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W, O., A. E. - D. H, E. I, M. H, Z. G, and F. H, "Comparison between Tl-201 and Tc99m MIBI scintimammography in palpable breast masses. Correlation with mammography and histopathology", 81st Scientific Assembly and Annual Meeting of Radiological Society of North America, North America, Nov 26- Dec 1, Submitted.
nehal hamdy elsaid, N. S. Ghanem, R. S. Mohamed, and N. A. E. G. M. Mohamed Aly Salem, "THE RELATIONSHIP BETWEEN SERUM OSTEOPROTEGRIN LEVEL AND CORONARY ARTERY CALCIFICATION IN TYPE 2 DIABETES MELLITUS PATIENTS", meditarrean group for the study of diabetes, Athens(Greece), 27-29 april 2017, Submitted.
Agrawal, P., T. Ganesh, and A. W. Mohamed, "Solution of Uncertain Solid Transportation Problem by Integer Gaining Sharing Knowledge Based Optimization Algorithm", 2020 International Conference on Computational Performance Evaluation (ComPE), pp. 158 - 162, 2-4 July 2020, Submitted. Abstract
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H, M., S. R, Z. G, and E. - H. Sh, "AFP as indicator for diagnosis and management of cancer", Seminar on nuclear techniques for the detection and management of cancer, Colombo, Srilanka, 12-15 August, Submitted.
El-Tayeb, S., M. A. Harith, and M. Z. Gheith, "The association pf tooth lead content in ancient and contemporary via LIBS technique", Life Science, vol. 11, issue 10, pp. 1215-1219, Submitted. 181_27162life111014_1215_1219.pdf
E., F., R. G.M., S. N., and M. G., "Balance Disturbance in Patients with Diabetic Sensory Polyneuropathy.", in Egypt J. Neurol. Psychiat. Neurosurg., vol. 51, issue 1, pp. 21-29, Submitted.
H.S., S., T. M.S, S. N.M., and R. G.M., "Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia? ", Journal of Headache and pain, issue 14, pp. 92, Submitted.
N.A., A., B. I.H., E. Y., A. E. - W. G.A, M. M. A. Hamdy G.c, and M. M.A., "CD4+CD25+ regulatory Tcells (TREG) in Systemic Lupus Erythematosus (SLE) patients: The possible influence of treatment with corticosteroids", Clinical immunology, vol. 127, issue 2, pp. 151-157, Submitted.
Husseiny, N. E. M., A. E. Sobky, A. M. Khalaf, M. Fateen, D. E. M. Demerdash, H. Youssef, M. Salah, S. E. S. A. E. Ghany, S. E. Husseiny, and M. Gamil, "Chronic immune thrombocytopenia. Egyptian experience", Comp Clin Pathol , issue 1618-5641, Submitted.
Husseiny, N. E. M., A. E. Sobky, A. M. Khalaf, M. Fateen, D. E. M. Demerdash, H. Youssef, M. Salah, S. E. S. A. E. Ghany, S. E. Husseiny, and M. Gamil, "Chronic immune thrombocytopenia. Egyptian experience", Comp Clin Pathol , issue 1618-5641, Submitted.
Sh, E. - H., M. F, M. H, Z. G, S. Z, and E. - S. K, "Comparative study of interventricular phase difference and pressure gradient in cases of isolated ventricular septal defect", . Eur J Nucl Med, vol. 20(10, pp. 921, Submitted.
Elbayoumi, K. M., E. R. Hassan, Z. A. M. S. Girh, A. M. M., H. M. Mekky, and M. A. Bosila, "Comparative study on immunogenicity of different inactivated Newcastle disease vaccines used in Egypt and role of prebiotic in improve immune response of commercial broiler chickens. ", Life Science Journal , vol. 11, issue 9, pp. 384-387. , Submitted.
Mahmoud, M. M., A. M. Shamseldeen, L. A. Rashed, A. E. Fares, A. Shamaa, and D. M. Gharib, "Contribution of volume overload to progression of cardiovascular disease in a rat model of chronic kidney disease", Canadian Journal of Physiology and Pharmacology, vol. 96(12), issue volume 96, Number 12, December 2018 , pp. 1197-1208, Submitted.
Farrag, A., A. ELFaramawy, M. A. Salem, R. A. Wahab, and S. Ghareeb, "Coronary artery ectasia diagnosed using multidetector computed tomography: morphology and relation to coronary artery calcification", Int J Cardiovasc Imaging 2013, vol. 29, issue ISSN 1569-5794, pp. 427-433, Submitted.
W., M., B. K., and R. G.M., "Correlation between Plantar Pressure and Plantar Microcirculation in Diabetic Peripheral Neuropathy Patients.", Egypt J. Neurol. Psychiat. Neurosurg, vol. 50, issue 2, pp. 177-186, Submitted.
