abstract

INTRODUCTION: The National Institutes of Health Stroke Scale (NIHSS), the most commonly used tool to quantify neurological deficit in acute stroke, was initially developed in English. We present our experience in developing and validating an Arabic version of the NIHSS (arNIHSS).


RESULTS: In 6months, 137 patients were recruited (mean age±standard deviation 62±12years; 48 women). For interrater agreement, weighted kappa value ranged from 0.36 to 0.66 and intraclass correlation coefficient (ICC) for the whole scale was excellent at 0.95 (95% confidence interval [CI] 0.94-0.97). For intrarater agreement, weighted kappa ranged from 0.52 to 1.0 and the ICC was 0.94 (95% CI 0.87-0.98). The construct validity of the arNIHSS is demonstrated by its correlation with the DWI-ASPECT and the 3months mRS score (Spearman correlation -0.46 and 0.58 respectively; P<0.001 for both).

CONCLUSION: We developed and validated a culturally adapted Arabic version of the NIHSS. Further validation in other Arab countries is recommended.

Hussein, H. A., M. M. Emara, M.A. Rohaim, K. Ganapathy, and A. M. Arafa, "Sequence Analysis of Infectious Bronchitis Virus (IBV) IS/1494 Like Strain Isolated From Broiler Chicken Co-infected With Newcastle Disease Virus (NDV) In Egypt during 2012", International Journal of Poultry Science, 2014.
Hussein, S. A., Y. Y. Sabri, M. A. Fouad, H. H. Al-Zawam, and N. M. Mohamed, "Role of different imaging modalities in the evaluation of normal and diseased thymus", The Egyptian Journal of Bronchology, vol. 14, issue 5, pp. 1-9, 2020.