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Gheita, T. A., S. Sayed, and H. A. Gheita, "Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome. ", Intl J Rheum Dis, issue doi: 10.1111/1756-185X.12426. [Epub ahead of print], 2014.
Gheita, T., S. Sayed, H. Gheita, and S. Kenawy, "Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome.", Int J Rheum Dis, vol. 19, issue 3, pp. 294-9, 2016.
Gheita, T. A., S. Sayed, H. A. Gheita, and S. A. Kenawy, "Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome.", International journal of rheumatic diseases, vol. 19, issue 3, pp. 294-9, 2016. Abstract

AIM: To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.

METHODS: The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS-28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25-OH-vitamin D was measured in patients and controls.

RESULTS: The patients' mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P < 0.001). Vitamin D significantly correlated with QoL index (r = 0.58, P < 0.001) and negatively with HAQ II (r = -0.36, P = 0.004) and BMI (r = -0.39, P = 0.001).

CONCLUSION: Special attention is required regarding vitamin D levels in RA patients with FMS and decreased QoL. Vitamin D should be corrected and supplementation considered among the RA management armamentarium.

Garf, K. E., A. E. Garf, huda marzouk, yomna farag, and L. Rashed, "Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus", Rheumatology International, 2015.
Garf, K. E., huda marzouk, yomna farag, L. Rasheed, and A. E. Garf, "Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus", Rheumatol Int. , vol. 35, issue 9, pp. 1535-40, 2015.
Garf, K. E., huda marzouk, yomna farag, A. E. Garf, and L. Rasheed, "vitamin D status in egyptian children with juvenile systemic lupus erythematosus", Rheumatology international, vol. 35, issue 0172-8172, pp. 1535-1540, 2015. published_vit_d_in_sle_.pdf
Sherief, L. M., A. Ali, A. Gaballa, G. M. Abdellatif, N. M. Kamal, M. R. Afify, D. H. Abdelmalek, S. A. El-Emari, A. S. A. Soliman, and W. A. Mokhtar, "Vitamin D status and healthy Egyptian adolescents Where do we stand?", Medicine, vol. 100, issue 29, pp. 1-6, 2021. vit_d_adolescents.pdf
Gendy, H. I. E., noha adly sadik, M. Y. Helmy, and L. A. Rashed, "Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients", Journal of Clinical & Translational Endocrinology, vol. 15, pp. 25-29, 2019.
Elsayed", "L. A., "O. M. Tork", "H. Seddieka", "R. M. Taha", and "N. I. Gomaa", Vitamin D protects diabetic rats from neuropathic changes by improving insulin sensitivity and up regulating vitamin D receptors., , 2015.
huda marzouk, E. E. Ghobrial, M. M. Khorshied, and M. M. Mohammed, "Vitamin D level in nephrotic syndrome, Factors of impact?", geget, vol. 14, 2019. vit_d_in_nephrotic.pdf
huda marzouk, E. E. Ghobrial, M. M. Khorshied, and M. M. Mohammed, "Vitamin D level in nephrotic syndrome, Factors of impact?", geget (The journal of the Egyptian Society of Pediatric Nephrology and Transplantation) , vol. 14, issue 2, pp. 54-61, 2019. vit_d.pdf
Rifai, N. M. E., G. A. F. A. Moety, H. M. Gaafar, and D. A. Hamed, "Vitamin D deficiency in Egyptian mothers and their neonates and possible related factors.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 27, issue 10, pp. 1064-8, 2014 Jul. Abstract

OBJECTIVE: To correlate vitamin D level in Egyptian mothers with that of their newborns, and examine risk factors related to maternal vitamin D deficiency.

METHODS: A cross-sectional study was carried out at the university teaching hospital in Cairo, Egypt. Serum 25(OH) D levels were measured by enzyme-linked immunosorbent assay in 135 pregnant women at ≥37 weeks' gestation immediately before delivery and in cord blood of their newborns.

RESULTS: The levels of serum 25(OH) D were 32.6 ± 21.4 ng/ml in mothers and 16.7 ± 10 ng/ml in their newborns. Maternal vitamin D level was strongly correlated with that of the newborns (r = 0.7, p < 0.0001). Maternal vitamin D deficiency/insufficiency and neonatal vitamin D deficiency/insufficiency were encountered in (40%, 28.9% and 60%, 32.6% respectively). Maternal vitamin D levels showed significant correlations with maternal body mass index (BMI; r = -0.201, p = 0.021), gestational age at delivery (r = 0.315, p ≤ 0.0001), fish consumption (r = 0.185, p = 0.032), educational level (r = 0.29, p = 0.001), and skin exposure (r = 0.247, p = 0.004).