Gouda, O. E., G. Osman, W. Salem, and S. H., "Cyclic Loading of Underground Cables Including the Variations of Backfill Soil Thermal Resistivity and Specific Heat With Temperature Variation", IEEE TRANSACTIONS ON POWER DELIVERY, vol. 33, issue 6, pp. 3122-3129, Submitted.
Mazny, D. A. E., D. S. Gadallah, and D. A. Kamel, "Effect of hydrosalpnix on uterine and ovarian hemodynamicsin women with tubal factor infertility", european journal of obstetrics and gynecology and reproductive biology, vol. 199, pp. 55-59, Submitted.
Halim, M. Z. A. E., P. D. F. A. R. A. Gawad, D. A. A. E. E. Rizk, and undefined, EFFECT OF AMIODARONE ON THE LUNG OF ADULT MALE ALBINO RAT AND THE POSSIBLE PROTECTIVE ROLE OF VITAMIN E: A HISTOLOGICAL AND ULTRASTRUCTURAL STUDY, , cairo, cairo university faculty of medicine, Submitted.
Nassar, K., E. Elfar, O. Tatar, J. Lueke, M. Lueke, A. Tura, H. Merz, A. Mohr, and S. Grisanti, Effect of applied treatment on the macrophage activity in CNV from AMD, , Submitted.
Halim, M. Z. A. E., P. D. N. Y. A. E. Halim, D. A. A. E. E. Rizk, and D. H. N. Gadallah, EFFECT OF CISPLATIN ON THE TESTIS OF ADULT ALBINO RAT AND THE POSSIBLE PROTECTIVE ROLE OF VITAMIN E: HISTOLOGICAL AND HISTOMORPHOMETRIC STUDY, , cairo, cairo university faculty of medicine, Submitted.
walid Ashraf, D. O. D. M., D. A. E. N. D. A. E. Sherif, D. H. E. A. D. A. Mowafi, D. A. A. E. D. Y. Nassar, and D. A. A. E. R. D. H. E. Ghawaby, "The Effect of High bolus dose Tirofiban Versus Conventional dose on angiographic complications and microvascular perfusion after PCI in patients with acute ST elevation myocardial infarction.", The Egyptian Heart Journal, vol. 60, issue 2, Submitted.
Awaad, M. H. H., A. Atta, B. SHALABY, H. B. Gharieb, M. Elmenawey, K. Madian, F. F. Eman, and A. N. Amal, The Efficacy of Na-Butyrate Encapsulated in Palm Fat on Experimentally Induced Necrotic Enteritis and Enumeration of intestinal resident Clostridium perfringens in Broiler Chickens, , Submitted. Abstract

Over more than five decades, cancer remains a national and international health problem regardless of the discovery of several dozens of novel anticancer drugs (natural and synthetic). Accordingly, screening of natural products for promising anti cancer activity is very initiative field of studies in several countries with diversity of gardenia. Breast and cervix cancers are of the most common gynecological female solid tumors that represent major health problem. Herein, we have assessed the cytotoxic characteristics of several molecules of natural origin (cerulinin, chrysin, honikiol, limonin, mevinolin, resveratrol, salicin, retinol, ascorbic acid and calciferol) against two different gynecological breast (MCF-7) and Cervix (HeLa) solid tumor cell lines. After exposure to serial concentrations of the test compounds, SRB-u assay was undertaken and viability assessment was performed via fitting to Emax model to identify the cytotoxicity parameters such as, IC50 and resistant fraction (R-value). Tested compounds showed cytotoxic efficacy against both gynecological solid tumor cell lines (MCF-7 and HeLa) with IC50's ranged from 0.61 to 131.1 μg/ml. In MCF-7 breast cancer cell line; cerulinin, honikiol, mevinolin and calciferol showed the highest potency with IC50 less than 5 μg/ml. Chrysin showed moderate potency with IC50 of 7.27 μg/ml. Ascorbic acid and resveratrol showed the weakest cytotoxic activity with IC50 more than 10 μg/ml. In HeLa cervix cancer cell line; cerulinin and mevinolin showed the highest potency with IC50 less than 5 μg/ml. Chrysin, honikiol, resveratrol and calciferol showed moderate potency with IC50 of ranging from 5-10 μg/ml. Ascorbic acid was the weakest cytotoxic molecule with IC50 more than 10 μg/ml. Limonine, salicin and retinol failed to exert any cytotoxic effect against MCF-7 or HeLa cancer cell lines in-vitro. RT-PCR analysis revealed that the cytotoxicity of these products is multi-factorial and not solely dependent on p53 expression. Impressively, molecules of potent and moderate potency (except chrysin) showed low resistant fraction in both gynecological solid tumor cancer cell lines. In conclusion, our data showed wide range of variable efficacy of several molecules of natural origin against two hormone dependent solid tumor cell lines.

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