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Fadel, F. I., M. A. Kotb, M. A. Abdel Mawla, R. M. Hasanin, amr mohamed salem, M. G. Fathallah, K. S. Amr, H. A. Ahmed, and D. M. Salah, "Primary Hyperoxaluria type 1 in children: Clinical Classification, Renal Replacement Therapy and Outcome in a Single Centre Experience.", Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2021. Abstract

INTRODUCTION: Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy. This study aimed to report clinical presentations, renal replacement therapy (RRT) and outcome of PH1 in end stage kidney disease (ESKD) children.

METHODS: This is an observational cohort study. Data of 22 patients with ESKD due to PH1 were analyzed at Pediatric Nephrology Unit, Faculty of Medicine Cairo University.

RESULTS: Infantile onset patients (n=10) had worst renal outcome (80% with ESRD at presentation, p=0.019) and worse patient outcome (mortality 40%, p=0.016) than juvenile (n=9) and late onset (PH1 n=3) patients. RRT modalities include peritoneal dialysis (PD) in 7 (31.8%), hemodialysis (HD) in 11(50 %) and, combined liver kidney transplantation (CLKT) in 4 (18.2%) patients. Infectious complications were encountered in 42.8% of PD patients. Better HD adequacy was observed with frequent HD (n=6) and/or HD via arteriovenous fistula (AVF) than with infrequent dialysis (n=5) and/or via central venous line (CVL) (P =0.0001 & 0.0047 respectively). Morbidity and mortality (infection related) rates of the whole cohort were 63.6% and 31.8% respectively.

CONCLUSIONS: Clinical presentation of PH1 varies according to the age of onset (infantile onset being the most aggressive form). Aggressive HD (better through AVF) is needed to achieve acceptable HD adequacy, PD was challenged by infection. Infection found to be the main cause of mortality even after successful CLKT. This article is protected by copyright. All rights reserved.

Fadel, F. I., S. H. Makar, A. E. Eskander, and A. H. Aon, "Decreasing intra-dialytic morbid events and assessment of dry weight in children on chronic hemodialysis using non-invasive changes in hematocrit.", Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 25, issue 5, pp. 1030-7, 2014 Sep. Abstract

Achieving dry weight after hemodialysis (HD) is critical as chronic fluid over-load can result in left ventricular hypertrophy, while small fluid shifts may result in intra-dialytic morbid events (IME). In the pediatric population, estimating dry weight can be difficult due to growth while on dialysis. Continuous non-invasive monitoring of the hematocrit (NIVM) has been proposed as a more accurate method of estimating dry weight. Fifteen pediatric patients on chronic HD (6 males and 9 females; mean age 11.4 ± 2.28 years) were included in an uncontrolled prospective study involving three phases. In phase 1, patients were observed for one month for their dry weight and frequency of IME. Phase 2 consisted of using NIVM-guided ultrafiltration algorithm for rate of blood volume (BV) reduction and post-dialysis refill, recommending an intra-dialytic reduction in BV of 8% in the first hour and <4% per hour thereafter and without significant post-dialytic vascular refill. Phase 3 comprised a one month period for comparing the results. IME decreased from 33 episodes per 180 sessions in phase 1 to 4 per 180 sessions during phase 3 (P = 0.04), without a significant difference in pre-systolic or post-systolic or mean BP before and after the intervention (all P >0.1). In phase 1, 40% of patients experienced no IME, 33% experienced one or two IME while 27% experienced more than two IME; during phase 3, 80% experienced no IME, 20% experienced one or two IME while no one experienced more than two IME. NIVM can serve as an objective method for determining dry weight as well as predicting and preventing IME in the pediatric population on maintenance HD.

Fadel, F., H. Bazaraa, R. Hachem, D. Salah, and H. Safouh, "Endothelial Dysfunction In Pediatric Renal Transplant Recipients", PEDIATRIC NEPHROLOGY, vol. 29, no. 9: SPRINGER 233 SPRING ST, NEW YORK, NY 10013 USA, pp. 1761–1761, 2014. Abstract
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Fadel, S. A., M. M. Gaafar, O. E. Teneer, and I. A. Attia, ROLE OF TOPOTECAN IN REFRACTORY NEUROBLASTOMA, , Cairo, Cairo, 2002.
Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, F. I., S. A. E. Sherbiny, A. M. Badr, H. A. F. E. Gebaly, and D. M. Osman, CHARACTERISTICS OF SEPTIC PEDIATRIC PATIENTS WITH ACUTE KIDNEY INJURY IN PICU, , 2018.
Fadel, M., K. Kassab, N. Sami, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current drug delivery, vol. 17, issue 5, 2020.
Fadel, M., K. Kassab, N. Samy, and S. Thabet, European Journal of Biomedical AND Pharmaceutical sciences, , 2015. Abstract
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Fadel, M., M. Nasr, R. M. Hassan, and S. S. Thabet, "Cationic zinc (II) phthalocyanine nanoemulsions for photodynamic inactivation of resistant bacterial strains.", Photodiagnosis and photodynamic therapy, vol. 34, pp. 102301, 2021. Abstract

