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Hussein, M. M., and S. M. Metwalli, "Interactive Belt Drive Mechanics Using CAD Program and Finite Element Validation", Assiut University International Conference MEATIP 5, March 29-31, Assiut, Egypt, Assiut University, pp. 301-311, 2011.
Hussein, E., "Non-Islamist parties in post-2011 Egypt: winners in an MB-free political sphere", Review of Economics and Political Science , vol. 6, issue 2, pp. 161-178, 2021.
Hussein, R., and S. Hassan, "Customer engagement on social media: how to enhance continuation of use ", Online Information Review, vol. 41, issue 7, pp. 1468-4527, 2017.
Hussein, E. R. M. A., N. T. Kazzal, and R. K. Abdallah, "A study of crossbreeding between Awassi and Karadi sheep, 2: Economic fattening of crossbred lambs in northern Iraq.", Mesopotamia Journal of Agriculture, 1976. Abstract
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Hussein, G. M., G. A. Abu El-Heba, S. M. Abdou, and N. A. Abdallah, "Optimization of transient gene expression system in Gerbera jemosonii petals", GM crops & food, vol. 4, issue 1: Taylor & Francis, pp. 50-57, 2013. Abstract
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Hussein, A. A. E. - D. M., Institute of Sudanese Studies in Egypt, 1947-1956, , Cairo, Center Arabisc for Printin, Submitted. d.hmd_bdldym-ktb_mhd_ldrst_lswdny.pdf
Hussein, R. E., E. d Laila Ahmed RASHED, B. E. Aboulhoda, G. M. A. Aziz, E. G. Abdelhady, Sarah A Ab-AAL, A. Shamseldeen, M. M. Khalifa, and H. Morsi, "The Role of Thymoquinone in Mitigating Carbon Tetrachloride-Induced Hepatocellular Carcinoma in Rats: Targeting the CHOP-1/JNK/P38 MAPK, NFêB/TNF-á/IL-10, and Bax/Bcl-2/Caspase-3 Signalling Pathways", Folia Biologica, vol. 69, issue 1, pp. 1-9, 2021.
Hussein, M. M., R. M. Gaafar, A. M. Abdel-Warith, W. A. Ahmed, Nasr Mohamed Ali Allahloubi, Ahmed Mohamed Abdel Warith, S. E. Salem, and I. M. Abdel-Salam, "Efficacy and Toxicity of Metronomic Chemotherapy in Metastatic Breast Cancer: Egyptian Experience.", Clinical breast cancer, vol. 17, issue 8, pp. 618-628, 2017 12. Abstract2017_efficacy_and_toxicity_of_metronomic_chemotherapy_in_metastatic_breast_cancer-_egyptian_experience.pdf

BACKGROUND: Metronomic chemotherapy (MC) has shown efficacy in patients with metastatic breast cancer (MBC). We therefore tested the efficacy and toxicity of MC in pretreated MBC.

PATIENTS AND METHODS: This prospective phase II study included 50 patients with heavily pretreated MBC who received MC in the form of continuous oral cyclophosphamide 50 mg/day and oral methotrexate 2.5 mg twice per day on days 1 and 2 every week. The primary end point was progression-free survival (PFS), whereas the secondary end points were response rate, overall survival (OS), and safety.

RESULTS: Forty-eight patients were assessed. One patient achieved complete response and 10 patients had partial response, whereas 19 patients had stable disease. The median PFS was 5 months, whereas the median OS was 7 months. Patients with negative progesterone receptors, Eastern Cooperative Oncology Group performance status (PS) 1, achieving response, and those who developed leucopenia, neutropenia, and anemia had significant prolonged PFS, whereas patients with early stage at presentation, receiving < 5 previous treatment lines, achieving response, and experiencing anemia with MC had significant superior OS. In multivariate analysis, achieving response, PS 1, a longer time interval from initial diagnosis until starting MC, and anemia were independent prognostic factors for longer PFS. Initial stage at presentation, number of previous treatment lines, and response were independent prognostic factors for OS.

