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Fadel, F. I., H. N. A. E. Mooty, H. M. Bazaraa, and S. M. Sabry, "Central venous catheters as a vascular access modality for pediatric hemodialysis", International urology and nephrology, vol. 40, issue 2, pp. 489-496, 2008.
Fadel, A. M., R. H. El-Gebaly, A. A. Aly, and F. F. Ibrahim, "Control of Ehrlich tumor growth by electromagnetic waves at resonance frequency (in vivo studies)", Electromagnetic biology and medicine, vol. 24, no. 1: Taylor & Francis, pp. 9–21, 2005. Abstract
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Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current Drug Delivery: Bentham Science Publishers, 2021. Abstract
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Fadel, M. M., K. E. G. -Iraqi, R. A. Ghandour, and M. A. Foad, "Feed Restriction Regimens Effects On Growth and Physiological Performance of Fattening rabbits", Journal of Egyptian veterinary medical Association, vol. 79, issue 3, pp. 791-802, 2019. rabbit_papper_.pdf
Fadel, M., G. Abdelbary, S. F. Elmenshawe, and E. Eissa, "Toluidine Blue Loaded Transferosomes for Topical Photodynamic Therapy: for-Mulation and Characterization", International Journal of Research in Pharmaceutical Sciences, 2011. Abstract

Targeted drug delivery systems have distinct advantages over conventional dosage forms. In the present ap-proach, flexible liposomal drug carriers (transferosomes) were formulated and their physicochemical properties were studied compared with conventional liposomal and niosomal formulae. Lipid vesicles composed of lecithin, cholesterol, span 60, and sodium deoxycholate (SDC) were prepared by thin film hydration method. Photodynamic treatment of subcutaneous Ehrlich tumor using prepared and pharmaceutically studied hydrogel containing 1% hydrophilic toluidine blue (TB) loaded transferosomes was evaluated. The results showed that transferosomes containing both span 60 and SDC were of the highest entrapment efficiency (> 82%), particle size (1.36 ?m) and released 52% of its content within 2 hours. The in vivo study on BALB/C mice showed that there was a marked increase in the survival time and decrease in the tumor size in mice group treated with transferosomal (span 60 and SDC) hydrogel for 1h followed by irradiation with 90J/cm2 from 650 nm diode laser twice weekly compared with animals treated with free TB and irradiated only. Furthermore, there was a marked deep necrosis of tumor cells, which may be attributed to the deep penetration of TB through skin layers. These findings suggest the use of TB loaded transferosomes in topical targeted photodynamic treatment of skin tumors.

Fadel, F. I., S. H. Makar, A. E. Eskander, and A. H. Aon, "Decreasing intra-dialytic morbid events and assessment of dry weight in children on chronic hemodialysis using non-invasive changes in hematocrit.", Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 25, issue 5, pp. 1030-7, 2014 Sep. Abstract

Achieving dry weight after hemodialysis (HD) is critical as chronic fluid over-load can result in left ventricular hypertrophy, while small fluid shifts may result in intra-dialytic morbid events (IME). In the pediatric population, estimating dry weight can be difficult due to growth while on dialysis. Continuous non-invasive monitoring of the hematocrit (NIVM) has been proposed as a more accurate method of estimating dry weight. Fifteen pediatric patients on chronic HD (6 males and 9 females; mean age 11.4 ± 2.28 years) were included in an uncontrolled prospective study involving three phases. In phase 1, patients were observed for one month for their dry weight and frequency of IME. Phase 2 consisted of using NIVM-guided ultrafiltration algorithm for rate of blood volume (BV) reduction and post-dialysis refill, recommending an intra-dialytic reduction in BV of 8% in the first hour and <4% per hour thereafter and without significant post-dialytic vascular refill. Phase 3 comprised a one month period for comparing the results. IME decreased from 33 episodes per 180 sessions in phase 1 to 4 per 180 sessions during phase 3 (P = 0.04), without a significant difference in pre-systolic or post-systolic or mean BP before and after the intervention (all P >0.1). In phase 1, 40% of patients experienced no IME, 33% experienced one or two IME while 27% experienced more than two IME; during phase 3, 80% experienced no IME, 20% experienced one or two IME while no one experienced more than two IME. NIVM can serve as an objective method for determining dry weight as well as predicting and preventing IME in the pediatric population on maintenance HD.

Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, F. I., M. A. Kotb, M. A. Abdel Mawla, R. M. Hasanin, amr mohamed salem, M. G. Fathallah, K. S. Amr, H. A. Ahmed, and D. M. Salah, "Primary hyperoxaluria type 1 in children: Clinical classification, renal replacement therapy, and outcome in a single centre experience.", Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2021. Abstract

Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy. This study aimed to report clinical presentations, renal replacement therapy (RRT), and outcome of PH1 in end stage kidney disease (ESKD) children. This is an observational cohort study. Data of 22 patients with ESKD due to PH1 were analyzed at Pediatric Nephrology Unit, Faculty of Medicine Cairo University. Infantile onset patients (n = 10) had worst renal outcome (80% with ESRD at presentation, p = 0.019) and worse patient outcome (mortality 40%, p = 0.016) than juvenile (n = 9) and late onset (PH1 n = 3) patients. RRT modalities include peritoneal dialysis (PD) in 7 (31.8%), hemodialysis (HD) in 11 (50%), and combined liver kidney transplantation (CLKT) in 4 (18.2%) patients. Infectious complications were encountered in 42.8% of PD patients. Better HD adequacy was observed with frequent HD (n = 6) and/or HD via arteriovenous fistula (AVF) than with infrequent dialysis (n = 5) and/or via central venous line (CVL) (p = 0.0001 and 0.0047, respectively). Morbidity and mortality (infection related) rates of the whole cohort were 63.6% and 31.8%, respectively. Clinical presentation of PH1 varies according to the age of onset (infantile onset being the most aggressive form). Aggressive HD (better through AVF) is needed to achieve acceptable HD adequacy, PD was challenged by infection. Infection found to be the main cause of mortality even after successful CLKT.

Fadel, F. I., M. F. Elshamaa, M. M. Nabhan, R. G. Essam, N. Kantoush, M. M. El Sonbaty, M. Raafat, and D. A. Abd-El Haleem, "Soluble adhesion molecules as markers of native arteriovenous fistula thrombosis in children on uremia.", Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, vol. 25, issue 7, pp. 675-82, 2014 Oct. Abstract

Vascular access represents a lifeline for children undergoing hemodialysis. A failure of vascular access among patients receiving regular hemodialysis is associated with increased morbidity, mortality and costs. We assessed the possibility of using soluble adhesion molecules as reliable predictors of vascular access failure in children on hemodialysis. Moreover, we evaluated whether there is an association among the different studied adhesion molecules in hemodialysis patients with thrombosed and non-thrombosed arteriovenous fistula fistulas (AVFs). This study included 55 hemodialysis children, 36 with good access and 19 with access failure, and 20 healthy volunteers. Forty-four patients had native AVFs and 11 patients had tunneled permanent catheter (11with thrombosed and 33 with non-thrombosed AVFs). Serum-soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin) and soluble P-selectin (sP-selectin) were measured using ELISA technique. A significant increase was found in the levels of sVCAM-1, sICAM-1, sE-selectin and sP-selectin versus controls and all hemodialysis patients, hemodialysis patients with good access and hemodialysis patients with access failure (P=0.001 for sVCAM-1 and sICAM-1 and P=0.0001 for sE-selectin and sP-selectin). A significant increase was found in the levels of sVCAM-1, sE-selectin and sP-selectin in both chronic hemodialysis patients with thrombosed and non-thrombosed native AVFs versus controls (P=0.0001 for all parameters). There was significant difference between both chronic hemodialysis patients with thrombosed and non-thrombosed native AVFs as regard to sVCAM-1 (54.64±30.82 versus 25.69±27.96ng/ml, P=0.04). Both sICAM-1 and sP-selectin were positively correlated with the erythropoietin (EPO) dose in hemodialysis children (r=0.31, P=0.04 and r=0.32, P=0.04, respectively). A significant positive association was found between E-selectin and sP-selectin in hemodialysis patients with thrombosed AVFs (r=0.83, P=0.04). There was a significant correlation between sVCAM-1 and EPO dose in thrombosed AVF group (r=0.84, P=0.01). The assessment of serum sVCAM-1 might be useful for the identification of the chronic hemodialysis patients at an increased risk for native AVFs thrombosis. The role of EPO in vascular access failure should be taken into consideration. The clinical relevance of these observations warrants further investigations.

