Publications

Export 14140 results:
Sort by: Author [ Title  (Asc)] Type Year
A B C D E [F] G H I J K L M N O P Q R S T U V W X Y Z   [Show ALL]
1
Fathi, M. A. A., A. A. Abd El-Hafeez, D. A. ElHamid, S. H. Abbas, M. M. Montano, and M. A. El-Aziz, "1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities.", Bioorganic chemistry, vol. 84, pp. 150-163, 2019. Abstractoxadiazole_paper.pdf

A new series of 1,3,4-oxadiazole/chalcone hybrids was designed, synthesized, identified with different spectroscopic techniques and biologically evaluated as inhibitors of EGFR, Src, and IL-6. The synthesized compounds showed promising anticancer activity, particularly against leukemia, with 8v being the most potent. The synthesized compounds exhibited strong to moderate cytotoxic activities against K-562, KG-1a, and Jurkat leukemia cell lines in MTT assays. Compound 8v showed the strongest cytotoxic activity with IC of 1.95 µM, 2.36 µM and 3.45 µM against K-562, Jurkat and KG-1a leukemia cell lines, respectively. Moreover; the synthesized compounds inhibited EGFR, Src, and IL-6. Compound 8v was most effective at inhibiting EGFR (IC = 0.24 μM), Src (IC = 0.96 μM), and IL-6 (% of control = 20%). Additionally, most of the compounds decreased STAT3 activation.

