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Hasanin, A., A. Mukhtar, A. El-adawy, H. Elazizi, ahmed lotfy, H. Nassar, and doaa ghaith, "Ventilator associated pneumonia caused by extensive-drug resistant Acinetobacter species: Colistin is the remaining choice", Egyptian Journal of Anaesthesia: Elsevier, 2016. Abstract
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Hasanin, A., A. Mukhtar, A. El-adawy, H. Elazizi, ahmed lotfy, H. Nassar, and doaa ghaith, "Ventilator associated pneumonia caused by extensive-drug resistant Acinetobacter species: Colistin is the remaining choice", Egyptian Journal of Anaesthesia, vol. 32, issue 3, pp. 409-413, 2016.
Lewis, S., J. Glen, D. Dawoud, S. Dias, J. Cobb, X. L. Griffin, N. Rossiter, M. Reed, C. Sharpin, G. Stansby, et al., "Venous thromboembolism prophylaxis strategies for people undergoing elective total knee replacement: a systematic review and network meta-analysis.", The Lancet. Haematology, vol. 6, issue 10, pp. e530-e539, 2019. Abstract

BACKGROUND: Hospital-associated venous thromboembolism is a major patient safety concern. Provision of prophylaxis to patients admitted for elective total knee replacement surgery has been proposed as an effective strategy to reduce the incidence of venous thromboembolism. We aimed to assess the relative efficacy and safety of all available prophylaxis strategies in this setting.

METHODS: We did a systematic review and Bayesian network meta-analyses of randomised controlled trials to assess the relative efficacy and safety of venous thromboembolism prophylaxis strategies and to populate an economic model that assessed the cost-effectiveness of these strategies and informed the updated National Institute for Health and Care Excellence (NICE) guideline recommendations for patients undergoing elective total knee replacement surgery. The Cochrane Library (CENTRAL), Embase, and Medline were last searched on June 19, 2017, with key terms relating to the population (venous thromboembolism and total knee replacement) and the interventions compared, including available pharmacological and mechanical interventions. Outcomes of interest were deep vein thrombosis (symptomatic and asymptomatic), pulmonary embolism, and major bleeding. Risk of bias was assessed, and relevant data extracted from the included randomised controlled trials for the network meta-analyses. Relative risks (RR; with 95% credible intervals [95% CrI]) compared to no prophylaxis, median ranks (with 95% CrI), and the probability of being the best intervention were calculated. The study was done in accordance with PRISMA guidelines.

FINDINGS: 25 randomised controlled trials were included in the network meta-analyses. 23 trials (19 interventions; n=15 028) were included in the deep vein thrombosis network, 12 in the pulmonary embolism network (13 interventions; n=15 555), and 19 in the major bleeding network (11 interventions; n=19 797). Risk of bias ranged from very low to high. Rivaroxaban ranked first for prevention of deep vein thrombosis (RR 0·12 [95% CrI 0·06-0·22]). Low molecular weight heparin (LMWH; standard prophylactic dose, 28-35 days) ranked first in the pulmonary embolism network (RR 0·02 [95% CrI 0·00-3·86]) and LMWH (low prophylactic dose, 10-14 days) ranked first in the major bleeding network (odds ratio 0·08 [95% CrI 0·00-1·76]), but the results for pulmonary embolism and major bleeding are highly uncertain.

INTERPRETATION: Single prophylaxis strategies are more effective in prevention of deep vein thrombosis in the elective total knee replacement population than combination strategies, with rivaroxaban being the most effective. The results of the pulmonary embolism and major bleeding meta-analyses are uncertain and no clear conclusion can be made other than what is biologically plausible (eg, that no prophylaxis and mechanical prophylaxis strategies should have the lowest risk of major bleeding).

FUNDING: National Institute for Health and Care Excellence.

Lewis, S., J. Glen, D. Dawoud, S. Dias, J. Cobb, X. Griffin, M. Reed, C. Sharpin, G. Stansby, and P. Barry, "Venous Thromboembolism Prophylaxis Strategies for People Undergoing Elective Total Hip Replacement: A Systematic Review and Network Meta-Analysis.", Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, vol. 22, issue 8, pp. 953-969, 2019. Abstract

OBJECTIVES: To assess the efficacy and safety of venous thromboembolism prophylaxis in people undergoing elective total hip replacement.

