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Fouda, M. A., R. M. Allam, F. M. Moftah, and R. A. M. El-Fetouh, "The Role of ID-NAT in Enhancing Blood Safety at the Egyptian National Cancer Institute - A 5 Year Experience", Journal of the Egyptian Society of Haematology & Research, vol. 14, issue 2, pp. 1-6, 2018.
Fouda, U. M., M. A. M. ElKassem, S. M. Hefny, and A. T. Hashem, "Role of middle cerebral artery, umbilical artery resistance indices and middle cerebral artery to umbilical artery resistance index ratio in predicting unfavorable perinatal outcomes of normotensive and hypertensive diabetic pregnancies ", Life Science Journal, vol. 10, issue 3, pp. 2371-2377, 2013. Abstract

Objective: To evaluate the role of middle cerebral artery (MCA), umbilical artery (UA)resistance indices (RI) and middle cerebral artery / umbilical artery resistance index ratio(MCA/UA RI) in predicting unfavorable perinatal outcomes in pregnancies complicated with diabetes mellitus. Methods: This prospective study included 96 women divided into 4 groups. Group 1 included 23 pregnant patients with preexisting diabetes, group 2 included 22 patients with gestational diabetes, group 3 included 24 diabetic pregnancies associated with hypertension and group 4 was a control group which included 27 patients with uncomplicated pregnancies. The umbilical artery and middle cerebral artery resistance indices were measured weekly starting from the 34th till the 38th week of pregnancy. Results: Abnormal UA RI (≥ 95th centile) had 78.57% sensitivity in detecting adverse perinatal outcomes in group 3 compared with 16.67 % and 0% sensitivity in group 1 and group 2 respectively. Abnormal MCA RI (≤ 5th centile) had 50% sensitivity in detecting adverse perinatal outcomes in group 3 compared with 0% sensitivity in groups 1 and 2. Abnormal MCA/UA RI (< 1) had 71.43 % sensitivity in detecting adverse perinatal outcomes in group 3 compared with 0 % sensitivity in groups 1 and 2. Conclusion: The abnormal UA RI, MCA RI and MCA/UA RI may be useful parameters in predicting adverse perinatal outcomes in diabetic pregnancies associated with hypertension. On the other hand, there were weak correlations between abnormal UA RI, MCA RI, MCA/UA RI and adverse perinatal outcomes of diabetic pregnancies not associated with hypertension. Therefore the results of the UA RI, MCA RI and MCA/UA RI should be interpreted with caution in the management of diabetic pregnancies, especially those not associated with hypertension, as adverse perinatal outcomes frequently occur in patients with normal Doppler indices.

Fouda, A. Y., H. A. Ahmed, B. Pillai, A. Kozak, T. Hardigan, A. Ergul, S. C. Fagan, and T. Ishrat, "Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke.", Neurochemistry international, vol. 158, pp. 105375, 2022. Abstract

We and others have previously shown that angiotensin II receptor type 2 receptor (AT2R) is upregulated in the contralesional hemisphere after stroke in normoglycemic Wistar rats. In this study, we examined the expression of AT2R in type 2 diabetic Goto-Kakizaki (GK) rats and control Wistars after stroke. We also tested the contribution of the contralesional AT2R in recovery after stroke through a specific knockdown of the AT2R in this hemisphere only. Two experiments were conducted. In the first experiment, GK rats were subjected to middle cerebral artery occlusion (MCAO) and treated with the angiotensin II receptor type 1 receptor (AT1R) blocker candesartan or saline at reperfusion. Stroke outcomes, as well as AT2R expression, were examined and compared to control Wistars at 24 h. In the second experiment, localized AT2R knockdown was achieved through intrastriatal injection of short hairpin RNA (shRNA) lentiviral particles or non-targeting control into the left-brain hemisphere of Wistar rats. After 14 days, rats were subjected to right MCAO and treated with the AT2R agonist, Compound 21 (C21), or saline for 7 days. Behavioral outcomes were assessed for up to 10 days. In the first experiment, stroke reduced the expression of AT2R in GK rats. Candesartan treatment failed to improve the neurobehavioral outcomes, preserve vascular integrity or reduce oxidative/nitrative stress or apoptotic markers at 24 h post stroke in these animals. In the second experiment, contralesional AT2R knockdown reduced the C21-mediated functional recovery after stroke. In conclusion, contralesional AT2R upregulation after stroke is blunted in diabetic rats which show reduced sensitivity to post-stroke candesartan treatment. Contralesional AT2R could be involved in C21-mediated functional recovery after stroke.

