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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, F. I., A. M. Abdelrahman, M. F. Mohamed, S. A. Habib, M. H. Ibrahim, Z. S. Sleem, H. M. Bazaraa, and M. M. Soli, "Plasma neutrophil gelatinase-associated lipocalin as an early biomarker for prediction of acute kidney injury after cardio-pulmonary bypass in pediatric cardiac surgery", Arch Med Sci, vol. 8, issue 2, pp. 250-255, 2012.
Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-step synthesis of polypyrrole-coated gold nanoparticles for use as a photothermally active nano-system", International Journal of Nanomedicine, vol. 15, pp. 2605 – 2615, 2020. AbstractWebsite
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Fadel, S., H. Hafiz, R. Khedr, H. Taha, N. Elkinaai, A. Younes, M. Elwakeel, N. Mohamed, and M. Tantawy, "CHARACTERISTICS AND OUTCOME OF HEPATOBLASTOMA PATIENTS: EXPERIENCE OF CHILDREN CANCER HOSPITAL EGYPT", PEDIATRIC BLOOD & CANCER, vol. 63: WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, pp. S172-S173, 2016. Abstract
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Fadel, S. A., M. M.Kamel, H. A. Hafez, and A. B. E. E. R. A. MOHAMED, "SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR-A LEVELS BEFORE AND AFTER INDUCTION THERAPY IN EGYPTIAN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA", EL AZHAR MEDICAL JOURNAL, vol. 42(4), issue 110-0400, pp. 705-712, 2013.
Fadel, M., M. Salah, N. Samy, and S. Mona, "Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris.", Journal of Drugs in Dermatology: JDD, vol. 8, no. 11, pp. 983–990, 2009. Abstract
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Fadel, M., G. Abdelbary, S. F. Elmenshawe, and E. Eissa, "Toluidine Blue Loaded Transferosomes for Topical Photodynamic Therapy: for-Mulation and Characterization", International Journal of Research in Pharmaceutical Sciences, 2011. Abstract

Targeted drug delivery systems have distinct advantages over conventional dosage forms. In the present ap-proach, flexible liposomal drug carriers (transferosomes) were formulated and their physicochemical properties were studied compared with conventional liposomal and niosomal formulae. Lipid vesicles composed of lecithin, cholesterol, span 60, and sodium deoxycholate (SDC) were prepared by thin film hydration method. Photodynamic treatment of subcutaneous Ehrlich tumor using prepared and pharmaceutically studied hydrogel containing 1% hydrophilic toluidine blue (TB) loaded transferosomes was evaluated. The results showed that transferosomes containing both span 60 and SDC were of the highest entrapment efficiency (> 82%), particle size (1.36 ?m) and released 52% of its content within 2 hours. The in vivo study on BALB/C mice showed that there was a marked increase in the survival time and decrease in the tumor size in mice group treated with transferosomal (span 60 and SDC) hydrogel for 1h followed by irradiation with 90J/cm2 from 650 nm diode laser twice weekly compared with animals treated with free TB and irradiated only. Furthermore, there was a marked deep necrosis of tumor cells, which may be attributed to the deep penetration of TB through skin layers. These findings suggest the use of TB loaded transferosomes in topical targeted photodynamic treatment of skin tumors.

Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-step synthesis of polypyrrole-coated gold nanoparticles for use as a photothermally active nano-system", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 2605, 2020. Abstract
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Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of resistant plantar warts", Current Drug Delivery, vol. 17, no. 5, pp. 396 – 405, 2020. AbstractWebsite
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of rose bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3: Faculty of Pharmacy, University of Benin, 2011. Abstract
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Fadel, M., K. Kassab, and T. Youssef, "Photodynamic efficacy of hypericin targeted by two delivery techniques to hepatocellular carcinoma cells", Lasers in medical science, vol. 25, no. 5: Springer-Verlag, pp. 675–683, 2010. Abstract
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Fadel, F. I., S. H. Makar, A. E. Eskander, and A. H. Aon, "Decreasing intra-dialytic morbid events and assessment of dry weight in children on chronic hemodialysis using non-invasive changes in hematocrit.", Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 25, issue 5, pp. 1030-7, 2014 Sep. Abstract

Achieving dry weight after hemodialysis (HD) is critical as chronic fluid over-load can result in left ventricular hypertrophy, while small fluid shifts may result in intra-dialytic morbid events (IME). In the pediatric population, estimating dry weight can be difficult due to growth while on dialysis. Continuous non-invasive monitoring of the hematocrit (NIVM) has been proposed as a more accurate method of estimating dry weight. Fifteen pediatric patients on chronic HD (6 males and 9 females; mean age 11.4 ± 2.28 years) were included in an uncontrolled prospective study involving three phases. In phase 1, patients were observed for one month for their dry weight and frequency of IME. Phase 2 consisted of using NIVM-guided ultrafiltration algorithm for rate of blood volume (BV) reduction and post-dialysis refill, recommending an intra-dialytic reduction in BV of 8% in the first hour and <4% per hour thereafter and without significant post-dialytic vascular refill. Phase 3 comprised a one month period for comparing the results. IME decreased from 33 episodes per 180 sessions in phase 1 to 4 per 180 sessions during phase 3 (P = 0.04), without a significant difference in pre-systolic or post-systolic or mean BP before and after the intervention (all P >0.1). In phase 1, 40% of patients experienced no IME, 33% experienced one or two IME while 27% experienced more than two IME; during phase 3, 80% experienced no IME, 20% experienced one or two IME while no one experienced more than two IME. NIVM can serve as an objective method for determining dry weight as well as predicting and preventing IME in the pediatric population on maintenance HD.

Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, F., H. Bazaraa, R. Hachem, D. Salah, and H. Safouh, "Endothelial Dysfunction In Pediatric Renal Transplant Recipients", PEDIATRIC NEPHROLOGY, vol. 29, no. 9: SPRINGER 233 SPRING ST, NEW YORK, NY 10013 USA, pp. 1761–1761, 2014. Abstract
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Fadel, M., M. Nasr, and S. S. Thabet, "Cationic zinc (II) phthalocyanine nanoemulsions for photodynamic inactivation of resistant bacterial strains", Photodiagnosis and Photodynamic Therapy,, vol. 34, , pp. 102301, 2021.
Fadel, F. I., A. M. Badr, M. M. Abdelkareem, M. Samir, M. Abdallah, F. M. Atia, and Y. M. Ramadan, Tei Index and its Relation to Outcome of Critically Ill Children on Continuous Renal Replacement Therapy, : Springer, pp. 1 - 7, 2023. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, 2011. Abstract
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Fadel, M., G. Abdelbary, F. Shahira, E. Eissa, and others, Toluidine blue loaded transferosomes for topical photodynamic therapy: formulation and characterization, : JK Welfare & Pharmascope Foundation, 2011. Abstract
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Fadel, M., and K. Kassab, "Evaluation of the photostability and photodynamic efficacy of Rose Bengal loaded in multivesicular liposomes", Tropical Journal of Pharmaceutical Research, vol. 10, no. 3, pp. 289 – 297, 2011. AbstractWebsite
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Fadel, M., D. A. El Fadeel, M. Ibrahim, R. M. Hathout, and A. I. El-Kholy, "One-Step Synthesis of Polypyrrole-Coated Gold Nanoparticles for Use as a Photothermally Active Nano-System", International Journal of Nanomedicine, vol. 15, pp. 2605-26015, 2020.
Fadel, F. I., H. M. Bazaraa, H. Badawy, H. A. Morsi, G. Saadi, M. A. Abdel Mawla, amr mohamed salem, E. A. Abd Alazem, R. Helmy, M. G. Fathallah, et al., "Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience.", Pediatric transplantation, vol. 24, issue 6, pp. e13724, 2020. Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Fadel, M., K. Kassab, N. Samy, D. A. El Fadeel, G. Yassin, and M. Nasr, "Nanovesicular photodynamic clinical treatment of recalcitrant plantar warts", Current drug delivery, vol. 17, issue 5, pp. 396-405, 2020.
Fadel, F. I., M. F. Elshamaa, M. M. Nabhan, R. G. Essam, N. Kantoush, M. M. El Sonbaty, M. Raafat, and D. A. Abd-El Haleem, "Soluble adhesion molecules as markers of native arteriovenous fistula thrombosis in children on uremia.", Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, vol. 25, issue 7, pp. 675-82, 2014 Oct. Abstract

Vascular access represents a lifeline for children undergoing hemodialysis. A failure of vascular access among patients receiving regular hemodialysis is associated with increased morbidity, mortality and costs. We assessed the possibility of using soluble adhesion molecules as reliable predictors of vascular access failure in children on hemodialysis. Moreover, we evaluated whether there is an association among the different studied adhesion molecules in hemodialysis patients with thrombosed and non-thrombosed arteriovenous fistula fistulas (AVFs). This study included 55 hemodialysis children, 36 with good access and 19 with access failure, and 20 healthy volunteers. Forty-four patients had native AVFs and 11 patients had tunneled permanent catheter (11with thrombosed and 33 with non-thrombosed AVFs). Serum-soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin) and soluble P-selectin (sP-selectin) were measured using ELISA technique. A significant increase was found in the levels of sVCAM-1, sICAM-1, sE-selectin and sP-selectin versus controls and all hemodialysis patients, hemodialysis patients with good access and hemodialysis patients with access failure (P=0.001 for sVCAM-1 and sICAM-1 and P=0.0001 for sE-selectin and sP-selectin). A significant increase was found in the levels of sVCAM-1, sE-selectin and sP-selectin in both chronic hemodialysis patients with thrombosed and non-thrombosed native AVFs versus controls (P=0.0001 for all parameters). There was significant difference between both chronic hemodialysis patients with thrombosed and non-thrombosed native AVFs as regard to sVCAM-1 (54.64±30.82 versus 25.69±27.96ng/ml, P=0.04). Both sICAM-1 and sP-selectin were positively correlated with the erythropoietin (EPO) dose in hemodialysis children (r=0.31, P=0.04 and r=0.32, P=0.04, respectively). A significant positive association was found between E-selectin and sP-selectin in hemodialysis patients with thrombosed AVFs (r=0.83, P=0.04). There was a significant correlation between sVCAM-1 and EPO dose in thrombosed AVF group (r=0.84, P=0.01). The assessment of serum sVCAM-1 might be useful for the identification of the chronic hemodialysis patients at an increased risk for native AVFs thrombosis. The role of EPO in vascular access failure should be taken into consideration. The clinical relevance of these observations warrants further investigations.

Fadel, F., H. M. Bazraa, S. M. Abdelrahman, M. G. Shoman, M. k Sayed, D. M. Salah, A. m Wahby, and H. F. Elgebaly, "Visfatin versus Flow-Mediated Dilatation as a Marker of Endothelial Dysfunction in Pediatric Renal Transplant Recipients", Open Access Macedonian Journal of medical Science, vol. 5, issue 1857-9655, pp. 222-227, 2017.
Fadel, M., K. Kassab, and D. A. Fadeel, "Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice", Lasers in medical science, vol. 25, no. 2: Springer-Verlag, pp. 283–292, 2010. Abstract
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