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Fadel, F., H. Bazaraa, R. Hachem, D. Salah, and H. Safouh, "Endothelial Dysfunction In Pediatric Renal Transplant Recipients", PEDIATRIC NEPHROLOGY, vol. 29, no. 9: SPRINGER 233 SPRING ST, NEW YORK, NY 10013 USA, pp. 1761–1761, 2014. Abstract
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Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current Drug Delivery: Bentham Science Publishers, 2021. Abstract
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Fadel, M., K. Kassab, N. Samy, and S. Thabet, European Journal of Biomedical AND Pharmaceutical sciences, , 2015. Abstract
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Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M. A., and A. A. Tawfik, "New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study", Clinical and experimental dermatology, vol. 40, issue 2: Wiley Online Library, pp. 116-122, 2015. Abstract

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Fadel, M., M. Nasr, R. M. Hassan, and S. S. Thabet, "Cationic zinc (II) phthalocyanine nanoemulsions for photodynamic inactivation of resistant bacterial strains", Photodiagnosis and Photodynamic Therapy, vol. 35, 2021.
Fadel, F. I., S. H. Makar, A. E. Eskander, and A. H. Aon, "Decreasing intra-dialytic morbid events and assessment of dry weight in children on chronic hemodialysis using non-invasive changes in hematocrit.", Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 25, issue 5, pp. 1030-7, 2014 Sep. Abstract

Achieving dry weight after hemodialysis (HD) is critical as chronic fluid over-load can result in left ventricular hypertrophy, while small fluid shifts may result in intra-dialytic morbid events (IME). In the pediatric population, estimating dry weight can be difficult due to growth while on dialysis. Continuous non-invasive monitoring of the hematocrit (NIVM) has been proposed as a more accurate method of estimating dry weight. Fifteen pediatric patients on chronic HD (6 males and 9 females; mean age 11.4 ± 2.28 years) were included in an uncontrolled prospective study involving three phases. In phase 1, patients were observed for one month for their dry weight and frequency of IME. Phase 2 consisted of using NIVM-guided ultrafiltration algorithm for rate of blood volume (BV) reduction and post-dialysis refill, recommending an intra-dialytic reduction in BV of 8% in the first hour and <4% per hour thereafter and without significant post-dialytic vascular refill. Phase 3 comprised a one month period for comparing the results. IME decreased from 33 episodes per 180 sessions in phase 1 to 4 per 180 sessions during phase 3 (P = 0.04), without a significant difference in pre-systolic or post-systolic or mean BP before and after the intervention (all P >0.1). In phase 1, 40% of patients experienced no IME, 33% experienced one or two IME while 27% experienced more than two IME; during phase 3, 80% experienced no IME, 20% experienced one or two IME while no one experienced more than two IME. NIVM can serve as an objective method for determining dry weight as well as predicting and preventing IME in the pediatric population on maintenance HD.

Fadel, M., M. Nasr, and S. S. Thabet, "Cationic zinc (II) phthalocyanine nanoemulsions for photodynamic inactivation of resistant bacterial strains", Photodiagnosis and Photodynamic Therapy,, vol. 34, , pp. 102301, 2021.
Fadel, F. I., H. M. Bazaraa, M. A. Abdel Mawla, and D. M. Salah, "Pediatric focal segmental glomerulosclerosis: favorable transplantation outcome with plasma exchange.", Italian journal of pediatrics, vol. 47, issue 1, pp. 236, 2021. Abstract

BACKGROUND: Although kidney transplantation (KTX) is the treatment of choice for pediatric end stage kidney disease (ESKD); concerns for recurrence in cases of focal segmental glomerulosclerosis (FSGS) are still present. This study aimed to investigate the outcome of KTX in children with ESKD secondary to FSGS, with implementation of preemptive perioperative plasma exchange (PE) for non-genetically proven patients.