Fouda, U. M., A. M. Sayed, A. - M. A. Abdou, D. R. I. b, I. F. M. c, and M. Z. M. d, Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome, , vol. 112, issue 3, 2011. cu_pdf.pdf
Fouda, A. S., K. H. Attia, A. M. Abouelezz, M. A. El-Ghafour, and M. H. Aboulfotouh, "Anchorage control using miniscrews in comparison to Essix appliance in treatment of postpubertal patients with Class II malocclusion using Carrière Motion Appliance.", The Angle Orthodontist, 2021. Abstract
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Fouda, A., M. Abdel-Nasser, A. M. Eid, S. Hassan, A. Abdel-Nasser, N. K. Alharbi, A. H. AlRokban, and G. Abdel-Maksoud, "An Eco-friendly approach utilizing green synthesized titanium dioxide nanoparticles for leather conservation against a fungal strain, Penicillium expansum AL1, involved in the biodeterioration of a historical manuscript", Biology, vol. 12, pp. 1-26., 2023.
Fouda, K. Z., "Effect of Low Energy versus Medium Energy Radial Shock Wave Therapy in The Treatment of Chronic Planter Fasciitis", International Journal of Physiotherapy , vol. 3, issue 1, pp. 5-10, 2016. final_article_2016.pdf
Fouda, M. E., and A. G. Radwan, "Fractional-order memristor response under dc and periodic signals", Circuits, Systems, and Signal Processing, vol. 34, no. 3: Springer US, pp. 961–970, 2015. Abstract
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Fouda, M. E., A. S. Elwakil, and A. Allagui, "Commercial supercapacitor parameter estimation from step voltage excitation", International Journal of Circuit Theory and Applications, vol. 47, no. 10, pp. 1705–1712, 2019. Abstract
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Fouda, M. E., A. G. Radwan, and A. Elwakil, "Memristor and Inverse Memristor: Modeling, Implementation and Experiments", Advances in Memristors, Memristive Devices and Systems: Springer International Publishing, pp. 371–392, 2017. Abstract
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Fouda, Abdel-Maksoud, G., Saad, F., Gobouri, A. A., M. Saleh, and El-Sadany, M.A., "The efficacy of silver nitrate (AgNO3) as a coating agent for protecting papers against high deteriorating microbes", Catalysts, vol. 11, issue 310, pp. 1-18, 2021.
Fouda, M. E., A. G. Radwan, and A. S. Elwakil, "Series and parallel circuit models containing memristors and inverse memristors", Electronics, Circuits, and Systems (ICECS), 2015 IEEE International Conference on: IEEE, pp. 292–295, 2015. Abstract
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Fouda, A. Y., A. S. Newsome, S. Spellicy, J. L. Waller, W. Zhi, D. C. Hess, A. Ergul, D. J. Edwards, S. C. Fagan, and J. A. Switzer, "Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial.", Stroke, vol. 48, issue 10, pp. 2885-2887, 2017 10. Abstract

BACKGROUND AND PURPOSE: Minocycline is under investigation as a neurovascular protective agent for stroke. This study evaluated the pharmacokinetic, anti-inflammatory, and safety profile of minocycline after intracerebral hemorrhage.

METHODS: This study was a single-site, randomized controlled trial of minocycline conducted from 2013 to 2016. Adults ≥18 years with primary intracerebral hemorrhage who could have study drug administered within 24 hours of onset were included. Patients received 400 mg of intravenous minocycline, followed by 400 mg minocycline oral daily for 4 days. Serum concentrations of minocycline after the last oral dose and biomarkers were sampled to determine the peak concentration, half-life, and anti-inflammatory profile.

RESULTS: A total of 16 consecutive eligible patients were enrolled, with 8 randomized to minocycline. Although the literature supports a time to peak concentration (T) of 1 hour for oral minocycline, the T was estimated to be at least 6 hours in this cohort. The elimination half-life (available on 7 patients) was 17.5 hours (SD±3.5). No differences were observed in inflammatory biomarkers, hematoma volume, or perihematomal edema. Concentrations remained at neuroprotective levels (>3 mg/L) throughout the dosing interval in 5 of 7 patients.

CONCLUSIONS: In intracerebral hemorrhage, a 400 mg dose of minocycline was safe and achieved neuroprotective serum concentrations. However, oral administration led to delayed absorption in these critically ill patients and should not be used when rapid, high concentrations are desired. Given the safety and pharmacokinetic profile of minocycline in intracerebral hemorrhage and promising data in the treatment of ischemic stroke, intravenous minocycline is an excellent candidate for a prehospital treatment trial.

CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01805895.

Fouda, U. M., M. M. Abou ElKassem, S. M. Hefny, R. M. Fouda, and A. T. Hashem, "Role of fetal echocardiography in the evaluation of structure and function of fetal heart in diabetic pregnancies.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 26, issue 6, pp. 571-5, 2013 Apr. Abstract

OBJECTIVE: To detect the structural and functional changes of fetal hearts in diabetic pregnancies by using Doppler echocardiography.

METHODS: This prospective study included 119 pregnant women divided into three groups. Group 1 included 47 pregnant patients with pre-existing diabetes mellitus (DM), group 2 included 40 patients with gestational diabetes and group 3 included 32 non-diabetic pregnant women. M-mode echocardiography was used to measure the thickness of the fetal ventricular walls and interventricular septum. The mitral and tricuspid early (E) and late (A) diastolic velocities and the ventricular shortening fraction were measured.

RESULTS: HbA1c % was significantly lower in gestational diabetes group compared with the pre-existing diabetes group. The interventricular septum was significantly thicker in the pre-existing diabetes group compared with other groups. Tricuspid and mitral E/A ratios were significantly lower in the pre-existing diabetes group compared with gestational diabetes and control groups. Moreover, there were no significant differences in the tricuspid and mitral E/A ratios between gestational diabetes group and the control group. The right and left ventricular shortening fractions were similar in the three groups.

CONCLUSION: Fetuses of women with well-controlled gestational diabetes lack the diastolic dysfunction that is present in fetuses of women with pre-existing diabetes.

Fouda, U. M., A. M. Sayed, D. I. Ramadan, and I. M. Fouda, "Efficacy and safety of two doses of low molecular weight heparin (enoxaparin) in pregnant women with a history of recurrent abortion secondary to antiphospholipid syndrome.", Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, vol. 30, issue 8, pp. 842-6, 2010. Abstract

The aim of this randomised controlled trial was to compare efficacy and safety of two doses of low molecular weight heparin (enoxaparin) in pregnant women with a history of recurrent abortion secondary to antiphospholipid syndrome. A total of 60 women with a minimum of three consecutive abortions before 10 weeks' gestation and positive lupus anticoagulant and/or anticardiolipin antibodies on at least two occasions at least 12 weeks apart were randomised into two groups based on computer generated randomisation list concealed in opaque envelopes. Pregnant women were treated with enoxaparin 40 mg plus low dose aspirin (LDA) (n = 30) or enoxaparin 20 mg plus LDA (n = 30). The live birth rate was 76.67% in enoxaparin 40 mg group and 70% in enoxaparin 20 mg group (p value = 0.559). There were no significant differences between both groups with respect to neonatal outcome, obstetric and maternal complications during pregnancy or puerperium. No cases of severe bleeding, thrombocytopenia or spontaneous fractures were reported in both groups.

Fouda, M. E., M. A. Khatib, and A. G. Radwan, "On the mathematical modeling of series and parallel memcapacitors", Microelectronics (ICM), 2013 25th International Conference on: IEEE, pp. 1–4, 2013. Abstract
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Fouda, M. E., A. AboBakr, A. S. Elwakil, A. G. Radwan, and A. M. Eltawil, "Simple MOS Transistor-Based Realization of Fractional-Order Capacitors", 2019 IEEE International Symposium on Circuits and Systems (ISCAS): IEEE, pp. 1–4, 2019. Abstract
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Fouda, A. S., M. H. AboulFotouh, K. H. Attia, and A. M. Aboulezezz, "Carriere Motion Appliance with Miniscrew Anchorage for Treatment of Class II, Division 1 Malocclusion", Journal of clinical orthodontics: JCO, vol. 54, issue 10, pp. 633-641, 2020. Abstract
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Fouda, R., H. Ammar, E. Sobhy, and A. M. Amin, "Unusual cause of pericardial effusion.", BMJ case reports, vol. 2012, 2012 Sep 04. Abstract

A 65-year-old Egyptian lady suffering from non-alcoholic liver cirrhosis was referred to our unit for evaluation of a massive pericardial effusion. Few weeks before presentation, she suffered from progressive abdominal distention and dyspnoea. She denied fever, rigors or other cardiorespiratory symptoms. Examination revealed shrunken liver, spleenomegaly and ascites. Chest was clear to auscultation and heart sounds were distant. Chest radiograph showed cardiomegaly and clear lung fields. Abdominal ultrasound confirmed the results of abdominal examination. Transthoracic echocardiogram (TTE) revealed a massive pericardial effusion (PEF) and rheumatic mitral stenosis. Chest tomography showed PEF and clear lung fields. One litre of exudate was removed via TTE-guided needle pericardiocentesis. A pericardio-peritoneal shunt was suspected, which was confirmed via a radioisotopic study. This case is among very few cases that reported PEF in a cirrhotic ascetic patient secondary to a radio-isotopically confirmed pericardio-peritoneal shunt in the literature.