CONCLUSION: Maternal vitamin D levels strongly correlate with neonatal levels. Maternal vitamin D deficiency is a real problem in Egypt; this is generally related to high BMI, low fish consumption, low educational level, and limited skin exposure.

Refaie, N. E. M., G. A. A. Moety, H. M. Gaafar, and D. A. Hamed, "Vitamin D deficiency in Egyptian mothers and their neonates and possible related factors", Journal of Maternal-fetal and neonatal Medicine, 2014.
Eitah, H. E., H. N. Attia, A. A. F. Soliman, A. A. Gamal El Din, K. Mahmoud, R. H. Sayed, Y. A. Maklad, and A. E. El-Sahar, "Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.", Toxicology and applied pharmacology, vol. 458, pp. 116324, 2023. Abstract

Growing evidence has indicated that vitamin D (Vit D) regulates cell proliferation and differentiation in cancer cells. Accordingly, the present study was conducted to investigate the possible beneficial effects of Vit D on diethylnitrosamine (DEN)-induced liver preneoplasia. The effect of Vit D on HepG2 cells was investigated using MTT assay. Additionally, liver preneoplasia was induced in Swiss male albino mice by giving overnight fasted animals 5 consecutive doses of DEN (75 mg/kg/week). Oral treatment with Vit D (200 IU/kg/day) was initiated either 2 weeks before DEN (first protocol) or 1 week after the first dose of DEN injection (second protocol). At the end of the experiment, tissue levels of GGT, DPP-4, TNF-α, IL-6, CYP2E1, and CYP3A4 were also estimated. Moreover, the histopathological study of liver tissue and immunohistochemical detection of GST-P, PCNA, and NF-κB were performed. Vit D exerted a significant cytotoxic effect on HepG2 cells via significantly increasing BAX, p53, and BAX/Bcl2 ratio, and significantly decreasing Bcl2 mRNA expression. In both in vivo protocols, Vit D was capable of normalizing relative liver weight, PCNA, altered hepatocellular foci, and ductular proliferation. Moreover, Vit D significantly reduced the DEN-induced elevation of AST, ALT, ALP, GGT, DDP-4, TNF-α, IL-6, CYP2E1, liver DNA damage, GST-P, NF-κB, nuclear hyperchromasia/pleomorphism, cholestasis, and inflammatory cell aggregates, but significantly increased CYP3A4 content. In conculsion, current results reflect the potential impact of Vit D in the management of early stages of liver cancer.

Eitah, H. E., H. N. Attia, A. A. F. Soliman, A. A. Gamal El Din, K. Mahmoud, R. H. Sayed, Y. A. Maklad, and A. E. El-Sahar, "Vitamin D ameliorates diethylnitrosamine-induced liver preneoplasia: A pivotal role of CYP3A4/CYP2E1 via DPP-4 enzyme inhibition.", Toxicology and applied pharmacology, vol. 458, pp. 116324, 2023. Abstract

Growing evidence has indicated that vitamin D (Vit D) regulates cell proliferation and differentiation in cancer cells. Accordingly, the present study was conducted to investigate the possible beneficial effects of Vit D on diethylnitrosamine (DEN)-induced liver preneoplasia. The effect of Vit D on HepG2 cells was investigated using MTT assay. Additionally, liver preneoplasia was induced in Swiss male albino mice by giving overnight fasted animals 5 consecutive doses of DEN (75 mg/kg/week). Oral treatment with Vit D (200 IU/kg/day) was initiated either 2 weeks before DEN (first protocol) or 1 week after the first dose of DEN injection (second protocol). At the end of the experiment, tissue levels of GGT, DPP-4, TNF-α, IL-6, CYP2E1, and CYP3A4 were also estimated. Moreover, the histopathological study of liver tissue and immunohistochemical detection of GST-P, PCNA, and NF-κB were performed. Vit D exerted a significant cytotoxic effect on HepG2 cells via significantly increasing BAX, p53, and BAX/Bcl2 ratio, and significantly decreasing Bcl2 mRNA expression. In both in vivo protocols, Vit D was capable of normalizing relative liver weight, PCNA, altered hepatocellular foci, and ductular proliferation. Moreover, Vit D significantly reduced the DEN-induced elevation of AST, ALT, ALP, GGT, DDP-4, TNF-α, IL-6, CYP2E1, liver DNA damage, GST-P, NF-κB, nuclear hyperchromasia/pleomorphism, cholestasis, and inflammatory cell aggregates, but significantly increased CYP3A4 content. In conculsion, current results reflect the potential impact of Vit D in the management of early stages of liver cancer.

