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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, F. I., M. F. Elshamaa, A. Salah, M. Nabhan, M. Rasheed, S. Kamel, D. Kandil, and E. H. Thabet, "Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection.", Transplant immunology, vol. 37, pp. 28-34, 2016. Abstract

BACKGROUND: An essential milestone in pediatric transplantation is to find noninvasive biomarkers to monitor acute rejection (AR). In this retrospective (Case-control) study, we examined the role of Fas -670A/G and Fas Ligand (FasL) -843C/T gene polymorphisms in allograft nephropathy in pediatric renal transplant recipients.

METHODS: In 47 pediatric kidney transplant recipients and 20 healthy controls, Fas -670A/G and FasL -843C/T gene polymorphisms as well as serum soluble Fas Ligand level (sFasL) were measured.

RESULTS: Serum sFasL levels were significantly higher in transplant recipients children than that in controls (548.25±298.64pg/ml vs 143.17±44.55pg/ml, p=0.0001). There was no significant difference between patients with AR and those without AR in regards to serum sFasL levels (567.70±279.87pg/ml vs 507.85±342.80pg/ml, p=0.56). Fas -670A/G genotypes or alleles were not significantly different between controls and transplant recipients and among transplant recipients with and without AR. (P>0.05 for all). FasL -843C/T genotypes were not different between transplant recipients and controls and among transplant recipients with and without AR (P>0.05 for all). However, Frequency of C allele in transplant patients was significantly higher than that in the control group (44.68% vs 25%, P=0.03). FasL -843C/T alleles were significantly different between patients with and without AR (P=0.03). The percentages of C allele were higher in children with AR (58.82% vs 36.67%). We found that serum FasL and serum creatinine were variables that were independently associated with AR.

CONCLUSION: This study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular AR.

Fadel, F. I., E. A. Elghoroury, M. F. Elshamaa, H. M. Bazaraa, D. M. Salah, N. M. A. Kassem, M. H. Ibrahim, G. S. El-Saaid, S. A. Nasr, and H. M. Koura, "Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.", International journal of biomedical science : IJBS, vol. 11, issue 3, pp. 121-30, 2015 Sep. Abstract

BACKGROUND AND OBJECTIVES: The role of CD4+CD25+ T regulatory cells (Tregs) in immune tolerance in experimental transplantation is very important but the clinical significance of circulating Tregs in the peripheral blood is undetermined. We evaluated the association between the frequency of T cell activation markers CD25 and CD71 and clinical parameters that may affect the level of these T cell markers.

METHODS: In 47peditric kidney transplant (KT) recipients and 20 healthy controls, the frequency of T cell activation markers, CD25 and CD71 was measured with flow cytometry after transplantation. Two clinical protocols of induction immunosuppression were used: (1) anti-thymocyte globulin (THYMO) group (n =29) and Basiliximab (BSX) group (n=10).

RESULTS: The percentage of circulating CD25 after KT was significantly lower than that in the controls. There is no significant difference between KT and the controls s regard to circulating CD71. The percentage of CD25 was significantly increased in children with acute rejection compared with those without acute rejection. Calcineurin inhibitors (CNIs) decreased the frequency of CD25 but mammalian target rapamycin (mTOR) inhibitor did not. The proportion of CD25 significantly decreased in THYMO group during the first year after transplantation.

CONCLUSION: The frequency of circulating T cell activation marker CD25 in pediatric KT recipients is strongly affected by CNIs, and a high frequency of CD25 is associated with acute rejection during the early posttransplant period. The measurement of T cell activation markers, may become a useful immune monitoring tool after kidney transplantation.

Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, F. I., H. N. A. E. Mooty, H. M. Bazaraa, and S. M. Sabry, "Central venous catheters as a vascular access modality for pediatric hemodialysis", International urology and nephrology, vol. 40, issue 2, pp. 489-496, 2008.
Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-step synthesis of polypyrrole-coated gold nanoparticles for use as a photothermally active nano-system", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 2605, 2020. Abstract
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Fadel, M., K. Kassab, D. A. E. A. Fadeel, M. Nasr, and N. M. E. Ghoubary, "Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model", Drug Development and Industrial Pharmacy, vol. 44, pp. 1809-1816, 2018.
Fadel, F., M. G. Shouman, A. A. Ibrahim, A. A. Wahby, E. Awadallah, M. A. A. Mawla, A. Selim, and D. M. Salah, "Perforin A and granzyme B as non invasive markers in early acute rejection in pediatric renal transplantation", Gene Reports, vol. 21, pp. 100931, 2020.
Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer, pp. 283–292, 2010. Abstract
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Fadel, S. A., H. M. Hussien, I. A. Sidhom, and H. E. A. Mahlawy, Early Detection and Treatment of Fungal Infection in High Risk Febrile Neutropenic Pediatric Patients With Hematologic Malignancies, , Cairo, Cairo, 2009.
Fadel, F., S. Makar, H. Zekri, and D. Hesham3, "Decreasing Hyperhomocysteinemia by Using On-Line Hemodiafiltration in Children on Regular Hemodialysis", Geget Journal of Egyptian Society Pediatric Nephrology and Transplantation, vol. 13, issue February, pp. 1-9, 2013. 7_hcy_hdf_geget.pdf
Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-step synthesis of polypyrrole-coated gold nanoparticles for use as a photothermally active nano-system", International Journal of Nanomedicine, vol. 15, pp. 2605 – 2615, 2020. AbstractWebsite
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Fadel, M., D. A. El Fadeel, A. Tawfik, A. I. El-Kholy, and Y. O. Mosaad, "Rose Bengal-gold-polypyrrole nanoparticles as a photothermal/ photodynamic dual treatment of recalcitrant plantar warts: Animal and clinical study", Journal of Drug Delivery Science and Technology, vol. 69 , pp. 103095, 2022.
Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, M., A. E. Kamel, and D. Louis, "Curcumin-loaded nanostructured lipid carriers prepared using Peceol™ and olive oil in photodynamic therapy: development and application in breast cancer cell line", International Journal of Nanomedicine, vol. 14, issue 14, pp. 5073–5085, 2019.
Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, M., K. Kassab, D. A. E. A. Fadeel, and M. A. Farag, "Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (Nmethyl- 4-pyridyl) porphyrin loaded in ethosomes", Photodiagnosis and Photodynamic Therapy , vol. 30, 2020.
Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, E., M. Faheemb, G. V. C. b, L. Nassef, A. N. a, M. G. A. Malika, S. Almasri, and I. F. Akyildiz, "Spectrum-aware bio-inspired routing in cognitive radio sensor networks for smart grid applications", Computer Communications, vol. 101, pp. 106–120, 2017. AbstractWebsite

Cognitive radio sensor networks (CRSNs) have been proposed to serve as a reliable, robust, and ef- ficient communications infrastructure that can address both the existing and future energy manage- ment requirements of the smart grid. The existing and envisioned applications of CRSN-based smart grid include substation automation, overhead transmission line monitoring, home energy management, ad- vanced metering infrastructure, wide-area situational awareness, demand response, outage management, distribution automation, asset management. To realize these applications, in this paper, honey bee mating optimization-based routing and cooperative channel assignment algorithms have been proposed. The de- veloped framework significantly decreases the probability of packet loss and preserves high link quality among sensor nodes in harsh smart grid spectrum environments. The proposed approach performance has been evaluated in terms of packet delivery ratio, delay, and energy consumption demonstrating that it has successfully addressed the QoS requirements of most of the SG applications presented.

Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current Drug Delivery, vol. 17, no. 5, pp. 396 – 405, 2020. AbstractWebsite
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Fadel, M. A., and A. A. Tawfik, "New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study", Clinical and experimental dermatology, vol. 40, no. 2, pp. 116–122, 2015. Abstract
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Fadel, M., D. A. El Fadeel, R. M. Ahmed, M. A. Ibrahim, and M. S. Hanafy, "Antitumor Efficiency of Doxorubicin Loaded in Liposomes and Poly Ethylene Glycol Coated Ferrofluid Nanoparticles", J Nanomater Mol Nanotechnol, vol. 1, issue 4, 2015. Abstract

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Fadel, M., and N. Samy, "3rd International Conference on", J Clin Exp Dermatol Res, vol. 4, no. 2, pp. 54, 2013. Abstract
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Fadel, F. I., M. F. Elshamaa, A. Salah, M. Nabhan, M. Rasheed, S. Kamel, D. Kandil, and E. H. Thabet, "Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection.", Transplant immunology, vol. 37, pp. 28-34, 2016 Jul. Abstract

BACKGROUND: An essential milestone in pediatric transplantation is to find noninvasive biomarkers to monitor acute rejection (AR). In this retrospective (Case-control) study, we examined the role of Fas -670A/G and Fas Ligand (FasL) -843C/T gene polymorphisms in allograft nephropathy in pediatric renal transplant recipients.

METHODS: In 47 pediatric kidney transplant recipients and 20 healthy controls, Fas -670A/G and FasL -843C/T gene polymorphisms as well as serum soluble Fas Ligand level (sFasL) were measured.

RESULTS: Serum sFasL levels were significantly higher in transplant recipients children than that in controls (548.25±298.64pg/ml vs 143.17±44.55pg/ml, p=0.0001). There was no significant difference between patients with AR and those without AR in regards to serum sFasL levels (567.70±279.87pg/ml vs 507.85±342.80pg/ml, p=0.56). Fas -670A/G genotypes or alleles were not significantly different between controls and transplant recipients and among transplant recipients with and without AR. (P>0.05 for all). FasL -843C/T genotypes were not different between transplant recipients and controls and among transplant recipients with and without AR (P>0.05 for all). However, Frequency of C allele in transplant patients was significantly higher than that in the control group (44.68% vs 25%, P=0.03). FasL -843C/T alleles were significantly different between patients with and without AR (P=0.03). The percentages of C allele were higher in children with AR (58.82% vs 36.67%). We found that serum FasL and serum creatinine were variables that were independently associated with AR.

CONCLUSION: This study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular AR.

Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, pp. 289 – 297, 2011. AbstractWebsite
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