Primary insulin-like growth factor-1 (IGF-1) deficiency (IGFD) is defined by low levels of IGF-1 without growth hormone (GH) deficiency and absence of secondary causes. The aim of this study was to evaluate IGF-1 in Egyptian children with idiopathic short stature (ISS) and describe patients with IGFD. Methods: This cross-sectional study included 50 children with ISS following up at the Diabetes Endocrine and Metabolism Pediatric Unit at Cairo University Pediatric Hospital. Children were included based on the following criteria: (1) short stature with current height standard deviation score (SDS) ≤-2.5; (2) age between 2 and 9 years in boys and 2 and 8 years in girls, and (3) prepubertal status. Exclusion criteria were: (1) identified cause of short stature and (2) pubertal children. IGF-1-deficient children were defined as children without GH deficiency and with IGF-1 levels below the 2.5th percentile. Results: Among 50 children with ISS, 14 (28%) patients had low IGF-1 levels, consistent with the diagnosis of primary IGFD. When compared with non-IGFD children, IGFD children had lower birth weight SDS (-1.8 vs. -0.7 SDS, p < 0.0001) and lower height SDS (-4.2 vs. -3.1 SDS, p < 0.05) and more delayed bone age (2.6 vs. 1.6 years, p = 0.001). Conclusion: Primary IGF-1 deficiency is found in 28% of children with ISS.

Glycolipids in five species of marine algae: two species of Rhodophyta Laurencia popillose Galaxoura cylindriea) ; and one species Ulva fasciata and two species of Phaeophyta Dilophys fasciola Taonia atomaria collected from Red and Mediterranean sea, respectively were extracted, purified on silica gel column chromatography and identified by liquid chromatography MS/MS. Total glycolipid contents (GL) (as % of total lipid) were found to be in ranges 10.9 to 28.7%. T. atomaria had the highest level (28.7%) followed by L. popillose(22.5 %).

We investigated the potential association between endothelial nitric oxide synthase (eNOS) gene polymorphism and erectile dysfunction (ED). The study was carried on 60 males with ED. All patients were subjected to medical and sexual history taking including the international index of erectile function (IIEF-5) questionnaire, general and genital examination and combined injection and stimulation test (ICI). Patients with a negative response were evaluated through a penile dynamic duplex to clarify the etiology of ED. eNOS genotype polymorphism was determined by restriction fragment length polymorphism (RFLP). The mean age of patientswas 49.7 years and mean ED

Objective Coronary heart disease (CHD) is a complex disease with both environmental and genetic determinants. The aim of this study was to assess the presence of fibrinogen b-chain (FGB)-455 G/A and prothrombin (PT) 20210 G/A polymorphisms in CHD Egyptian patients and to correlate the co-existence of both polymorphisms with the clinical and laboratory data of the patients.