BACKGROUND: The growing emergence of microbial resistance to antibiotics represents a worldwide challenge. Antimicrobial photodynamic inactivation (aPDI) has been introduced as an alternative technique, especially when combined with nanotechnology. Therefore, this study was designed to investigate the therapeutic merits of combined aPDI and nanoemulsion in infections caused by resistant bacterial strains.

METHODS: Cationic zinc (II) phthalocyanine nanoemulsions (ZnPc-NE) were prepared using isopropyl myristate (IPM) as oil phase, egg phosphatidylcholine (egg PC) as emulsifier, and N-cetyl-N,N,N-trimethyl ammonium bromide (CTAB). Nanoemulsions were characterized for particle size, polydispersity, zeta potential, viscosity, and skin deposition. The in-vitro aPDI was investigated on human resistant pathogens; gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and gram-negative Multidrug-resistant strain of Escherichia coli (MDR E. coli), under different experimental conditions. In addition, in-vivo model of abrasion wound infected by MDR E. coli was induced in rats to investigate the therapeutic potential of the selected formulation.

RESULTS: It was evident that the selected ZnPc formulation (20 % IPM, 2 % egg PC and 0.5 % CTAB) displayed a particle size of 209.9 nm, zeta potential +73.1 mV, and 23.66 % deposition of ZnPc in skin layers. Furthermore, the selected formulation combined with light achieved almost 100 % eradication of the two bacterial strains, with superior bacterial load reduction and wound healing propertiesin-vivo, compared to either the nanoemulsion formulation or laser alone.

CONCLUSION: ZnPc nanoemulsion improved antimicrobial photodynamic therapy in inactivating resistant bacterial infections and provided a promising therapeutic means of treating serious infections, and hence could be applied in diseases caused by other bacterial strains.

Fadel, M. A., and A. A. Tawfik, "New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study", Clinical and experimental dermatology, vol. 40, issue 2: Wiley Online Library, pp. 116-122, 2015. Abstract

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Fadel, F., H. M. Bazraa, S. M. Abdelrahman, M. G. Shoman, M. k Sayed, D. M. Salah, A. m Wahby, and H. F. Elgebaly, "Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients", Open Access Macedonian Journal of medical Science, vol. 5, issue 1857-9655, pp. 222-227, 2017.
Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M., D. A. El Fadeel, A. Tawfik, A. I. El-Kholy, and Y. O. Mosaad, "Rose Bengal-gold-polypyrrole nanoparticles as a photothermal/ photodynamic dual treatment of recalcitrant plantar warts: Animal and clinical study", Journal of Drug Delivery Science and Technology, vol. 69 , pp. 103095, 2022.
Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-step synthesis of polypyrrole-coated gold nanoparticles for use as a photothermally active nano-system", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 2605, 2020. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer, pp. 675–683, 2010. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, M., K. Kassab, Doaa A. Abd El Fadeel, M. Nasr, and N. M. E. Ghoubary, "Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model", Drug Development and Industrial Pharmacy, vol. Nov;44, issue (11):, pp. 1809-1816., 2018.
Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer, pp. 283–292, 2010. Abstract
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Fadel, F. I., D. M. Salah, and H. M. Bazaraa, "Localized Renal Graft Aspergillosis in a Child after Kidney Transplantation: Case Report and Review of Literature", Virology & Mycology, vol. 5, issue 3, pp. 160-164, 2016.
Fadel, G., L. Z. Mohamed, O. A. El Kady, A. A. Elhabak, M. A. Adly, and S. A. Abolkassem, "Studying the Microstructure, Physical and Mechanical Properties of Al Matrix Reinforced with Bi-Modal Particles Coated with Either Ni or Cu", Transactions of the Indian Institute of Metals, vol. 75, issue 6, pp. 1-11, 2022. fadel2022_article_studyingthemicrostructurephysi.pdf
Fadel, M. A., and A. A. Tawfik, "New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study", Clinical and experimental dermatology, vol. 40, no. 2, pp. 116–122, 2015. Abstract
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