METHODS: Forty FSGS pediatric kidney transplant recipients were studied. Of them: 12 patients (30%) had genetically proven NPHS2 mutations/familial and 28 (70%) were sporadic FSGS patients. All sporadic patients electively received 6 perioperative PE sessions. Patients with recurrence of proteinuria (n = 13; including 3 patients with genetic/familial and 10 patients with sporadic FSGS) were managed with PE and Rituximab (RTX). Kaplan-Meier curves were used to analyze graft and recurrence free survival data.

RESULTS: The mean follow-up duration after KTX was 3.8 ± 2.86 years. Recurrence of proteinuria was encountered early postoperative in 11 patients (27.5%) and late (1.6 and 2.9 years after KTX) in 2 patients (5%). All patients with early recurrence achieved complete remission, while patients with late recurrence developed graft failure. Current serum creatinine and proteinuria levels were not different in patients received PE (n = 31) and patients did not PE (n = 9) (p = 0.308 and 0.287 respectively). Current serum creatinine and proteinuria levels in sporadic patients (n = 28) after prophylactic perioperative PE were not different from those of genetic/ familial patients (n = 12) (p = 0.303 and 0.144 respectively). Proteinuria was less in patients underwent native nephrectomy than others immediately postoperative and at assessment (p = 0.002 & 0.0031 respectively). One-year graft and patient survival was 93.8% with a mean 1-year serum creatinine of 0.67 ± 0.25 mg/dl. Three graft losses (7.5%) were due to chronic rejection 3.3, 3.75 and 4.17 years after KTX and 2 patients' mortality (5%) occurred early postoperative (first 2 weeks).

CONCLUSION: FSGS transplanted children have favorable outcomes with perioperative PE for non-genetically proven cases. Early recurrence after KTX can be successfully managed with PE and RTX.

Fadel, F. I., S. Sabry, M. A. A. Mawla, R. E. E. Galal, D. M. Salah, R. Helmy, Y. Ramadan, W. Elzayat, M. Abdelfattah, and E. A. Abd Alazem, "Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience.", Italian journal of pediatrics, vol. 48, issue 1, pp. 149, 2022. Abstract

BACKGROUND: Chronic kidney disease stage 5 (CKD 5) populations have peculiar risk for severe Covid-19 infection. Moreover; pediatric data are sparse and lacking. The aim of this study is to report our experience in CKD 5 children treated by hemodialysis (CKD 5D) and CKD 5 children after kidney transplantation (KTR) during one year of Covid-19 pandemic.

METHODS: Retrospective analysis of 57 CKD 5 children with Covid-19 like symptoms during 1 year pandemic was performed. A cohort of 19 confirmed patients (13 CKD 5D and 6 KTR) was analyzed in details as regard clinical, laboratory, radiological criteria, management and their short term outcome.

RESULTS: CONCLUSION: Pediatric patients on regular HD (CKD 5D) are at higher risk and worse outcome of Covid-19 infection than KT recipients (KTR). Pre-existing HTN and shorter duration after KT are potential risk factors. Reversible AGD after KT and CVC related infections in HD patients are additional presenting features of Covid-19 infection.

Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., K. Kassab, D. A. E. A. Fadeel, M. Nasr, and N. M. E. Ghoubary, "Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model", Drug Development and Industrial Pharmacy, vol. 44, pp. 1809-1816, 2018.
Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-Step Synthesis of Polypyrrole-Coated Gold Nanoparticles for Use as a Photothermally Active Nano-System", International Journal of Nanomedicine, vol. 15, pp. 2605-26015, 2020.
Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer, pp. 675–683, 2010. Abstract
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Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of recalcitrant plantar warts", Current drug delivery, vol. 17, issue 5, pp. 396-405, 2020.
Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer, pp. 283–292, 2010. Abstract
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Fadel, N., H. el dahab, and S. hassan osman, the efficacy of fentanyl in management of emrgence hypertension in neurosurgery patients , , cairo, cairo university, 2011.
Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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