Mohammed, B. M., D. Kraskauskas, S. I. Ward, P. Ghosh, B. J. Fisher, D. F. Brophy, A. A. Fowler, D. R. Yager, and R. Natarajan, "VITAMIN C IN WOUND HEALING: A NEW PERSPECTIVE", WOUND REPAIR AND REGENERATION, vol. 23, issue 2: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. A32-A33, 2015. Abstract
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Mohammed, B. M., D. Kraskauskas, S. I. Ward, P. Ghosh, B. J. Fisher, D. F. Brophy, A. A. Fowler, D. R. Yager, and R. Natarajan, Vitamin C In Wound Healing: A New Perspective, , vol. 23, issue 2, pp. A33, 2015. Abstract
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Guldner, C., I. Diogo, E. Bernd, S. Drager, M. Mandapathi, A. Teymoortash, H. Negm, and T. Wilhelm, "Visualization of anatomy in normal and pathological middle ears by cone beam CT", Eur Arch Otorhinolaryngol, vol. 274, issue 2, pp. 737-742, 2017.
Aboulela, W., M. S. Elsheemy, M. Shoukry, A. M. Shouman, A. I. Shoukry, W. Ghoneima, M. ElGhoneimy, H. A. Morsi, M. A. Mohsen, and H. Badawy, "Visual internal urethrotomy for management of urethral strictures in boys: a comparison of short-term outcome of holmium laser versus cold knife.", International urology and nephrology, vol. 50, issue 4, pp. 605-609, 2018 Apr. Abstract

PURPOSE: To compare efficacy and safety of visual internal urethrotomy (VIU) using holmium laser (Ho:YAG) (group A) versus cold knife (group B) in children with urethral strictures. It may be the first comparative study on this issue in children.

METHODS: This study compared Ho:YAG group, which was evaluated prospectively from January 2014 till January 2016, versus cold knife group, which was a historical control performed from March 2008 till February 2010. Children ≤ 13 years old with urethral strictures ≤ 1.5 cm were included successively. Recurrent cases, congenital obstructions and cases with complete arrest of dye in voiding cystourethrography were excluded. Scar tissue was incised at twelve o'clock. Outcome was compared using Student's t, Mann-Whitney, Chi-square or Fisher exact tests as appropriate.

RESULTS: Each group included 21 patients. Mean age was 6.27 ± 3.23 (2-13) years old. Mean stricture length was 1.02 versus 1 cm in group A versus B, respectively (p = 0.862). Ten cases of penile/bulbous strictures and another 11 cases of membranous strictures were found in each group. There was no significant difference between both groups in preoperative data. Success rate for initial VIU was 66.7% in group A versus 38% in group B (p = 0.064). This was associated with significantly higher Q in group A (mean 16.52 vs 12.09 ml/s; p = 0.03). Success rate after two trials of VIU was 76.2% for group A and 47.61% for group B (p = 0.057). No complications were reported in both groups.

CONCLUSION: Laser VIU has a higher success rate than cold knife VIU for urethral strictures ≤ 1.5 cm in children with significantly higher Q. Both are easy to perform, low invasive and safe.

Aboulela, W., M. S. Elsheemy, M. Shoukry, A. M. Shouman, A. I. Shoukry, W. Ghoneima, M. ElGhoneimy, H. A. Morsi, M. A. Mohsen, and H. Badawy, "Visual internal urethrotomy for management of urethral strictures in boys: a comparison of short-term outcome of holmium laser versus cold knife.", International urology and nephrology, vol. 50, issue 4, pp. 605-609, 2018 Apr. Abstract

PURPOSE: To compare efficacy and safety of visual internal urethrotomy (VIU) using holmium laser (Ho:YAG) (group A) versus cold knife (group B) in children with urethral strictures. It may be the first comparative study on this issue in children.