Shawali, A. S., A. A. Fahmi, H. M. Hassaneen, H. A. Abdellah, and M. A. Abdelhmid, "1,3-Dipolar Cycloaddition Reactions of Diphenylnitrilimine with Esters of α, β- Didehydro Amino Acids.", J. Chem. Res., vol. 360, pp. 2936, 1992.
Fahmy, S. M., N. M. Abed, R. M. Mohareb, and M. H. Elnagdi, "1- Activated Nitriles In Heterocyclic Synthesis: A Novel Synthesis of Pyrimidine, Pyridine and Isoxazole Derivatives", Synthesis, vol. 6, pp. 490, 1982.
Fahmy, S. M., N. M. Abed, R. M. Mohareb, and M. H. Elnagdi, "1- Activated Nitriles In Heterocyclic Synthesis: A Novel Synthesis of Pyrimidine, Pyridine and Isoxazole Derivatives", Synthesis, vol. 6, pp. 490, 1982.
khedr, S., and M. abdel fattah, "1- Diagnostic value of virtual colonoscopy in evaluation of colorectal neoplasm", The Egypt.Journal of Radiology & Nuc.Med. ,, vol. Vol.29, , issue No.2, 1998.
Fouda, K. Z., and M. E. H. Laithy, "1. Effect of low energy versus medium energy radial shock wave therapy in the treatment of chronic planter fasciitis. ", Int J Physiother., vol. 3, issue 1, pp. 5-10, 2016.
Abou-Bakr, S., N. H. Fahim, A. F. El-Kholy, M.A.M.Ibrahim, R. R. Sadek, and A. A. Nigm, 1. Genetic parameters for some milk production traits of Holstein cows in a commercial herd in Egypt, , 2006.
Bakkaloglu, B., P. Fontaine, A. N. Mohieldin, S. Peng, S. J. Fang, F. Dulger, and A. Bellaouar, "A 1.5V Multi-mode Quad-band RF Receiver for GSM/EDGE/CDMA2K in 90nm Digital CMOS Process", IEEE Journal of Solid-State Circuits, vol. 41, issue 5, pp. 1149-1159, 2006.
Rouchdy, A., A. Farouk, A. E. sharkawy, and S. Abdelaziz, "11- Aortic valve sparing techmiques in ascending aortic aneurysm and dissection: immediate and early results ", EJCTS, vol. 20, issue 1-2, 2012.
F., F., T. A.F, and N. A, "12. Toxicopathological and genotoxic potential of perfluorooctanoic acid administration in albino rats", Egypt. J. Comp. Path & Clinical Path. , vol. 27, issue 1, pp. 1-17, 2014.
Khedr, R., M. A. Waged, M. Fathy, and W. Zekri, "1534. Prevalence and Outcome of Neutropenic Enterocolitis Among Pediatric Acute Myeloid Leukemia Patients: A Developing Country Experience", Open Forum Infectious Diseases, vol. 5, issue Suppl 1: Oxford University Press, pp. S476, 2018. Abstract
n/a
Khedr, R., M. A. Waged, M. Fathy, and W. Zekri, "1534. Prevalence and Outcome of Neutropenic Enterocolitis Among Pediatric Acute Myeloid Leukemia Patients: A Developing Country Experience", Open Forum Infectious Diseases, vol. 5, issue Suppl 1: Oxford University Press, pp. S476, 2018. Abstract
n/a
nehal hamdy, A. Fathy, Sameh Gamal, and W. Rabeae, 154-P Study of Serum Prolactin as a Cardiovascular Risk Factor in Type 2 Diabetes Mellitus, , 2012.
Elkhatib, M. A. W., A. Mroueh, R. W. Rafeh, F. Sleiman, H. Fouad, E. I. Saad, M. A. Fouda, O. Elgaddar, K. Issa, A. H. Eid, et al., 17 siRNA-and miRNA-based therapeutics for liver fibrosis Zhen Zhao, Chien-Yu Lin, and Kun Cheng, Kansas City, Missouri 30 RNAi therapeutic strategies for acute respiratory distress syndrome, , Submitted. Abstract
n/a
Farouk, Y., "1701 (2006) : LA SITUATION AU MOYEN-ORIENT", Les grandes résolutions du Conseil de sécurité des Nations unies, Paris, Dalloz, 2012. 1701_la_situation_au_moyen_orient.pdf
Alnahas, Z., manal el menyawi, M. Fawzy, O. Shaker, and G. Ragab, "173. 25-HYDROXYVITAMIN D3 DEFICIENCY AND VITAMIN D RECEPTOR POLYMORPHISMS IN EGYPTIAN BEHÇET’S DISEASE PATIENTS: A PILOT STUDY", Rheumatology, vol. 58, issue Supplement_2: Oxford University Press, pp. kez060, 2019. Abstract
n/a
Salem, H., H. Fathy, W. Fawzy, A. El Shinofi, A. Lotfi, and A. E. R. Hegazy, "1894 INDUCTION OF SPERMATOGENESIS IN MEN WITH NON OBSTRUCTIVE AZOOSPERMIA AFTER MICROSURGICAL VARICOCELECTOMY FOR THE TREATMENT OF VARICOCELE: CORRELATION WITH TESTICULAR HISTOPATHOLOGY AND HORMONAL PROFILE", The Journal of Urology, vol. 189, no. 4: Elsevier, pp. e776, 2013. Abstract
n/a
Emad, A., A. R. Rashad, I. S. Fahim, and T. Ismail, "1D (1-Dimensional) Si PN Junction with Organic Materials and Transparent Conductive Oxides (TCOs) Alternatives", 2020 IEEE PES/IAS PowerAfrica: IEEE, pp. 1–5, 2020. Abstract
n/a
Dawood, K. M., N. M. Elwan, A. A. Farahat, and B. F. Abdel-Wahab, "1H-Benzimidazole-2-acetonitriles as Synthon in Fused Benzimidazole Synthesis", J. Heterocycl. Chem., vol. 47, issue 2, pp. 243-267, 2010.
2
Yousry, C., R. Fahmy, T. Essam, and S. E. Kheshen, "2) Nanoparticles as tool for enhanced ophthalmic delivery of Vancomycin: multidistrict- based microbiological study, solid lipid nanoparticles formulation and evaluation", Drug Development and Industrial Pharmacy, vol. 42, pp. 1752-1762 , 2016.
Farghaly, T. A., M. A. Abdallah, and Z. A. Muhammad, "2,7-Diarylidene-cycloheptanone, Hydrazonoyl Chlorides and Heterocyclic Amines as Precursors for Synthesis of Bioactive new Fused Cycloheptapyrimidine Derivatives", Current Organic Synthesis, vol. 13, issue 2, pp. 291-299, 2016.
Salem, M. E., A. F. Darweesh, A. E. M. Mekky, A. M. Farag, and A. H. M. Elwahy, "2-Bromo-1-(1H-pyrazol-4-yl) ethanone: Versatile Precursor for Novel Mono-and Bis [pyrazolylthiazoles]", Journal of Heterocyclic Chemistry, 2016. Abstract
n/a
Salem, M. E., A. F. Darweesh, A. E. M. Mekky, A. M. Farag, and A. H. M. Elwahy, "2-Bromo-1-(1H-pyrazol-4-yl) ethanone: Versatile Precursor for Novel Mono-and Bis [pyrazolylthiazoles]", Journal of Heterocyclic Chemistry, vol. 54, no. 1: Wiley Online Library, pp. 226–234, 2017. Abstract
n/a
Salem, M. E., A. F. Darweesh, A. E. M. Mekky, A. M. Farag, and A. H. M. Elwahy, "2-Bromo-1-(1H-pyrazol-4-yl) ethanone: Versatile Precursor for Novel Mono-and Bis [pyrazolylthiazoles]", Journal of Heterocyclic Chemistry, vol. 54, no. 1: Wiley Online Library, pp. 226–234, 2017. Abstract
n/a
Tourism