METHODS: Systematic review and Bayesian network meta-analyses of randomized controlled trials were conducted for 3 outcomes: deep vein thrombosis (DVT), pulmonary embolism (PE), and major bleeding (MB). MEDLINE, EMBASE, and Cochrane Library (CENTRAL) databases were searched. Study quality was assessed using the Cochrane risk-of-bias checklist. Fixed- and random-effects models were fitted and compared. The median relative risk (RR) and odds ratio (OR) compared with no prophylaxis, with their 95% credible intervals (CrIs), rank, and probability of being the best, were calculated.

RESULTS: Forty-two (n = 24 374, 26 interventions), 30 (n = 28 842, 23 interventions), and 24 (n = 31 792, 15 interventions) randomized controlled trials were included in the DVT, PE, and MB networks, respectively. Rivaroxaban had the highest probability of being the most effective intervention for DVT (RR 0.06 [95% CrI 0.01-0.29]). Strategy of low-molecular-weight heparin followed by aspirin had the highest probability of reducing the risk of PE and MB (RR 0.0011 [95% CrI 0.00-0.096] and OR 0.37 [95% CrI 0.00-26.96], respectively). The ranking of efficacy estimates across the 3 networks, particularly PE and MB, had very wide CrIs, indicating high degree of uncertainty.

CONCLUSIONS: A strategy of low-molecular-weight heparin given for 10 days followed by aspirin for 28 days had the best benefit-risk balance, with the highest probability of being the best on the basis of the results of the PE and MB network meta-analyses. Nevertheless, there is considerable uncertainty around the median ranks of the interventions.

Kamel, K. M., A. M. Gad, S. M. Mansour, M. M. Safar, and H. M. Fawzy, "Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis.", Life sciences, vol. 226, pp. 68-76, 2019. Abstract

AIMS: Rheumatoid arthritis is usually accompanied by various comorbidities especially on the psychological side such as depression. This study aimed at revealing the potential curative effects of venlafaxine (VFX), a serotonin/norepinephrine reuptake inhibitor (SNRI), on experimentally-induced arthritis in rats.

METHODS: Arthritis was induced by injecting complete Freund's adjuvant (CFA, 0.1 ml, s.c.). One day thereafter, VFX (50 mg/kg, p.o.) was given for 21 days. Methotrexate was used as a standard disease modifying anti-rheumatic drug.

KEY FINDINGS: CFA injection caused prominent arthritis evident by the increase in the hind paw and ankle diameter accompanied by elevating tumor necrosis factor-alpha, interleukin-6, interleukin-17 and matrix metalloproteinase-3 levels, effects that were diminished by VFX. Moreover, VFX down regulated gene expressions of receptor activator of nuclear factor kappa-B (NF-кB) ligand and signal transducer and activator of transcription-3 beside hampering immunohistochemical expression of vascular endothelial growth factor and NF-кB. This SNRI also improved the oxidant status of the hind limb as compared to the arthritic group. Nonetheless, MTX was better in amendment of arthritis authenticated by its effect on some inflammatory and oxidative stress biomarkers.

SIGNIFICANCE: This study provides a novel therapeutic use of VFX as a considerable anti-arthritic drug and offers an incentive to expand its use in RA.