METHODS: This study compared Ho:YAG group, which was evaluated prospectively from January 2014 till January 2016, versus cold knife group, which was a historical control performed from March 2008 till February 2010. Children ≤ 13 years old with urethral strictures ≤ 1.5 cm were included successively. Recurrent cases, congenital obstructions and cases with complete arrest of dye in voiding cystourethrography were excluded. Scar tissue was incised at twelve o'clock. Outcome was compared using Student's t, Mann-Whitney, Chi-square or Fisher exact tests as appropriate.

RESULTS: Each group included 21 patients. Mean age was 6.27 ± 3.23 (2-13) years old. Mean stricture length was 1.02 versus 1 cm in group A versus B, respectively (p = 0.862). Ten cases of penile/bulbous strictures and another 11 cases of membranous strictures were found in each group. There was no significant difference between both groups in preoperative data. Success rate for initial VIU was 66.7% in group A versus 38% in group B (p = 0.064). This was associated with significantly higher Q in group A (mean 16.52 vs 12.09 ml/s; p = 0.03). Success rate after two trials of VIU was 76.2% for group A and 47.61% for group B (p = 0.057). No complications were reported in both groups.

CONCLUSION: Laser VIU has a higher success rate than cold knife VIU for urethral strictures ≤ 1.5 cm in children with significantly higher Q. Both are easy to perform, low invasive and safe.

Aboulela, W., M. S. Elsheemy, M. Shoukry, A. M. Shouman, A. I. Shoukry, W. Ghoneima, E. M. Ghoneimy, H. A. Morsi, M.Abdelmohsen, and H. Badawy, "Visual internal urethrotomy for management of urethral strictures in boys: a comparison of short-term outcome of holmium laser versus cold knife", International Urology and Nephrology, vol. 50, issue April 2018 (4), pp. 605–609, 2018. aboulela2018_article_visualinternalurethrotomyforma.pdf
Elbanna, S. M. E., A. E. E. Arab, and N. A. Ghallab, "VISFATIN LEVELS IN GINGIVAL CREVICULAR FLUID OF PATIENTS WITH PERIODONTAL DISEASE", Egyptian Dental Journal, vol. 60, issue 1, 2014.
Rehiem, H., R. F. Salam, T. H. Gado, and L. Rashed, "visfatin G-948T polymorphisim in Egyptian type 2 diabetes ", Journal of American science , vol. 6, issue 10, pp. 509-514, 2010. visfatin_america.pdf
Adel, M., A. H. A. Elbehery, S. K. Aziz, R. K. Aziz, H. - P. Grossart, and R. Siam, "Viruses-to-mobile genetic elements skew in the deep Atlantis II brine pool sediments.", Scientific reports, vol. 6, pp. 32704, 2016 Sep 06. Abstract

The central rift of the Red Sea has 25 brine pools with different physical and geochemical characteristics. Atlantis II (ATIID), Discovery Deeps (DD) and Chain Deep (CD) are characterized by high salinity, temperature and metal content. Several studies reported microbial communities in these brine pools, but few studies addressed the brine pool sediments. Therefore, sediment cores were collected from ATIID, DD, CD brine pools and an adjacent brine-influenced site. Sixteen different lithologic sediment sections were subjected to shotgun DNA pyrosequencing to generate 1.47 billion base pairs (1.47 × 10(9) bp). We generated sediment-specific reads and attempted to annotate all reads. We report the phylogenetic and biochemical uniqueness of the deepest ATIID sulfur-rich brine pool sediments. In contrary to all other sediment sections, bacteria dominate the deepest ATIID sulfur-rich brine pool sediments. This decrease in virus-to-bacteria ratio in selected sections and depth coincided with an overrepresentation of mobile genetic elements. Skewing in the composition of viruses-to-mobile genetic elements may uniquely contribute to the distinct microbial consortium in sediments in proximity to hydrothermally active vents of the Red Sea and possibly in their surroundings, through differential horizontal gene transfer.

El-Hammady, M., A. N. Girgis, H. M. Mazyad, and M. A. Shafie, "Virus diseases of some medicinal plants in Egypt VI. Effect of different viruses on growth and total alkaloids of Egyptian henbane (Hyoscyamus muticus L.).", Acta Phytopathologica Academiae Scientiarum Hungaricae, vol. 17, issue 3/4, pp. 261-268, 1982. Abstract
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