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Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. AbstractPediatric kidney transplantation in Egypt: Results of 10-year single-center experience.pdf

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in Medical Science, vol. 25, no. 2, pp. 283 – 292, 2010. AbstractWebsite
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Fadel, M., K. Kassab, Doaa A. Abd El Fadeel, and M. A. Farag, "Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (Nmethyl-4-pyridyl) porphyrin loaded in ethosomes", Photodiagnosis and Photodynamic Therapy, vol. 30 , issue 10, pp. 1789 , 2020.
Fadel, F. I., H. M. Bazaraa, M. A. Abdel Mawla, and D. M. Salah, "Pediatric focal segmental glomerulosclerosis: favorable transplantation outcome with plasma exchange.", Italian journal of pediatrics, vol. 47, issue 1, pp. 236, 2021. Abstract

BACKGROUND: Although kidney transplantation (KTX) is the treatment of choice for pediatric end stage kidney disease (ESKD); concerns for recurrence in cases of focal segmental glomerulosclerosis (FSGS) are still present. This study aimed to investigate the outcome of KTX in children with ESKD secondary to FSGS, with implementation of preemptive perioperative plasma exchange (PE) for non-genetically proven patients.

METHODS: Forty FSGS pediatric kidney transplant recipients were studied. Of them: 12 patients (30%) had genetically proven NPHS2 mutations/familial and 28 (70%) were sporadic FSGS patients. All sporadic patients electively received 6 perioperative PE sessions. Patients with recurrence of proteinuria (n = 13; including 3 patients with genetic/familial and 10 patients with sporadic FSGS) were managed with PE and Rituximab (RTX). Kaplan-Meier curves were used to analyze graft and recurrence free survival data.

RESULTS: The mean follow-up duration after KTX was 3.8 ± 2.86 years. Recurrence of proteinuria was encountered early postoperative in 11 patients (27.5%) and late (1.6 and 2.9 years after KTX) in 2 patients (5%). All patients with early recurrence achieved complete remission, while patients with late recurrence developed graft failure. Current serum creatinine and proteinuria levels were not different in patients received PE (n = 31) and patients did not PE (n = 9) (p = 0.308 and 0.287 respectively). Current serum creatinine and proteinuria levels in sporadic patients (n = 28) after prophylactic perioperative PE were not different from those of genetic/ familial patients (n = 12) (p = 0.303 and 0.144 respectively). Proteinuria was less in patients underwent native nephrectomy than others immediately postoperative and at assessment (p = 0.002 & 0.0031 respectively). One-year graft and patient survival was 93.8% with a mean 1-year serum creatinine of 0.67 ± 0.25 mg/dl. Three graft losses (7.5%) were due to chronic rejection 3.3, 3.75 and 4.17 years after KTX and 2 patients' mortality (5%) occurred early postoperative (first 2 weeks).

CONCLUSION: FSGS transplanted children have favorable outcomes with perioperative PE for non-genetically proven cases. Early recurrence after KTX can be successfully managed with PE and RTX.

Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., K. Kassab, T. Youssef, and A. I. El-Kholy, "One-step synthesis of phyto-polymer coated gold nanospheres as a delivery system to enhance resveratrol cytotoxicity", Drug Development and Industrial Pharmacy, vol. 45, issue 6: Taylor & Francis, pp. 937-945, 2019. Abstract
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Fadel, F., M. G. Shouman, A. A. Ibrahim, A. A. Wahby, E. Awadallah, M. A. A. Mawla, A. Selim, and D. M. Salah, "Perforin A and granzyme B as non invasive markers in early acute rejection in pediatric renal transplantation", Gene Reports, vol. 21, pp. 100931, 2020.
Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of drugs in dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer, pp. 675–683, 2010. Abstract
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Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, M., K. Kassab, N. Sami, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current drug delivery, vol. 17, issue 5, 2020.
Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., M. Salah, N. Samy, and M. Soliman, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris", Journal of Drugs in Dermatology, vol. 8, no. 11, pp. 983 – 990, 2009. AbstractWebsite
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Fadel, S. A., M. M. Gaafar, O. E. Teneer, and I. A. Attia, ROLE OF TOPOTECAN IN REFRACTORY NEUROBLASTOMA, , Cairo, Cairo, 2002.
prof dr fatina fadel, prof dr amal mostafa, lecturer dr. ahmed salah, and lecturer dr hanan abd el aziz, complications and long term outcome of peritoneal dialysis in children, : cairo, 2014.
Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, M., K. Kassab, D. A. Abdel Fadeel, M. Nasr, and N. M. E. Ghoubary, "Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model", Drug Development and Industrial Pharmacy, vol. 44, no. 11, pp. 1809 – 1816, 2018. AbstractWebsite
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Fadel, F., N. El-Anwar, F. A. W. A. Maksoud, N. Mohamed, and Y. Ramadan, Cardiovascular complications and indoxyl sulfate are related to longer duration of end stage renal disease in children, , vol. 3, issue 1: Cairo University, Faculty of Medicine, Department of Pediatrics, pp. 50 - 56, 2023. Abstract
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Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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Fadel, M., K. Kassab, D. A. Abdel Fadeel, and M. A. Farag, "Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (N-methyl-4-pyridyl) porphyrin loaded in ethosomes", Photodiagnosis and Photodynamic Therapy, vol. 30, 2020. AbstractWebsite
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Fadel, M., K. Kassab, N. Samy, and G. Yassin, "TRANSFEROSOMAL METHYLENE BLUE MEDIATED PHOTODYNAMIC THERAPY FOR TREATMENT OF PLANTAR WARTS", LASERS IN SURGERY AND MEDICINE, vol. 47, no. 4: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. 381–381, 2015. Abstract
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Fadel, F. I., M. A. Kotb, M. A. Abdel Mawla, R. M. Hasanin, amr mohamed salem, M. G. Fathallah, K. S. Amr, H. A. Ahmed, and D. M. Salah, "Primary hyperoxaluria type 1 in children: Clinical classification, renal replacement therapy, and outcome in a single centre experience.", Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2021. Abstract

Primary hyperoxaluria type 1 (PH1) is a rare disease that is challenged by the overproduced oxalate and commonly presented with radiopaque renal stones or obstructive uropathy. This study aimed to report clinical presentations, renal replacement therapy (RRT), and outcome of PH1 in end stage kidney disease (ESKD) children. This is an observational cohort study. Data of 22 patients with ESKD due to PH1 were analyzed at Pediatric Nephrology Unit, Faculty of Medicine Cairo University. Infantile onset patients (n = 10) had worst renal outcome (80% with ESRD at presentation, p = 0.019) and worse patient outcome (mortality 40%, p = 0.016) than juvenile (n = 9) and late onset (PH1 n = 3) patients. RRT modalities include peritoneal dialysis (PD) in 7 (31.8%), hemodialysis (HD) in 11 (50%), and combined liver kidney transplantation (CLKT) in 4 (18.2%) patients. Infectious complications were encountered in 42.8% of PD patients. Better HD adequacy was observed with frequent HD (n = 6) and/or HD via arteriovenous fistula (AVF) than with infrequent dialysis (n = 5) and/or via central venous line (CVL) (p = 0.0001 and 0.0047, respectively). Morbidity and mortality (infection related) rates of the whole cohort were 63.6% and 31.8%, respectively. Clinical presentation of PH1 varies according to the age of onset (infantile onset being the most aggressive form). Aggressive HD (better through AVF) is needed to achieve acceptable HD adequacy, PD was challenged by infection. Infection found to be the main cause of mortality even after successful CLKT.