Salama, Abd El-Ghani, M., Gadalla, M., Ramadan, A., Galal, H., and A. Gaafar, "Vegetation patterns and floristic composition along elevational gradient on Jabal Musa, South Sinai, Egypt", Catrina, vol. 17, issue 1, pp. 41-57, 2018.
Salama, F., M. A. El-Ghani, A. Amro, and A. Gaafar, "Vegetation dynamics and species diversity in a Saharan oasis, Egypt", Notulae Scientia Biologicae, vol. 10, issue 3, pp. 363-372, 2018. vegetation_dynamics_and_species_diversity_in_a_saharan_oasis_egypt.pdf
Hegazy, A. K., G. M. Fahmy, M. I. Ali, and N. H. Gomaa, "Vegetation diversity in natural and agro-ecosystems of arid lands", Community Ecology, vol. 5, issue 2, pp. 163-176, 2004.
Salama, F., M. A. El-Ghani, N. El-Tayeh, and H. Galal, "Vegetation analysis and species distribution in the lower tributaries of Wadi Qena, Eastern Desert, Egypt", Jordan Journal of Biological Sciences, vol. 11, issue 4, pp. 407-418, 2018. vegetation_analysis_and_species_distribution_inf_wadi_qena_of_egypt.pdf
Adly, A. A., D. Davino, A. Giustiniani, and C. Visone, "Vector magnetic hysteresis modeling of stress annealed galfenol", Journal of Applied Physics, vol. 113, no. 17: AIP Publishing, pp. 17A931, 2013. Abstract
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Elzarga, A. A. A., A. A. Osman, M. Gamal, M. M. Khafagy, and I. S. Osman, "Vector Analysis of Femtosecond Laser-Assisted Arcuate Keratotomy for Post-Keratoplasty Astigmatic Correction.", Ophthalmic research, pp. 1-7, 2019. Abstract

PURPOSE: To study the astigmatic correction of high post-keratoplasty astigmatism using Femtosecond laser (FSL)-assisted Arcuate Keratotomy (FS-AK).

METHODS: A prospective interventional cohort study. We enrolled 17 eyes with high degree of irregular astigmatism, scheduled for FS-AK. FSL was used to perform paired arcuate incisions 1.00 mm inside the graft. Patients' uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and astigmatic change were recorded and followed up to 1 year after surgery. Vector analysis using Alpins' method was done to analyze the astigmatic correction.

RESULTS: FS-AK reduced the refractive astigmatism at final follow-up visit at 12 months (p = 0.0008, repeated-measures analysis of variance [ANOVA]). The procedure improved the UCVA over the follow-up period (p = 0.007, repeated-measures ANOVA), with a similar effect on the BCVA (p = 0.046, repeated-measures ANOVA). There was a mild correlation between the target-induced astigmatism and the surgically induced astigmatism (R2 = 0.245) with a tendency to overcorrect more than under correct the astigmatism. A constant rotational error in the counterclockwise direction was also detected.

CONCLUSIONS: FS-AK improves the visual outcome and reduces the refractive cylinder in post-penetrating keratoplasty astigmatism. The predictability of astigmatism correction was variable in reducing post-keratoplasty astigmatism. Refinement of the treatment nomogram for such cases is highly recommended.

Hassan, A. H., E. M. Hamed, E. Badr, O. Elsharqawy, T. Ismail, S. R. I. Gabran, Y. Ismail, and H. Mostafa, "A VCO-Based MPPT Circuit for Low-Voltage Energy Harvesters", VLSI (ISVLSI), 2017 IEEE Computer Society Annual Symposium on: IEEE, pp. 580–584, 2017. Abstract
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Elgengehy, F. T., S. M. Gamal, N. Sobhy, I. Siam, A. M. Soliman, G. W. Elhady, and T. A. Gheita, "Vasculitis damage index in Behçet's disease.", Advances in rheumatology (London, England), vol. 61, issue 1, pp. 33, 2021. Abstract

BACKGROUND: Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet's disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet's disease (BD) to determine if VDI could be used to assess damage in patients with BD.

METHODS: A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann-Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables.

RESULTS: In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003).

CONCLUSION: VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index.

Elgengehy, F. T., S. M. Gamal, N. Sobhy, I. Siam, A. M. Soliman, G. W. Elhady, and T. A. Gheita, "Vasculitis damage index in Behçet's disease.", Advances in rheumatology (London, England), vol. 61, issue 1, pp. 33, 2021. Abstract

BACKGROUND: Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet's disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet's disease (BD) to determine if VDI could be used to assess damage in patients with BD.

METHODS: A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann-Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables.

RESULTS: In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003).

CONCLUSION: VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index.

Elgengehy, F. T., S. M. Gamal, N. Sobhy, I. Siam, A. M. Soliman, G. W. Elhady, and T. A. Gheita, "Vasculitis damage index in Behçet's disease.", Advances in rheumatology (London, England), vol. 61, issue 1, pp. 33, 2021. Abstract

BACKGROUND: Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet's disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet's disease (BD) to determine if VDI could be used to assess damage in patients with BD.