CONCLUSIONS: MC is an attractive treatment approach that is effective and less toxic. There are certain groups of patients who seem to benefit more, especially those who experienced toxicity with treatment. Larger trials are warranted to assess this approach early in the course of the disease and with other more active agents.

Hussein, H. M., R. S. Alshammari, S. S. Al-Barak, N. D. Alshammari, S. N. Alajlan, and O. W. Althomali, "A Systematic Review and Meta-analysis Investigating the Pain-Relieving Effect of Interferential Current on Musculoskeletal Pain", American Journal of Physical Medicine & Rehabilitation, vol. 101, issue 7, pp. 624-633, 2022.
Hussein, A. A., S. Dibaj, N. Hinata, E. Field, K. O'leary, B. Kuvshinoff, J. L. Mohler, G. Wilding, and K. A. Guru, "Development and Validation of a Quality Assurance Score for Robot-Assisted Radical Cystectomy: a 10-Year Analysis.", Urology, 2016 Aug 1. Abstract

OBJECTIVE: To develop quality assessment tool to evaluate surgical performance for robot-assisted radical cystectomy (RARC) program.

METHODS: A prospectively maintained quality assurance database of 425 consecutive RARCs performed by a single surgeon between 2005 and 2015 was retrospectively reviewed. Potentially modifiable factors, related to the management and perioperative care of patients were used to evaluate patient care. Criteria included: Preoperative (administration of neoadjuvant chemotherapy); Operative (operative time <6.5 hours and estimated blood loss <500cc); Pathologic (negative soft tissue surgical margins and lymph node yield ≥20); and Postoperative (no high grade complications, readmission or non-cancer related mortality within 30 d).The Quality Cystectomy Score (QCS) was developed (1 star: achieving ≤2 criteria or mortality within 30 d; 2 stars: 3 or 4 criteria met; and 3 stars: 5 or 6 criteria met; 4 stars: 7 or all criteria met). Univariate and multivariate Cox proportional hazard regression models were fitted to test for the association between QCS and survival outcomes.

RESULTS: Most patients (85%) achieved at least 3 stars, and more patients achieved 4 stars with time. High QCS was associated with better recurrence free (RFS), cancer specific (CSS) and overall survival (OS) (p-values <0.05). None of the patients with 1-star were alive at 1 yr. Patients with 4 stars achieved the best survival rates (RFS 62%, CSS 70% and OS 53% at 5 yrs) (log rank p<0.0001).

CONCLUSION: Continuous assessment for quality improvement facilitated implementation and maintenance of robot-assisted program for bladder cancer.

Hussein, A. A., C. J. Welty, N. Ameli, J. E. Cowan, M. Leapman, S. P. Porten, K. Shinohara, and P. R. Carroll, "Untreated Gleason Grade Progression on Serial Biopsies during Prostate Cancer Active Surveillance: Clinical Course and Pathological Outcomes.", The Journal of urology, vol. 194, issue 1, pp. 85-90, 2015 Jul. Abstract

PURPOSE: We describe the outcomes of patients with low risk localized prostate cancer who were upgraded on a surveillance biopsy while on active surveillance and evaluated whether delayed treatment was associated with adverse outcome.

MATERIALS AND METHODS: We included men in the study with lower risk disease managed initially with active surveillance and upgraded to Gleason score 3+4 or greater. Patient demographics and disease characteristics were compared. Kaplan-Meier curve was used to estimate the treatment-free probability stratified by initial upgrade (3+4 vs 4+3 or greater), Cox regression analysis was used to examine factors associated with treatment and multivariate logistic regression analysis was used to evaluate the factors associated with adverse outcome at surgery.