Fouda, M. E., A. E. Eltawil, and F. J. Kurdahi, "On One Step Row Readout Technique of Selector-less Resistive Arrays", 2017 IEEE 60th International Midwest Symposium on Circuits and Systems (MWSCAS), 2017. Abstract
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Fouda, R., H. Ammar, E. Sobhy, and A. M. Amin, "Unusual cause of pericardial effusion.", BMJ case reports, vol. 2012, 2012. Abstract

A 65-year-old Egyptian lady suffering from non-alcoholic liver cirrhosis was referred to our unit for evaluation of a massive pericardial effusion. Few weeks before presentation, she suffered from progressive abdominal distention and dyspnoea. She denied fever, rigors or other cardiorespiratory symptoms. Examination revealed shrunken liver, spleenomegaly and ascites. Chest was clear to auscultation and heart sounds were distant. Chest radiograph showed cardiomegaly and clear lung fields. Abdominal ultrasound confirmed the results of abdominal examination. Transthoracic echocardiogram (TTE) revealed a massive pericardial effusion (PEF) and rheumatic mitral stenosis. Chest tomography showed PEF and clear lung fields. One litre of exudate was removed via TTE-guided needle pericardiocentesis. A pericardio-peritoneal shunt was suspected, which was confirmed via a radioisotopic study. This case is among very few cases that reported PEF in a cirrhotic ascetic patient secondary to a radio-isotopically confirmed pericardio-peritoneal shunt in the literature.

Fouda, A., G. Abdel-Maksoud, M. A. Abdel-Rahman, A. M. Eid, M. G. Barghoth, and M. A. - H. El-Sadany, "Monitoring the effect of biosynthesized nanoparticles against biodeterioration of cellulose-based materials by Aspergillus niger", Cellulose , vol. 26, pp. 6583–6597, 2019.
Fouda, U. M., N. M. Salah Eldin, K. A. Elsetohy, H. A. Tolba, M. M. Shaban, and S. M. Sobh, "Diclofenac plus lidocaine gel for pain relief during intrauterine device insertion. A randomized, double-blinded, placebo-controlled study.", Contraception, vol. 93, issue 6, pp. 513-8, 2016 Jun. Abstract

OBJECTIVE: To determine the effectiveness of diclofenac potassium combined with 2% lidocaine gel in reducing the pain of intrauterine device (IUD) insertion.

STUDY DESIGN: We randomized 90 parous women requesting copper T380A IUD insertion in a 1:1 ratio to active or placebo treatment. Active treatment included administration of two 50-mg diclofenac potassium tablets 1h before IUD insertion, application of 3mL of 2% lidocaine gel on the anterior cervical lip 3min before IUD insertion and placement of a cotton swab soaked in 2% lidocaine gel in the cervical canal 3min before IUD insertion. Women in the placebo group received placebo tablets and gel. Participants assessed pain intensity using a 10-cm visual analog scale (VAS). We considered a 2-cm difference in VAS pain score between both groups during IUD insertion to be a clinically significant difference.

RESULTS: Subjects receiving active treatment, as compared to placebo, experienced less pain during tenaculum placement (1.66±0.85 vs. 2.33±1.19, p=.003) and IUD insertion (3.14±0.92 vs. 3.94±1.3, p=.001). Women who delivered only by cesarean section had higher pain scores with IUD insertion compared with women with previous vaginal deliveries (4.41±1.24 vs. 3.29±1.05, p=.001).

CONCLUSION: Diclofenac potassium combined with 2% lidocaine gel slightly reduced pain scores during tenaculum application and copper IUD insertion in parous women; however, the reduction in pain scores lacked clinical significance.

IMPLICATIONS: Although we found a statistically significant lowering of pain scores with pretreatment with diclofenac potassium and lidocaine gel in parous women having copper IUD placement, the reduction is not clinically relevant. These findings may be more relevant for nulliparous women who experience more pain than parous women with IUD insertion and support studies of diclofenac potassium and lidocaine gel in this population.

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