METHODS: A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann-Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables.

RESULTS: In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P < 0.0001); cataract (P < 0.0001); and diabetes (P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P < 0.0001), biological agent (P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003).

CONCLUSION: VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index.

mohamed alshazily, amr safwat, ali el garem, and hesham anwar, "vascularized flaps versus free grafts in endoscopic reconstruction of skull base defects", medical journal of Cairo university, vol. 85, issue 3, pp. 20, 2016. vascularized_flaps_versus_free_grafts_in_endoscopic_reconstruction_of_large_skull_base_defects.docx
El‐Hinnawy, Y. H., N. E. Ghobashy, R. A. M. Halim, and G. A. S. Elwafa, "Vascular Endothelial Growth Factor in hypersensitivity pneumonitis and connective tissue disease‐associated interstitial lung disease", The Egyptian Journal of Bronchology, vol. 18, issue 32, 2024.
Taha, S., S. M. Gamal, M. Nabil, N. Naeem, D. labib, I. Siam, and T. A. Gheita, "Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients.", Revista brasileira de reumatologia, vol. 57, issue 2, pp. 149-153, 2017 Mar - Apr. Abstract

AIM: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.

PATIENTS AND METHODS: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).

RESULTS: Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p<0.001] and GG [10% vs 66.7%, p<0.001]).

CONCLUSION: Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

Taha, S., S. M. Gamal, M. Nabil, N. Naeem, D. labib, I. Siame, and T. A. Gheita, "Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients", REVISTA BRASILEIRA DE REUMATOLOGIA, vol. 57, issue 2, pp. 149-153, 2017.
A.S.Soliman, M.B.Mostafa, and G.A.Ragab, "Vascular changes in the soft tissues of the fetlock joint of donkeys undergoing various hoof deformities", Alex.J.Vet.Science, vol. 8, issue 1, pp. 7-12, 1992. 8767_001.jpg
Osman, M. S., K. K. Ali, and J. F. Gómez-Aguilar, "A variety of new optical soliton solutions related to the nonlinear Schrödinger equation with time-dependent coefficients", Optik, vol. 222, pp. 165389, 2020.
Khaled, S. A., L. Dam´e, M. A. Semeida, M. Y. Amin, A. Ghitas, S. Yousef, and P. Stoeva, "VARIATIONS OF THE HYDROGEN LYMAN-ALPHA LINE THROUGHOUT SOLAR CYCLE 24 ON ESA/PROBA-2 AND SORCE/SOLSTICE DATA", Comptes rendus de l’Acad´emie bulgare des Sciences, vol. 73, issue 9, pp. 1260-1269, 2020. bhth_sfynz.pdf
Khaled, S. A., L. Dam´e, M. A. Semeida, M. Y. Amin, A. Ghitas, S. Yousef, and P. Stoeva, "VARIATIONS OF THE HYDROGEN LYMAN-ALPHA LINE THROUGHOUT SOLAR CYCLE 24 ON ESA/PROBA-2 AND SORCE/SOLSTICE DATA", Comptes rendus de l’Acad´emie bulgare des Sciences, vol. 73, issue 9, pp. 1260-1269, 2020.
mostafa, Hafez, H., Hegazy, O., Fattah, A. M. A., Mohamed, Mustafa, E., A. A. Gobouri, and E. Azab, "Variations of structural and functional traits of Azolla pinnata R. Br. in response to crude oil pollution in arid regions. ", Sustainability (MDPI), vol. 13, issue 2142, pp. 1-16, 2021.
Mostafa, A. A., R. M. Hafez, A. K. Hegazy, A. A. - E. M. Fattah, N. H. Mohamed, Y. M. Mustafa, A. A. Gobouri, and E. Azab, "Variations of Structural and Functional Traits of Azolla pinnata R. Br. in Response to Crude Oil Pollution in Arid Regions", Sustainability, vol. 13, pp. 2142, 2021. sustainability-13-02142-v2.pdf
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