RESULTS: The final cohort comprised 219 men, with 150 (68%) upgraded to 3+4 and 69 (32%) to 4+3 or greater. Median time to upgrade was 23 months (IQR 11-49). A total of 163 men (74%) sought treatment, the majority (69%) with radical prostatectomy. The treatment-free survival rate at 5 years was 22% for 3+4 and 10% for 4+3 or greater upgrade. Upgrade to 4+3 or greater, higher prostate specific antigen density at diagnosis and shorter time to initial upgrade were associated with treatment. At surgical pathology 34% of cancers were downgraded while 6% were upgraded. Cancer volume at initial upgrade was associated with adverse pathological outcome at surgery (OR 3.33, 95% CI 1.19-9.29, p=0.02).

CONCLUSIONS: After Gleason score upgrade most patients elected treatment with radical prostatectomy. Among men who deferred definitive intervention, few experienced additional upgrading. At radical prostatectomy only 6% of cases were upgraded further and only tumor volume at initial upgrade was significantly associated with adverse pathological outcome.

Hussein, H. T., H. A. Hassan, H. H. R. Madkor, A. A. Abdel-Ghany, and K. A. Ahmed, "THE ROLE OF VISFATIN AND CYTOGLOBIN IN OBESE DIABETIC RATS: THE MODULATORY EFFECTS OF RASPBERRY KETONE", Bulletin of Pharmaceutical Sciences Assiut University, vol. 43, issue 1, pp. 53-72, 2020.
Hussein, M. N., A. Heinemann, D. A. Shokry, M. Elgebely, klaus pueschel, and F. M. Hassan, "Postmortem computed tomography differentiation between intraperitoneal decomposition gas and pneumoperitoneum", International Journal of Legal Medicine, vol. 136, issue 1, pp. 229-235, 2022.
Hussein, A. A., N. A. Sabry, M. S. Abdalla, and S. F. Farid, "A prospective, randomised clinical study comparing triple therapy regimen to hydrocortisone monotherapy in reducing mortality in septic shock patients", International Journal of Clinical Practice, vol. 75, issue 9, 2021. AbstractWebsite

Objectives: This prospective, comparative and randomised clinical study evaluated the effectiveness of triple therapy regimen (hydrocortisone, thiamine and vitamin C) versus hydrocortisone alone in reducing the mortality rate and preventing progressive organ dysfunction in septic shock patients. Methods: A total of 94 patients were randomly assigned to one of two groups: the first group received hydrocortisone 50 mg/6-h IV for 7 days or till intensive care unit (ICU) discharge, if sooner, followed by tapering. The second group received hydrocortisone 50 mg/6-h IV for 7 days or ICU discharge followed by tapering, vitamin C 1.5 g/6-h IV for 4 days or till ICU discharge and thiamine 200 mg/12-h IV for 4 days or till ICU discharge. Results: The triple therapy regimen showed a non-significant reduction in 28-day mortality compared to hydrocortisone alone (17 [36.2%] vs. 21 [44.7%]; P =.4005), but it was significantly lower than the control group regarding shock time and the duration of vasopressor use in days (4.000 [3.000-7.000]; 5.000 [4.000-8.000], [P =.0100]). The patients in the control group were likely to get 0.59 more in SCr level than those in the intervention group by a linear regression model which was significant (P <.05). Also, the number of patients who developed a fever after 216 hours was significantly higher in the control group (P value =.0299). Conclusion: Vitamin C, thiamine, and hydrocortisone regimen for septic shock management showed non-significant efficacy in decreasing 28-day mortality when compared to hydrocortisone monotherapy. On the other hand, it showed significant efficacy in decreasing the shock time and duration on vasopressors. © 2021 John Wiley & Sons Ltd

Hussein, R. A., M. F. O. Hameed, J. El-Azab, W. S. Abdelaziz, and S. S. A. Obayya, "Analysis of ultra-high birefringent fully-anisotropic photonic crystal fiber", Optical and Quantum Electronics, vol. 47, issue 8, pp. 2993–3007, 2015.
Hussein, H. A., S. M. Abdelmawella, E. H. Esmail, A. H. Ragab, R. Roshdy, and N. Kishk, "Grief Versus Depression in Multiple Sclerosis Patients", Neuropsychiatry, vol. 7, no. 5: International Journal of Clinical Skills, pp. 487–493, 2017. Abstract
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Hussein, A. A., Y. E. Ahmed, J. D. Kozlowski, P. May, J. Nyquist, S. Sexton, L. Curtin, J. O. Peabody, H. Abol-Enein, and K. A. Guru, "Robot-Assisted Approach to W Configuration Urinary Diversion:A Step-by-Step Technique.", BJU international, 2017 Feb 20. Abstract