Fadel, F., H. M. Bazraa, S. M. Abdelrahman, M. G. Shouman, M. K. Sayed, D. M. Salah, A. A. Wahby, and H. F. Elgebaly, "Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients.", Open access Macedonian journal of medical sciences, vol. 5, issue 2, pp. 222-227, 2017 Apr 15. Abstract

BACKGROUND: Renal transplantation (RTx) is the treatment of choice for paediatric end-stage renal disease (ESRD). A major cause of morbidity and mortality after RTx is cardiovascular disease. Independent predictors of cardiovascular events were shown to constitute an endothelial dysfunction (ED). This study aims to evaluate Visfatin serum level in comparison to brachial artery flow-mediated dilatation (FMD) as a marker of endothelial dysfunction in paediatric RTx recipients.

METHODS: Visfatin serum level has been evaluated in 30 patients on regular hemodialysis (HD), 36 patients post-RTx and 30 controls as a measure for ED, and has been compared to brachial artery FMD.

RESULTS: Visfatin level in transplant recipients was significantly lower than the hemodialysis group as well as FMD was better in transplant recipients. In spite of marked improvement of FMD and marked reduction of visfatin in post-RTx no direct statistical correlation was found between serum Visfatin level and flow-mediated dilatation.

CONCLUSION: Pediatric RTx recipients show lower serum Visfatin level and better FMD than those on regular hemodialysis, reflecting less endothelial dysfunction (ED) and less cardiovascular risk. FMD in kidney transplant recipients tends to be less than normal subjects while visfatin level of the same group is similar to controls. Pediatric RTx appears to have a positive impact on the growth development of children with ESRD.

Fadel, M., D. A. El Fadeel, R. M. Ahmed, M. A. Ibrahim, and M. S. Hanafy, "Antitumor Efficiency of Doxorubicin Loaded in Liposomes and Poly Ethylene Glycol Coated Ferrofluid Nanoparticles", J Nanomater Mol Nanotechnol, vol. 1, issue 4, 2015. Abstract

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Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, M., K. Kassab, N. Samy, and S. Thabet, "INDOCYANINE GREEN TRANSFEROSOMAL HYDROGEL WITH ENHANCED STABILITY AND SKIN PERMEATION FOR TREATMENT OF ACNE VULGARIS: (IN-VITRO AND CLINICAL STUDY)", EuropEan Journal of Biomedical AND Pharmaceutical sciences, vol. 2, issue 1, pp. 20-36, 2015. article_ejbps_volume_2_february_issue_1_1423113076.pdf
Fadel, M., K. Kassab, Doaa A. Abd El Fadeel, and M. A. Farag, "Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (Nmethyl-4-pyridyl) porphyrin loaded in ethosomes", Photodiagnosis and Photodynamic Therapy, vol. 30 , issue 10, pp. 1789 , 2020.
Fadel, S., H. Hafiz, R. Khedr, H. Taha, N. Elkinaai, A. Younes, M. Elwakeel, N. Mohamed, and M. Tantawy, "CHARACTERISTICS AND OUTCOME OF HEPATOBLASTOMA PATIENTS: EXPERIENCE OF CHILDREN CANCER HOSPITAL EGYPT", PEDIATRIC BLOOD & CANCER, vol. 63: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. S172-S173, 2016. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of rose bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3: Faculty of Pharmacy, University of Benin, 2011. Abstract
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Fadel, N., H. el dahab, and S. hassan osman, the efficacy of fentanyl in management of emrgence hypertension in neurosurgery patients , , cairo, cairo university, 2011.
Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., A. E. Kamel, and D. Louis, "Curcumin-loaded nanostructured lipid carriers prepared using Peceol™ and olive oil in photodynamic therapy: development and application in breast cancer cell line", International Journal of Nanomedicine, vol. 14, issue 14, pp. 5073–5085, 2019.
Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-Step Synthesis of Polypyrrole-Coated Gold Nanoparticles for Use as a Photothermally Active Nano-System", International Journal of Nanomedicine, vol. 15, pp. 2605-26015, 2020.