INTRODUCTION: To describe a detailed step-by-step approach of our technique to robot-assisted intracorporeal "W" orthotopic ileal neobladder (ICNB).

METHODS: Five patients underwent robot-assisted radical cystectomy (RARC), extended pelvic lymph node dissection (ePLND) and ICNB. ICNB was divided into 6 key steps to facilitate and enable a detailed analysis and auditing of the technique. No conversion to open surgery was required. Timing for each step was noted. All patients had at least 3 months of follow up.

RESULTS: Mean age was 57 years. Mean overall console and diversion times were 357 and 193 minutes, respectively. None of the patients had any evidence of residual disease following RARC. Four of five patients experienced complications; 3 developed fevers due to urinary tract infection (one required readmission), and 1 patient developed myocardial infarction and required coronary angiography and stenting. Looking at the timing for the individual steps, bowel detubularization and construction of posterior plate were consistently the longest among the key steps (average 46 minutes, 13% of the overall operative time), followed by uretero-ileal anastomosis (37 minutes, 10%), neobladder-urethral anastomosis (23 minutes, 6%) and identification and fixation of the bowel (26 minutes, 7%).

CONCLUSION: We described our step-by-step technique and initial perioperative outcomes of our first five intracorporeal neobladders with "W" configuration This article is protected by copyright. All rights reserved.

Hussein, H. E., S. B. Mohamed, A. Alagib, and T. B. AbdElkareim, "Molecular detection and characterization of Theileria spp. infecting cattle in Sennar State, Sudan", Parasitology Research , vol. 117, pp. 1271–1276 , 2018. molecular_detection_and_characterization_of_theileria_spp.pdf
Hussein, M. M. M., H. A. Mansour, and H. A. Ashour, "Response of Paspalum vaginatum Turfgrass Grown under Shade Conditions to Paclobutrazol and Trinexapac-Ethyl as Plant Growth Retardants (PGRs)", J. of Hort. Sci. & Ornamental Plants, vol. 4, issue 2, pp. 134-147, 2012. Abstract
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Hussein, M. M., and S. M. Metwalli, "INTERACTIVE BELT DRIVE MECHANICS USING CAD PROGRAM AND FINITE ELEMENT VALIDATION", FIFTH ASSIUT UNIVERSITY INTERNATIONAL CONFERENCE ON MECHANICAL ENGINEERING ADVANCED TECHNOLOGY FOR INDUSTRIAL PRODUCTION, Assiut, Egypt, 29-31 March, 2011.
Hussein, H. M. E., T. A. Ali, and N. A. D. I. A. H. RAFAT, "A review on the techniques for building all-optical photonic crystal logic gates", Optics & Laser Technology, vol. 106, pp. 385 - 397, 2018. AbstractWebsite

Recently, photonic crystals have emerged to contribute in building all-optical computers and optical communication systems. This is due to the urgent need for faster computers and mobiles with high speed processing of data and with higher data transmission rates. In this paper we review the operation of photonic crystal logic gates and depict the different design techniques that produce a wide range of structures realizing the logic functions. We investigate several techniques such as self-collimated beam, multi-mode interference, interference based defect method and nonlinear Kerr materials based gates. As a summary, we compare the various key features of each design and illustrate the advantages and disadvantages of each design technique.

Hussein, R. Z. K., N. K. Attia, M. K. Fouad, and S. T. Elsheltawy, "Experimental investigation and process simulation of biolubricant production from waste cooking oil", Biomass and Bioenergy, vol. 144, 2021.